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To avoid clustering, the particles of mixed MnZn ferrite were synthesized directly in a medical-grade silicone polymer solution. The particles were characterized by transmission electron microscopy, powder X-ray diffraction, soft X-ray absorption spectroscopy, vibrating sample magnetometry, temperature-dependent nuclear magnetic resonance relaxometry (20 \u00b0C to 60 \u00b0C, at 3.0 T), and magnetic resonance imaging (at 3.0 T). Synthesized nanoparticles were the size of 4.4 nm \u00b1 2.1 nm and exhibited superparamagnetic behavior. Bulk silicone material showed a good shape stability within the study\u2019s temperature range. Embedded nanoparticles did not influence spin\u2013lattice relaxation, but they shorten the longer component of spin\u2013spin nuclear relaxation times of silicone\u2019s protons. However, these protons exhibited an extremely high r2* relaxivity (above 1200 L s\u22121 mmol\u22121) due to the presence of particles, with a moderate decrease in the magnetization with temperature. With an increased temperature decrease of r2*, this ferro\u2013silicone can be potentially used as a temperature indicator in high-temperature MRIg ablations (40 \u00b0C to 60 \u00b0C).<\/jats:p>","DOI":"10.3390\/ijms24065685","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T03:33:57Z","timestamp":1679024037000},"page":"5685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9872-3762","authenticated-orcid":false,"given":"Joshua A.","family":"Stoll","sequence":"first","affiliation":[{"name":"Colorado Springs Center for the BioFrontiers Institute, University of Colorado, 1420 Austin Bluffs Pkwy, Colorado Springs, CO 80918, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-5297","authenticated-orcid":false,"given":"Dorota","family":"Lachowicz","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-2084","authenticated-orcid":false,"given":"Angelika","family":"Kmita","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gajewska","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-3496","authenticated-orcid":false,"given":"Marcin","family":"Sikora","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-1405","authenticated-orcid":false,"given":"Katarzyna","family":"Berent","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-7886","authenticated-orcid":false,"given":"Marek","family":"Przybylski","sequence":"additional","affiliation":[{"name":"Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Russek","sequence":"additional","affiliation":[{"name":"National Institute of Standards and Technology, 325 Broadway St., Boulder, CO 80305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew J.","family":"Celinski","sequence":"additional","affiliation":[{"name":"Colorado Springs Center for the BioFrontiers Institute, University of Colorado, 1420 Austin Bluffs Pkwy, Colorado Springs, CO 80918, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz H.","family":"Hankiewicz","sequence":"additional","affiliation":[{"name":"Colorado Springs Center for the BioFrontiers Institute, University of Colorado, 1420 Austin Bluffs Pkwy, Colorado Springs, CO 80918, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kelesidis, G.A., and Kholghy, M.R. 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