{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:59:09Z","timestamp":1760147949407,"version":"build-2065373602"},"reference-count":129,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"UEFISCDI, iBioStroke","doi-asserted-by":"publisher","award":["136\/2020","192\/2020"],"award-info":[{"award-number":["136\/2020","192\/2020"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"umbrella of the ERA-NET EuroNanoMed project","doi-asserted-by":"publisher","award":["136\/2020","192\/2020"],"award-info":[{"award-number":["136\/2020","192\/2020"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In the clinic, the death certificate is issued if brain electrical activity is no longer detectable. However, recent research has shown that in model organisms and humans, gene activity continues for at least 96 h postmortem. The discovery that many genes are still working up to 48 h after death questions our definition of death and has implications for organ transplants and forensics. If genes can be active up to 48 h after death, is the person technically still alive at that point? We discovered a very interesting parallel between genes that were upregulated in the brain after death and genes upregulated in the brains that were subjected to medically-induced coma, including transcripts involved in neurotransmission, proteasomal degradation, apoptosis, inflammation, and most interestingly, cancer. Since these genes are involved in cellular proliferation, their activation after death could represent the cellular reaction to escape mortality and raises the question of organ viability and genetics used for transplantation after death. One factor limiting the organ availability for transplantation is religious belief. However, more recently, organ donation for the benefit of humans in need has been seen as \u201cposthumous giving of organs and tissues can be a manifestation of love spreading also to the other side of death\u201d.<\/jats:p>","DOI":"10.3390\/ijms24065744","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T03:33:57Z","timestamp":1679024037000},"page":"5744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective"],"prefix":"10.3390","volume":"24","author":[{"given":"Cezar-Ivan","family":"Coli\u021b\u0103","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy Carol Davila, 020276 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denissa-Greta","family":"Olaru","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University for Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Coli\u021b\u0103","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy Carol Davila, 020276 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk M.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Chair of Vascular Neurology, Dementia and Ageing, Department of Neurology, University Hospital Essen, 45147 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Coli\u021b\u0103","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy Carol Davila, 020276 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Glavan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University for Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-8605","authenticated-orcid":false,"given":"Aurel","family":"Popa-Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University for Medicine and Pharmacy Craiova, 200349 Craiova, Romania"},{"name":"Chair of Vascular Neurology, Dementia and Ageing, Department of Neurology, University Hospital Essen, 45147 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160267","DOI":"10.1098\/rsob.160267","article-title":"Tracing the Dynamics of Gene Transcripts after Organismal Death","volume":"7","author":"Pozhitkov","year":"2017","journal-title":"Open Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1700066","DOI":"10.1002\/bies.201700066","article-title":"Gene Expression in the Twilight of Death: The Increase of Thousands of Transcripts Has Implications to Transplantation, Cancer, and Forensic Research","volume":"39","author":"Pozhitkov","year":"2017","journal-title":"Bioessays"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Noble, P.A., and Pozhitkov, A.E. 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