{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:32:47Z","timestamp":1787851967273,"version":"build-2784847793"},"reference-count":76,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research R&amp;D Project","award":["PJ01508901"],"award-info":[{"award-number":["PJ01508901"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aster koraiensis Nakai (AK) leaf reportedly ameliorates health problems, such as diabetes. However, the effects of AK on cognitive dysfunction or memory impairment remain unclear. This study investigated whether AK leaf extract could attenuate cognitive impairment. We found that AK extract reduced the production of nitric oxide (NO), tumour necrosis factor (TNF)-\u03b1, phosphorylated-tau (p-tau), and the expression of inflammatory proteins in lipopolysaccharide- or amyloid-\u03b2-treated cells. AK extract exhibited inhibitory activity of control specific binding on N-methyl-D-aspartate (NMDA) receptors. Scopolamine-induced AD models were used chronically in rats and acutely in mice. Relative to negative controls (NC), hippocampal choline acetyltransferase (ChAT) and B-cell lymphoma 2 (Bcl2) activity was increased in rats chronically treated with scopolamine and fed an AK extract-containing diet. In the Y-maze test, spontaneous alterations were increased in the AK extract-fed groups compared to NC. Rats administered AK extract showed increased escape latency in the passive avoidance test. In the hippocampus of rats fed a high-AK extract diet (AKH), the expression of neuroactive ligand\u2013receptor interaction-related genes, including Npy2r, Htr2c, and Rxfp1, was significantly altered. In the Morris water maze assay of mice acutely treated with scopolamine, the swimming times in the target quadrant of AK extract-treated groups increased significantly to the levels of the Donepezil and normal groups. We used Tg6799 A\u03b2-overexpressing 5XFAD transgenic mice to investigate A\u03b2 accumulation in animals. In the AD model using 5XFAD, the administration of AK extract decreased amyloid-\u03b2 (A\u03b2) accumulation and increased the number of NeuN antibody-reactive cells in the subiculum relative to the control group. In conclusion, AK extract ameliorated memory dysfunction by modulating ChAT activity and Bcl2-related anti-apoptotic pathways, affecting the expression of neuroactive ligand\u2013receptor interaction-related genes and inhibiting A\u03b2 accumulation. Therefore, AK extract could be a functional material improving cognition and memory.<\/jats:p>","DOI":"10.3390\/ijms24065765","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:33:31Z","timestamp":1679286811000},"page":"5765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action"],"prefix":"10.3390","volume":"24","author":[{"given":"Seung-Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saetbyeol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwi Yeong","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minho","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Konyang University, Gwanjeodong-ro 158, Soe-gu, Daejeon 35365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-2328","authenticated-orcid":false,"given":"Yun-Jeong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Wook","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Biotechnology and Convergence, College of Cosmetics and Pharm, Daegu Haany University, Kyungsan 38610, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunkwon","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Konyang University, Gwanjeodong-ro 158, Soe-gu, Daejeon 35365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Konyang University, Gwanjeodong-ro 158, Soe-gu, Daejeon 35365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hwi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science (NIHHS), Eumseong 27709, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","unstructured":"Alzheimer\u2019s Disease International (2022, August 05). 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