{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:41:02Z","timestamp":1776692462967,"version":"3.51.2"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eli Lilly and Company, AbbVie GK, Sun Pharma, Maruho Takagi Dermatology Foundation, JSPS KAKENHI","award":["JP22H04922 (AdAMS)"],"award-info":[{"award-number":["JP22H04922 (AdAMS)"]}]},{"name":"Eli Lilly and Company, AbbVie GK, Sun Pharma, Maruho Takagi Dermatology Foundation, JSPS KAKENHI","award":["FY2021-2023 JPMXP0621467949"],"award-info":[{"award-number":["FY2021-2023 JPMXP0621467949"]}]},{"name":"Eli Lilly and Company, AbbVie GK, Sun Pharma, Maruho Takagi Dermatology Foundation, JSPS KAKENHI","award":["22K08379"],"award-info":[{"award-number":["22K08379"]}]},{"name":"MEXT Promotion of Distinctive Joint Research Center Program","award":["JP22H04922 (AdAMS)"],"award-info":[{"award-number":["JP22H04922 (AdAMS)"]}]},{"name":"MEXT Promotion of Distinctive Joint Research Center Program","award":["FY2021-2023 JPMXP0621467949"],"award-info":[{"award-number":["FY2021-2023 JPMXP0621467949"]}]},{"name":"MEXT Promotion of Distinctive Joint Research Center Program","award":["22K08379"],"award-info":[{"award-number":["22K08379"]}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["JP22H04922 (AdAMS)"],"award-info":[{"award-number":["JP22H04922 (AdAMS)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["FY2021-2023 JPMXP0621467949"],"award-info":[{"award-number":["FY2021-2023 JPMXP0621467949"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["22K08379"],"award-info":[{"award-number":["22K08379"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Intense itching significantly reduces the quality of life, and atopic dermatitis is associated with psychiatric conditions, such as anxiety and depression. Psoriasis, another inflammatory skin disease, is often complicated by psychiatric symptoms, including depression; however, the pathogenesis of these mediating factors is poorly understood. This study used a spontaneous dermatitis mouse model (KCASP1Tg) and evaluated the psychiatric symptoms. We also used Janus kinase (JAK) inhibitors to manage the behaviors. Gene expression analysis and RT-PCR of the cerebral cortex of KCASP1Tg and wild-type (WT) mice were performed to examine differences in mRNA expression. KCASP1Tg mice had lower activity, higher anxiety-like behavior, and abnormal behavior. The mRNA expression of S100a8 and Lipocalin 2 (Lcn2) in the brain regions was higher in KCASP1Tg mice. Furthermore, IL-1\u03b2 stimulation increased Lcn2 mRNA expression in astrocyte cultures. KCASP1Tg mice had predominantly elevated plasma Lcn2 compared to WT mice, which improved with JAK inhibition, but behavioral abnormalities in KCASP1Tg mice did not improve, despite JAK inhibition. In summary, our data revealed that Lcn2 is closely associated with anxiety symptoms, but the anxiety and depression symptoms caused by chronic skin inflammation may be irreversible. This study demonstrated that active control of skin inflammation is essential for preventing anxiety.<\/jats:p>","DOI":"10.3390\/ijms24065942","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T07:09:31Z","timestamp":1679468971000},"page":"5942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course"],"prefix":"10.3390","volume":"24","author":[{"given":"Shohei","family":"Iida","sequence":"first","affiliation":[{"name":"Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-6949","authenticated-orcid":false,"given":"Hirotaka","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-0830","authenticated-orcid":false,"given":"Yoshiaki","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Habe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-5448","authenticated-orcid":false,"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Miyakawa","sequence":"additional","affiliation":[{"name":"Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-5202","authenticated-orcid":false,"given":"Keiichi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.anai.2019.04.020","article-title":"Comorbidities and the impact of atopic dermatitis","volume":"123","author":"Silverberg","year":"2019","journal-title":"Ann. 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