{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:22:49Z","timestamp":1792178569809,"version":"4.4.0"},"reference-count":283,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"framework of the \u201cNauka-2030\u201d, No. 1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cardiovascular, rheumatic, kidney, and neurodegenerative diseases and mental disorders are a common cause of deterioration in the quality of life up to severe disability and death worldwide. Many pathological conditions, including this group of diseases, are based on increased cell death through apoptosis. It is known that this process is associated with signaling pathways controlled by a group of gaseous signaling molecules called gasotransmitters. They are unique messengers that can control the process of apoptosis at different stages of its implementation. However, their role in the regulation of apoptotic signaling in these pathological conditions is often controversial and not completely clear. This review analyzes the role of nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and sulfur dioxide (SO2) in apoptotic cell death in cardiovascular, rheumatic, kidney, and neurodegenerative diseases. The signaling processes involved in apoptosis in schizophrenia, bipolar, depressive, and anxiety disorders are also considered. The role of gasotransmitters in apoptosis in these diseases is largely determined by cell specificity and concentration. NO has the greatest dualism; scales are more prone to apoptosis. At the same time, CO, H2S, and SO2 are more involved in cytoprotective processes.<\/jats:p>","DOI":"10.3390\/ijms24076014","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T03:07:57Z","timestamp":1679540877000},"page":"6014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-5410","authenticated-orcid":false,"given":"Stanislav","family":"Rodkin","sequence":"first","affiliation":[{"name":"Faculty of Bioengineering and Veterinary Medicine, Department of Bioengineering, Don State Technical University, Rostov-on-Don 344000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizaram","family":"Nwosu","sequence":"additional","affiliation":[{"name":"Faculty of Bioengineering and Veterinary Medicine, Department of Bioengineering, Don State Technical University, Rostov-on-Don 344000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9007-5246","authenticated-orcid":false,"given":"Alexander","family":"Sannikov","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Rostov State Medical University, Rostov-on-Don 344022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-3024","authenticated-orcid":false,"given":"Anton","family":"Tyurin","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Bashkir State Medical University, Ufa 450008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0952-6856","authenticated-orcid":false,"given":"Vasilii Sergeevich","family":"Chulkov","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy, South-Ural State Medical University, Chelyabinsk 454092, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Raevskaya","sequence":"additional","affiliation":[{"name":"Faculty of Bioengineering and Veterinary Medicine, Department of Bioengineering, Don State Technical University, Rostov-on-Don 344000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-3989","authenticated-orcid":false,"given":"Alexey","family":"Ermakov","sequence":"additional","affiliation":[{"name":"Faculty of Bioengineering and Veterinary Medicine, Department of Bioengineering, Don State Technical University, Rostov-on-Don 344000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniya","family":"Kirichenko","sequence":"additional","affiliation":[{"name":"Faculty of Bioengineering and Veterinary Medicine, Department of Bioengineering, Don State Technical University, Rostov-on-Don 344000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-0404","authenticated-orcid":false,"given":"Mitkhat","family":"Gasanov","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases #1, Rostov State Medical University, Rostov-on-Don 344022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3806157","DOI":"10.1155\/2016\/3806157","article-title":"Getting to NO Alzheimer\u2019s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide","volume":"2016","author":"Balez","year":"2016","journal-title":"Oxid. 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