{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:10:17Z","timestamp":1788282617956,"version":"build-2803163510"},"reference-count":86,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Several neurodegenerative disorders are characterized by the accumulation of misfolded proteins and are collectively known as proteinopathies. Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and Huntington\u2019s disease (HD) represent some of the most common neurodegenerative disorders whose steady increase in prevalence is having a major socio-economic impact on our society. Multiple laboratories have reported hundreds of changes in gene expression in selective brain regions of AD, PD, and HD brains. While the mechanisms underlying these changes remain an active area of investigation, alterations in the expression of noncoding RNAs, which are common in AD, PD, and HD, may account for some of the changes in gene expression in proteinopathies. In this review, we discuss the role of miR-128, which is highly expressed in mammalian brains, in AD, PD, and HD. We highlight how alterations in miR-128 may account, at least in part, for the gene expression changes associated with proteinopathies. Indeed, miR-128 is involved, among other things, in the regulation of neuronal plasticity, cytoskeletal organization, and neuronal death, events linked to various proteinopathies. For example, reducing the expression of miR-128 in a mouse model of AD ameliorates cognitive deficits and reduces neuropathology. Overall, the data in the literature suggest that targeting miR-128 might be beneficial to mitigate the behavioral phenotype associated with these diseases.<\/jats:p>","DOI":"10.3390\/ijms24076024","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T03:07:57Z","timestamp":1679540877000},"page":"6024","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Role of miR-128 in Neurodegenerative Diseases"],"prefix":"10.3390","volume":"24","author":[{"given":"Marika","family":"Lanza","sequence":"first","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres, 31-98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-3690","authenticated-orcid":false,"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres, 31-98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-7430","authenticated-orcid":false,"given":"Salvatore","family":"Oddo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres, 31-98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-6387","authenticated-orcid":false,"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres, 31-98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Casili","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres, 31-98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fgene.2015.00002","article-title":"Non-coding RNA: What is functional and what is junk?","volume":"6","author":"Palazzo","year":"2015","journal-title":"Front. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.jmb.2016.02.019","article-title":"Noncoding RNAs: Regulators of the Mammalian Transcription Machinery","volume":"428","author":"Eidem","year":"2016","journal-title":"J. Mol. Biol."},{"key":"ref_4","first-page":"100707","article-title":"Identification and characterization of long noncoding RNAs provide insight into the regulation of gene expression in response to heat stress in rainbow trout (Oncorhynchus mykiss)","volume":"36","author":"Quan","year":"2020","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7046-9_1","article-title":"MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease","volume":"1617","author":"Xue","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12033-007-9013-8","article-title":"The MicroRNA (miRNA): Overview of the RNA Genes that Modulate Gene Function","volume":"38","author":"Ying","year":"2008","journal-title":"Mol. Biotechnol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1182\/blood-2006-01-030015","article-title":"MicroRNAs: Regulators of gene expression and cell differentiation","volume":"108","author":"Shivdasani","year":"2006","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1261\/rna.032185.111","article-title":"Does base-pairing strength play a role in microRNA repression?","volume":"18","author":"Carmel","year":"2012","journal-title":"RNA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrn.2017.90","article-title":"Noncoding RNAs in neurodegeneration","volume":"18","author":"Salta","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhang, H., Yao, L., Zheng, Z., Koc, S., and Lu, G. (2022). The Role of Non-Coding RNAs in the Pathogenesis of Parkinson\u2019s Disease: Recent Advancement. Pharmaceuticals, 15.","DOI":"10.3390\/ph15070811"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Denham, A.N., Drake, J., Gavrilov, M., Taylor, Z.N., Bacanu, S.-A., and Vladimirov, V.I. (2022). Long Non-Coding RNAs: The New Frontier into Understanding the Etiology of Alcohol Use Disorder. Non-Coding RNA, 8.","DOI":"10.3390\/ncrna8040059"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1093\/hmg\/ddac202","article-title":"Non-coding RNAs and Alzheimer\u2019s disease: Perspectives from omics studies","volume":"31","author":"Wang","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1474-4422(11)70286-1","article-title":"Non-coding RNAs with essential roles in neurodegenerative disorders","volume":"11","author":"Salta","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrg3863","article-title":"RNA-mediated epigenetic regulation of gene expression","volume":"16","author":"Holoch","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.32607\/20758251-2017-9-4-13-25","article-title":"Non-Coding RNAs as Transcriptional Regulators In Eukaryotes","volume":"9","author":"Burenina","year":"2017","journal-title":"Acta Nat."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/embor.2011.110","article-title":"Regulation of mammalian DNA methyltransferases: A route to new mechanisms","volume":"12","author":"Denis","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1181046","article-title":"MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice","volume":"326","author":"Williams","year":"2009","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"16230","DOI":"10.1073\/pnas.0808830105","article-title":"MicroRNA-directed transcriptional gene silencing in mammalian cells","volume":"105","author":"Kim","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.nbd.2011.12.006","article-title":"Long non-coding RNAs in Huntington\u2019s disease neurodegeneration","volume":"46","author":"Johnson","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, Biogenesis, Mechanism, and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pharmthera.2007.01.003","article-title":"Therapeutic RNA interference for neurodegenerative diseases: From promise to progress","volume":"114","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Mathis, S., and Le Masson, G. (2018). RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis. Biomedicines, 6.","DOI":"10.3390\/biomedicines6010009"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Garofalo, M., Pandini, C., Sproviero, D., Pansarasa, O., Cereda, C., and Gagliardi, S. (2021). Advances with Long Non-Coding RNAs in Alzheimer\u2019s Disease as Peripheral Biomarker. Genes, 12.","DOI":"10.3390\/genes12081124"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-2836(02)00655-1","article-title":"Poly(A)-binding Protein is Associated with Neuronal BC1 and BC200 Ribonucleoprotein Particles","volume":"321","author":"Muddashetty","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.0701532104","article-title":"Dendritic BC200 RNA in aging and in Alzheimer\u2019s disease","volume":"104","author":"Mus","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15476286.2016.1248020","article-title":"Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment","volume":"14","author":"Takemata","year":"2016","journal-title":"RNA Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg.2016.20","article-title":"Endogenous microRNA sponges: Evidence and controversy","volume":"17","author":"Thomson","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fphys.2017.00005","article-title":"The Multifaceted Role of SNARE Proteins in Membrane Fusion","volume":"8","author":"Han","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s12035-012-8359-5","article-title":"Non-coding RNAs in Alzheimer\u2019s Disease","volume":"47","author":"Tan","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm1784","article-title":"Expression of a noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of \u03b2-secretase","volume":"14","author":"Faghihi","year":"2008","journal-title":"Nat. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Koelsch, G. (2017). BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer\u2019s Disease Pathology. Molecules, 22.","DOI":"10.3390\/molecules22101723"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3892\/mmr.2014.2351","article-title":"Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression","volume":"10","author":"Liu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.11.010","article-title":"Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain","volume":"73","author":"He","year":"2012","journal-title":"Neuron"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.1244193","article-title":"MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice","volume":"342","author":"Tan","year":"2013","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1261\/rna.5980303","article-title":"A microRNA array reveals extensive regulation of microRNAs during brain development","volume":"9","author":"Krichevsky","year":"2003","journal-title":"RNA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.yexcr.2013.07.031","article-title":"miR-128 and its target genes in tumorigenesis and metastasis","volume":"319","author":"Li","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_39","first-page":"e89169","article-title":"Myocardial microRNAs associated with reverse remodeling in human heart failure","volume":"2","author":"Sucharov","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e11324","DOI":"10.7554\/eLife.11324","article-title":"MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex","volume":"5","author":"Zhang","year":"2016","journal-title":"eLife"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Guidi, M., Mui\u00f1os-Gimeno, M., Kagerbauer, B., Mart\u00ed, E., Estivill, X., and Espinosa-Parrilla, Y. (2010). Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol. Biol., 11.","DOI":"10.1186\/1471-2199-11-95"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1158\/0008-5472.CAN-08-2629","article-title":"Targeting of the Bmi-1 Oncogene\/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal","volume":"68","author":"Godlewski","year":"2008","journal-title":"Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3892\/ol.2015.3927","article-title":"miR-128 regulates the apoptosis and proliferation of glioma cells by targeting RhoE","volume":"11","author":"Shang","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1096\/fj.09-134965","article-title":"MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness","volume":"23","author":"Evangelisti","year":"2009","journal-title":"FASEB J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1074\/mcp.M900159-MCP200","article-title":"Quantitative Proteomic Profiling of Prostate Cancer Reveals a Role for miR-128 in Prostate Cancer","volume":"9","author":"Khan","year":"2010","journal-title":"Mol. Cell. Proteom."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.ejca.2014.06.005","article-title":"microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C","volume":"50","author":"Hu","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3324\/haematol.2013.099515","article-title":"MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia","volume":"99","author":"Mets","year":"2014","journal-title":"Haematologica"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhuang, L., Xu, L., Wang, P., and Meng, Z. (2015). Serum miR-128-2 Serves as a Prognostic Marker for Patients with Hepatocellular Carcinoma. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117274"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3389\/fphar.2019.01202","article-title":"miR-128 Functions as an OncomiR for the Downregulation of HIC1 in Breast Cancer","volume":"10","author":"Li","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"a006239","DOI":"10.1101\/cshperspect.a006239","article-title":"Epidemiology of Alzheimer Disease","volume":"2","author":"Mayeux","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-2006-9S311","article-title":"Synaptic remodeling during aging and in Alzheimer\u2019s disease","volume":"9","author":"Masliah","year":"2006","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0197-4580(03)00084-8","article-title":"Hippocampus and entorhinal cortex in mild cognitive impairment and early AD","volume":"25","author":"Pennanen","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.neuron.2015.01.025","article-title":"Pathological Tau Disrupts Ongoing Network Activity","volume":"85","author":"Yamin","year":"2015","journal-title":"Neuron"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1750-1326-4-48","article-title":"Alzheimer\u2019s disease: Synaptic dysfunction and A\u03b2","volume":"4","author":"Shankar","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ana.20101","article-title":"Progressive age-related development of Alzheimer-like pathology in APP\/PS1 mice","volume":"55","author":"Trinchese","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Improta-Caria, A.C., Nonaka, C.K.V., Cavalcante, B.R.R., De Sousa, R.A.L., J\u00fanior, R.A., and Souza, B.S.D.F. (2020). Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144977"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41398-020-01184-8","article-title":"MiRNA-15b and miRNA-125b are associated with regional A\u03b2-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints","volume":"11","author":"Vergallo","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2018.11.004","article-title":"MicroRNA-128 knockout inhibits the development of Alzheimer\u2019s disease by targeting PPAR\u03b3 in mouse models","volume":"843","author":"Liu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Siedlecki-Wullich, D., Mi\u00f1ano-Molina, A., and Rodr\u00edguez-\u00c1lvarez, J. (2021). microRNAs as Early Biomarkers of Alzheimer\u2019s Disease: A Synaptic Perspective. Cells, 10.","DOI":"10.3390\/cells10010113"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Shao, N.-Y., Hu, H.Y., Yan, Z., Xu, Y., Hu, H., Menzel, C., Li, N., Chen, W., and Khaitovich, P. (2010). Comprehensive survey of human brain microRNA by deep sequencing. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-409"},{"key":"ref_61","first-page":"163","article-title":"Angiotensin-converting enzyme levels and activity in Alzheimer\u2019s disease: Differences in brain and CSF ACE and association with ACE1 genotypes","volume":"1","author":"Miners","year":"2009","journal-title":"Am. J. Transl. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2147\/NDT.S290925","article-title":"Serum miR-128 Serves as a Potential Diagnostic Biomarker for Alzheimer\u2019s Disease","volume":"17","author":"Zhang","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fneur.2020.00288","article-title":"The Regulation of microRNAs in Alzheimer\u2019s Disease","volume":"11","author":"Kou","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1007\/s12031-021-01862-2","article-title":"miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons","volume":"71","author":"Sheinin","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1101\/gr.199828.115","article-title":"Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks","volume":"26","author":"McSweeney","year":"2016","journal-title":"Genome Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nn.2891","article-title":"The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory","volume":"14","author":"Lin","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Angelopoulou, E., Paudel, Y.N., Papageorgiou, S.G., and Piperi, C. (2022). Environmental Impact on the Epigenetic Mechanisms Underlying Parkinson\u2019s Disease Pathogenesis: A Narrative Review. Brain Sci., 12.","DOI":"10.3390\/brainsci12020175"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Stoker, T.B., and Greenland, J.C. (2018). Parkinson\u2019s Disease: Pathogenesis and Clinical Aspects, Codon Publications.","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and Treatment of Parkinson Disease: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1159\/000495872","article-title":"MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson\u2019s Disease by Binding to AXIN1","volume":"51","author":"Zhou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.18632\/aging.102636","article-title":"HIF-1\u03b1\/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt\/\u03b2-catenin signaling pathway in Parkinson\u2019s disease models","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"769184","DOI":"10.3389\/fmolb.2021.769184","article-title":"Molecular Strategies to Target Protein Aggregation in Huntington\u2019s Disease","volume":"8","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajhg.2015.12.018","article-title":"The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease","volume":"98","author":"Keum","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Konovalova, J., Gerasymchuk, D., Parkkinen, I., Chmielarz, P., and Domanskyi, A. (2019). Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236055"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/mds.26020","article-title":"Huntingtin-lowering strategies in Huntington\u2019s disease: Antisense oligonucleotides, small RNAs, and gene editing","volume":"29","author":"Aronin","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1756-6606-7-46","article-title":"microRNA-128a dysregulation in transgenic Huntington\u2019s disease monkeys","volume":"7","author":"Kocerha","year":"2014","journal-title":"Mol. Brain"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1093\/nar\/gkq575","article-title":"A myriad of miRNA variants in control and Huntington\u2019s disease brain regions detected by massively parallel sequencing","volume":"38","author":"Pantano","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","article-title":"Altered microRNA regulation in Huntington\u2019s disease models","volume":"227","author":"Lee","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Langfelder, P., Gao, F., Wang, N., Howland, D., Kwak, S., Vogt, T.F., Aaronson, J.S., Rosinski, J., Coppola, G., and Horvath, S. (2018). MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190550"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/mds.25237","article-title":"Seizures in juvenile Huntington\u2019s disease: Frequency and characterization in a multicenter cohort","volume":"27","author":"Cloud","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.0611625104","article-title":"Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior","volume":"104","author":"Gantois","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e1640","DOI":"10.1002\/wrna.1640","article-title":"Artificial miRNAs as therapeutic tools: Challenges and opportunities","volume":"12","author":"Pewinska","year":"2021","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"873","DOI":"10.4161\/auto.19629","article-title":"MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis","volume":"8","author":"Xu","year":"2012","journal-title":"Autophagy"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1002\/cpim.78","article-title":"Protocols for the Analysis of microRNA Expression, Biogenesis, and Function in Immune Cells","volume":"126","author":"Zhang","year":"2019","journal-title":"Curr. Protoc. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6024\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:01:05Z","timestamp":1760122865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":86,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076024"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076024","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,23]]}}}