{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:00:02Z","timestamp":1777528802547,"version":"3.51.4"},"reference-count":78,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a typical type-2 inflammation involving several cytokines and is associated with epithelial cell dysfunction. Oncostatin M (OSM) (belonging to the interleukin(IL)-6 family) could be a key driver of epithelial barrier dysfunction. Therefore, we investigated the presence of OSM and IL-6 and the expression pattern of tight junctions (TJs) in the nasal tissue of CRSwNP patients and controls using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and Western blotting. Then, their potential role in the epithelial barrier was evaluated in vitro in 27 different primary cultures of human nasal epithelial cells (HNECs) by measuring TJ expression and transepithelial electric resistance (TEER) with or without OSM or IL-6 (1, 10, and 100 ng\/mL). The effect on ciliary beating efficiency was evaluated by high-speed videomicroscopy and on repair mechanisms with a wound healing model with or without OSM. OSM and IL-6 were both overexpressed, and TJ (ZO-1 and occludin) expression was decreased in the nasal polyps compared to the control mucosa. OSM (100 ng\/mL) but not IL-6 induced a significant decrease in TJ expression, TEER, and ciliary beating efficiency in HNECs. After 24 h, the wound repair rate was significantly higher in OSM-stimulated HNECs at 100 ng\/mL. These results suggest that OSM could become a new target for monoclonal antibodies.<\/jats:p>","DOI":"10.3390\/ijms24076094","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T03:50:21Z","timestamp":1679629821000},"page":"6094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-8559","authenticated-orcid":false,"given":"Florent","family":"Carsuzaa","sequence":"first","affiliation":[{"name":"Laboratoire Inflammation Tissus Epith\u00e9liaux et Cytokines (LITEC), UR15560, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"Service ORL, Chirurgie Cervico-Maxillo-Faciale et Audiophonologie, Centre Hospitalier Universitaire de Poitiers, F-86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Bequignon","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Intercommunal de Cr\u00e9teil, Service d\u2019Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, F-94010 Cr\u00e9teil, France"},{"name":"CNRS EMR 7000, F-94010 Cr\u00e9teil, France"},{"name":"INSERM, IMRB, Univ Paris Est Creteil, F-94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Bartier","sequence":"additional","affiliation":[{"name":"CNRS EMR 7000, F-94010 Cr\u00e9teil, France"},{"name":"INSERM, IMRB, Univ Paris Est Creteil, F-94010 Cr\u00e9teil, France"},{"name":"Service d\u2019ORL, de Chirurgie Cervico Faciale, H\u00f4pital Henri-Mondor, Assistance Publique des H\u00f4pitaux de Paris, F-94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Coste","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Intercommunal de Cr\u00e9teil, Service d\u2019Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, F-94010 Cr\u00e9teil, France"},{"name":"CNRS EMR 7000, F-94010 Cr\u00e9teil, France"},{"name":"INSERM, IMRB, Univ Paris Est Creteil, F-94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Dufour","sequence":"additional","affiliation":[{"name":"Laboratoire Inflammation Tissus Epith\u00e9liaux et Cytokines (LITEC), UR15560, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"Service ORL, Chirurgie Cervico-Maxillo-Faciale et Audiophonologie, Centre Hospitalier Universitaire de Poitiers, F-86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Bainaud","sequence":"additional","affiliation":[{"name":"Laboratoire Inflammation Tissus Epith\u00e9liaux et Cytokines (LITEC), UR15560, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"Service Immunologie et Inflammation, Centre Hospitalier Universitaire de Poitiers, F-86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Claude","family":"Lecron","sequence":"additional","affiliation":[{"name":"Laboratoire Inflammation Tissus Epith\u00e9liaux et Cytokines (LITEC), UR15560, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"},{"name":"Service Immunologie et Inflammation, Centre Hospitalier Universitaire de Poitiers, F-86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Louis","sequence":"additional","affiliation":[{"name":"CNRS EMR 7000, F-94010 Cr\u00e9teil, France"},{"name":"INSERM, IMRB, Univ Paris Est Creteil, F-94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-4963","authenticated-orcid":false,"given":"St\u00e9phane","family":"Tringali","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d\u2019ORL, d\u2019Otoneurochirurgie et de Chirurgie Cervico-Faciale, F-69310 Pierre B\u00e9nite, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Ma\u00efeutique Lyon Sud-Charles M\u00e9rieux, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, F-69003 Lyon, France"},{"name":"UMR 5305, Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, Institut de Biologie et Chimie des Prot\u00e9ines, CNRS, Universit\u00e9 Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Favot","sequence":"additional","affiliation":[{"name":"Laboratoire Inflammation Tissus Epith\u00e9liaux et Cytokines (LITEC), UR15560, Universit\u00e9 de Poitiers, F-86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-2286","authenticated-orcid":false,"given":"Maxime","family":"Fieux","sequence":"additional","affiliation":[{"name":"CNRS EMR 7000, F-94010 Cr\u00e9teil, France"},{"name":"INSERM, IMRB, Univ Paris Est Creteil, F-94010 Cr\u00e9teil, France"},{"name":"Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d\u2019ORL, d\u2019Otoneurochirurgie et de Chirurgie Cervico-Faciale, F-69310 Pierre B\u00e9nite, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Ma\u00efeutique Lyon Sud-Charles M\u00e9rieux, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, F-69003 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic Rhinosinusitis in Europe--an Underestimated Disease. 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