{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:52:28Z","timestamp":1791823948995,"version":"4.3.4"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}]},{"name":"Project InPacTus\u2014Innovative products and technologies from eucalyptus","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}]},{"name":"European Regional Development Fund (ERDF)","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}]},{"name":"European Regional Development Fund (ERDF)","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}]},{"name":"European Regional Development Fund (ERDF)","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CICECO\u2013Aveiro Institute of Materials","doi-asserted-by":"publisher","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"LAQV-REQUIMTE","doi-asserted-by":"publisher","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIBB","doi-asserted-by":"publisher","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FCT\/MEC","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}]},{"name":"FCT\/MEC","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}]},{"name":"FCT\/MEC","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"FCT\/MEC","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"FCT\/MEC","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}]},{"name":"FCT\/MEC","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\/MEC","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"FCT\/MEC","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"FCT\/MEC","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"FCT\/MEC","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}]},{"name":"FCT\/MEC","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"],"award-info":[{"award-number":["Project N.\u00ba 21874 (POCI-01-0247-FEDER-021874)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"],"award-info":[{"award-number":["COMPETE 2020 n\u00ba 246\/AXIS II\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["PIDDAC"],"award-info":[{"award-number":["PIDDAC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["2021.03348.CEECIND"],"award-info":[{"award-number":["2021.03348.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>E. globulus leaves have been mainly exploited for essential oil recovery or for energy generation in industrial pulp mills, neglecting the abundance of valuable families of extractives, namely, triterpenic acids, that might open new ways for the integrated valorization of this biomass. Therefore, this study highlights the lipophilic characterization of E. globulus leaves before and after hydrodistillation, aiming at the integrated valorization of both essential oils and triterpenic acids. The lipophilic composition of E. globulus leaves after hydrodistillation is reported for the first time. Extracts were obtained by dichloromethane Soxhlet extraction and analyzed by gas chromatography-mass spectrometry. In addition, their cytotoxicity on different cell lines representative of the innate immune system, skin, liver, and intestine were evaluated. Triterpenic acids, such as betulonic, oleanolic, betulinic and ursolic acids, were found to be the main components of these lipophilic extracts, ranging from 30.63\u201337.14 g kg\u22121 of dry weight (dw), and representing 87.7\u201389.0% w\/w of the total content of the identified compounds. In particular, ursolic acid was the major constituent of all extracts, representing 46.8\u201350.7% w\/w of the total content of the identified compounds. Other constituents, such as fatty acids, long-chain aliphatic alcohols and \u03b2-sitosterol were also found in smaller amounts in the studied extracts. This study also demonstrates that the hydrodistillation process does not affect the recovery of compounds of greatest interest, namely, triterpenic acids. Therefore, the results establish that this biomass residue can be considered as a promising source of value-added bioactive compounds, opening new strategies for upgrading pulp industry residues within an integrated biorefinery context.<\/jats:p>","DOI":"10.3390\/ijms24076226","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:05:40Z","timestamp":1679889940000},"page":"6226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-4253","authenticated-orcid":false,"given":"C\u00e1tia. S. D.","family":"Oliveira","sequence":"first","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-512X","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Moreira","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cellular Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6754","authenticated-orcid":false,"given":"Maria T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cellular Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-5056","authenticated-orcid":false,"given":"Cl\u00e1udia M. F.","family":"Pereira","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cellular Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-7619","authenticated-orcid":false,"given":"S\u00f3nia A. O.","family":"Santos","sequence":"additional","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-8416","authenticated-orcid":false,"given":"Armando J. D.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s41061-017-0133-8","article-title":"Valorisation of biowastes for the production of green materials using chemical methods","volume":"375","author":"Dugmore","year":"2017","journal-title":"Top. Curr. Chem."},{"key":"ref_2","unstructured":"De Jong, E., Higson, A., Walsh, P., and Wellisch, M. (2012). IEA Bioenergy Task 42 Report, IEA Bioenergy."},{"key":"ref_3","unstructured":"Waldron, K.W. (2014). Advances in Biorefineries: Biomass and Waste Supply Chain Exploitation, Woodhead Publishing."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sadhukhan, J., Ng, K.S., and Hernandez, E.M. (2014). Biorefineries and Chemical Processes: Design, Integration and Sustainability Analysis, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781118698129"},{"key":"ref_5","unstructured":"CELPA (2018). Boletim Estat\u00edstico da CELPA\u2014Ind\u00fastria Papeleira Portuguesa, CELPA."},{"key":"ref_6","unstructured":"ICNF (2019). IFN6\u2014Principais resultados\u2014relat\u00f3rio sum\u00e1rio, Instituto da Conserva\u00e7\u00e3o da Natureza e das Florestas."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.indcrop.2018.06.070","article-title":"Potential of Eucalyptus globulus industrial bark as a biorefinery feedstock: Chemical and fuel characterization","volume":"123","author":"Neiva","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1515\/HF.2002.059","article-title":"Lipophilic extractives of the inner and outer barks of Eucalyptus globulus","volume":"56","author":"Freire","year":"2002","journal-title":"Holzforschung"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1515\/HF.2002.024","article-title":"Identification of new hydroxy fatty acids and ferulic acid esters in the wood of Eucalyptus globulus","volume":"56","author":"Freire","year":"2002","journal-title":"Holzforschung"},{"key":"ref_10","first-page":"475","article-title":"Eucalyptus biomass residues from agro-forest and pulping industries as sources of high-value triterpenic compounds","volume":"45","author":"Domingues","year":"2011","journal-title":"Cellul. Chem. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1021\/jf201801q","article-title":"Characterization of phenolic components in polar extracts of Eucalyptus globulus Labill. bark by high-performance liquid chromatography-mass spectrometry","volume":"59","author":"Santos","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.indcrop.2009.09.002","article-title":"Eucalyptus globulus biomass residues from pulping industry as a source of high value triterpenic compounds","volume":"31","author":"Domingues","year":"2010","journal-title":"Ind. Crops Prod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.energy.2012.06.026","article-title":"Potentials of lignocellulosic bioethanols produced from hardwood in Taiwan","volume":"44","author":"Ko","year":"2012","journal-title":"Energy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.fuel.2011.12.013","article-title":"Bioethanol production from autohydrolyzed Eucalyptus globulus by simultaneous saccharification and fermentation operating at high solids loading","volume":"94","author":"Garrote","year":"2012","journal-title":"Fuel"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0926-6690(96)00200-2","article-title":"Analysis of the variation of the essential oil composition of Eucalyptus globulus Labill. from Portugal using multivariate statistical analysis","volume":"6","author":"Silvestre","year":"1997","journal-title":"Ind. Crops Prod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2221-1691(12)60220-2","article-title":"Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus","volume":"2","author":"Bachir","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20487","DOI":"10.3390\/molecules201119706","article-title":"Chemical composition and in-vitro evaluation of the antimicrobial and antioxidant activities of essential oils extracted from seven Eucalyptus species","volume":"20","author":"Ghaffar","year":"2015","journal-title":"Molecules"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jfda.2018.05.010","article-title":"Antioxidant activity, neuroprotective properties and bioactive constituents analysis of varying polarity extracts from Eucalyptus globulus leaves","volume":"26","author":"Liaudanskas","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"ref_19","first-page":"734","article-title":"Chemical composition, antioxidant, anti-inflammatory and antitumor activities of Eucalyptus globulus labill","volume":"56","author":"Nile","year":"2018","journal-title":"Indian J. Exp. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/pca.2396","article-title":"Qualitative and semi-quantitative analysis of phenolics in Eucalyptus globulus leaves by high-performance liquid chromatography coupled with diode array detection and electrospray ionisation mass spectrometry","volume":"24","author":"Meudec","year":"2013","journal-title":"Phytochem. Anal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.3390\/molecules20034720","article-title":"Antimicrobial and antioxidant activities and phenolic profile of Eucalyptus globulus Labill. and Corymbia ficifolia (F. Muell.) K.D. Hill & L.A.S. Johnson Leaves","volume":"20","author":"Dezsi","year":"2015","journal-title":"Molecules"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.supflu.2018.01.010","article-title":"Extraction of Eucalyptus leaves using solvents of distinct polarity. Cluster analysis and extracts characterization","volume":"135","author":"Rodrigues","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_23","first-page":"481","article-title":"Chemical and structural analysis of Eucalyptus globulus and E. camaldulensis leaf cuticles: A lipidized cell wall region","volume":"5","author":"Cabral","year":"2014","journal-title":"Front. Plant Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1039\/C5AY02009C","article-title":"Supercritical carbondioxide extraction of essential oils from leaves of Eucalyptus globulus L., their analysis and application","volume":"8","author":"Singh","year":"2016","journal-title":"Anal. Methods"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111473","DOI":"10.1016\/j.indcrop.2019.111473","article-title":"Green approaches for the extraction of antioxidants from eucalyptus leaves","volume":"138","author":"Moreira","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/1874331501610010052","article-title":"Beneficial and healthy properties of Eucalyptus plants: A great potential use","volume":"10","author":"Vecchio","year":"2016","journal-title":"Open Agric. J."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Coppen, J.J.W. (2002). Eucalyptus: The Genus Eucalyptus, Taylor & Francis.","DOI":"10.4324\/9780203219430"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Barbosa, L.C.A., Filomeno, C.A., and Teixeira, R.R. (2016). Chemical variability and biological activities of Eucalyptus spp. essential oils. Molecules, 21.","DOI":"10.3390\/molecules21121671"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/food.200390009","article-title":"Antioxidant activity of Egyptian Eucalyptus camaldulensis var. brevirostris leaf extracts","volume":"47","author":"Marx","year":"2003","journal-title":"Food\/Nahrung"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.indcrop.2013.09.032","article-title":"Antibacterial activity and synergistic effects between Eucalyptus globulus leaf residues (essential oils and extracts) and antibiotics against several isolates of respiratory tract infections (Pseudomonas aeruginosa)","volume":"52","author":"Pereira","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Moreira, P., Sousa, F.J., Matos, P., Brites, G.S., Gon\u00e7alves, M.J., Cavaleiro, C., Figueirinha, A., Salgueiro, L., Batista, M.T., and Branco, P.C. (2022). Chemical composition and effect against skin alterations of bioactive extracts obtained by the hydrodistillation of Eucalyptus globulus leaves. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14030561"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2174\/1570193X113106660001","article-title":"Bioactive triterpenic acids: From agroforestry biomass residues to promising therapeutic tools","volume":"11","author":"Domingues","year":"2014","journal-title":"Mini Rev. Org. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41429-020-0285-6","article-title":"Antimicrobial and antibiofilm activities of ursolic acid against carbapenem-resistant Klebsiella pneumoniae","volume":"73","author":"Qian","year":"2020","journal-title":"J. Antibiot."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.apjtm.2016.05.015","article-title":"Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage","volume":"9","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1078\/094471103321659807","article-title":"Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension","volume":"10","author":"Somova","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0367-326X(03)00123-0","article-title":"Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses","volume":"74","author":"Pavlova","year":"2003","journal-title":"Fitoterapia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ja.2010.2","article-title":"Anti-leishmanial activity of betulin derivatives","volume":"63","author":"Alakurtti","year":"2010","journal-title":"J. Antibiot."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00436-009-1394-0","article-title":"Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice","volume":"105","author":"Costa","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.phytochem.2004.12.026","article-title":"Cytotoxic triterpenes from the aerial roots of Ficus microcarpa","volume":"66","author":"Chiang","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/np50104a008","article-title":"Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids","volume":"57","author":"Fujioka","year":"1994","journal-title":"J. Nat. Prod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-2006-957988","article-title":"Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas","volume":"61","author":"Giner","year":"1995","journal-title":"Planta Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.indcrop.2012.06.056","article-title":"Lipophilic extractives from the bark of Eucalyptus grandis x globulus, a rich source of methyl morolate: Selective extraction with supercritical CO2","volume":"43","author":"Patinha","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12380","DOI":"10.1021\/jf404230z","article-title":"Ipomoea batatas (L.) Lam.: A rich source of lipophilic phytochemicals","volume":"61","author":"Cordeiro","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biotechadv.2015.02.012","article-title":"Forest biorefinery: Potential of poplar phytochemicals as value-added co-products","volume":"33","author":"Devappa","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.indcrop.2019.02.028","article-title":"Valorisation of bark lipophilic fractions from three Portuguese Salix species: A systematic study of the chemical composition and inhibitory activity on Escherichia coli","volume":"132","author":"Ramos","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"ref_46","unstructured":"Mushtaq, M., and Anwar, F. (2021). A Centum of Valuable Plant Bioactives, Academic Press."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/molecules14010540","article-title":"Biological and pharmacological activities of squalene and related compounds: Potential uses in cosmetic dermatology","volume":"14","author":"Huang","year":"2009","journal-title":"Molecules"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/cbdd.12608","article-title":"Synthesis and biological evaluation of novel ursolic acid derivatives as potential anticancer prodrugs","volume":"86","author":"Yang","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxlet.2008.01.001","article-title":"Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: Evaluation by the comet assay","volume":"177","author":"Ramos","year":"2008","journal-title":"Toxicol. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejps.2016.10.019","article-title":"pH-Sensitive mesoporous silica nanoparticles anticancer prodrugs for sustained release of ursolic acid and the enhanced anti-cancer efficacy for hepatocellular carcinoma cancer","volume":"96","author":"Li","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bcp.2014.11.014","article-title":"UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma","volume":"93","author":"Dong","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11030-020-10154-7","article-title":"Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents","volume":"26","author":"Zhang","year":"2022","journal-title":"Mol. Divers."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9711","DOI":"10.1021\/jf501487v","article-title":"Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 on macrophages","volume":"62","author":"Jang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/08923973.2015.1021355","article-title":"Ursolic acid isolated from guava leaves inhibits inflammatory mediators and reactive oxygen species in LPS-stimulated macrophages","volume":"37","author":"Kim","year":"2015","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_55","first-page":"664","article-title":"The effect of ursolic and oleanolic acids on human skin fibroblast cells","volume":"49","author":"Paduch","year":"2011","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jep.2011.07.037","article-title":"Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers","volume":"137","author":"Qiang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mlala, S., Oyedeji, A.O., Gondwe, M., and Oyedeji, O.O. (2019). Ursolic acid and its derivatives as bioactive agents. Molecules, 24.","DOI":"10.3390\/molecules24152751"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.lfs.2016.01.017","article-title":"Ursolic acid (UA): A metabolite with promising therapeutic potential","volume":"146","author":"Kashyap","year":"2016","journal-title":"Life Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbrc.2020.07.125","article-title":"Ursolic acid inhibits pigmentation by increasing melanosomal autophagy in B16F1 cells","volume":"531","author":"Park","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1158\/1940-6207.CAPR-15-0098","article-title":"Effect of combined treatment with ursolic acid and resveratrol on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate","volume":"8","author":"Cho","year":"2015","journal-title":"Cancer Prev. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1246510","DOI":"10.1155\/2020\/1246510","article-title":"Inhibitory effect of ursolic acid on ultraviolet B radiation-induced oxidative stress and proinflammatory response-mediated senescence in human skin dermal fibroblasts","volume":"2020","author":"Samivel","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"112166","DOI":"10.1016\/j.biopha.2021.112166","article-title":"Regulation of decorin by ursolic acid protects against non-alcoholic steatohepatitis","volume":"143","author":"Zheng","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3389\/fphar.2019.01321","article-title":"Ursolic acid improves intestinal damage and bacterial dysbiosis in liver fibrosis mice","volume":"10","author":"Wan","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1039\/D0FO00829J","article-title":"Ursolic acid alleviates hypercholesterolemia and modulates the gut microbiota in hamsters","volume":"11","author":"Hao","year":"2020","journal-title":"Food Funct."},{"key":"ref_65","first-page":"4675","article-title":"Ursolic acid alleviates inflammation and against diabetes-induced nephropathy through TLR4-mediated inflammatory pathway","volume":"18","author":"Li","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.biopha.2017.11.032","article-title":"Ursolic acid ameliorates oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy rats","volume":"97","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11745-005-1388-y","article-title":"Identification of \u03947 phytosterols and phytosteryl glucosides in the wood and bark of several Acacia species","volume":"40","author":"Freire","year":"2005","journal-title":"Lipids"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Santos, S., Trindade, S., Oliveira, C., Parreira, P., Rosa, D., Duarte, M., Ferreira, I., Cruz, M., Rego, A., and Abreu, M. (2017). Lipophilic fraction of cultivated Bifurcaria bifurcata R. Ross: Detailed composition and in vitro prospection of current challenging bioactive properties. Mar. Drugs, 15.","DOI":"10.3390\/md15110340"},{"key":"ref_69","unstructured":"Sittampalam, G.S., Coussens, N.B.P., Brimacombe, K., Grossman, A.B., Arkin, M.B., Auld, D.B., Austin, C., Baell, J.B., Bejcek, B.B., and Chung, T. (2004). Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery, Available online: https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full\/10.1111\/cts.12570."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6226\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:03:06Z","timestamp":1760122986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,25]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076226"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076226","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,25]]}}}