{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:13:44Z","timestamp":1791922424009,"version":"4.3.4"},"reference-count":43,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment. There are many mechanisms of radiation treatment exposure to toxicities. Our aim was to summarize the literature about known mechanisms of radiation-induced cardiac toxicities. We performed a systematic review of the literature on the PubMed database until October 2022 about cardiovascular toxicities and radiation therapy exposure. Only systematic reviews, meta-analyses, and reviews were selected. Out of 1429 publications screened, 43 papers met inclusion criteria and were selected for the umbrella review process. Microvascular and macrovascular complications could lead to adverse cardiac effects. Many radiotherapy-associated risk factors were responsible, such as the site of radiation treatment, beam proximity to heart tissues, total dosage, the number of radiotherapy sessions, adjuvant chemotherapeutic agents used, and patient traditional cardiovascular risk factors, patient age, and gender. Moreover, important dosage cutoff values could increase the incidence of cardiac toxicities. Finally, the time from radiation exposure to cardiac side effects was assessed. Our report highlighted mechanisms, radiation dosage values, and the timeline of cardiovascular toxicities after radiation therapy. All of the above may be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.<\/jats:p>","DOI":"10.3390\/ijms24076272","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:05:40Z","timestamp":1679889940000},"page":"6272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-0184","authenticated-orcid":false,"given":"Konstantinos C.","family":"Siaravas","sequence":"first","affiliation":[{"name":"Second Department of Cardiology, University Hospital of Ioannina, University Campus, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Katsouras","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, University Hospital of Ioannina, University Campus, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-4945","authenticated-orcid":false,"given":"Chrissa","family":"Sioka","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Ioannina, University Campus, 45110 Ioannina, Greece"},{"name":"Faculty of Medicine, School of Health Sciences, University of Ioannina, University Campus, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1055\/s-0041-1729885","article-title":"The Growing Impact of Cardiovascular Oncology: Epidemiology and Pathophysiology","volume":"47","author":"Tufano","year":"2021","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaccao.2022.07.005","article-title":"Permissive Cardiotoxicity: The Clinical Crucible of Cardio-Oncology","volume":"4","author":"Porter","year":"2022","journal-title":"JACC CardioOncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s11912-022-01238-8","article-title":"Radiation-Induced Cardiovascular Disease: Mechanisms, Prevention, and Treatment","volume":"24","author":"Koutroumpakis","year":"2022","journal-title":"Curr. Oncol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1080\/09553002.2021.1956007","article-title":"The cardiac toxicity of radiotherapy\u2014A review of characteristics, mechanisms, diagnosis, and prevention","volume":"97","author":"Wei","year":"2021","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"887705","DOI":"10.3389\/fcvm.2022.887705","article-title":"Radiotherapy-Induced Cardiotoxicity: The Role of Multimodality Cardiovascular Imaging","volume":"9","author":"Podlesnikar","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1748-717X-6-151","article-title":"Myocardial perfusion imaging with (99 m)Tc-tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: A case-control study","volume":"6","author":"Sioka","year":"2011","journal-title":"Radiat. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/14656566.2018.1446080","article-title":"Treating cardiovascular complications of radiotherapy: A role for new pharmacotherapies","volume":"19","author":"Donis","year":"2018","journal-title":"Expert. Opin. Pharmacother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3579143","DOI":"10.1155\/2020\/3579143","article-title":"Oxidative Stress in Radiation-Induced Cardiotoxicity","volume":"2020","author":"Ping","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Liang, Z., He, Y., and Hu, X. (2022). Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810617"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"946137","DOI":"10.3389\/fcvm.2022.946137","article-title":"Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments","volume":"9","author":"Sun","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.repc.2021.04.011","article-title":"Cardio-oncology: Understanding the different mechanisms of cardiovascular toxicity","volume":"41","author":"Toste","year":"2022","journal-title":"Rev. Port. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11864-021-00868-7","article-title":"Cardiotoxicity of Radiation Therapy: Mechanisms, Management, and Mitigation","volume":"22","author":"Ell","year":"2021","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.radonc.2022.04.030","article-title":"Murine models of radiation cardiotoxicity: A systematic review and recommendations for future studies","volume":"173","author":"Walls","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Diaz-Gavela, A.A., Figueiras-Graillet, L., Luis, A.M., Salas Segura, J., Ciervide, R., Del Cerro Penalver, E., Counago, F., Arenas, M., and Lopez-Fernandez, T. (2021). Breast Radiotherapy-Related Cardiotoxicity. When, How, Why. Risk Prevention and Control Strategies. Cancers, 13.","DOI":"10.3390\/cancers13071712"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/HCO.0000000000000404","article-title":"Radiotherapy, chemotherapy and atherosclerosis","volume":"32","author":"Min","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/pbc.20346","article-title":"Pathology of radiation and anthracycline cardiotoxicity","volume":"44","author":"Berry","year":"2005","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Choksey, A., and Timm, K.N. (2021). Cancer Therapy-Induced Cardiotoxicity-A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010441"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jtho.2020.11.002","article-title":"Cardiac Toxicity of Thoracic Radiotherapy: Existing Evidence and Future Directions","volume":"16","author":"Banfill","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e020243","DOI":"10.1161\/JAHA.120.020243","article-title":"Morphological Plaque Characteristics and Clinical Outcomes in Patients with Acute Coronary Syndrome and a Cancer History","volume":"10","author":"Tanimura","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000510573","article-title":"Modern Radiotherapy and Risk of Cardiotoxicity","volume":"65","author":"Koutroumpakis","year":"2020","journal-title":"Chemotherapy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e021686","DOI":"10.1161\/JAHA.121.021686","article-title":"Radiation-Induced Cardiovascular Disease: Review of an Underrecognized Pathology","volume":"10","author":"Eisenberg","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11886-020-01380-4","article-title":"Contemporary Understandings of Cardiovascular Disease After Cancer Radiotherapy: A Focus on Ischemic Heart Disease","volume":"22","author":"Kim","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jcmg.2018.04.028","article-title":"Radiation-Associated Cardiac Disease: A Practical Approach to Diagnosis and Management","volume":"11","author":"Desai","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.canrad.2020.07.001","article-title":"Radio-induced cardiotoxicity: From physiopathology and risk factors to adaptation of radiotherapy treatment planning and recommended cardiac follow-up","volume":"24","author":"Kirova","year":"2020","journal-title":"Cancer Radiother."},{"key":"ref_25","first-page":"242","article-title":"Cancer-Associated Thrombosis: A Taiwanese Perspective on Therapeutic Options with Focus on Non-Vitamin K Antagonist Oral Anticoagulants","volume":"39","author":"Shao","year":"2023","journal-title":"Acta Cardiol. Sin."},{"key":"ref_26","first-page":"205","article-title":"Late Sequelae of Radiotherapy\u2014The Effect of Technical and Conceptual Innovations in Radiation Oncology","volume":"118","author":"Hoeller","year":"2021","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11936-018-0627-x","article-title":"Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment","volume":"20","author":"Spetz","year":"2018","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11886-021-01446-x","article-title":"Cardiovascular Disease Amongst Women Treated for Breast Cancer: Traditional Cytotoxic Chemotherapy, Targeted Therapy, and Radiation Therapy","volume":"23","author":"Chen","year":"2021","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jaccao.2021.06.007","article-title":"Past, Present, and Future of Radiation-Induced Cardiotoxicity: Refinements in Targeting, Surveillance, and Risk Stratification","volume":"3","author":"Bergom","year":"2021","journal-title":"JACC CardioOncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11864-021-00869-6","article-title":"Cardiovascular Complications Associated with Contemporary Lung Cancer Treatments","volume":"22","author":"Sase","year":"2021","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/raon-2018-0035","article-title":"Pericardial disease after breast cancer radiotherapy","volume":"53","author":"Marinko","year":"2018","journal-title":"Radiol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.jacc.2013.01.090","article-title":"Cardiac complications of thoracic irradiation","volume":"61","author":"Jaworski","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.7150\/ijbs.35460","article-title":"Radiation-induced heart disease: A review of classification, mechanism and prevention","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_34","unstructured":"ESC Scientific Document Group (2023). 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). G. Ital. Cardiol., 24, e1\u2013e130."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"665303","DOI":"10.3389\/fcvm.2021.665303","article-title":"Coronary Stent Healing in Cancer Patients\u2014An Optical Coherence Tomography Perspective","volume":"8","author":"Aziz","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ahj.2017.08.015","article-title":"\u201cBringing on the light\u201d in a complex clinical scenario: Optical coherence tomography-guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry)","volume":"194","author":"Iliescu","year":"2017","journal-title":"Am. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"274","DOI":"10.14797\/mdcj-15-4-274","article-title":"Cardiovascular Toxicities of Radiation Therapy","volume":"15","author":"Lewis","year":"2019","journal-title":"Methodist. Debakey Cardiovasc. J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Schlaak, R.A., SenthilKumar, G., Boerma, M., and Bergom, C. (2020). Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity. Cancers, 12.","DOI":"10.3390\/cancers12020415"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.acvd.2016.10.003","article-title":"Radiotherapy-induced right ventricular remodelling: The missing piece of the puzzle","volume":"110","author":"Tadic","year":"2017","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e014668","DOI":"10.1161\/JAHA.119.014668","article-title":"Exploratory Review of the Role of Statins, Colchicine, and Aspirin for the Prevention of Radiation-Associated Cardiovascular Disease and Mortality","volume":"9","author":"Silver","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e16507","DOI":"10.1097\/MD.0000000000016507","article-title":"BNP as a potential biomarker for cardiac damage of breast cancer after radiotherapy: A meta-analysis","volume":"98","author":"Zhang","year":"2019","journal-title":"Medicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.21873\/anticanres.13272","article-title":"Breast Radiotherapy and Early Adverse Cardiac Effects. The Role of Serum Biomarkers and Strain Echocardiography","volume":"39","author":"Gkantaifi","year":"2019","journal-title":"Anticancer. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fcvm.2020.00041","article-title":"Cardiovascular Damage Associated With Chest Irradiation","volume":"7","author":"Mrotzek","year":"2020","journal-title":"Front. Cardiovasc. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6272\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:03:46Z","timestamp":1760123026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":43,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076272"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076272","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,27]]}}}