{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:06:45Z","timestamp":1792292805397,"version":"4.4.0"},"reference-count":135,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Phytochemicals represent a large and diverse group of naturally occurring compounds, bioactive nutrients, or phytonutrients produced by plants, widely found in fruits, vegetables, whole grains products, legumes, beans, herbs, seeds, nuts, tea, and dark chocolate. They are classified according to their chemical structures and functional properties. Flavonoids belong to the phenolic class of phytochemicals with potential solid pharmacological effects as modulators of multiple signal transduction pathways. Their beneficial effect on the human body is associated with their antioxidant, anti-inflammatory, antimutagenic, and anticarcinogenic properties. Flavonoids are also widely used in various nutritional, pharmaceutical, medical, and cosmetic applications. In our review, we discuss the positive effect of flavonoids on chronic skin diseases such as vitiligo, psoriasis, acne, and atopic dermatitis.<\/jats:p>","DOI":"10.3390\/ijms24076324","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T02:11:40Z","timestamp":1679969500000},"page":"6324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases"],"prefix":"10.3390","volume":"24","author":[{"given":"Be\u00e1ta","family":"\u010ci\u017em\u00e1rov\u00e1","sequence":"first","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Hubkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edra","family":"Tome\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-0125","authenticated-orcid":false,"given":"Anna","family":"Birkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","first-page":"70","article-title":"Phytochemicals\u2019 Role in Good Health","volume":"15","author":"Webb","year":"2013","journal-title":"Today\u2019s Dietit."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/1750-3841.12101","article-title":"Dietary bioactive compounds and their health implications","volume":"78","author":"Liu","year":"2013","journal-title":"J. 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