{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:51:45Z","timestamp":1791348705682,"version":"4.3.1"},"reference-count":65,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["SQ2021YFA1100604-02"],"award-info":[{"award-number":["SQ2021YFA1100604-02"]}]},{"name":"National Key Research and Development Program of China","award":["U21A20369"],"award-info":[{"award-number":["U21A20369"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFS0191"],"award-info":[{"award-number":["2021YFS0191"]}]},{"name":"National Natural Science Foundation of China","award":["SQ2021YFA1100604-02"],"award-info":[{"award-number":["SQ2021YFA1100604-02"]}]},{"name":"National Natural Science Foundation of China","award":["U21A20369"],"award-info":[{"award-number":["U21A20369"]}]},{"name":"National Natural Science Foundation of China","award":["2021YFS0191"],"award-info":[{"award-number":["2021YFS0191"]}]},{"name":"Science and Technology Programof Sichuan Province","award":["SQ2021YFA1100604-02"],"award-info":[{"award-number":["SQ2021YFA1100604-02"]}]},{"name":"Science and Technology Programof Sichuan Province","award":["U21A20369"],"award-info":[{"award-number":["U21A20369"]}]},{"name":"Science and Technology Programof Sichuan Province","award":["2021YFS0191"],"award-info":[{"award-number":["2021YFS0191"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dental follicle stem cells (DFSCs) have been verified to promote periodontal regeneration in an inflammatory microenvironment. When coping with inflammatory stimulation, DFSCs highly express periostin, a bioactive molecule closely related to periodontal homeostasis. It is worth exploring whether and how periostin plays a role in the promotion of periodontal regeneration by DFSCs. By tracking the fate of DFSCs, it was found that DFSCs significantly contributed to periodontal regeneration in rat periodontal defects while they had a low survival rate. They highly expressed periostin and improved the immune microenvironment in the defect area, especially via the recruitment and reprogramming of macrophages. Silencing periostin attenuated the effects of DFSCs in promoting periodontal regeneration and regulating macrophages. Recombinant human periostin (rhPeriostin) could not only directly promote macrophage reprogramming through the integrin \u03b1M\/phosphorylated extracellular signal-regulated kinase (p-Erk)\/Erk signaling pathway, but it also exhibited the potential to promote periodontal regeneration in rats when loaded in a collagen matrix. These results indicated that periostin is actively involved in the process by which DFSCs promote periodontal regeneration through the regulation of macrophages and is a promising molecular agent to promote periodontal regeneration. This study provides new insight into the mechanism by which DFSCs promote periodontal regeneration and suggests a new approach for periodontal regeneration therapy.<\/jats:p>","DOI":"10.3390\/ijms24076353","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T04:37:15Z","timestamp":1679978235000},"page":"6353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dental Follicle Stem Cells Promote Periodontal Regeneration through Periostin-Mediated Macrophage Infiltration and Reprogramming in an Inflammatory Microenvironment"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiuqun","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Huo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China School of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Diseases, & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu 610041, China"},{"name":"Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12250","article-title":"Cellular therapy in periodontal regeneration","volume":"79","author":"Vignoletti","year":"2019","journal-title":"Periodontology 2000"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101336","DOI":"10.1016\/j.nantod.2021.101336","article-title":"Stem cell Janus patch for periodontal regeneration","volume":"42","author":"Yan","year":"2022","journal-title":"Nano Today"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13287-020-01938-7","article-title":"Stem cell therapies for periodontal tissue regeneration: A network meta-analysis of preclinical studies","volume":"11","author":"Li","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2041731419894361","DOI":"10.1177\/2041731419894361","article-title":"EphrinB2 regulates osteogenic differentiation of periodontal ligament stem cells and alveolar bone defect regeneration in beagles","volume":"10","author":"Wang","year":"2019","journal-title":"J. Tissue Eng."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/joor.12882","article-title":"SFRP2 promotes stem cells from apical papilla-mediated periodontal tissue regeneration in miniature pig","volume":"47","author":"Li","year":"2019","journal-title":"J. Oral Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.dental.2019.05.016","article-title":"Treated dentin matrix particles combined with dental follicle cell sheet stimulate periodontal regeneration","volume":"35","author":"Yang","year":"2019","journal-title":"Dent. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jre.12684","article-title":"Clinical application of mesenchymal stem cells in periodontal regeneration: A systematic review and meta-analysis","volume":"55","author":"Novello","year":"2019","journal-title":"J. Periodontal Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/jcpe.13368","article-title":"Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial","volume":"47","author":"Fierravanti","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13287-016-0288-1","article-title":"Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: A randomized clinical trial","volume":"7","author":"Chen","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41551-021-00729-6","article-title":"Therapeutic implications of transplanted-cell death","volume":"5","author":"Wagoner","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"653209","DOI":"10.3389\/fgene.2021.653209","article-title":"Exploring the Imbalance of Periodontitis Immune System from the Cellular to Molecular Level","volume":"12","author":"He","year":"2021","journal-title":"Front. Genet."},{"key":"ref_13","first-page":"219","article-title":"Roles of Immune Cells and Mechanisms of Immune Responses in Periodontitis","volume":"24","author":"Xu","year":"2021","journal-title":"Chin. J. Dent. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/stem.728","article-title":"MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Periodontitis","volume":"29","author":"Liu","year":"2011","journal-title":"STEM CELLS"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/jbmr.440","article-title":"High levels of \u03b2-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway","volume":"26","author":"Liu","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/ten.tea.2016.0334","article-title":"Periodontal-Derived Mesenchymal Cell Sheets Promote Periodontal Regeneration in Inflammatory Microenvironment","volume":"23","author":"Guo","year":"2017","journal-title":"Tissue Eng. Part A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/IJN.S350869","article-title":"Lipopolysaccharide-Preconditioned Dental Follicle Stem Cells Derived Small Extracellular Vesicles Treating Periodontitis via Reactive Oxygen Species\/Mitogen-Activated Protein Kinase Signaling-Mediated Antioxidant Effect","volume":"17","author":"Huang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1007\/s00018-017-2644-4","article-title":"Periostin and its interacting proteins in the construction of extracellular architectures","volume":"74","author":"Kii","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1177\/0194599819838782","article-title":"Periostin and Inflammatory Disease: Implications for Chronic Rhinosinusitis","volume":"160","author":"Lehmann","year":"2019","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/path.4747","article-title":"Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis","volume":"239","author":"Wang","year":"2016","journal-title":"J. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1002\/jcb.28275","article-title":"Overexpression of periostin is positively associated with gastric cancer metastasis through promoting tumor metastasis and invasion","volume":"120","author":"Zhong","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1007\/s00018-017-2645-3","article-title":"Functions of Periostin in dental tissues and its role in periodontal tissues\u2019 regeneration","volume":"74","author":"Du","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.1128\/MCB.25.24.11131-11144.2005","article-title":"periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype","volume":"25","author":"Rios","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1902\/jop.2008.070624","article-title":"Periostin Is Essential for the Integrity and Function of the Periodontal Ligament During Occlusal Loading in Mice","volume":"79","author":"Rios","year":"2008","journal-title":"J. Periodontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/jre.12277","article-title":"Periostin of human periodontal ligament fibroblasts promotes migration of human mesenchymal stem cell through the v3 integrin\/FAK\/PI3K\/Akt pathway","volume":"50","author":"Matsuzawa","year":"2015","journal-title":"J. Periodontal Res."},{"key":"ref_26","first-page":"405","article-title":"Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor -\u03b1 and Porphyromonas gingivalis lipopolysaccharides","volume":"49","author":"Volk","year":"2013","journal-title":"J. Periodontal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/03008207.2017.1306060","article-title":"Periostin promotes migration, proliferation, and differentiation of human periodontal ligament mesenchymal stem cells","volume":"59","author":"Wu","year":"2017","journal-title":"Connect. Tissue Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"117184","DOI":"10.1016\/j.lfs.2019.117184","article-title":"Periostin reverses high glucose-inhibited osteogenesis of periodontal ligament stem cells via AKT pathway","volume":"242","author":"Yan","year":"2019","journal-title":"Life Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.actbio.2019.02.004","article-title":"Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats","volume":"88","author":"He","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.actbio.2019.03.021","article-title":"Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration","volume":"89","author":"Chew","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/JLB.4MR0421-756R","article-title":"Intersection between macrophages and periodontal pathogens in periodontitis","volume":"110","author":"Wang","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acsbiomaterials.0c00882","article-title":"Small Extracellular Vesicles from Lipopolysaccharide-Preconditioned Dental Follicle Cells Promote Periodontal Regeneration in an Inflammatory Microenvironment","volume":"6","author":"Shi","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1038\/s41598-022-23721-9","article-title":"IL-6\/ERK signaling pathway participates in type I IFN-programmed, unconventional M2-like macrophage polarization","volume":"13","author":"Yang","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1089\/scd.2019.0012","article-title":"Dental Follicle Stem Cells: Tissue Engineering and Immunomodulation","volume":"28","author":"Zhang","year":"2019","journal-title":"Stem Cells Dev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bi, R., Lyu, P., Song, Y., Li, P., Song, D., Cui, C., and Fan, Y. (2021). Function of Dental Follicle Progenitor\/Stem Cells and Their Potential in Regenerative Medicine: From Mechanisms to Applications. Biomolecules, 11.","DOI":"10.3390\/biom11070997"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1177\/0022034512452430","article-title":"Bone Repair Using Periodontal Ligament Progenitor Cell-seeded Constructs","volume":"91","author":"Tour","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8574","DOI":"10.1016\/j.biomaterials.2010.06.026","article-title":"Periodontal regeneration using engineered bone marrow mesenchymal stromal cells","volume":"31","author":"Yang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1159\/000360276","article-title":"Human Gingiva-Derived Mesenchymal Stromal Cells Contribute to Periodontal Regeneration in Beagle Dogs","volume":"198","author":"Yu","year":"2013","journal-title":"Cells Tissues Organs"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Iwasaki, K., Akazawa, K., Nagata, M., Komaki, M., Honda, I., Morioka, C., Yokoyama, N., Ayame, H., Yamaki, K., and Tanaka, Y. (2019). The Fate of Transplanted Periodontal Ligament Stem Cells in Surgically Created Periodontal Defects in Rats. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010192"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/ten.tea.2014.0151","article-title":"Periodontal Cell Implantation Contributes to the Regeneration of the Periodontium in an Indirect Way","volume":"21","author":"Yu","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"108417","DOI":"10.1016\/j.celrep.2020.108417","article-title":"Keratinocyte- Macrophage Crosstalk by the Nrf2\/Ccl2\/EGF Signaling Axis Orchestrates Tissue Repair","volume":"33","author":"Tiruneh","year":"2020","journal-title":"Cell Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2015.07.021","article-title":"Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves","volume":"162","author":"Cattin","year":"2015","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41586-020-2857-9","article-title":"Macrophage-derived glutamine boosts satellite cells and muscle regeneration","volume":"587","author":"Shang","year":"2020","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/odi.12983","article-title":"Macrophage polarization in human gingival tissue in response to periodontal disease","volume":"25","author":"Zhou","year":"2018","journal-title":"Oral Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"603817","DOI":"10.3389\/fmolb.2020.603817","article-title":"Injecting Immunosuppressive M2 Macrophages Alleviates the Symptoms of Periodontitis in Mice","volume":"7","author":"Miao","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.archoralbio.2017.03.006","article-title":"Enhanced activity of macrophage M1\/M2 phenotypes in periodontitis","volume":"96","author":"Yang","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fimmu.2020.00330","article-title":"Disruption of Monocyte and Macrophage Homeostasis in Periodontitis","volume":"11","author":"Almubarak","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1159\/000495873","article-title":"Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-beta 3 and TSP-1 to Elicit Macrophage M2 Polarization","volume":"51","author":"Chen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ncb3090","article-title":"Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth","volume":"17","author":"Zhou","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"80521","DOI":"10.18632\/oncotarget.11825","article-title":"Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR","volume":"7","author":"Guo","year":"2016","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ajpath.2016.11.010","article-title":"Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes\/Macrophages after Spinal Cord Injury","volume":"187","author":"Yokota","year":"2017","journal-title":"Am. J. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/cas.13567","article-title":"Cross-talk between ovarian cancer cells and macrophages through periostin promotes macrophage recruitment","volume":"109","author":"Tang","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ymthe.2020.01.011","article-title":"Cardiac Nestin+ Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage Polarization","volume":"28","author":"Liao","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12079-017-0422-6","article-title":"Periostin function in communication with extracellular matrices","volume":"12","author":"Kudo","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/imcb.12018","article-title":"Integrin \u03b1M activation and upregulation on esophageal eosinophils and periostin-mediated eosinophil survival in eosinophilic esophagitis","volume":"96","author":"Vimalathas","year":"2018","journal-title":"Immunol. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.archoralbio.2011.07.010","article-title":"PERIOSTIN regulates MMP-2 expression via the alpha v beta 3 integrin\/ERK pathway in human periodontal ligament cells","volume":"57","author":"Watanabe","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Liu, J., Wang, L., Liu, W., Li, Q., Jin, Z., and Jin, Y. (2014). Dental Follicle Cells Rescue the Regenerative Capacity of Periodontal Ligament Stem Cells in an Inflammatory Microenvironment. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108752"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Iwasaki, K., Peng, Y., Kanda, R., Umeda, M., and Ishikawa, I. (2022). Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031011"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1111\/jcmm.13286","article-title":"Administration of signalling molecules dictates stem cell homing for in situ regeneration","volume":"21","author":"Li","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Liu, A.-Q., Hu, C.-H., Jin, F., Zhang, L.-S., and Xuan, K. (2018). Contributions of Bioactive Molecules in Stem Cell-Based Periodontal Regeneration. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041016"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/sctm.18-0181","article-title":"Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations","volume":"8","author":"Xu","year":"2018","journal-title":"STEM CELLS Transl. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e12369","DOI":"10.1111\/cpr.12369","article-title":"Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions","volume":"50","author":"Tang","year":"2017","journal-title":"Cell Prolif."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3727\/096368912X656036","article-title":"Comparative Study of Human Dental Follicle Cell Sheets and Periodontal Ligament Cell Sheets for Periodontal Tissue Regeneration","volume":"22","author":"Guo","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-022-02721-6","article-title":"Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC\/PKC\/MAPK pathway","volume":"13","author":"Yi","year":"2022","journal-title":"Stem Cell Res. 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