{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:30:08Z","timestamp":1783420208755,"version":"3.54.6"},"reference-count":155,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>One the main research goals of bioinorganic chemists is the synthesis of novel coordination compounds possessing biological potency. Within this context, three novel iron(III) complexes with the non-steroidal anti-inflammatory drugs diflunisal and diclofenac in the presence or absence of the nitrogen donors 1,10-phenanthroline or pyridine were isolated and characterized by diverse techniques. The complexes were evaluated for their ability to scavenge in vitro free radicals such as hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, revealing their selective potency towards hydroxyl radicals. The in vitro inhibitory activity of the complexes towards the enzymes acetylcholinesterase and butyrylcholinesterase was evaluated, and their potential to achieve neuroprotection appeared promising. The interaction of the complexes with calf-thymus DNA was examined in vitro, revealing their ability to intercalate in-between DNA nucleobases. The affinity of the complexes for serum albumins was evaluated in vitro and revealed their tight and reversible binding.<\/jats:p>","DOI":"10.3390\/ijms24076391","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T02:03:53Z","timestamp":1680055433000},"page":"6391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules"],"prefix":"10.3390","volume":"24","author":[{"given":"Filitsa","family":"Dimiza","sequence":"first","affiliation":[{"name":"Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-3180","authenticated-orcid":false,"given":"Amalia","family":"Barmpa","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Chronakis","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, GR-57400 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios G.","family":"Hatzidimitriou","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Sanakis","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Nanotechnology, National Centre of Scientific Research \u201cDemokritos\u201d, GR-15310 Agia Paraskevi, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios N.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, GR-57400 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-7265","authenticated-orcid":false,"given":"George","family":"Psomas","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Grijota, F.J., Toro-Rom\u00e1n, V., Siquier-Coll, J., Robles-Gil, M.C., Mu\u00f1oz, D., and Maynar-Mari\u00f1o, M. (2022). Total Iron Concentrations in Different Biological Matrices\u2014Influence of Physical Training. Nutrients, 14.","DOI":"10.3390\/nu14173549"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Neves, J., Haider, T., Gassmann, M., and Muckenthaler, M.U. (2019). Iron Homeostasis in the Lungs\u2014A Balance between Health and Disease. Pharmaceuticals, 12.","DOI":"10.3390\/ph12010005"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"172614","DOI":"10.1016\/j.ejphar.2019.172614","article-title":"Iron Chelators in Obesity Therapy\u2014Old Drugs from a New Perspective?","volume":"861","author":"Gambero","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sukhbaatar, N., and Weichhart, T. (2018). Iron Regulation: Macrophages in Control. Pharmaceuticals, 11.","DOI":"10.3390\/ph11040137"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lin, J.-F., Wu, C.-C., Liao, Y.-J., Jakfar, S., Tang, Z.-B., Chen, J.-K., and Lin, F.H. (2019). In Vitro and In Vivo Evaluations of Mesoporous Iron Particles for Iron Bioavailability. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215291"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7831\/ras.3.1","article-title":"Role of iron in plant growth and metabolism","volume":"3","author":"Rout","year":"2015","journal-title":"Rev. Agric. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0098-2997(00)00006-6","article-title":"The roles of iron in health and disease","volume":"22","author":"Lieu","year":"2001","journal-title":"Mol. Asp. Med."},{"key":"ref_9","first-page":"1895","article-title":"The Role of Iron Homeostasis and Iron-Mediated ROS in Cancer","volume":"11","author":"Ying","year":"2021","journal-title":"Am. J. Cancer. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.canlet.2019.08.007","article-title":"Iron and Lung Cancer","volume":"464","author":"Kuang","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1349-7006.2008.01001.x","article-title":"Role of Iron in Carcinogenesis: Cancer as a Ferrotoxic Disease","volume":"100","author":"Toyokuni","year":"2009","journal-title":"Cancer Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.bbadis.2018.08.030","article-title":"Role of Iron Metabolism in Heart Failure: From Iron Deficiency to Iron Overload","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The Role of Iron in Brain Ageing and Neurodegenerative Disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00702-016-1508-7","article-title":"Role of Iron in Neurodegenerative Diseases","volume":"123","author":"Li","year":"2016","journal-title":"J. Neural Transm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.biocel.2017.05.003","article-title":"Role of Iron in the Pathogenesis of Respiratory Disease","volume":"88","author":"Ali","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Arias, L.S., Pessan, J.P., Vieira, A.P.M., de Lima, T.M.T., Delbem, A.C.B., and Monteiro, D.R. (2018). Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity. Antibiotics, 7.","DOI":"10.3390\/antibiotics7020046"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1039\/C5NJ01449B","article-title":"Recent Advances in Iron Complexes as Potential Anticancer Agents","volume":"40","author":"Wani","year":"2016","journal-title":"New J. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.carbpol.2016.12.069","article-title":"Antimicrobial and Antioxidant Activities of Flammulina Velutipes Polysacchrides and Polysacchride-Iron(III) Complex","volume":"161","author":"Dong","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129946","DOI":"10.1016\/j.molstruc.2021.129946","article-title":"Iron(III) and Zinc(II) Monodentate Schiff Base Metal Complexes: Synthesis, Characterisation and Biological Activities","volume":"1231","author":"Naureen","year":"2021","journal-title":"J. Mol. Struct."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ica.2006.07.102","article-title":"Interaction of Fe(III) with Herbicide-Carboxylato Ligands. Di-, Tri- and Tetra-Nuclear Compounds: Structure, Antimicrobial Study and DNA Interaction","volume":"360","author":"Dimitrakopoulou","year":"2007","journal-title":"Inorg. Chim. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.toxrep.2015.04.005","article-title":"Antioxidant and Free Radical Scavenging Activity of Iron Chelators","volume":"2","author":"Adjimani","year":"2015","journal-title":"Toxicol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"111410","DOI":"10.1016\/j.jinorgbio.2021.111410","article-title":"Trinuclear and Tetranuclear Iron(III) Complexes with Fenamates: Structure and Biological Profile","volume":"218","author":"Dimiza","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuropharm.2013.07.004","article-title":"Therapeutics of Alzheimer\u2019s Disease: Past, Present and Future","volume":"76","author":"Anand","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_24","unstructured":"Prince, M.J., Wimo, A., Guerchet, M.M., Ali, G.C., Wu, Y., and Prina, M. (2015). World Alzheimer Report 2015\u2014The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends, Alzheimer\u2019s Disease International (ADI), Frontiers Media SA."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1586\/14737175.2015.990884","article-title":"Pharmacotherapy of Alzheimer\u2019s Disease: Current and Future Trends","volume":"15","author":"Geldenhuys","year":"2015","journal-title":"Expert. Rev. Neurother."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The Amyloid Hypothesis of Alzheimer\u2019s Disease at 25 Years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.12.118","article-title":"A Pilot Study on the Effect of Lactoferrin on Alzheimer\u2019s Disease Pathological Sequelae: Impact of the p-Akt\/PTEN Pathway","volume":"111","author":"Mohamed","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.conb.2006.09.002","article-title":"The Role of Acetylcholine in Learning and Memory","volume":"16","author":"Hasselmo","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejmech.2018.09.031","article-title":"Donepezil-Based Multi-Functional Cholinesterase Inhibitors for Treatment of Alzheimer\u2019s Disease","volume":"158","author":"Li","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Collins, A.E., Saleh, T.M., and Kalisch, B.E. (2022). Naturally Occurring Antioxidant Therapy in Alzheimer\u2019s Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11020213"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/NEN.0b013e3181cb5af4","article-title":"Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex","volume":"69","author":"Ansari","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_32","first-page":"2050","article-title":"Resveratrol Improves Cognition and Reduces Oxidative Stress in Rats with Vascular Dementia","volume":"8","author":"Ma","year":"2013","journal-title":"Neural. Regen. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1212\/WNL.43.8.1609","article-title":"Clinical Trial of Indomethacin in Alzheimer\u2019s Disease","volume":"43","author":"Rogers","year":"1993","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The Molecular Pathology of Alzheimer\u2019s Disease","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1212\/WNL.50.4.986","article-title":"Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer-Type Pathology in Aging","volume":"50","author":"Mackenzie","year":"1998","journal-title":"Neurology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0024-3205(99)00645-1","article-title":"Treatment and Survival Study in the C57BL\/6J\u2013APCMin\/+ (Min) Mouse with R-Flurbiprofen","volume":"66","author":"Wechter","year":"2000","journal-title":"Life Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1039\/C7NJ00794A","article-title":"Photoluminescence and Magnetic Analysis of a Family of Lanthanide (III) Complexes Based on Diclofenac","volume":"41","author":"Oyarzabal","year":"2017","journal-title":"New J. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jinorgbio.2012.12.002","article-title":"A Novel Copper(II) Mononuclear Complex with the Non-Steroidal Anti-Inflammatory Drug Diclofenac: Structural Characterization and Biological Activity","volume":"120","author":"Sayen","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"k3426","DOI":"10.1136\/bmj.k3426","article-title":"Diclofenac Use and Cardiovascular Risks: Series of Nationwide Cohort Studies","volume":"362","author":"Schmidt","year":"2018","journal-title":"BMJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110982","DOI":"10.1016\/j.biopha.2020.110982","article-title":"Early Use of Non-Steroidal Anti-Inflammatory Drugs in COVID-19 Might Reverse Pathogenesis, Prevent Complications and Improve Clinical Outcomes","volume":"133","author":"Kelleni","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"155317","DOI":"10.1016\/j.scitotenv.2022.155317","article-title":"Non-Steroidal Anti-Inflammatory Drugs in the Era of the COVID-19 Pandemic in the Context of the Human and the Environment","volume":"834","author":"Guzik","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jinorgbio.2010.08.013","article-title":"Interaction of Copper(II) with the Non-Steroidal Anti-Inflammatory Drugs Naproxen and Diclofenac: Synthesis, Structure, DNA- and Albumin-Binding","volume":"105","author":"Dimiza","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jinorgbio.2018.07.009","article-title":"Copper(II) Diclofenac Complexes: Synthesis, Structural Studies and Interaction with Albumins and Calf-Thymus DNA","volume":"187","author":"Kumar","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"12785","DOI":"10.1039\/C7DT02789C","article-title":"A Reactive Oxygen Species-Generating, Cyclooxygenase-2 Inhibiting, Cancer Stem Cell-Potent Tetranuclear Copper(II) Cluster","volume":"46","author":"Lu","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1080\/00958972.2016.1227802","article-title":"New Metal Complexes with Diclofenac Containing 2-Pyridineethanol or 2-Pyridinepropanol: Synthesis, Structural, Spectroscopic, Thermal Properties, Catechol Oxidase and Carbonic Anhydrase Activities","volume":"69","author":"Caglar","year":"2016","journal-title":"J. Coord. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1080\/00958972.2015.1098633","article-title":"Neutral and Cationic Manganese(II)-Diclofenac Complexes: Structure and Biological Evaluation","volume":"68","author":"Zampakou","year":"2015","journal-title":"J. Coord. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1021\/acs.inorgchem.7b00655","article-title":"Toward Multifunctional Materials Incorporating Stepladder Manganese(III) Inverse-[9-MC-3]-Metallacrowns and Anti-Inflammatory Drugs","volume":"56","author":"Tarushi","year":"2017","journal-title":"Inorg. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"114570","DOI":"10.1016\/j.poly.2020.114570","article-title":"In Vitro Evaluation of Leishmanicidal Properties of a New Family of Monodimensional Coordination Polymers Based on Diclofenac Ligand","volume":"184","author":"Cepeda","year":"2020","journal-title":"Polyhedron"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0277-5387(00)84327-2","article-title":"Metal Complexes of the Anti-Inflammatory Drug Sodium [2-[(2,6-Dichlorophenyl)Amino]Phenyl]Acetate (Diclofenac Sodium). Molecular and Crystal Structure of Cadmium Diclofenac","volume":"12","author":"Mentzafos","year":"1993","journal-title":"Polyhedron"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.saa.2003.11.027","article-title":"Preparations and Spectroscopic Studies of Organotin Complexes of Diclofenac","volume":"60","author":"Kourkoumelis","year":"2004","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.poly.2013.05.043","article-title":"Ni(II) Complexes with Non-Steroidal Anti-Inflammatory Drug Diclofenac: Structure and Interaction with DNA and Albumins","volume":"61","author":"Kyropoulou","year":"2013","journal-title":"Polyhedron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"111194","DOI":"10.1016\/j.jinorgbio.2020.111194","article-title":"Zn(II) Complexes of (E)-4-(2-(Pyridin-2-Ylmethylene)Hydrazinyl)Quinazoline in Combination with Non-Steroidal Anti-Inflammatory Drug Sodium Diclofenac: Structure, DNA Binding and Photo-Cleavage Studies, Antioxidant Activity and Interaction with Albumin","volume":"211","author":"Kakoulidou","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1021\/acs.inorgchem.0c03550","article-title":"Anchoring Drugs to a Zinc(II) Coordination Polymer Network: Exploiting Structural Rationale toward the Design of Metallogels for Drug-Delivery Applications","volume":"60","author":"Biswas","year":"2021","journal-title":"Inorg. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1107\/S2056989016014730","article-title":"Crystal Structure of a Mixed-Ligand Silver(I) Complex of the Non-Steroidal Anti-Inflammatory Drug Diclofenac and Pyrimidine","volume":"72","author":"Dege","year":"2016","journal-title":"Acta Crystallogr. E Crystallogr. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10787-999-0002-3","article-title":"Ibuprofen, the Propionics and NSAIDs: Personal Reflections over Four Decades","volume":"7","author":"Adams","year":"1999","journal-title":"Inflammopharmacology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1834-7819.1993.tb05494.x","article-title":"Diflunisal\u2014A Long-Acting Non-Steroidal Anti-Inflammatory Drug","volume":"38","author":"Lawton","year":"1993","journal-title":"Aust. Dent. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2165\/00003495-198019020-00002","article-title":"Diflunisal: A Review of Its Pharmacological Properties and Therapeutic Use in Pain and Musculoskeletal Strains and Sprains and Pain in Osteoarthritis","volume":"19","author":"Brogden","year":"2012","journal-title":"Drugs"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cardfail.2019.11.024","article-title":"Stabilization of Cardiac Function with Diflunisal in Transthyretin (ATTR) Cardiac Amyloidosis","volume":"26","author":"Lohrmann","year":"2020","journal-title":"J. Card. Fail."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1751-7133.2012.00303.x","article-title":"Diflunisal for ATTR Cardiac Amyloidosis","volume":"18","author":"Helmke","year":"2012","journal-title":"Congest. Heart Fail."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1016\/S0735-1097(21)04650-7","article-title":"Treating Transthyretin Amyloid Cardiomyopathy: A Comparison of Diflunisal and Tafamidis","volume":"77","author":"Gilad","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.jinorgbio.2011.09.004","article-title":"Non-Steroidal Anti-Inflammatory Drug Diflunisal Interacting with Cu(II). Structure and Biological Features","volume":"105","author":"Fountoulaki","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jinorgbio.2015.12.015","article-title":"Cobalt(II) Complexes with Non-Steroidal Anti-Inflammatory Drugs and \u03b1-Diimines","volume":"160","author":"Tsiliou","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jinorgbio.2016.06.003","article-title":"Nickel-Diflunisal Complexes: Synthesis, Characterization, in Vitro Antioxidant Activity and Interaction with DNA and Albumins","volume":"162","author":"Perontsis","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jinorgbio.2017.02.010","article-title":"Zinc Complexes of Diflunisal: Synthesis, Characterization, Structure, Antioxidant Activity, and in Vitro and in Silico Study of the Interaction with DNA and Albumins","volume":"170","author":"Tarushi","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"m441","DOI":"10.1107\/S1600536802012655","article-title":"Di-n-Butylbis(2\u2032,4\u2032-Difluoro-4-Hydroxybiphenyl-3-Carboxylato-O,O\u2032)Tin(IV)","volume":"58","author":"Hans","year":"2002","journal-title":"Acta Crystallogr. Sect. E Struct. Rep. Online"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hc.10057","article-title":"Synthesis, Characterization, and Biological Studies of Tri- and Diorganotin(IV) Complexes with 2,4-Difluoro-4-Hydroxy-[1,1]-Biphenyle-3-Carbolic Acid: Crystal Structure of [(CH3)3Sn(C13H7O3F2)]","volume":"13","author":"Ahmad","year":"2002","journal-title":"Heteroat. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"12904","DOI":"10.1039\/C4DT00957F","article-title":"Stability and Toxicity of Heteroleptic Organometallic Bi(v) Complexes towards Leishmania Major","volume":"43","author":"Ong","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"18215","DOI":"10.1039\/C5DT03335G","article-title":"Stability and Toxicity of Tris-Tolyl Bismuth(v) Dicarboxylates and Their Biological Activity towards Leishmania Major","volume":"44","author":"Ong","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"13846","DOI":"10.1002\/chem.202102207","article-title":"Osteosarcoma Stem Cell Potent Gallium(III)-Polypyridyl Complexes Bearing Diflunisal","volume":"27","author":"Xiao","year":"2021","journal-title":"Chem. A Eur. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jinorgbio.2018.07.007","article-title":"In Vitro and in Silico Study of the Biological Activity of Manganese(III) Inverse-[9-MC-3]-Metallacrowns and Manganese(II) Complexes with the Anti-Inflammatory Drugs Diclofenac or Indomethacin","volume":"187","author":"Geromichalos","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"110688","DOI":"10.1016\/j.jinorgbio.2019.04.002","article-title":"Cobalt(II) Complexes with the Non-Steroidal Anti-Inflammatory Drug Diclofenac and Nitrogen-Donor Ligands","volume":"196","author":"Perontsis","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ejic.201500769","article-title":"Copper(II) Inverse-[9-Metallacrown-3] Compounds Accommodating Nitrato or Diclofenac Ligands: Structure, Magnetism, and Biological Activity","volume":"2016","author":"Tarushi","year":"2016","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/ejic.201500078","article-title":"Structurally Diverse Manganese(II)-Diclofenac Complexes Showing Enhanced Antioxidant Activity and Affinity to Serum Albumins in Comparison to Sodium Diclofenac","volume":"2015","author":"Zampakou","year":"2015","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"213259","DOI":"10.1016\/j.ccr.2020.213259","article-title":"Copper(II) and Zinc(II) Coordination Compounds of Non-Steroidal Anti-Inflammatory Drugs: Structural Features and Antioxidant Activity","volume":"412","author":"Psomas","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"111357","DOI":"10.1016\/j.jinorgbio.2021.111357","article-title":"Copper(II) Complexes with Meclofenamate Ligands: Structure, Interaction with DNA and Albumins, Antioxidant and Anticholinergic Activity","volume":"217","author":"Barmpa","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"111507","DOI":"10.1016\/j.jinorgbio.2021.111507","article-title":"Nickel(II)-Meclofenamate Complexes: Structure, in Vitro and in Silico DNA- and Albumin-Binding Studies, Antioxidant and Anticholinergic Activity","volume":"222","author":"Barmpa","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110906","DOI":"10.1016\/j.jinorgbio.2019.110906","article-title":"Manganese(II) Coordination Compounds of Carboxylate Non-Steroidal Anti-Inflammatory Drugs","volume":"203","author":"Dimiza","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.2217\/fon.09.127","article-title":"New Hopes from Old Drugs: Revisiting DNA-Binding Small Molecules as Anticancer Agents","volume":"5","author":"Gurova","year":"2009","journal-title":"Future Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/1869","article-title":"Crystal Structure of Human Serum Albumin Complexed with Fatty Acid Reveals an Asymmetric Distribution of Binding Sites","volume":"5","author":"Curry","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/358209a0","article-title":"Atomic structure and chemistry of human serum albumin","volume":"358","author":"He","year":"1992","journal-title":"Nature"},{"key":"ref_81","first-page":"327","article-title":"Chapter 33. Plasma Protein Binding of Drugs","volume":"31","author":"Olson","year":"1996","journal-title":"Annu. Rep. Med. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0010-8545(00)80009-0","article-title":"The Use of Conductivity Measurements in Organic Solvents for the Characterisation of Coordination Compounds","volume":"7","author":"Geary","year":"1971","journal-title":"Coord. Chem. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1002\/chem.200400114","article-title":"Structural and Electrochemical Studies of Novel Bis(\u03bc-Methoxo)Diiron Complexes: Observation of FeIIIFeIV and FeIVFeIV States Resonating with Phenoxyl Radicals","volume":"10","author":"Houjou","year":"2004","journal-title":"Chem.-A Eur. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1002\/ejic.201001340","article-title":"Asymmetrically Dibridged Diiron(III) Complexes with Aminebis(Phenoxide)-Based Ligands for a Magnetostructural Study","volume":"2011","author":"Wagner","year":"2011","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1039\/b818578f","article-title":"Methoxo-Bridged Diiron(Iii) Complex of m-Xylylenebis(Acetylacetonate) Showing Remarkable Thermal Stability for Encapsulated Dichloromethane","volume":"33","author":"Dutta","year":"2009","journal-title":"New J. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1515\/znb-2005-0905","article-title":"Synthesis, Crystal Structure, and Spectroscopic and Magnetic Properties of a Dinuclear Iron(III) Complex Asymmetrically Bridged by a Phenoxo and a Methoxo Group","volume":"60b","author":"Zeyrek","year":"2005","journal-title":"Z. Naturforsch."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.5012\/bkcs.2010.31.12.3617","article-title":"Synthesis, Crystal Structure, and Magnetic Properties of Dinuclear Iron(III) Complexes with Methoxo Bridges","volume":"31","author":"Shin","year":"2010","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_88","first-page":"135","article-title":"The Molecular Structure and Magnetic Properties of the Dimeric N,N\u2032-Ethylenebis(Salicylamine)Fe(III)-Methoxo-N,N\u2032-Ethylene(o-Hydroxylphenyl-Glycine)Salicylamine Fe(III): A Complex with a p-Monodentate Acetato Bridge, Inorg","volume":"152","author":"Spartalian","year":"1988","journal-title":"Chim. Acta"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3390\/molecules20022115","article-title":"Synthesis, Crystal Structure, Spectroscopic Properties and Potential Biological Activities of Salicylate?Neocuproine Ternary Copper(II) Complexes","volume":"20","author":"Valko","year":"2015","journal-title":"Molecules"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Van der Horn, J.A., Souvignier, B., and Lutz, M. (2017). Crystallization, Structure Determination and Reticular Twinning in Iron(Iii) Salicylate: Fe[(Hsal)(Sal)(H2O)2]. Crystals, 7.","DOI":"10.3390\/cryst7120377"},{"key":"ref_91","first-page":"290","article-title":"Copper(II) 3,5-Dinitrosalicylate-The Unique System for Co-Crystal Formation by Gentle Changes in Preparation Procedure","volume":"1","author":"Valigura","year":"2008","journal-title":"Acta Chim. Slovaca"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"130942","DOI":"10.1016\/j.molstruc.2021.130942","article-title":"Mono- and Binuclear Cu (II) 3,5-Diiodosalicylates: Structures and Features of Non-Covalent Interactions in Crystalline State","volume":"1244","author":"Bondarenko","year":"2021","journal-title":"J. Mol. Struct."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.poly.2004.08.015","article-title":"Structural Confirmation of the 3,5-Dinitrosalicylato Anion Coordination Ability to Metal Ion: Crystal Structure, Spectral and Magnetic Properties of the [Cu3{3,5-(NO2)2sal2\u2212} 2{3,5-(NO2)2sal1\u2212}2(H2O)4]\u00b74H2O","volume":"23","author":"Valigura","year":"2004","journal-title":"Polyhedron"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1039\/c1dt10739a","article-title":"Self-Assembled Decanuclear NaI2MnII4MnIII4 Complexes: From Discrete Clusters to 1-D and 2-D Structures, with the MnII4MnIII4 Unit Displaying a Large Spin Ground State and Probable SMM Behaviour","volume":"40","author":"Langley","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.jorganchem.2010.04.035","article-title":"Formation of a Novel Hexanuclear ZrIV Cage Compound with Bridging Chelating Ligand: [(CpZr)6(\u03bc-O2C\u2013C6H2Cl2\u20132-O)9(OH2)3]\u00b7H2O","volume":"695","author":"Li","year":"2010","journal-title":"J. Organomet. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1039\/C7DT00049A","article-title":"Synthesis, Structure and Paramagnetic NMR Analysis of a Series of Lanthanide-Containing [LnTi6O3(OiPr)9(Salicylate)6] Cages","volume":"46","author":"Li","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1039\/b207722a","article-title":"Heterometallic CeIII\u2013FeIII-Salicylate Networks: Models for Corrosion Mitigation of Steel Surfaces by the \u2032Green\u2032 Inhibitor, Ce(Salicylate)3","volume":"2","author":"Deacon","year":"2002","journal-title":"Chem. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.poly.2004.01.006","article-title":"Synthesis, EPR and M\u00f6ssbauer Spectral Studies of New Iron(III) Complexes with 2-Benzoylpyridine-N(4),N(4)-(Butane-1,4-Diyl) Thiosemicarbazone (HBpypTsc): X-Ray Structure of [Fe(BpypTsc)2]FeCl4\u00b72H2O and the Free Ligand","volume":"23","author":"Sreekanth","year":"2004","journal-title":"Polyhedron"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1071\/CH00043","article-title":"Synthesis and Crystal Structures of [Fe(Bpe6)2Cl2] and [Fe(Bpe6)2Cl2]+[FeCl4]\u2212 (Bpe6 = 1,2-Bis(Phosphorinan-1-Yl)Ethane)","volume":"53","author":"Field","year":"2000","journal-title":"Aust. J. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/zaac.200600003","article-title":"The Coordination Chemistry of Iron with the 1,4-Bis(2-Pyridyl-Methyl) Piperazine Ligand","volume":"632","author":"Ostermeier","year":"2006","journal-title":"Z. Anorg. Allg. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1016\/j.poly.2007.04.041","article-title":"X-ray Crystallographic Structure and Physical Properties of the Pentacoordinated [TPAFeCl]+ Complex","volume":"26","author":"Kim","year":"2007","journal-title":"Polyhedron"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"m1774","DOI":"10.1107\/S1600536805025456","article-title":"Bis[Hydrotris(1-Pyrazolyl)Borato-\u03ba3N,N\u2032,N\u2033] Iron(III) Tetrachloroferrate(III) Acetonitrile Solvate","volume":"61","author":"Hong","year":"2005","journal-title":"Acta Crystallogr. Sect. E Struct. Rep. Online"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1039\/a608138j","article-title":"Synthesis and Crystal Structure of the Iron(II)-Iron(III) Complex [FeL][FeCl4]Cl [L = 1,4,7-Tris(Pyrazol-3-Ylmethyl)-1,4,7-Triazacyclononane]","volume":"8","author":"Vaira","year":"1997","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Nakamoto, K. (2009). Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B: Applications in Coordination, Organometallic, and Bioinorganic Chemistry, Wiley. [6th ed.].","DOI":"10.1002\/9780470405840"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jorganchem.2003.11.040","article-title":"Preparation and Structural Studies on Dibutyltin(IV) Complexes with Pyridine Mono- and Dicarboxylic Acids","volume":"689","author":"Szorcsik","year":"2004","journal-title":"J. Organomet. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1021\/ic010106a","article-title":"Molecular and Electronic Structure of Octahedral O-Aminophenolato and o-Iminobenzosemiquinonato Complexes of V(V), Cr(III), Fe(III), and Co(III). Experimental Determination of Oxidation Levels of Ligands and Metal Ions","volume":"40","author":"Chun","year":"2001","journal-title":"Inorg. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1021\/ic001127s","article-title":"Syntheses, Structures, and Reactivity of Low Spin Iron(III) Complexes Containing a Single Carboxamido Nitrogen in a [FeN5L] Chromophore","volume":"40","author":"Rowland","year":"2001","journal-title":"Inorg. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/ic0009371","article-title":"Syntheses and Structural Characterization of Dinuclear and Tetranuclear Iron(III) Complexes with Dinucleating Ligands and Their Reactions with Hydrogen Peroxide\u2021","volume":"40","author":"Westerheide","year":"2001","journal-title":"Inorg. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0020-1693(98)00197-2","article-title":"A \u03bc-Oxo Diiron Complex of a New Binucleating Tetrapyridyl Ligand","volume":"282","author":"Berchet","year":"1998","journal-title":"Inorg. Chim. Acta"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Greenwood, N.N., and Gibb, T.C. (1971). M\u00f6ssbauer Spectroscopy, Chapman and Hall Ltd.","DOI":"10.1007\/978-94-009-5697-1"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1021\/ic00122a024","article-title":"Polyiron(III)-Alkoxo Clusters: A Novel Trinuclear Complex and Its Relevance to the Extended Lattices of Iron Oxides and Hydroxides","volume":"34","author":"Caneschi","year":"1995","journal-title":"Inorg. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.crci.2006.09.008","article-title":"J-Strain and Antisymmetric Exchange in a Polynuclear Compound Containing the {Fe3O}7+ Core","volume":"10","author":"Sanakis","year":"2007","journal-title":"Comptes Rendus Chim."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"126779","DOI":"10.1016\/j.jtemb.2021.126779","article-title":"Metallobiology and Therapeutic Chelation of Biometals (Copper, Zinc and Iron) in Alzheimer\u2019s Disease: Limitations, and Current and Future Perspectives","volume":"67","author":"Fasae","year":"2021","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s13311-014-0312-z","article-title":"Biometals and Their Therapeutic Implications in Alzheimer\u2019s Disease","volume":"12","author":"Ayton","year":"2015","journal-title":"Neurotherapeutics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.envres.2017.07.048","article-title":"Metals and Neurodegenerative Diseases. A Systematic Review","volume":"159","author":"Cicero","year":"2017","journal-title":"Environ. Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Sales, T.A., Prandi, I.G., de Castro, A.A., Leal, D.H.S., da Cunha, E.F.F., Kuca, K., and Ramalho, T.C. (2019). Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081829"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jinorgbio.2016.05.001","article-title":"Targeting Copper(II)-Induced Oxidative Stress and the Acetylcholinesterase System in Alzheimer\u2019s Disease Using Multifunctional Tacrine-Coumarin Hybrid Molecules","volume":"161","author":"Hamulakova","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jinorgbio.2016.09.010","article-title":"Copper(II) and Zinc(II) Complexes with Flavanone Derivatives: Identification of Potential Cholinesterase Inhibitors by on-Flow Assays","volume":"164","author":"Sarria","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative Stress: A Concept in Redox Biology and Medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1021\/ic00351a012","article-title":"Metal Complexes of the Antiinflammatory Drug Piroxicam","volume":"29","author":"Cini","year":"1990","journal-title":"Inorg. Chem."},{"key":"ref_121","first-page":"465","article-title":"Ageing and Health: Free Radicals and Oxidative Stress","volume":"18","author":"Jaleel","year":"2008","journal-title":"J. Coll. Phys. Surg. Pak."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1039\/c3dt50268f","article-title":"Quinolones and Non-Steroidal Anti-Inflammatory Drugs Interacting with Copper(II), Nickel(II), Cobalt(II) and Zinc(II): Structural Features, Biological Evaluation and Perspectives","volume":"42","author":"Psomas","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Slavova-Kazakova, A., Karama\u0107, M., Kancheva, V., and Amarowicz, R. (2016). Antioxidant Activity of Flaxseed Extracts in Lipid Systems. Molecules, 21.","DOI":"10.3390\/molecules21010017"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/14756366.2016.1222583","article-title":"Study of the Antioxidant Activity of Thymus Sibthorpii Bentham (Lamiaceae)","volume":"31","author":"Kontogiorgis","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/1475636031000069291","article-title":"Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-Inflammatory\/Antioxidant Agents","volume":"18","author":"Kontogiorgis","year":"2003","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_126","unstructured":"Halliwell, B., and Gutteridge, J.M.C. (1999). Free Radicals in Biology and Medicine, Oxford University Press. [3rd ed.]."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jinorgbio.2013.07.013","article-title":"Antioxidant Capacity and DNA-Interaction Studies of Zinc Complexes with a Non-Steroidal Anti-Inflammatory Drug, Mefenamic Acid","volume":"128","author":"Tarushi","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jinorgbio.2007.09.008","article-title":"Differences in Structure, Physiological Stability, Electrochemistry, Cytotoxicity, DNA and Protein Binding Properties between Two Ru(III) Complexes","volume":"102","author":"Tan","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jlumin.2006.06.013","article-title":"Interaction of the Flavonoid Hesperidin with Bovine Serum Albumin: A Fluorescence Quenching Study","volume":"126","author":"Wang","year":"2007","journal-title":"J. Lumin."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ijbiomac.2020.01.134","article-title":"Probing the Interaction of Rivastigmine Tartrate, an Important Alzheimer\u2019s Drug, with Serum Albumin: Attempting Treatment of Alzheimer\u2019s Disease","volume":"148","author":"Shamsi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Lakowicz, J.R. (2006). Principles of Fluorescence Spectroscopy, Plenum Press. [3rd ed.].","DOI":"10.1007\/978-0-387-46312-4"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1039\/b808357f","article-title":"A Reassessment of the Association between Azulene and [60]Fullerene. Possible Pitfalls in the Determination of Binding Constants through Fluorescence Spectroscopy","volume":"39","author":"Stella","year":"2008","journal-title":"Chem. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1039\/C8NJ01182F","article-title":"A Step-Ladder Manganese(III) Metallacrown Hosting Mefenamic Acid and a Manganese(II)-Mefanamato Complex: Synthesis, Characterization and Cytotoxic Activity","volume":"42","author":"Tarushi","year":"2018","journal-title":"New J. Chem."},{"key":"ref_134","unstructured":"Hardman, J.G., Limbird, L.E., and Gilman, A.G. (2001). Goodman and Gilman\u2019s the Pharmacological Basis of Therapeutics, McGraw Hill. [10th ed.]."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1039\/b710949k","article-title":"Metallo-Intercalators and Metallo-Insertors","volume":"44","author":"Zeglis","year":"2007","journal-title":"Chem. Commun."},{"key":"ref_136","first-page":"399","article-title":"DNA-Binding Drugs Caught in Action: The Latest 3D Pictures of Drug-DNA Complexes","volume":"3","author":"Boer","year":"2008","journal-title":"Dalton Trans."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1021\/ja00190a046","article-title":"Mixed-Ligand Complexes of Ruthenium(II): Factors Governing Binding to DNA","volume":"111","author":"Pyle","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1021\/ja9734049","article-title":"Binding Mode of Norfloxacin to Calf Thymus DNA","volume":"120","author":"Son","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/ar00177a001","article-title":"On Demonstrating DNA Intercalation","volume":"23","author":"Long","year":"1990","journal-title":"Acc. Chem. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1021\/bi00394a013","article-title":"Polycyclic Aromatic Hydrocarbons Physically Intercalate into Duplex Regions of Denatured DNA","volume":"26","author":"Wolfe","year":"1987","journal-title":"Biochemistry"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jinorgbio.2007.10.005","article-title":"Synthesis, Structure and Interactions with DNA of Novel Tetranuclear, [Mn4(II\/II\/II\/IV)] Mixed Valence Complexes","volume":"102","author":"Dimitrakopoulou","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jinorgbio.2009.04.003","article-title":"Toward the Development of Metal-Based Synthetic Nucleases: DNA Binding and Oxidative DNA Cleavage of a Mixed Copper(II) Complex with N-(9H-Purin-6-Yl)Benzenesulfonamide and 1,10-Phenantroline. Antitumor Activity in Human Caco-2 Cells and Jurkat T Lymphocytes. Evaluation of P53 and Bcl-2 Proteins in the Apoptotic Mechanism","volume":"103","author":"Alzuet","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jinorgbio.2009.10.020","article-title":"A Novel 1,2,4-Triazole-Based Copper(II) Complex: Synthesis, Characterization, Magnetic Property and Nuclease Activity","volume":"104","author":"Li","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0162-0134(98)10019-3","article-title":"Dinuclear Palladium(II) Complexes Containing Two Monofunctional [Pd(En)(Pyridine)Cl]+ Units Bridged by Se or S. Synthesis, Characterization, Cytotoxicity and Kinetic Studies of DNA-Binding","volume":"70","author":"Zhao","year":"1998","journal-title":"J. Inorg. Biochem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0301-4622(93)E0101-A","article-title":"Fluorescence Lifetime Analysis of DNA Intercalated Ethidium Bromide and Quenching by Free Dye","volume":"50","author":"Heller","year":"1994","journal-title":"Biophys. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0022-2836(61)80047-8","article-title":"A procedure for the isolation of deoxyribonucleic acid from micro-organisms","volume":"3","author":"Marmur","year":"1961","journal-title":"J. Mol. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1021\/ja01640a067","article-title":"A Further Examination of the Molecular Weight and Size of Desoxypentose Nucleic Acid","volume":"76","author":"Reichmann","year":"1954","journal-title":"J. Am. Chem. Soc."},{"key":"ref_148","unstructured":"Bruker Analytical X-Ray Systems, Inc. (2006). Apex2, Version 2 User Manual, M86-E01078, Bruker Analytical X-ray Systems, Inc."},{"key":"ref_149","unstructured":"Siemens Industrial Automation, Inc. (1996). SADABS: Area-Detector Absorption Correction, Siemens Industrial Automation, Inc."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1107\/S0021889807029238","article-title":"SUPERFLIP\u2014A Computer Program for the Solution of Crystal Structures by Charge Flipping in Arbitrary Dimensions","volume":"40","author":"Palatinus","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1107\/S0021889803021800","article-title":"CRYSTALS Version 12: Software for Guided Crystal Structure Analysis","volume":"36","author":"Betteridge","year":"2003","journal-title":"J. Appl. Crystallogr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue Sulfhydryl Groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1021\/bi973101r","article-title":"Ionization-Reactivity Relationships for Cysteine Thiols in Polypeptides","volume":"37","author":"Bulaj","year":"1998","journal-title":"Biochemistry"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/14756366.2018.1530224","article-title":"Synthesis, Preliminarily Biological Evaluation and Molecular Docking Study of New Olaparib Analogues as Multifunctional PARP-1 and Cholinesterase Inhibitors","volume":"34","author":"Gao","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1042\/bj0550416","article-title":"The Colorimetric Estimation of Formaldehyde by Means of the Hantzsch Reaction","volume":"55","author":"Nash","year":"1953","journal-title":"Biochem. J."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6391\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:05:25Z","timestamp":1760123125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":155,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076391"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076391","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]}}}