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However, how the circadian clock contributes to TLE remains elusive. A recent circadian analysis of the ventral hippocampal transcriptome of pilocarpine-induced TLE mice revealed as many as 1650 rhythmically expressed transcripts. Here, a comparison of the mouse ventral hippocampal transcriptome with the human epilepsy-related gene set identified 315 possible mouse epilepsy-related genes. Rhythmicity analysis classified them into arrhythmicity, loss-of-rhythmicity, gain-of-rhythmicity, and rhythmicity-maintaining groups. KEGG and GO analyses of these mouse epilepsy genes suggest their involvement in circadian entrainment. In TLE mice, Htr1d, Drd2, and Chrna3 lose rhythmicity, but P2rx7 gains rhythmicity; the up-regulation of Htr1d and Drd2 and down-regulation of Chrna3 inhibit adenylate cyclase (AC), and up-regulation of Htr1d, Drd2, and P2rx7 activates protein kinase C (PKC). Together, these results suggest that epilepsy can disrupt the circadian dynamics of the epileptic genes, shed light on possible TLE pathogenesis, and provide potential targets for TLE diagnosis and chronotherapy.<\/jats:p>","DOI":"10.3390\/ijms24076400","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T02:03:53Z","timestamp":1680055433000},"page":"6400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy"],"prefix":"10.3390","volume":"24","author":[{"given":"Sha","family":"Sun","sequence":"first","affiliation":[{"name":"Center for Circadian Clocks, Soochow University, Suzhou 215123, China"},{"name":"School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-3147","authenticated-orcid":false,"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Circadian Clocks, Soochow University, Suzhou 215123, China"},{"name":"School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1046\/j.1528-1157.2001.10401.x","article-title":"A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE Task Force on Classification and Terminology","volume":"42","author":"Engel","year":"2001","journal-title":"Epilepsia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.seizure.2012.03.014","article-title":"Circadian profiles of focal epileptic seizures: A need for reappraisal","volume":"21","author":"Mirzoev","year":"2012","journal-title":"Seizure"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eaat5979","DOI":"10.1126\/sciadv.aat5979","article-title":"The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy","volume":"6","author":"Ceglia","year":"2020","journal-title":"Sci. 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