{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T17:21:18Z","timestamp":1784481678519,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","award":["\u201cISPA EMERGENTES IFV 2020\u201d"],"award-info":[{"award-number":["\u201cISPA EMERGENTES IFV 2020\u201d"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","award":["FISS-21-RD21\/0002\/0041"],"award-info":[{"award-number":["FISS-21-RD21\/0002\/0041"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","award":["PT 20\/00161"],"award-info":[{"award-number":["PT 20\/00161"]}]},{"name":"Health Institute Carlos III, Plan Nacional de I+D+I","award":["\u201cISPA EMERGENTES IFV 2020\u201d"],"award-info":[{"award-number":["\u201cISPA EMERGENTES IFV 2020\u201d"]}]},{"name":"Health Institute Carlos III, Plan Nacional de I+D+I","award":["FISS-21-RD21\/0002\/0041"],"award-info":[{"award-number":["FISS-21-RD21\/0002\/0041"]}]},{"name":"Health Institute Carlos III, Plan Nacional de I+D+I","award":["PT 20\/00161"],"award-info":[{"award-number":["PT 20\/00161"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>PTEN-induced kinase-1 (PINK1) is the initiator of the canonical mitophagy pathway. Our aim was to study the immunoexpression of PINK1 in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver (CRLM). Tissue arrays were produced, and immunohistochemical studies were analyzed by the H-Score method. The mean immunoexpression of PINK1 in normal tissues was between 40 to 100 points. In tumoral tissues, positive PINK1 immunoexpression was observed in all samples, and no differences were noted between CRCs. In CRLMs, a significant under-expression was noted for PINK1 from the rectum (71.3 \u00b1 30.8; p &lt; 0.042) compared to other sites. Altered PINK1 immunoexpression in CRCs, either higher than 100 points or lower than 40 points, was associated with worse overall survival (OS) (p &lt; 0.012) due to a shorter post-metastatic survival (PMS) (p &lt; 0.023), and it was found to be a significant independent predictor of prognosis in a multivariate model for OS and PMS (HR = 1.972, 95% CI 0.971\u20134.005; p = 0.022. HR = 2.023, 95% CI 1.003\u20134.091; p = 0.037, respectively). In conclusion, altered PINK1 immunoexpression determined in CRCs with resected CRLM predicts a worse prognosis, possibly due to the abnormal function of mitophagy.<\/jats:p>","DOI":"10.3390\/ijms24076506","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T02:30:20Z","timestamp":1680229820000},"page":"6506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PINK1 Immunoexpression Predicts Survival in Patients Undergoing Hepatic Resection for Colorectal Liver Metastases"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3261-3958","authenticated-orcid":false,"given":"Juan Carlos","family":"Celis-Pinto","sequence":"first","affiliation":[{"name":"Department of Pathology, Central University Hospital of Asturias (HUCA), University of Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-8614","authenticated-orcid":false,"given":"Adela Alonso","family":"Fern\u00e1ndez-Velasco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central University Hospital of Asturias (HUCA), University of Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-4498","authenticated-orcid":false,"given":"Mar\u00eda Daniela","family":"Corte-Torres","sequence":"additional","affiliation":[{"name":"Biobank of Principality of Asturias, 33011 Oviedo, Spain"},{"name":"Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-3522","authenticated-orcid":false,"given":"Jorge","family":"Santos-Juanes","sequence":"additional","affiliation":[{"name":"Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Dermatology, Central University Hospital of Asturias (HUCA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-0493","authenticated-orcid":false,"given":"Noelia","family":"Blanco-Agud\u00edn","sequence":"additional","affiliation":[{"name":"Department of Functional Biology, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin Manuel","family":"Pi\u00f1a Batista","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central University Hospital of Asturias (HUCA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Merayo-Lloves","sequence":"additional","affiliation":[{"name":"Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Instituto Universitario Fern\u00e1ndez-Vega, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-3762","authenticated-orcid":false,"given":"Luis M.","family":"Quir\u00f3s","sequence":"additional","affiliation":[{"name":"Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Functional Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto Universitario Fern\u00e1ndez-Vega, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-6493","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Fern\u00e1ndez-Vega","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central University Hospital of Asturias (HUCA), University of Oviedo, 33011 Oviedo, Spain"},{"name":"Biobank of Principality of Asturias, 33011 Oviedo, Spain"},{"name":"Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Instituto Universitario Fern\u00e1ndez-Vega, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Malki, A., ElRuz, R.A., Gupta, I., Allouch, A., Vranic, S., and Al Moustafa, A.E. (2020). Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010130"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: Integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"ref_7","first-page":"4326082","article-title":"Integrating Systemic Therapies into the Multimodality Treatment of Resectable Colorectal Liver Metastases","volume":"2018","author":"Cheung","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3322\/canjclin.49.4.231","article-title":"Surgical therapy of hepatic colorectal metastasis","volume":"49","author":"Fong","year":"1999","journal-title":"CA Cancer J. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/01.sla.0000217629.94941.cf","article-title":"Epidemiology and management of liver metastases from colorectal cancer","volume":"244","author":"Manfredi","year":"2006","journal-title":"Ann. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/cncr.24081","article-title":"Survival after hepatic resection of colorectal cancer metastases: A national experience","volume":"115","author":"Robertson","year":"2009","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40170-015-0130-8","article-title":"Mitophagy and cancer","volume":"3","author":"Chourasia","year":"2015","journal-title":"Cancer Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.semcancer.2017.04.008","article-title":"Expanding perspectives on the significance of mitophagy in cancer","volume":"47","author":"Drake","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lin, W., and Kang, U.J. (2010). Structural determinants of PINK1 topology and dual subcellular distribution. BMC Cell Biol., 11.","DOI":"10.1186\/1471-2121-11-90"},{"key":"ref_14","first-page":"590","article-title":"PINK1 signalling in cancer biology","volume":"1846","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.biopha.2018.06.128","article-title":"Silencing of PINK1 represses cell growth, migration and induces apoptosis of lung cancer cells","volume":"106","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2016.10.088","article-title":"Mitophagy: Link to cancer development and therapy","volume":"482","author":"Kulikov","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4103\/1673-5374.295314","article-title":"Deciphering the dual role and prognostic potential of PINK1 across cancer types","volume":"16","author":"Dai","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_18","first-page":"617","article-title":"Dual Role of Mitophagy in Cancer Drug Resistance","volume":"38","author":"Yan","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.canlet.2021.12.032","article-title":"PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages","volume":"529","author":"Xu","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.3892\/or.2017.5486","article-title":"High expression of PINK1 promotes proliferation and chemoresistance of NSCLC","volume":"37","author":"Zhang","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"569887","DOI":"10.3389\/fonc.2020.569887","article-title":"Pan-Cancer Analysis of the Mitophagy-Related Protein PINK1 as a Biomarker for the Immunological and Prognostic Role","volume":"10","author":"Zhu","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.amjsurg.2021.03.007","article-title":"Surgical and oncologic outcomes following repeat hepatic resection of colorectal liver metastasis: Who benefits?","volume":"221","author":"Wong","year":"2021","journal-title":"Am. J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/s41588-019-0507-7","article-title":"The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies","volume":"51","author":"Angus","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-019-1689-y","article-title":"Pan-cancer whole-genome analyses of metastatic solid tumours","volume":"575","author":"Priestley","year":"2019","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"29765","DOI":"10.1038\/srep29765","article-title":"Patterns of metastasis in colon and rectal cancer","volume":"6","author":"Riihimaki","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.ejso.2021.03.245","article-title":"Complete pathological response in rectal cancer utilising novel treatment strategies for neo-adjuvant therapy: A systematic review","volume":"47","author":"Wilson","year":"2021","journal-title":"J. Eur. Soc. Surg. Oncol. Br. Assoc. Surg. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/his.13793","article-title":"Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review","volume":"74","author":"Almangush","year":"2019","journal-title":"Histopathology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/jso.25017","article-title":"Prognostic significance of poorly differentiated clusters and tumor budding in colorectal liver metastases","volume":"117","author":"Fonseca","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fmed.2019.00247","article-title":"Evaluation of Tumor Budding in Primary Colorectal Cancer and Corresponding Liver Metastases Based on H&E and Pancytokeratin Staining","volume":"6","author":"Blank","year":"2019","journal-title":"Front. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/jso.24910","article-title":"The RAS mutation status predicts survival in patients undergoing hepatic resection for colorectal liver metastases: The results from a genetic analysis of all-RAS","volume":"117","author":"Amikura","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/SLA.0b013e3182a5025a","article-title":"RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases","volume":"258","author":"Vauthey","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/bjs.9870","article-title":"Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases","volume":"102","author":"Brudvik","year":"2015","journal-title":"Br. J. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1016\/j.clcc.2017.01.004","article-title":"Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis","volume":"16","author":"Tosi","year":"2017","journal-title":"Clin. Color. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3233\/CBM-170984","article-title":"Potential biomarkers for the early diagnosis of colorectal adenocarcinoma\u2014Transcriptomic analysis of four clinical stages","volume":"22","author":"Janikowska","year":"2018","journal-title":"Cancer Biomark."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"eaay9691","DOI":"10.1126\/sciadv.aay9691","article-title":"The clonal evolution of metastatic colorectal cancer","volume":"6","author":"Dang","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature10762","article-title":"Clonal evolution in cancer","volume":"481","author":"Greaves","year":"2012","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Bednarczyk, M., Muc-Wierzgon, M., Dziegielewska-Gesiak, S., Fatyga, E., and Waniczek, D. (2023). Transcription of Autophagy Associated Gene Expression as Possible Predictors of a Colorectal Cancer Prognosis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020418"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100748","DOI":"10.1016\/j.mgene.2020.100748","article-title":"PTEN-induced putative kinase 1 (PINK1) down-regulation in breast cancer samples in association with mitotic rate","volume":"25","author":"Yaghoobi","year":"2020","journal-title":"Meta Gene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1200\/JCO.2015.62.0138","article-title":"Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non\u2013Small-Cell Lung Cancer and Brain Metastasis","volume":"34","author":"Johung","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2217\/mmt.15.38","article-title":"Biology and treatment of BRAF mutant metastatic melanoma","volume":"3","author":"Kong","year":"2016","journal-title":"Melanoma Manag."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1200\/OP.21.00172","article-title":"Current and Future Management of HER2-Positive Metastatic Breast Cancer","volume":"17","author":"Prat","year":"2021","journal-title":"JCO Oncol. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1038\/s41418-021-00760-9","article-title":"Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production","volume":"28","author":"Yin","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2018.07.012","article-title":"PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism","volume":"46","author":"Li","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1158\/0008-5472.CAN-15-3079","article-title":"PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma","volume":"76","author":"Agnihotri","year":"2016","journal-title":"Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.2147\/CMAR.S262466","article-title":"PINK1 Overexpression Promotes Cell Migration and Proliferation via Regulation of Autophagy and Predicts a Poor Prognosis in Lung Cancer Cases","volume":"12","author":"Lu","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.5582\/bst.2018.01263","article-title":"Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1\/Parkin-dependent mitophagy in primary chondrocytes","volume":"12","author":"Wang","year":"2019","journal-title":"Biosci. Trends"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41419-022-04649-4","article-title":"Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-\u03b2\/PI3K\/AKT signaling transduction","volume":"13","author":"Xiao","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.pathol.2020.10.010","article-title":"The 2019 World Health Organization Classification of appendiceal, colorectal and anal canal tumours: An update and critical assessment","volume":"53","author":"Ahadi","year":"2021","journal-title":"Pathology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3389\/fonc.2019.01255","article-title":"RAS, Cellular Plasticity, and Tumor Budding in Colorectal Cancer","volume":"9","author":"Maffeis","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/PAS.0000000000000504","article-title":"Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort","volume":"39","author":"Graham","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10735-013-9483-x","article-title":"Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: An immunohistochemical and electron microscopic study","volume":"44","author":"Eid","year":"2013","journal-title":"J. Mol. Histol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13402-017-0362-4","article-title":"Establishing cut-off points with clinical relevance for bcl-2, cyclin D1, p16, p21, p27, p53, Sox11 and WT1 expression in glioblastoma\u2014A short report","volume":"41","author":"Garcia","year":"2018","journal-title":"Cell. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12253-018-0387-7","article-title":"Miki (Mitotic Kinetics Regulator) Immunoexpression in Normal Liver, Cirrhotic Areas and Hepatocellular Carcinomas: A Preliminary Study with Clinical Relevance","volume":"26","author":"Garcia","year":"2020","journal-title":"Pathol. Oncol. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6506\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:21Z","timestamp":1760123241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076506"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076506","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}