{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:11:10Z","timestamp":1785849070005,"version":"3.56.0"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59-year-old, non-neutropenic male patient, was admitted to an intensive care unit (ICU) due to respiratory distress syndrome, following a partial gastrectomy. As a result of duodenal stump leakage, re-laparotomy was required, abdominal drains were provided and central line catheters were exchanged. Multiple isolates of Candida orthopsilosis drawn from consecutive blood cultures were identified, despite ongoing echinocandin therapy and confirmed in vitro echinocandins susceptibility of the isolated strain. Species identification was verified via ITS region sequencing. Herein, we report the well-documented\u2014per clinical data and relevant laboratory diagnosis\u2014first case of a bloodstream infection caused by Candida orthopsilosis in Poland.<\/jats:p>","DOI":"10.3390\/ijms24076541","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T03:02:01Z","timestamp":1680231721000},"page":"6541","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-0515","authenticated-orcid":false,"given":"Magdalena","family":"Mnichowska-Polanowska","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Adamowicz","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology and Intensive Therapy, Teaching Hospital No 1, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Wojciechowska-Koszko","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1486-1093","authenticated-orcid":false,"given":"Anna","family":"Kisiel","sequence":"additional","affiliation":[{"name":"Institute of Marine and Environmental Sciences, University of Szczecin, 70-383 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-0323","authenticated-orcid":false,"given":"Bartosz","family":"Wojciuk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Jarosz","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology and Intensive Therapy, Teaching Hospital No 1, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-1013","authenticated-orcid":false,"given":"Barbara","family":"Do\u0142\u0119gowska","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00134-019-05599-w","article-title":"ESICM\/ESCMID task force on practical management of invasive candidiasis in critically ill patients","volume":"45","author":"Antonelli","year":"2019","journal-title":"Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Doi, A.M., Pignatari, A.C.C., Edmond, M.B., Marra, A.R., Camargo, L.F., Siqueira, R.A., da Mota, V.P., and Colombo, A.L. 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