{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:28:19Z","timestamp":1769354899177,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Science and Higher Education of the Russian Federation","award":["075-01129-23-00"],"award-info":[{"award-number":["075-01129-23-00"]}]},{"name":"The Ministry of Science and Higher Education of the Russian Federation","award":["20.003.22.800"],"award-info":[{"award-number":["20.003.22.800"]}]},{"name":"The Ministry of Science and Higher Education of the Russian Federation","award":["21-74-20110"],"award-info":[{"award-number":["21-74-20110"]}]},{"name":"Federal Medical and Biological Agency of Russia","award":["075-01129-23-00"],"award-info":[{"award-number":["075-01129-23-00"]}]},{"name":"Federal Medical and Biological Agency of Russia","award":["20.003.22.800"],"award-info":[{"award-number":["20.003.22.800"]}]},{"name":"Federal Medical and Biological Agency of Russia","award":["21-74-20110"],"award-info":[{"award-number":["21-74-20110"]}]},{"name":"Russian Scientific Foundation","award":["075-01129-23-00"],"award-info":[{"award-number":["075-01129-23-00"]}]},{"name":"Russian Scientific Foundation","award":["20.003.22.800"],"award-info":[{"award-number":["20.003.22.800"]}]},{"name":"Russian Scientific Foundation","award":["21-74-20110"],"award-info":[{"award-number":["21-74-20110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>THz radiation induces a variety of processes in cells and has attracted the attention of researchers in recent decades. Here, data on the effects of high-intensity terahertz (THz) radiation on human directly reprogrammed neural progenitor cells (drNPCs) and on neuroblastoma cells (SK-N-BE (2)) were obtained for the first time. The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1\u20133 THz) THz pulses with the intensity of 21 GW\/cm2 and the electric field strength of 2.8 MV\/cm for 30 min induced neither a noticeable genotoxic effect nor a statistically significant change in the proliferative activity and cell differentiation. It was also shown that the combined effect of THz radiation and salinomycin, a promising antitumor agent, on neuroblastoma cells did not enhance the genotoxic effect of this antibiotic. However, further studies involving chemotherapy drugs and other exposure parameters are warranted to introduce this new concept into anti-tumor clinical practice and to enhance the efficacy of the existing approaches.<\/jats:p>","DOI":"10.3390\/ijms24076558","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T10:19:33Z","timestamp":1680257973000},"page":"6558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-5283","authenticated-orcid":false,"given":"Dmitry","family":"Sitnikov","sequence":"first","affiliation":[{"name":"Joint Institute for High Temperatures, Russian Academy of Sciences, 125412 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Revkova","sequence":"additional","affiliation":[{"name":"Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, 119435 Moscow, Russia"},{"name":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-409X","authenticated-orcid":false,"given":"Inna","family":"Ilina","sequence":"additional","affiliation":[{"name":"Joint Institute for High Temperatures, Russian Academy of Sciences, 125412 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimma","family":"Shatalova","sequence":"additional","affiliation":[{"name":"Center for Genetics and Life Sciences, Division of Genetics and Genetic Technologies, Sirius University of Science and Technology, 354340 Sochi, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Komarov","sequence":"additional","affiliation":[{"name":"Joint Institute for High Temperatures, Russian Academy of Sciences, 125412 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Struleva","sequence":"additional","affiliation":[{"name":"Joint Institute for High Temperatures, Russian Academy of Sciences, 125412 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Konoplyannikov","sequence":"additional","affiliation":[{"name":"Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, 119435 Moscow, Russia"},{"name":"Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kalsin","sequence":"additional","affiliation":[{"name":"Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, 119435 Moscow, Russia"},{"name":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-4245","authenticated-orcid":false,"given":"Vladimir","family":"Baklaushev","sequence":"additional","affiliation":[{"name":"Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, 119435 Moscow, Russia"},{"name":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia"},{"name":"Federal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency, 117513 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"013001","DOI":"10.1088\/2040-8986\/ab4dc3","article-title":"The Progress and Perspectives of Terahertz Technology for Diagnosis of Neoplasms: A Review","volume":"22","author":"Zaytsev","year":"2020","journal-title":"J. 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