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These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain, this organ is susceptible to many different types of damage that result in the loss of neuronal tissue and therefore in alterations in the functionality of the affected regions. Nevertheless, the mammalian brain has developed mechanisms to respond to these injuries, potentiating its capacity to generate new neurons from neural stem cells and altering the homeostatic processes that occur in neurogenic niches. These alterations may lead to the generation of new neurons within the damaged brain regions. Notwithstanding, the activation of these repair mechanisms, regeneration of neuronal tissue within brain injuries does not naturally occur. In this review, we discuss how the different neurogenic niches respond to different types of brain injuries, focusing on the capacity of the progenitors generated in these niches to migrate to the injured regions and activate repair mechanisms. We conclude that the search for pharmacological drugs that stimulate the migration of newly generated neurons to brain injuries may result in the development of therapies to repair the damaged brain tissue.<\/jats:p>","DOI":"10.3390\/ijms24076587","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T03:08:31Z","timestamp":1680491311000},"page":"6587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-9050","authenticated-orcid":false,"given":"Noelia","family":"Geribaldi-Dold\u00e1n","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda y Embriolog\u00eda Humanas, Facultad de Medicina, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain"},{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-5550","authenticated-orcid":false,"given":"Livia","family":"Carrascal","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Departamento de Biomedicina, Biotecnolog\u00eda y Salud P\u00fablica, \u00c1rea de Fisiolog\u00eda, Facultad de Medicina, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Oliva-Montero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Departamento de Biomedicina, Biotecnolog\u00eda y Salud P\u00fablica, \u00c1rea de Fisiolog\u00eda, Facultad de Medicina, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pardillo-D\u00edaz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Departamento de Biomedicina, Biotecnolog\u00eda y Salud P\u00fablica, \u00c1rea de Fisiolog\u00eda, Facultad de Medicina, Universidad de C\u00e1diz, 11003 C\u00e1diz, 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