{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:23:44Z","timestamp":1785803024861,"version":"3.56.0"},"reference-count":125,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vaincre la mucoviscidose","award":["RC20190502431"],"award-info":[{"award-number":["RC20190502431"]}]},{"name":"Vaincre la mucoviscidose","award":["RF20220503058"],"award-info":[{"award-number":["RF20220503058"]}]},{"name":"Gregory Lemarchal","award":["RC20190502431"],"award-info":[{"award-number":["RC20190502431"]}]},{"name":"Gregory Lemarchal","award":["RF20220503058"],"award-info":[{"award-number":["RF20220503058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cystic fibrosis (CF) is a serious genetic disease that leads to premature death, mainly due to impaired lung function. CF lungs are characterized by ongoing inflammation, impaired immune response, and chronic bacterial colonization. Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are the two most predominant bacterial agents of these chronic infections. Both can colonize the lungs for years by developing host adaptation strategies. In this review, we examined the mechanisms by which SA and PA adapt to the host immune response. They are able to bypass the physical integrity of airway epithelia, evade recognition, and then modulate host immune cell proliferation. They also modulate the immune response by regulating cytokine production and by counteracting the activity of neutrophils and other immune cells. Inhibition of the immune response benefits not only the species that implements them but also other species present, and we therefore discuss how these mechanisms can promote the establishment of coinfections in CF lungs.<\/jats:p>","DOI":"10.3390\/ijms24076609","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T03:08:31Z","timestamp":1680491311000},"page":"6609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["How Staphylococcus aureus and Pseudomonas aeruginosa Hijack the Host Immune Response in the Context of Cystic Fibrosis"],"prefix":"10.3390","volume":"24","author":[{"given":"Aubin","family":"Souche","sequence":"first","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France"},{"name":"Institut des Agents Infectieux, Hospices Civils de Lyon, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vandenesch","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France"},{"name":"Institut des Agents Infectieux, Hospices Civils de Lyon, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dol\u00e9ans-Jordheim","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France"},{"name":"Institut des Agents Infectieux, Hospices Civils de Lyon, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-3543","authenticated-orcid":false,"given":"Karen","family":"Moreau","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ajic.2018.12.021","article-title":"Impact of Colonizing Organism in the Respiratory Tract on the Incidence, Duration, and Time between Subsequent Hospitalizations among Patients with Cystic Fibrosis","volume":"47","author":"Cios","year":"2019","journal-title":"Am. J. Infect. Control"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Scotet, V., L\u2019Hostis, C., and F\u00e9rec, C. (2020). The Changing Epidemiology of Cystic Fibrosis: Incidence, Survival and Impact of the CFTR Gene Discovery. Genes, 11.","DOI":"10.3390\/genes11060589"},{"key":"ref_3","unstructured":"Dehillotte, C., and Lemonnier, L. (2022). Registre fran\u00e7ais de la mucoviscidose\u2014Bilan des donn\u00e9es 2021 Vaincre la Mucoviscidose Paris."},{"key":"ref_4","unstructured":"Cystic Fibrosis Foundation Patient Registry (2022). 2021 Annual Data Report Bethesda, Maryland \u00a92022 Cystic Fibrosis Foundation."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nm.2715","article-title":"Cystic Fibrosis: A Mucosal Immunodeficiency Syndrome","volume":"18","author":"Cohen","year":"2012","journal-title":"Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1038\/s41396-020-00741-9","article-title":"Trophic Cooperation Promotes Bacterial Survival of Staphylococcus Aureus and Pseudomonas Aeruginosa","volume":"14","author":"Camus","year":"2020","journal-title":"ISME J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fcimb.2020.00266","article-title":"Impact of Coexistence Phenotype between Staphylococcus Aureus and Pseudomonas Aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients","volume":"10","author":"Briaud","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jcf.2012.12.003","article-title":"Association between Staphylococcus Aureus Alone or Combined with Pseudomonas Aeruginosa and the Clinical Condition of Patients with Cystic Fibrosis","volume":"12","author":"Hubert","year":"2013","journal-title":"J. Cyst. Fibros."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1164\/rccm.202004-1322OC","article-title":"Sustained Coinfections with Staphylococcus Aureus and Pseudomonas Aeruginosa in Cystic Fibrosis","volume":"203","author":"Fischer","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.semcdb.2017.04.003","article-title":"Staphylococcus Aureus Pore-Forming Toxins: The Interface of Pathogen and Host Complexity","volume":"72","author":"Seilie","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm728","article-title":"Staphylococcus Aureus Extracellular Adherence Protein Serves as Anti-Inflammatory Factor by Inhibiting the Recruitment of Host Leukocytes","volume":"8","author":"Chavakis","year":"2002","journal-title":"Nat. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.20031636","article-title":"Chemotaxis Inhibitory Protein of Staphylococcus Aureus, a Bacterial Antiinflammatory Agent","volume":"199","author":"Veldkamp","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1462-5822.2006.00709.x","article-title":"Early Expression of SCIN and CHIPS Drives Instant Immune Evasion by Staphylococcus Aureus","volume":"8","author":"Rooijakkers","year":"2006","journal-title":"Cell. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/ni1235","article-title":"Immune Evasion by a Staphylococcal Complement Inhibitor That Acts on C3 Convertases","volume":"6","author":"Rooijakkers","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000334604","article-title":"Staphylococcus Aureus Virulence Is Enhanced by Secreted Factors That Block Innate Immune Defenses","volume":"4","author":"Jongerius","year":"2012","journal-title":"J. Innate Immun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro3521","article-title":"Staphylococcal Manipulation of Host Immune Responses","volume":"13","author":"Thammavongsa","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chekabab, S.M., Silverman, R.J., Lafayette, S.L., Luo, Y., Rousseau, S., and Nguyen, D. (2015). Staphylococcus Aureus Inhibits IL-8 Responses Induced by Pseudomonas Aeruginosa in Airway Epithelial Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137753"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1128\/IAI.00748-08","article-title":"Inhibition of Endothelial Interleukin-8 Production and Neutrophil Transmigration by Staphylococcus Aureus Beta-Hemolysin","volume":"77","author":"Tajima","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/infdis\/jiv124","article-title":"Staphylococcus Aureus Inhibits Neutrophil-Derived IL-8 to Promote Cell Death","volume":"212","author":"Zurek","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Guggenberger, C., Wolz, C., Morrissey, J.A., and Heesemann, J. (2012). Two Distinct Coagulase-Dependent Barriers Protect Staphylococcus Aureus from Neutrophils in a Three Dimensional in Vitro Infection Model. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002434"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/physrev.00009.2015","article-title":"Innate Immune Signaling Activated by MDR Bacteria in the Airway","volume":"96","author":"Parker","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1084\/jem.20090097","article-title":"Staphylococcus Aureus Synthesizes Adenosine to Escape Host Immune Responses","volume":"206","author":"Thammavongsa","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13187","DOI":"10.1073\/pnas.1407616111","article-title":"Staphylococcus Aureus Secretes a Unique Class of Neutrophil Serine Protease Inhibitors","volume":"111","author":"Stapels","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1128\/AAC.48.12.4673-4679.2004","article-title":"Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus Aureus-Derived Proteinases","volume":"48","author":"Mydel","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.172.2.1169","article-title":"Staphylococcus Aureus Resists Human Defensins by Production of Staphylokinase, a Novel Bacterial Evasion Mechanism","volume":"172","author":"Jin","year":"2004","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Garcia, Y.M., Barwinska-Sendra, A., Tarrant, E., Skaar, E.P., Waldron, K.J., and Kehl-Fie, T.E. (2017). A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus Aureus to Calprotectin and Nutritional Immunity. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006125"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/infdis\/jiy012","article-title":"Adaptation of Staphylococcus Aureus to Airway Environments in Patients with Cystic Fibrosis by Upregulation of Superoxide Dismutase M and Iron-Scavenging Proteins","volume":"217","author":"Treffon","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e13158","DOI":"10.1111\/cmi.13158","article-title":"Importance of Superoxide Dismutases A and M for Protection of Staphylococcus Aureus in the Oxidative Stressful Environment of Cystic Fibrosis Airways","volume":"22","author":"Treffon","year":"2020","journal-title":"Cell. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1084\/jem.20050846","article-title":"Staphylococcus Aureus Golden Pigment Impairs Neutrophil Killing and Promotes Virulence through Its Antioxidant Activity","volume":"202","author":"Liu","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1128\/JB.01524-06","article-title":"Catalase (KatA) and Alkyl Hydroperoxide Reductase (AhpC) Have Compensatory Roles in Peroxide Stress Resistance and Are Required for Survival, Persistence, and Nasal Colonization in Staphylococcus Aureus","volume":"189","author":"Cosgrove","year":"2007","journal-title":"J. Bacteriol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.1242255","article-title":"Staphylococcus Aureus Degrades Neutrophil Extracellular Traps to Promote Immune Cell Death","volume":"342","author":"Thammavongsa","year":"2013","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.3389\/fimmu.2019.02552","article-title":"High Nuclease Activity of Long Persisting Staphylococcus Aureus Isolates within the Airways of Cystic Fibrosis Patients Protects against NET-Mediated Killing","volume":"10","author":"Herzog","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1159\/000319909","article-title":"Nuclease Expression by Staphylococcus Aureus Facilitates Escape from Neutrophil Extracellular Traps","volume":"2","author":"Berends","year":"2010","journal-title":"J. Innate Immun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1038\/ncomms6105","article-title":"Pseudomonas Aeruginosa Eradicates Staphylococcus Aureus by Manipulating the Host Immunity","volume":"5","author":"Pernet","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.4049\/jimmunol.1402665","article-title":"Staphylococcus Aureus Adenosine Inhibits SPLA2-IIA\u2013Mediated Host Killing in the Airways","volume":"194","author":"Pernet","year":"2015","journal-title":"J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e00575-13","DOI":"10.1128\/mBio.00575-13","article-title":"Role of Protein A in the Evasion of Host Adaptive Immune Responses by Staphylococcus Aureus","volume":"4","author":"Falugi","year":"2013","journal-title":"mBio"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mib.2011.10.012","article-title":"Recurrent Infections and Immune Evasion Strategies of Staphylococcus Aureus","volume":"15","author":"Kim","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrmicro1289","article-title":"Immune Evasion by Staphylococci","volume":"3","author":"Foster","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e02270-19","DOI":"10.1128\/mBio.02270-19","article-title":"Staphylococcus Aureus Exploits the Host Apoptotic Pathway to Persist during Infection","volume":"10","author":"Winstel","year":"2019","journal-title":"mBio"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cmet.2020.04.017","article-title":"Pseudomonas Aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation","volume":"31","author":"Riquelme","year":"2020","journal-title":"Cell Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/s41467-021-21718-y","article-title":"Staphylococcus Aureus Induces an Itaconate-Dominated Immunometabolic Response That Drives Biofilm Formation","volume":"12","author":"Tomlinson","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e01281-17","DOI":"10.1128\/mBio.01281-17","article-title":"The Metallophore Staphylopine Enables Staphylococcus Aureus to Compete with the Host for Zinc and Overcome Nutritional Immunity","volume":"8","author":"Grim","year":"2017","journal-title":"mBio"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1099930","article-title":"Iron-Source Preference of Staphylococcus Aureus Infections","volume":"305","author":"Skaar","year":"2004","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Radin, J.N., Kelliher, J.L., Sol\u00f3rzano, P.K.P., and Kehl-Fie, T.E. (2016). The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus Aureus to Resist Calprotectin-Induced Manganese Starvation. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1006040"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"C357","DOI":"10.1152\/ajpcell.00373.2016","article-title":"Effects of Pseudomonas Aeruginosa on CFTR Chloride Secretion and the Host Immune Response","volume":"312","author":"Stanton","year":"2017","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"C844","DOI":"10.1152\/ajpcell.00002.2014","article-title":"Thapsigargin Blocks Pseudomonas Aeruginosa Homoserine Lactone-Induced Apoptosis in Airway Epithelia","volume":"306","author":"Schwarzer","year":"2014","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrmicro2199","article-title":"The Type III Secretion System of Pseudomonas Aeruginosa: Infection by Injection","volume":"7","author":"Hauser","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1128\/IAI.72.11.6463-6470.2004","article-title":"Differential Immune Modulatory Activity of Pseudomonas Aeruginosa Quorum-Sensing Signal Molecules","volume":"72","author":"Hooi","year":"2004","journal-title":"Infect Immun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00430-009-0111-z","article-title":"Influence of Pseudomonas Aeruginosa Quorum Sensing Signal Molecule N-(3-Oxododecanoyl) Homoserine Lactone on Mast Cells","volume":"198","author":"Li","year":"2009","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1365-2567.2009.03160.x","article-title":"HHQ and PQS, Two Pseudomonas Aeruginosa Quorum-Sensing Molecules, down-Regulate the Innate Immune Responses through the Nuclear Factor-\u039aB Pathway","volume":"129","author":"Kim","year":"2010","journal-title":"Immunology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1500199","DOI":"10.1126\/sciadv.1500199","article-title":"Cystic Fibrosis\u2013Adapted Pseudomonas Aeruginosa Quorum Sensing LasR Mutants Cause Hyperinflammatory Responses","volume":"1","author":"LaFayette","year":"2015","journal-title":"Sci. Adv."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Koeppen, K., Hampton, T.H., Jarek, M., Scharfe, M., Gerber, S.A., Mielcarz, D.W., Demers, E.G., Dolben, E.L., Hammond, J.H., and Hogan, D.A. (2016). A Novel Mechanism of Host-Pathogen Interaction through SRNA in Bacterial Outer Membrane Vesicles. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005672"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4049\/jimmunol.1300368","article-title":"The Bacterial Quorum-Sensing Signal Molecule N -3-Oxo-Dodecanoyl-l-Homoserine Lactone Reciprocally Modulates Pro- and Anti-Inflammatory Cytokines in Activated Macrophages","volume":"191","author":"Sananes","year":"2013","journal-title":"J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1128\/IAI.00803-15","article-title":"Pseudomonas Aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells","volume":"83","author":"Bortolotti","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1574-695X.2008.00533.x","article-title":"Pseudomonas Aeruginosa Quorum-Sensing Signal Molecules Interfere with Dendritic Cell-Induced T-Cell Proliferation","volume":"55","author":"Skindersoe","year":"2009","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/IAI.66.1.36-42.1998","article-title":"The Pseudomonas Aeruginosa Quorum-Sensing Signal Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone Has Immunomodulatory Activity","volume":"66","author":"Telford","year":"1998","journal-title":"Infect. Immun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1128\/iai.58.10.3363-3368.1990","article-title":"Pseudomonas Aeruginosa Alginate in Cystic Fibrosis Sputum and the Inflammatory Response","volume":"58","author":"Pedersen","year":"1990","journal-title":"Infect. Immun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e88912","DOI":"10.1172\/jci.insight.88912","article-title":"The Role for Neutrophil Extracellular Traps in Cystic Fibrosis Autoimmunity","volume":"1","author":"Skopelja","year":"2016","journal-title":"JCI Insight"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1189\/jlb.0511260","article-title":"Sialoglycoproteins Adsorbed by Pseudomonas Aeruginosa Facilitate Their Survival by Impeding Neutrophil Extracellular Trap through Siglec-9","volume":"91","author":"Khatua","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Floyd, M., Winn, M., Cullen, C., Sil, P., Chassaing, B., Yoo, D., Gewirtz, A.T., Goldberg, J.B., McCarter, L.L., and Rada, B. (2016). Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas Aeruginosa. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005987"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3389\/fimmu.2019.01670","article-title":"Regulation of Pseudomonas Aeruginosa-Mediated Neutrophil Extracellular Traps","volume":"10","author":"Theprungsirikul","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lovewell, R.R., Collins, R.M., Acker, J.L., O\u2019Toole, G.A., Wargo, M.J., and Berwin, B. (2011). Step-Wise Loss of Bacterial Flagellar Torsion Confers Progressive Phagocytic Evasion. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002253"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1165\/rcmb.2002-0141OC","article-title":"Pseudomonas Aeruginosa Elastase Degrades Surfactant Proteins A and D","volume":"28","author":"Mariencheck","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kuang, Z., Hao, Y., Walling, B.E., Jeffries, J.L., Ohman, D.E., and Lau, G.W. (2011). Pseudomonas Aeruginosa Elastase Provides an Escape from Phagocytosis by Degrading the Pulmonary Surfactant Protein-A. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027091"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"30871","DOI":"10.1074\/jbc.M400796200","article-title":"Degradation of Pulmonary Surfactant Protein D by Pseudomonas Aeruginosa Elastase Abrogates Innate Immune Function","volume":"279","author":"Alcorn","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"L368","DOI":"10.1152\/ajplung.00036.2007","article-title":"Role of PAR2 in Murine Pulmonary Pseudomonal Infection","volume":"294","author":"Moraes","year":"2008","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1099\/mic.0.2006\/003863-0","article-title":"Rapid Necrotic Killing of Polymorphonuclear Leukocytes Is Caused by Quorum-Sensing-Controlled Production of Rhamnolipid by Pseudomonas Aeruginosa","volume":"153","author":"Jensen","year":"2007","journal-title":"Microbiology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.4049\/jimmunol.168.4.1861","article-title":"Induction of Neutrophil Apoptosis by the Pseudomonas Aeruginosa Exotoxin Pyocyanin: A Potential Mechanism of Persistent Infection","volume":"168","author":"Usher","year":"2002","journal-title":"J. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Reinhart, A.A., and Oglesby-Sherrouse, A.G. (2016). Regulation of Pseudomonas Aeruginosa Virulence by Distinct Iron Sources. Genes, 7.","DOI":"10.3390\/genes7120126"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/JB.01491-14","article-title":"Adaptation of Iron Homeostasis Pathways by a Pseudomonas Aeruginosa Pyoverdine Mutant in the Cystic Fibrosis Lung","volume":"196","author":"Nguyen","year":"2014","journal-title":"J. Bacteriol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jcf.2018.11.002","article-title":"Pseudomonas Aeruginosa Colonization Causes PD-L1 Overexpression on Monocytes, Impairing the Adaptive Immune Response in Patients with Cystic Fibrosis","volume":"18","author":"Toledano","year":"2019","journal-title":"J. Cyst. Fibros."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"102984","DOI":"10.1016\/j.ebiom.2020.102984","article-title":"The Pseudomonas Aeruginosa Protease LasB Directly Activates IL-1\u03b2","volume":"60","author":"Sun","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Mayer, M.L., Sheridan, J.A., Blohmke, C.J., Turvey, S.E., and Hancock, R.E.W. (2011). The Pseudomonas Aeruginosa Autoinducer 3O-C12 Homoserine Lactone Provokes Hyperinflammatory Responses from Cystic Fibrosis Airway Epithelial Cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016246"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/j.1462-5822.2006.00734.x","article-title":"Pseudomonas Aeruginosa Autoinducer Modulates Host Cell Responses through Calcium Signalling","volume":"8","author":"Shiner","year":"2006","journal-title":"Cell. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4049\/jimmunol.167.1.366","article-title":"IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer N-3-Oxododecanoyl Homoserine Lactone Is Transcriptionally Regulated by NF-\u039aB and Activator Protein-2","volume":"167","author":"Smith","year":"2001","journal-title":"J. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1128\/iai.61.4.1180-1184.1993","article-title":"LasR of Pseudomonas Aeruginosa Is a Transcriptional Activator of the Alkaline Protease Gene (Apr) and an Enhancer of Exotoxin a Expression","volume":"61","author":"Gambello","year":"1993","journal-title":"Infect. Immun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1051\/medsci\/2021085","article-title":"La mucoviscidose: Du g\u00e8ne \u00e0 la th\u00e9rapeutique","volume":"37","year":"2021","journal-title":"M\u00e9decine\/Sciences"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0092-8674(93)90353-R","article-title":"Molecular Mechanisms of CFTR Chloride Channel Dysfunction in Cystic Fibrosis","volume":"73","author":"Welsh","year":"1993","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e23627","DOI":"10.1002\/jcla.23627","article-title":"Virulence Factors Impair Epithelial Junctions during Bacterial Infection","volume":"35","author":"Zheng","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1462-5822.2010.01548.x","article-title":"Alveolar Epithelium Protects Macrophages from Quorum Sensing-Induced Cytotoxicity in a Three-Dimensional Co-Culture Model","volume":"13","author":"Sarker","year":"2011","journal-title":"Cell. Microbiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000492680","article-title":"Biofilm-Leukocyte Cross-Talk: Impact on Immune Polarization and Immunometabolism","volume":"11","author":"Yamada","year":"2019","journal-title":"J. Innate Immun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1099\/mic.0.031443-0","article-title":"Pseudomonas Aeruginosa Recognizes and Responds Aggressively to the Presence of Polymorphonuclear Leukocytes","volume":"155","author":"Alhede","year":"2009","journal-title":"Microbiology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-800262-9.00001-9","article-title":"Pseudomonas Aeruginosa Biofilms","volume":"Volume 86","author":"Alhede","year":"2014","journal-title":"Advances in Applied Microbiology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1128\/IAI.73.6.3693-3701.2005","article-title":"Enhanced Pseudomonas Aeruginosa Biofilm Development Mediated by Human Neutrophils","volume":"73","author":"Walker","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e01021-15","DOI":"10.1128\/mBio.01021-15","article-title":"Staphylococcus Aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin","volume":"6","author":"Scherr","year":"2015","journal-title":"mBio"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1042\/CS20200066","article-title":"UPR Modulation of Host Immunity by Pseudomonas Aeruginosa in Cystic Fibrosis","volume":"134","author":"Bedi","year":"2020","journal-title":"Clin. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1096\/fj.201700075R","article-title":"Peroxisome Proliferator-Activated Receptor-\u03b3 Agonists Attenuate Biofilm Formation by Pseudomonas Aeruginosa","volume":"31","author":"Bedi","year":"2017","journal-title":"FASEB J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1128\/IAI.00164-16","article-title":"Enhanced Clearance of Pseudomonas Aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma","volume":"84","author":"Bedi","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1165\/rcmb.2008-0021OC","article-title":"Impaired Interleukin-8 Chemokine Secretion by Staphylococcus Aureus\u2013Activated Epithelium and T-Cell Chemotaxis in Cystic Fibrosis","volume":"42","author":"Deslee","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Thammavongsa, V., Schneewind, O., and Missiakas, D.M. (2011). Enzymatic Properties of Staphylococcus Aureus Adenosine Synthase (AdsA). BMC Biochem., 12.","DOI":"10.1186\/1471-2091-12-56"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate Is a Danger Signal That Induces IL-1\u03b2 via HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcb.2013.11.008","article-title":"Succinate: A Metabolic Signal in Inflammation","volume":"24","author":"Mills","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41577-019-0128-5","article-title":"Itaconate: The Poster Child of Metabolic Reprogramming in Macrophage Function","volume":"19","author":"Artyomov","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"20632","DOI":"10.1038\/s41598-021-00073-4","article-title":"Pseudomonas Aeruginosa Transcriptome Adaptations from Colonization to Biofilm Infection of Skin Wounds","volume":"11","author":"Karna","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e02629-19","DOI":"10.1128\/mBio.02629-19","article-title":"IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors to Restrict Intracellular Replication of Legionella Pneumophila","volume":"10","author":"Price","year":"2019","journal-title":"mBio"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Naujoks, J., Tabeling, C., Dill, B.D., Hoffmann, C., Brown, A.S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., and Dorhoi, A. (2016). IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005408"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"eaav4634","DOI":"10.1126\/scitranslmed.aav4634","article-title":"CFTR-PTEN\u2013Dependent Mitochondrial Metabolic Dysfunction Promotes Pseudomonas Aeruginosa Airway Infection","volume":"11","author":"Riquelme","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1038\/s41467-019-13078-5","article-title":"4-Octyl Itaconate Inhibits Aerobic Glycolysis by Targeting GAPDH to Exert Anti-Inflammatory Effects","volume":"10","author":"Liao","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41589-019-0323-5","article-title":"S-Glycosylation-Based Cysteine Profiling Reveals Regulation of Glycolysis by Itaconate","volume":"15","author":"Qin","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate Is an Anti-Inflammatory Metabolite That Activates Nrf2 via Alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"100160","DOI":"10.1074\/jbc.RA120.015975","article-title":"Heme Protects Pseudomonas Aeruginosa and Staphylococcus Aureus from Calprotectin-Induced Iron Starvation","volume":"296","author":"Zygiel","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"17132","DOI":"10.1038\/s41598-017-16765-9","article-title":"Pseudomonas Aeruginosa Zinc Uptake in Chelating Environment Is Primarily Mediated by the Metallophore Pseudopaline","volume":"7","author":"Lhospice","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/JB.00072-15","article-title":"Iron Depletion Enhances Production of Antimicrobials by Pseudomonas Aeruginosa","volume":"197","author":"Nguyen","year":"2015","journal-title":"J. Bacteriol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"11951","DOI":"10.1038\/ncomms11951","article-title":"The Innate Immune Protein Calprotectin Promotes Pseudomonas Aeruginosa and Staphylococcus Aureus Interaction","volume":"7","author":"Wakeman","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1128\/JB.00100-21","article-title":"Calprotectin-Mediated Zinc Chelation Inhibits Pseudomonas Aeruginosa Protease Activity in Cystic Fibrosis Sputum","volume":"203","author":"Vermilyea","year":"2021","journal-title":"J. Bacteriol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Cho, H., Jeong, D.-W., Liu, Q., Yeo, W.-S., Vogl, T., Skaar, E.P., Chazin, W.J., and Bae, T. (2015). Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus Aureus Infections. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005026"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil Extracellular Traps Kill Bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Urban, C.F., Ermert, D., Schmid, M., Abu-Abed, U., Goosmann, C., Nacken, W., Brinkmann, V., Jungblut, P.R., and Zychlinsky, A. (2009). Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida Albicans. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000639"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/thoraxjnl-2017-210134","article-title":"Delayed Neutrophil Apoptosis Enhances NET Formation in Cystic Fibrosis","volume":"73","author":"Gray","year":"2018","journal-title":"Thorax"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e00358-21","DOI":"10.1128\/mSphere.00358-21","article-title":"Association of Diverse Staphylococcus Aureus Populations with Pseudomonas Aeruginosa Coinfection and Inflammation in Cystic Fibrosis Airway Infection","volume":"6","author":"Wieneke","year":"2021","journal-title":"mSphere"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e00538-16","DOI":"10.1128\/mBio.00538-16","article-title":"Staphylococcus Aureus Protein A Mediates Interspecies Interactions at the Cell Surface of Pseudomonas Aeruginosa","volume":"7","author":"Armbruster","year":"2016","journal-title":"mBio"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1128\/IAI.00144-10","article-title":"Pseudomonas Aeruginosa Evasion of Phagocytosis Is Mediated by Loss of Swimming Motility and Is Independent of Flagellum Expression","volume":"78","author":"Amiel","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ijmm.2018.02.003","article-title":"Staphylococcus Aureus in the Airways of Cystic Fibrosis Patients\u2014A Retrospective Long-Term Study","volume":"308","author":"Schwerdt","year":"2018","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_115","first-page":"mgen000513","article-title":"From Genotype to Phenotype: Adaptations of Pseudomonas Aeruginosa to the Cystic Fibrosis Environment","volume":"7","author":"Camus","year":"2021","journal-title":"Microb. Genom."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e01592-14","DOI":"10.1128\/mBio.01592-14","article-title":"Environmental Heterogeneity Drives within-Host Diversification and Evolution of Pseudomonas Aeruginosa","volume":"5","author":"Markussen","year":"2014","journal-title":"mBio"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ng.3148","article-title":"Convergent Evolution and Adaptation of Pseudomonas Aeruginosa within Patients with Cystic Fibrosis","volume":"47","author":"Marvig","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1073\/pnas.0602138103","article-title":"Genetic Adaptation by Pseudomonas Aeruginosa to the Airways of Cystic Fibrosis Patients","volume":"103","author":"Smith","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1165\/rcmb.2017-0356OC","article-title":"Long-Term Microevolution of Pseudomonas Aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs","volume":"59","author":"Klockgether","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fmicb.2020.00230","article-title":"Antibiotic Treatment and Age Are Associated with Staphylococcus Aureus Carriage Profiles during Persistence in the Airways of Cystic Fibrosis Patients","volume":"11","author":"Westphal","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"617784","DOI":"10.3389\/fmicb.2021.617784","article-title":"How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions between Pseudomonas Aeruginosa and Staphylococcus Aureus","volume":"12","author":"Camus","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijmm.2019.05.002","article-title":"The Prevalence of Staphylococcus Aureus with Mucoid Phenotype in the Airways of Patients with Cystic Fibrosis\u2014A Prospective Study","volume":"309","author":"Lennartz","year":"2019","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/cid\/ciz106","article-title":"Chronic Staphylococcus Aureus Lung Infection Correlates with Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence","volume":"69","author":"Tan","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1128\/JB.00912-07","article-title":"In Vivo Mutations of Thymidylate Synthase (Encoded by ThyA) Are Responsible for Thymidine Dependency in Clinical Small-Colony Variants of Staphylococcus Aureus","volume":"190","author":"Chatterjee","year":"2008","journal-title":"J. Bacteriol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1128\/CMR.00069-15","article-title":"Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections","volume":"29","author":"Kahl","year":"2016","journal-title":"Clin. Microbiol. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6609\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:08:11Z","timestamp":1760123291000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":125,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076609"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076609","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,1]]}}}