{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:06:11Z","timestamp":1792789571416,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"INSERM, CNRS and the Laboratory of Excellence Ion Channel Science and Therapeutics","doi-asserted-by":"publisher","award":["ANR-11-LABX-0015"],"award-info":[{"award-number":["ANR-11-LABX-0015"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"INSERM, CNRS and the Laboratory of Excellence Ion Channel Science and Therapeutics","doi-asserted-by":"publisher","award":["la Fondation Leducq"],"award-info":[{"award-number":["la Fondation Leducq"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"INSERM, CNRS and the Laboratory of Excellence Ion Channel Science and Therapeutics","doi-asserted-by":"publisher","award":["Espoir en t\u00eate 2022\/23"],"award-info":[{"award-number":["Espoir en t\u00eate 2022\/23"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"INSERM, CNRS and the Laboratory of Excellence Ion Channel Science and Therapeutics","doi-asserted-by":"publisher","award":["Soutien \u00e0 la recherche 2021"],"award-info":[{"award-number":["Soutien \u00e0 la recherche 2021"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"C.J. lab","award":["ANR-11-LABX-0015"],"award-info":[{"award-number":["ANR-11-LABX-0015"]}]},{"name":"C.J. lab","award":["la Fondation Leducq"],"award-info":[{"award-number":["la Fondation Leducq"]}]},{"name":"C.J. lab","award":["Espoir en t\u00eate 2022\/23"],"award-info":[{"award-number":["Espoir en t\u00eate 2022\/23"]}]},{"name":"C.J. lab","award":["Soutien \u00e0 la recherche 2021"],"award-info":[{"award-number":["Soutien \u00e0 la recherche 2021"]}]},{"name":"Fondation pour la Recherche sur le Cerveau","award":["ANR-11-LABX-0015"],"award-info":[{"award-number":["ANR-11-LABX-0015"]}]},{"name":"Fondation pour la Recherche sur le Cerveau","award":["la Fondation Leducq"],"award-info":[{"award-number":["la Fondation Leducq"]}]},{"name":"Fondation pour la Recherche sur le Cerveau","award":["Espoir en t\u00eate 2022\/23"],"award-info":[{"award-number":["Espoir en t\u00eate 2022\/23"]}]},{"name":"Fondation pour la Recherche sur le Cerveau","award":["Soutien \u00e0 la recherche 2021"],"award-info":[{"award-number":["Soutien \u00e0 la recherche 2021"]}]},{"name":"University of Montpellier","award":["ANR-11-LABX-0015"],"award-info":[{"award-number":["ANR-11-LABX-0015"]}]},{"name":"University of Montpellier","award":["la Fondation Leducq"],"award-info":[{"award-number":["la Fondation Leducq"]}]},{"name":"University of Montpellier","award":["Espoir en t\u00eate 2022\/23"],"award-info":[{"award-number":["Espoir en t\u00eate 2022\/23"]}]},{"name":"University of Montpellier","award":["Soutien \u00e0 la recherche 2021"],"award-info":[{"award-number":["Soutien \u00e0 la recherche 2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes in the mechanical environment and transducing these signals into electrical responses, which can adjust a variety of cardiac parameters such as heart rate and contractility. However, pathological conditions can disrupt this intricate mechanosensory system and manifest as potentially life-threatening cardiac arrhythmias. Mechanosensitive ion channels are thought to be the main proponents of mechanoelectric feedback as they provide a rapid response to mechanical stimulation and can directly affect cardiac electrical activity. Here, we demonstrate that the mechanosensitive ion channel PIEZO1 is expressed in zebrafish cardiomyocytes. Furthermore, chemically prolonging PIEZO1 activation in zebrafish results in cardiac arrhythmias. indicating that this ion channel plays an important role in mechanoelectric feedback. This also raises the possibility that PIEZO1 gain of function mutations could be linked to heritable cardiac arrhythmias in humans.<\/jats:p>","DOI":"10.3390\/ijms24076720","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T04:09:50Z","timestamp":1680581390000},"page":"6720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prolonged Piezo1 Activation Induces Cardiac Arrhythmia"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-3384","authenticated-orcid":false,"given":"Laura","family":"Rolland","sequence":"first","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Giovanni","family":"Torrente","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-0419","authenticated-orcid":false,"given":"Emmanuel","family":"Bourinet","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dounia","family":"Maskini","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Drouard","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Neuromyogene Institut, Claude Bernard University, Lyon 1, 69008 Villeurbanne, France"},{"name":"Service de Rythmologie, Hospices Civils de Lyon, 69500 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-0063","authenticated-orcid":false,"given":"Chris","family":"Jopling","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6099-3898","authenticated-orcid":false,"given":"Ad\u00e8le","family":"Faucherre","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"ref_1","unstructured":"Desai, D.S., and Hajouli, S. 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