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and Innovation Programme","award":["K134939"],"award-info":[{"award-number":["K134939"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["739593"],"award-info":[{"award-number":["739593"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["2019-2.1.7-ERA-NET-2021-00015"],"award-info":[{"award-number":["2019-2.1.7-ERA-NET-2021-00015"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["NVKP_16-1-2016-0017"],"award-info":[{"award-number":["NVKP_16-1-2016-0017"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["RRF-2.3.1-21-2022-00003"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00003"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2021-EGA-23"],"award-info":[{"award-number":["TKP2021-EGA-23"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2021-NVA-15"],"award-info":[{"award-number":["TKP2021-NVA-15"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["NKFIH-1277-2\/2020"],"award-info":[{"award-number":["NKFIH-1277-2\/2020"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["K134939"],"award-info":[{"award-number":["K134939"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["739593"],"award-info":[{"award-number":["739593"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["2019-2.1.7-ERA-NET-2021-00015"],"award-info":[{"award-number":["2019-2.1.7-ERA-NET-2021-00015"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["NVKP_16-1-2016-0017"],"award-info":[{"award-number":["NVKP_16-1-2016-0017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The proinflammatory cascade that is activated at the time of brain death plays a crucial role in organ procurement. Our aim of this study was to explore the relationship between the clinical outcome of orthotopic heart transplantation, as well as cytokine and apolipoprotein profiles of the pericardial fluid obtained at donation. Interleukin, adipokine and lipoprotein levels in the pericardial fluid, as well as clinical data of twenty donors after brain death, were investigated. Outcome variables included primary graft dysfunction, the need for posttransplantation mechanical cardiac support and International Society for Heart and Lung Transplantation grade \u2265 2R rejection. Hormone management and donor risk scores were also investigated. Lower levels of IL-6 were observed in primary graft dysfunction (median: 36.72 [IQR: 19.47\u201362.90] versus 183.67 [41.21\u2013452.56]; p = 0.029) and in the need for mechanical cardiac support (44.12 [20.12\u201385.70] versus 247.13 [38.51\u2013510.38]; p = 0.043). Rejection was associated with lower ApoAII (p = 0.021), ApoB100 (p = 0.032) and ApoM levels (p = 0.025). Lower adipsin levels were detected in those patients receiving desmopressin (p = 0.037); moreover, lower leptin levels were found in those patients receiving glucocorticoid therapy (p = 0.045), and higher T3 levels were found in those patients treated with L-thyroxine (p = 0.047) compared to those patients not receiving these hormone replacement therapies. IL-5 levels were significantly associated with UNOS-D score (p = 0.004), Heart Donor Score (HDS) and Adapted HDS (p &lt; 0.001). The monitoring of immunological and metabolic changes in donors after brain death may help in the prediction of potential complications after heart transplantation, thus potentially optimizing donor heart allocation.<\/jats:p>","DOI":"10.3390\/ijms24076780","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:42:44Z","timestamp":1680673364000},"page":"6780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Donor Pericardial Interleukin and Apolipoprotein Levels May Predict the Outcome after Human Orthotopic Heart Transplantation"],"prefix":"10.3390","volume":"24","author":[{"given":"\u00c9va","family":"P\u00e1llinger","sequence":"first","affiliation":[{"name":"Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-7897","authenticated-orcid":false,"given":"Andrea","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1624-7630","authenticated-orcid":false,"given":"Evelin","family":"T\u00f6reki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet Zs\u00f3fia","family":"Bencs\u00e1th","sequence":"additional","affiliation":[{"name":"Doctoral School of Theoretical and Translational Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-7389","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"Sz\u00e9csi","sequence":"additional","affiliation":[{"name":"Doctoral School of Theoretical and Translational Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Losoncz","sequence":"additional","affiliation":[{"name":"Doctoral School of Theoretical and Translational Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1t\u00e9","family":"Oleszka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tivadar","family":"H\u00fcttl","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-2623","authenticated-orcid":false,"given":"Annam\u00e1ria","family":"Kosztin","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-206X","authenticated-orcid":false,"given":"Edit I.","family":"Buzas","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1085 Budapest, Hungary"},{"name":"HCEMM-SU Extracellular Vesicle Research Group, Semmelweis University, 1085 Budapest, Hungary"},{"name":"ELKH-SE Translational Extracellular Vesicle Research Group, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Radovits","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.healun.2022.08.030","article-title":"Donor heart selection: Evidence-based guidelines for providers","volume":"42","author":"Copeland","year":"2022","journal-title":"J. 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