{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:04:25Z","timestamp":1791612265323,"version":"4.3.4"},"reference-count":109,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The bony skeleton, as a structural foundation for the human body, is essential in providing mechanical function and movement. The human skeleton is a highly specialized and dynamic organ that undergoes continuous remodeling as it adapts to the demands of its environment. Advances in research over the last decade have shone light on the various hormones that influence this process, modulating the metabolism and structural integrity of bone. More recently, novel and non-traditional functions of hypothalamic, pituitary, and adipose hormones and their effects on bone homeostasis have been proposed. This review highlights recent work on physiological bone remodeling and discusses our knowledge, as it currently stands, on the systemic interplay of factors regulating this interaction. In this review, we provide a summary of the literature on the relationship between bone physiology and hormones including kisspeptin, neuropeptide Y, follicle-stimulating hormone (FSH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), growth hormone (GH), leptin, and adiponectin. The discovery and understanding of this new functionality unveils an entirely new layer of physiologic circuitry.<\/jats:p>","DOI":"10.3390\/ijms24076840","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T05:54:39Z","timestamp":1680760479000},"page":"6840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Bones and Hormones: Interaction between Hormones of the Hypothalamus, Pituitary, Adipose Tissue and Bone"],"prefix":"10.3390","volume":"24","author":[{"given":"Olga","family":"Niwczyk","sequence":"first","affiliation":[{"name":"Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-0886","authenticated-orcid":false,"given":"Monika","family":"Grymowicz","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Medical University of Warsaw, 00-315 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Szcz\u0119snowicz","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hajbos","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Medical University of Warsaw, 00-315 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kostrzak","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-9079","authenticated-orcid":false,"given":"Micha\u0142","family":"Budzik","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Medical University of Warsaw, 00-315 Warsaw, Poland"},{"name":"Department of Cancer Prevention, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Maciejewska-Jeske","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Bala","sequence":"additional","affiliation":[{"name":"UCD School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-5433","authenticated-orcid":false,"given":"Roman","family":"Smolarczyk","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Medical University of Warsaw, 00-315 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u0142a\u017cej","family":"M\u0119czekalski","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/physiol.00061.2014","article-title":"Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement","volume":"31","author":"Siddiqui","year":"2016","journal-title":"Physiology"},{"key":"ref_2","first-page":"1081","article-title":"Bone\u2019s mechanostat: A 2003 update","volume":"275A","author":"Frost","year":"2003","journal-title":"Anat. Rec. Adv. Integr. Anat. Evol. Biol."},{"key":"ref_3","first-page":"1256","article-title":"Black Dennis, Rosen Clifford, Osteoporosis: Basic and Clinical Aspects, Shlomo Melmed MB ChB, MACP","volume":"30","author":"Francisco","year":"2020","journal-title":"Williams Textb. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/jcp.25969","article-title":"Osteoblast role in osteoarthritis pathogenesis","volume":"232","author":"Maruotti","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J. Bone Miner. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-022-00219-8","article-title":"Bone remodeling: An operational process ensuring survival and bone mechanical competence","volume":"10","author":"Bolamperti","year":"2022","journal-title":"Bone Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115163","DOI":"10.1016\/j.bone.2019.115163","article-title":"Age at attainment of peak bone mineral density and its associated factors: The National Health and Nutrition Examination Survey 2005\u20132014","volume":"131","author":"Xue","year":"2020","journal-title":"Bone"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s10237-022-01623-z","article-title":"Experimental-based mechanobiological modeling of the anabolic and catabolic effects of breast cancer on bone remodeling","volume":"21","author":"Oumghar","year":"2022","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kim, J.-M., Lin, C., Stavre, Z., Greenblatt, M.B., and Shim, J.-H. (2020). Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells, 9.","DOI":"10.3390\/cells9092073"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1196\/annals.1365.035","article-title":"Bone remodeling","volume":"1092","author":"Hadjidakis","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"a031237","DOI":"10.1101\/cshperspect.a031237","article-title":"Regulation of Bone Remodeling by Parathyroid Hormone","volume":"8","author":"Wein","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/dmu009","article-title":"The kisspeptin-GnRH pathway in human reproductive health and disease","volume":"20","author":"Skorupskaite","year":"2014","journal-title":"Hum. Reprod. Updat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.molmed.2021.05.008","article-title":"Clinical Potential of Kisspeptin in Reproductive Health","volume":"27","author":"Abbara","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.fertnstert.2016.01.029","article-title":"Spontaneous endogenous pulsatile release of kisspeptin is temporally coupled with luteinizing hormone in healthy women","volume":"105","author":"Meczekalski","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1073\/pnas.1834399100","article-title":"Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54","volume":"100","author":"Genin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa073443","article-title":"A GPR54-activating mutation in a patient with central precocious puberty","volume":"358","author":"Teles","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ygyno.2010.08.018","article-title":"Kisspeptin-10 inhibits bone-directed migration of GPR54-positive breast cancer cells: Evidence for a dose\u2013window effect","volume":"119","author":"Olbrich","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Weinman, M.A., Fischer, J.A., Jacobs, D.C., Goodall, C.P., Bracha, S., and Chappell, P.E. (2019). Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5363-4"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-08046-4","article-title":"Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones","volume":"10","author":"Herber","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1210\/clinem\/dgac117","article-title":"Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men","volume":"107","author":"Comninos","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tanaka, M., Yamada, S., and Watanabe, Y. (2021). The Role of Neuropeptide Y in the Nucleus Accumbens. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147287"},{"key":"ref_23","first-page":"37","article-title":"Physiological and Therapeutic Roles of Neuropeptide Y on Biological Functions","volume":"1237","author":"Shende","year":"2020","journal-title":"Emerg. Approaches"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"695623","DOI":"10.3389\/fcell.2021.695623","article-title":"Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies","volume":"9","author":"Huang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pneurobio.2013.10.002","article-title":"Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection","volume":"112","author":"Martins","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1677\/JME-10-0015","article-title":"Hypothalamic regulation of bone","volume":"45","author":"Driessler","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.18632\/aging.103129","article-title":"Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP\/PKA\/CREB pathway","volume":"12","author":"Xie","year":"2020","journal-title":"Aging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2100808","DOI":"10.1002\/advs.202100808","article-title":"Neuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y","volume":"8","author":"Zhang","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_29","first-page":"209","article-title":"Bone-specific overexpression of NPY modulates osteogenesis","volume":"12","author":"Matic","year":"2012","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Baldock, P.A., Lee, N.J., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E.J., Zhang, L., Enriquez, R.F., and Wong, I.P. (2009). Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0008415"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"833485","DOI":"10.3389\/fendo.2022.833485","article-title":"The Role of NPY in the Regulation of Bone Metabolism","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/0006-291X(85)91726-7","article-title":"Neuromedin U-8 and U-25: Novel uterus stimulating and hypertensive peptides identified in porcine spinal cord","volume":"130","author":"Minamino","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/bbrc.2001.5945","article-title":"A Role for Neuromedin U in Stress Response","volume":"289","author":"Hanadaa","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/bbrc.2000.3669","article-title":"Central Effects of Neuromedin U in the Regulation of Energy Homeostasis","volume":"277","author":"Nakazato","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/bbrc.2000.3502","article-title":"Purification and Identification of Neuromedin U as an Endogenous Ligand for an Orphan Receptor GPR66 (FM3)","volume":"276","author":"Kojima","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/nm1640","article-title":"Central control of bone remodeling by neuromedin U","volume":"13","author":"Sato","year":"2007","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbrc.2020.02.003","article-title":"Neuromedin U (NMU) regulates osteoblast differentiation and activity","volume":"524","author":"Hsiao","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1365-2826.1997.00651.x","article-title":"Immunohistochemical Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and Adrenal Gland","volume":"9","author":"Koylu","year":"1997","journal-title":"J. Neuroendocr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2826.2003.00960.x","article-title":"Cocaine- and Amphetamine-Regulated Transcript is Present in Hypothalamic Neuroendocrine Neurones and is Released to the Hypothalamic-Pituitary Portal Circuit","volume":"15","author":"Larsen","year":"2003","journal-title":"J. Neuroendocr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/en.2008-0109","article-title":"Cocaine and Amphetamine-Regulated Transcript May Regulate Bone Remodeling as a Circulating Molecule","volume":"149","author":"Singh","year":"2008","journal-title":"Endocrinology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cmet.2009.07.006","article-title":"Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells","volume":"10","author":"Idris","year":"2009","journal-title":"Cell Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1124\/mol.106.026435","article-title":"Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling","volume":"70","author":"Tam","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2006.01.051","article-title":"FSH Directly Regulates Bone Mass","volume":"125","author":"Sun","year":"2006","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbrc.2010.02.112","article-title":"FSH-receptor isoforms and FSH-dependent gene transcription in human monocytes and osteoclasts","volume":"394","author":"Robinson","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, W., Yu, C., Zhang, X., Zhang, H., Guan, Q., Zhao, J., and Xu, J. (2015). Follicle-Stimulating Hormone Increases the Risk of Postmenopausal Osteoporosis by Stimulating Osteoclast Differentiation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134986"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coemr.2018.02.006","article-title":"Prolactinoma and Bone","volume":"3","author":"Chiloiro","year":"2018","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bone.2007.11.008","article-title":"Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor \u03baB ligand\/osteoprotegerin ratio","volume":"42","author":"Seriwatanachai","year":"2008","journal-title":"Bone"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2009.05231.x","article-title":"ACTH is a novel regulator of bone mass","volume":"1192","author":"Isales","year":"2010","journal-title":"Ann. New York Acad. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1073\/pnas.0912176107","article-title":"ACTH protects against glucocorticoid-induced osteonecrosis of bone","volume":"107","author":"Zaidi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/thy.1998.8.1059","article-title":"Expression of Thyrotropin Receptor on Clonal Osteoblast-like Rat Osteosarcoma Cells","volume":"8","author":"Inoue","year":"1998","journal-title":"Thyroid"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","article-title":"TSH Is a Negative Regulator of Skeletal Remodeling","volume":"115","author":"Abe","year":"2003","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1196\/annals.1346.033","article-title":"TSH and Bone Loss","volume":"1068","author":"Sun","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1073\/pnas.0712395105","article-title":"Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss","volume":"105","author":"Sun","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000182189","article-title":"Growth Hormone and Bone","volume":"36","author":"Bouillon","year":"1991","journal-title":"Horm. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2015.09.017","article-title":"Skeletal effects of growth hormone and insulin-like growth factor-I therapy","volume":"432","author":"Lindsey","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1359\/jbmr.090723","article-title":"Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1)","volume":"25","author":"Fritton","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cmet.2013.05.010","article-title":"Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives","volume":"18","author":"Dalamaga","year":"2013","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1172\/JCI200317490","article-title":"The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men","volume":"111","author":"Chan","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"73","DOI":"10.12703\/P6-73","article-title":"Leptin signaling","volume":"6","author":"Park","year":"2014","journal-title":"F1000Prime Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.metabol.2014.08.004","article-title":"Physiology of leptin: Energy homeostasis, neuroendocrine function and metabolism","volume":"64","author":"Park","year":"2015","journal-title":"Metabolism"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/sms.12194","article-title":"A time-efficient reduction of fat mass in 4 days with exercise and caloric restriction","volume":"25","author":"Calbet","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8481","DOI":"10.1073\/pnas.0505429103","article-title":"Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans","volume":"103","author":"Chan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(05)66830-4","article-title":"Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa","volume":"366","author":"Chan","year":"2005","journal-title":"Lancet"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tcm.2014.08.001","article-title":"Adiponectin and insulin cross talk: The microvascular connection","volume":"24","author":"Zhao","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.bja.2018.01.016","article-title":"Adiponectin regulates thermal nociception in a mouse model of neuropathic pain","volume":"120","author":"Sun","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Khoramipour, K., Chamari, K., Hekmatikar, A., Ziyaiyan, A., Taherkhani, S., Elguindy, N., and Bragazzi, N. (2021). Adiponectin: Structure, Physiological Functions, Role in Diseases, and Effects of Nutrition. Nutrients, 13.","DOI":"10.3390\/nu13041180"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/cphy.c170046","article-title":"Adiponectin Regulation and Function","volume":"8","author":"Fang","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1210\/er.2017-00226","article-title":"Effects of Leptin on the Skeleton","volume":"39","author":"Reid","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1002\/jcb.27726","article-title":"Novel leptin receptor signaling mutants identify location and sex-dependent modulation of bone density, adiposity, and growth","volume":"120","author":"McCabe","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.biochi.2012.04.015","article-title":"Understanding leptin-dependent regulation of skeletal homeostasis","volume":"94","author":"Motyl","year":"2012","journal-title":"Biochimie"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jcb.10385","article-title":"A unified model for the action of leptin on bone turnover","volume":"88","author":"Gordeladze","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_73","first-page":"145","article-title":"Bone mass regulation of leptin and postmenopausal osteoporosis with obesity","volume":"9","author":"Legiran","year":"2012","journal-title":"Bone Abstr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/jbmr.65","article-title":"Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1\u03b1,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob\/ob Mice","volume":"25","author":"Tsuji","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin Regulates Bone Formation via the Sympathetic Nervous System","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2009.06.051","article-title":"A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure","volume":"138","author":"Yadav","year":"2009","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(00)81558-5","article-title":"Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass","volume":"100","author":"Ducy","year":"2000","journal-title":"Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/jbmr.367","article-title":"Skeletal phenotype of the leptin receptor-deficient db\/db mouse","volume":"26","author":"Williams","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jbmr.1734","article-title":"Peripheral leptin regulates bone formation","volume":"28","author":"Turner","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.peptides.2009.07.021","article-title":"Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation","volume":"30","author":"Kalra","year":"2009","journal-title":"Peptides"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.metabol.2014.10.021","article-title":"The role of leptin in regulating bone metabolism","volume":"64","author":"Upadhyay","year":"2015","journal-title":"Metabolism"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Misch, M., and Puthanveetil, P. (2022). The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105439"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/bs.vh.2020.12.021","article-title":"Role of hormones in sarcopenia","volume":"115","author":"Priego","year":"2021","journal-title":"Vitam. Horm."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2147\/CIA.S64625","article-title":"Divergent effects of obesity on fragility fractures","volume":"9","author":"Gonnelli","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1210\/jc.2013-3346","article-title":"Insulin Is Inversely Associated with Bone Mass, Especially in the Insulin-Resistant Population: The Korea and US National Health and Nutrition Examination Surveys","volume":"99","author":"Choi","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"15778","DOI":"10.3390\/ijms150915778","article-title":"Leptin Induces Oncostatin M Production in Osteoblasts by Downregulating miR-93 through the Akt Signaling Pathway","volume":"15","author":"Yang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbrc.2005.03.210","article-title":"Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast","volume":"331","author":"Oshima","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_88","first-page":"1112","article-title":"Adiponectin inhibits the differentiation and maturation of osteoclasts via the mTOR pathway in multiple myeloma","volume":"45","author":"Liu","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_89","first-page":"1228","article-title":"Effects of adiponectin on osteoclastogenesis from mouse bone marrow-derived monocytes","volume":"17","author":"Wu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3389\/fendo.2019.00815","article-title":"Adiponectin Deficiency Triggers Bone Loss by Up-Regulation of Osteoclastogenesis and Down-Regulation of Osteoblastogenesis","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-020-00122-0","article-title":"Adiponectin signalling in bone homeostasis, with age and in disease","volume":"9","author":"Lewis","year":"2021","journal-title":"Bone Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1210\/endrev\/bnab015","article-title":"The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens","volume":"42","author":"Mills","year":"2021","journal-title":"Endocr. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00198-002-1307-x","article-title":"The association of endogenous hormone concentrations and bone mineral density measures in pre- and perimenopausal women of four ethnic groups: SWAN","volume":"14","author":"Sowers","year":"2003","journal-title":"Osteoporos. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cca.2008.09.027","article-title":"Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese Women","volume":"400","author":"Xu","year":"2009","journal-title":"Clin. Chim. Acta"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"28971","DOI":"10.1073\/pnas.2014588117","article-title":"First-in-class humanized FSH blocking antibody targets bone and fat","volume":"117","author":"Gera","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"14574","DOI":"10.1073\/pnas.1212806109","article-title":"Blocking antibody to the \u03b2-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmed.2006.11.004","article-title":"FSH and bone\u2013important physiology or not?","volume":"13","author":"Prior","year":"2006","journal-title":"Trends Mol. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"bqaa111","DOI":"10.1210\/endocr\/bqaa111","article-title":"Estrogen Versus FSH Effects on Bone Metabolism: Evidence from Interventional Human Studies","volume":"161","author":"Khosla","year":"2020","journal-title":"Endocrinology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1210\/jc.2013-3246","article-title":"FSH suppression does not affect bone turnover in eugonadal men","volume":"99","author":"Uihlein","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cmet.2006.04.007","article-title":"FSH versus estrogen: Who\u2019s guilty of breaking bones?","volume":"3","author":"Baron","year":"2006","journal-title":"Cell Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/GME.0000000000000655","article-title":"Association between circulatory levels of adipokines and bone mineral density in postmenopausal women","volume":"23","author":"Cervellati","year":"2016","journal-title":"Menopause J. N. Am. Menopause Soc."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12018-021-09275-w","article-title":"Adipokines and chronic rheumatic diseases: From inflammation to bone involvement","volume":"18","author":"Cici","year":"2020","journal-title":"Clin. Rev. Bone Miner. Metab."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/JIR.S203590","article-title":"Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD","volume":"12","author":"Azizieh","year":"2019","journal-title":"J. Inflamm. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/term.2915","article-title":"Effect of adiponectin secreted from adipose-derived stem cells on bone-fat balance and bone defect healing","volume":"13","author":"Yang","year":"2019","journal-title":"J. Tissue. Eng. Regen. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2021.762335","article-title":"Paracrine Effects of Recombinant Human Adiponectin Promote Bone Regeneration","volume":"9","author":"Gong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_106","first-page":"974","article-title":"Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice","volume":"5","author":"Leite","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12195-021-00699-4","article-title":"Exosomes form adipose tissues derived mesenchymal stem cells overexpressing microRNA-146a alleviate diabetic osteoporosis in rats","volume":"15","author":"Zhang","year":"2022","journal-title":"Cell. Mol. Bioeng."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Aibar-Almazan, A., Voltez-Martinez, A., Castellote-Caballero, Y., Afanador-Restrepo, D.F., Carcelen-Fraile, M.C., and Lopez-Riuz, E. (2022). Current status of the diagnosis and management of osteoporosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169465"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6840\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:11:07Z","timestamp":1760123467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":109,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24076840"],"URL":"https:\/\/doi.org\/10.3390\/ijms24076840","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,6]]}}}