{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:39:59Z","timestamp":1793407199882,"version":"4.5.0"},"reference-count":61,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["MOST108-2320-B-040-017"],"award-info":[{"award-number":["MOST108-2320-B-040-017"]}]},{"name":"National Science and Technology Council","award":["CSMU-INT-110-02"],"award-info":[{"award-number":["CSMU-INT-110-02"]}]},{"DOI":"10.13039\/501100008641","name":"Chung Shan Medical University","doi-asserted-by":"publisher","award":["MOST108-2320-B-040-017"],"award-info":[{"award-number":["MOST108-2320-B-040-017"]}],"id":[{"id":"10.13039\/501100008641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008641","name":"Chung Shan Medical University","doi-asserted-by":"publisher","award":["CSMU-INT-110-02"],"award-info":[{"award-number":["CSMU-INT-110-02"]}],"id":[{"id":"10.13039\/501100008641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Purple sweet potato (PSP) powder with anthocyanins possesses the ability to reduce oxidative stress and inflammation. Studies have presumed a positive correlation between body fat and dry eye disease (DED) in adults. The regulation of oxidative stress and inflammation has been proposed as the mechanism underlying DED. This study developed an animal model of high fat diet (HFD)-induced DED. We added 5% PSP powder to the HFD to evaluate the effects and underlying mechanisms in mitigating HFD-induced DED. A statin drug, atorvastatin, was also added to the diet separately to assess its effect. The HFD altered the structure of lacrimal gland (LG) tissue, reduced LG secretory function, and eliminated the expression of proteins related to DED development, including \u03b1-smooth muscle actin and aquaporin-5. Although PSP treatment could not significantly reduce body weight or body fat, it ameliorated the effects of DED by preserving LG secretory function, preventing ocular surface erosion, and preserving LG structure. PSP treatment increased superoxide dismutase levels but reduced hypoxia-inducible factor 1-\u03b1 levels, indicating that PSP treatment reduced oxidative stress. PSP treatment increased ATP-binding cassette transporter 1 and acetyl-CoA carboxylase 1 levels in LG tissue, signifying that PSP treatment regulated lipid homeostasis maintenance to reduce the effects of DED. In conclusion, PSP treatment ameliorated the effects of HFD-induced DED through the regulation of oxidative stress and lipid homeostasis in the LG.<\/jats:p>","DOI":"10.3390\/ijms24086983","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T03:49:29Z","timestamp":1681098569000},"page":"6983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Purple Sweet Potato Powder Containing Anthocyanin Mitigates High-Fat-Diet-Induced Dry Eye Disease"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-8690","authenticated-orcid":false,"given":"Ming-Cheng","family":"Chiang","sequence":"first","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 40221, Taiwan"},{"name":"Department of Ophthalmology, Cathay General Hospital, Taipei 10687, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cathay General Hospital, Taipei 10687, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Optometry, Chung Shan Medical University, Taichung 40221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-6728","authenticated-orcid":false,"given":"Dai-Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 40221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Optometry, Chung Shan Medical University, Taichung 40221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lung","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40221, Taiwan"},{"name":"Yi-Yeh Biotechnology Co., Taichung 40221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-1913","authenticated-orcid":false,"given":"Huei-Jane","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40221, Taiwan"},{"name":"Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul. 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