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MC_UU_00007\/10"]}]},{"name":"MRC Human Genetics Unit programme grant \u2018Quantitative traits in health and disease\u2019","award":["602525"],"award-info":[{"award-number":["602525"]}]},{"name":"MRC Human Genetics Unit programme grant \u2018Quantitative traits in health and disease\u2019","award":["KK.01.1.1.01.0010"],"award-info":[{"award-number":["KK.01.1.1.01.0010"]}]},{"name":"MRC Human Genetics Unit programme grant \u2018Quantitative traits in health and disease\u2019","award":["KK.01.2.2.03.0006"],"award-info":[{"award-number":["KK.01.2.2.03.0006"]}]},{"name":"MRC Human Genetics Unit programme grant \u2018Quantitative traits in health and disease\u2019","award":["U. MC_UU_00007\/10"],"award-info":[{"award-number":["U. MC_UU_00007\/10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Infectious diseases still threaten global human health, and host genetic factors have been indicated as determining risk factors for observed variations in disease susceptibility, severity, and outcome. We performed a genome-wide meta-analysis on 4624 subjects from the 10,001 Dalmatians cohort, with 14 infection-related traits. Despite a rather small number of cases in some instances, we detected 29 infection-related genetic associations, mostly belonging to rare variants. Notably, the list included the genes CD28, INPP5D, ITPKB, MACROD2, and RSF1, all of which have known roles in the immune response. Expanding our knowledge on rare variants could contribute to the development of genetic panels that could assist in predicting an individual\u2019s life-long susceptibility to major infectious diseases. In addition, longitudinal biobanks are an interesting source of information for identifying the host genetic variants involved in infectious disease susceptibility and severity. Since infectious diseases continue to act as a selective pressure on our genomes, there is a constant need for a large consortium of biobanks with access to genetic and environmental data to further elucidate the complex mechanisms behind host\u2013pathogen interactions and infectious disease susceptibility.<\/jats:p>","DOI":"10.3390\/ijms24087006","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T07:11:43Z","timestamp":1681110703000},"page":"7006","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-646X","authenticated-orcid":false,"given":"Andrea","family":"Gelemanovi\u0107","sequence":"first","affiliation":[{"name":"Department of Public Health, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"\u0106atipovi\u0107 Ardali\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajka","family":"Pribisali\u0107","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9405-9550","authenticated-orcid":false,"given":"Caroline","family":"Hayward","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-6052","authenticated-orcid":false,"given":"Ivana","family":"Kol\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Split School of Medicine, 21000 Split, Croatia"},{"name":"Department of General Courses, Algebra University College, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-1862","authenticated-orcid":false,"given":"Ozren","family":"Pola\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Split School of Medicine, 21000 Split, Croatia"},{"name":"Department of General Courses, Algebra University College, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMra1108296","article-title":"The Perpetual Challenge of Infectious Diseases","volume":"366","author":"Fauci","year":"2012","journal-title":"N. 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