{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:57:37Z","timestamp":1791874657741,"version":"4.3.4"},"reference-count":184,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Polyphenols have attracted tremendous attention due to their pro-health properties, including their antioxidant, anti-inflammatory, antibacterial and neuroprotective activities. Atherosclerosis is a vascular disorder underlying several CVDs. One of the main risk factors causing atherosclerosis is the type and quality of food consumed. Therefore, polyphenols represent promising agents in the prevention and treatment of atherosclerosis, as demonstrated by in vitro, animal, preclinical and clinical studies. However, most polyphenols cannot be absorbed directly by the small intestine. Gut microbiota play a crucial role in converting dietary polyphenols into absorbable bioactive substances. An increasing understanding of the field has confirmed that specific GM taxa strains mediate the gut microbiota\u2013atherosclerosis axis. The present study explores the anti-atherosclerotic properties and associated underlying mechanisms of polyphenols. Moreover, it provides a basis for better understanding the relationship between dietary polyphenols, gut microbiota, and cardiovascular benefits.<\/jats:p>","DOI":"10.3390\/ijms24087146","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T02:29:15Z","timestamp":1681352955000},"page":"7146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The Influence of Polyphenols on Atherosclerosis Development"],"prefix":"10.3390","volume":"24","author":[{"given":"Agnieszka","family":"Zi\u00f3\u0142kiewicz","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry, Medical University of Lublin, Dr Wiotolda Chod\u017aki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-6313","authenticated-orcid":false,"given":"Kamila","family":"Kasprzak-Drozd","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Medical University of Lublin, Dr Wiotolda Chod\u017aki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-257X","authenticated-orcid":false,"given":"Robert","family":"Rusinek","sequence":"additional","affiliation":[{"name":"Institute of Agrophysics, Polish Academy of Sciences, Do\u015bwiadczalna 4, 20-290 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Markut-Miot\u0142a","sequence":"additional","affiliation":[{"name":"Department of Lung Diseases and Children Rheumatology, Medical University of Lublin, Prof. Antoniego G\u0119bali 6, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-3302","authenticated-orcid":false,"given":"Anna","family":"Oniszczuk","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Medical University of Lublin, Dr Wiotolda Chod\u017aki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Poznyak, A., Grechko, A.V., Poggio, P., Myasoedova, V.A., Alfieri, V., and Orekhov, A.N. 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