{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:04:52Z","timestamp":1791493492861,"version":"4.3.4"},"reference-count":151,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite recent advances, prognosis of acute myeloid leukemia (AML) remains unsatisfactory due to poor response to therapy or relapse. Among causes of resistance, over-expression of multidrug resistance (MDR) proteins represents a pivotal mechanism. ABCG2 is an efflux transporter responsible for inducing MDR in leukemic cells; through its ability to extrude many antineoplastic drugs, it leads to AML resistance and\/or relapse, even if conflicting data have been reported to date. Moreover, ABCG2 may be co-expressed with other MDR-related proteins and is finely regulated by epigenetic mechanisms. Here, we review the main issues regarding ABCG2 activity and regulation in the AML clinical scenario, focusing on its expression and the role of polymorphisms, as well as on the potential ways to inhibit its function to counteract drug resistance to, eventually, improve outcomes in AML patients.<\/jats:p>","DOI":"10.3390\/ijms24087147","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T02:29:15Z","timestamp":1681352955000},"page":"7147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["ABCG2 in Acute Myeloid Leukemia: Old and New Perspectives"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-4468","authenticated-orcid":false,"given":"Daniela","family":"Damiani","sequence":"first","affiliation":[{"name":"Division of Hematology and Stem Cell Transplantation, Udine Hospital, P.le Santa Maria della Misericordia, 5, 33100 Udine, Italy"},{"name":"Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-2621","authenticated-orcid":false,"given":"Mario","family":"Tiribelli","sequence":"additional","affiliation":[{"name":"Division of Hematology and Stem Cell Transplantation, Udine Hospital, P.le Santa Maria della Misericordia, 5, 33100 Udine, Italy"},{"name":"Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrc1592","article-title":"Leukaemia stem cells and the evolution of cancer-stem-cell research","volume":"5","author":"Huntly","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"149ra118","DOI":"10.1126\/scitranslmed.3004315","article-title":"Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia","volume":"4","author":"Jan","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1182\/blood-2008-07-172007","article-title":"Age and acute myeloid leukemia: Real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry","volume":"113","author":"Juliusson","year":"2009","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/jamaoncol.2018.5625","article-title":"Association of Chemotherapy for Solid Tumors With Development of Therapy-Related Myelodysplastic Syndrome or Acute Myeloid Leukemia in the Modern Era","volume":"5","author":"Morton","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/cncr.33458","article-title":"De novo acute myeloid leukemia: A population-based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) database, 1980 to 2017","volume":"127","author":"Sasaki","year":"2021","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.clml.2021.05.016","article-title":"Acute Myeloid Leukemia: Historical Perspective and Progress in Research and Therapy Over 5 Decades","volume":"21","author":"Kantarjian","year":"2021","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"Dohner","year":"2022","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ajh.26822","article-title":"Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Shimony","year":"2023","journal-title":"Am. J. Hematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100645","DOI":"10.1016\/j.drup.2019.100645","article-title":"The multi-factorial nature of clinical multidrug resistance in cancer","volume":"46","author":"Assaraf","year":"2019","journal-title":"Drug Resist. Updat"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev-pharmtox-010715-103111","article-title":"Toward a Better Understanding of the Complexity of Cancer Drug Resistance","volume":"56","author":"Gottesman","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_11","first-page":"1174","article-title":"Cellular resistance to actinomycin D in Chinese hamster cells in vitro: Cross-resistance, radioautographic, and cytogenetic studies","volume":"30","author":"Biedler","year":"1970","journal-title":"Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0005-2736(73)90191-0","article-title":"Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells","volume":"323","author":"Dano","year":"1973","journal-title":"Biochim. Et Biophys. Acta (BBA)-Biomembr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","article-title":"A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants","volume":"455","author":"Juliano","year":"1976","journal-title":"Biochim. Et Biophys. Acta (BBA)-Biomembr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1073\/pnas.83.2.337","article-title":"Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells","volume":"83","author":"Gros","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1073\/pnas.83.12.4538","article-title":"Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells","volume":"83","author":"Roninson","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.febslet.2005.12.060","article-title":"The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research","volume":"580","author":"Gottesman","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1042\/BST20150139","article-title":"ABC transporter research: Going strong 40 years on","volume":"43","author":"Theodoulou","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.cb.08.110192.000435","article-title":"ABC transporters: From microorganisms to man","volume":"8","author":"Higgins","year":"1992","journal-title":"Annu. Rev. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.genom.6.080604.162122","article-title":"Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates","volume":"6","author":"Dean","year":"2005","journal-title":"Annu. Rev. Genomics. Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s43556-021-00041-4","article-title":"Drug resistance: From bacteria to cancer","volume":"2","author":"Patel","year":"2021","journal-title":"Mol. Biomed."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-2275(20)31588-1","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"42","author":"Dean","year":"2001","journal-title":"J. Lipid Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2016.03.001","article-title":"ABC transporters as mediators of drug resistance and contributors to cancer cell biology","volume":"26","author":"Fletcher","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.bbrc.2019.04.134","article-title":"p62\/mTOR\/LXRalpha pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage","volume":"514","author":"Liang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1038\/ncomms7354","article-title":"The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity","volume":"6","author":"Sag","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4049\/jimmunol.0902372","article-title":"ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation","volume":"184","author":"Armstrong","year":"2010","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni.3462","article-title":"Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cmet.2019.02.016","article-title":"Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression","volume":"29","author":"Goossens","year":"2019","journal-title":"Cell Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3892\/etm.2017.4393","article-title":"ABCG1 as a potential oncogene in lung cancer","volume":"13","author":"Tian","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.canlet.2019.03.011","article-title":"ABCG1 and Pgp identify drug resistant, self-renewing osteosarcoma cells","volume":"453","author":"Roundhill","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_30","first-page":"1869","article-title":"Expression of LXR-beta, ABCA1 and ABCG1 in human triple-negative breast cancer tissues","volume":"42","author":"Pan","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sano, O., Tsujita, M., Shimizu, Y., Kato, R., Kobayashi, A., Kioka, N., Remaley, A.T., Michikawa, M., Ueda, K., and Matsuo, M. (2016). ABCG1 and ABCG4 Suppress gamma-Secretase Activity and Amyloid beta Production. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155400"},{"key":"ref_32","first-page":"691","article-title":"The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC","volume":"11","author":"Zhang","year":"2008","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1194\/jlr.M054544","article-title":"Relative roles of ABCG5\/ABCG8 in liver and intestine","volume":"56","author":"Wang","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/09537104.2020.1779926","article-title":"ABCG5 and ABCG8 gene variations associated with sitosterolemia and platelet dysfunction","volume":"32","author":"Bastida","year":"2021","journal-title":"Platelets"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"783","DOI":"10.5551\/jat.RV17024","article-title":"Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease","volume":"25","author":"Tada","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-981-15-6082-8_8","article-title":"Recent Advances in the Critical Role of the Sterol Efflux Transporters ABCG5\/G8 in Health and Disease","volume":"1276","author":"Wang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1016\/S0021-9258(19)38781-2","article-title":"Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein","volume":"265","author":"Chen","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/(SICI)1097-4644(19970615)65:4<513::AID-JCB7>3.0.CO;2-R","article-title":"Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression","volume":"65","author":"Lee","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15665","DOI":"10.1073\/pnas.95.26.15665","article-title":"A multidrug resistance transporter from human MCF-7 breast cancer cells","volume":"95","author":"Doyle","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygeno.2006.03.001","article-title":"Evolution of the vertebrate ABC gene family: Analysis of gene birth and death","volume":"88","author":"Annilo","year":"2006","journal-title":"Genomics"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s003350010237","article-title":"An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR\/ABCP) has an unusual ATP-binding domain","volume":"12","author":"Mickley","year":"2001","journal-title":"Mamm. Genome"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0167-4781(01)00270-6","article-title":"Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene","volume":"1520","author":"Hassel","year":"2001","journal-title":"Biochim. Biophys. Acta (BBA)-Gene Struct. Expr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/(SICI)1098-2264(200001)27:1<110::AID-GCC14>3.0.CO;2-4","article-title":"Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines","volume":"27","author":"Knutsen","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.bcp.2012.01.002","article-title":"Role of breast cancer resistance protein (BCRP\/ABCG2) in cancer drug resistance","volume":"83","author":"Natarajan","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"24218","DOI":"10.1074\/jbc.M313599200","article-title":"The stem cell marker Bcrp\/ABCG2 enhances hypoxic cell survival through interactions with heme","volume":"279","author":"Krishnamurthy","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1158\/0008-5472.CAN-03-3583","article-title":"Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene","volume":"64","author":"Ee","year":"2004","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/mol.107.041087","article-title":"Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells","volume":"73","author":"Wang","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1158\/1541-7786.MCR-10-0270","article-title":"Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway","volume":"9","author":"To","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"23812","DOI":"10.1074\/jbc.M604890200","article-title":"Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells","volume":"281","author":"Szatmari","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbrc.2008.07.149","article-title":"Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells","volume":"375","author":"Honorat","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1182\/blood-2005-10-009084","article-title":"ABCG2 expression, function, and promoter methylation in human multiple myeloma","volume":"108","author":"Turner","year":"2006","journal-title":"Blood"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1128\/MCB.00331-08","article-title":"Regulation of ABCG2 expression at the 3\u2032 untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line","volume":"28","author":"To","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1158\/1535-7163.MCT-09-0292","article-title":"Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2","volume":"8","author":"To","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjc.6605724","article-title":"hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations","volume":"103","author":"Wang","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1124\/mol.108.054163","article-title":"MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP\/ABCG2) in human cancer cells","volume":"75","author":"Pan","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1124\/dmd.104.003228","article-title":"Regulation of the cell surface expression of human BCRP\/ABCG2 by the phosphorylation state of Akt in polarized cells","volume":"33","author":"Takada","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/abbs\/gmr050","article-title":"Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K\/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells","volume":"43","author":"Zhang","year":"2011","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/17425255.4.1.1","article-title":"ABCG2: Structure, function and role in drug response","volume":"4","author":"Polgar","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1002\/1873-3468.13947","article-title":"The ABCG2\/BCRP transporter and its variants-from structure to pathology","volume":"594","author":"Sarkadi","year":"2020","journal-title":"FEBS Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.str.2006.08.014","article-title":"Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2","volume":"14","author":"McDevitt","year":"2006","journal-title":"Structure"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2008.11.003","article-title":"ABCG2: A perspective","volume":"61","author":"Robey","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1038\/sj.onc.1206938","article-title":"Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)","volume":"22","author":"Doyle","year":"2003","journal-title":"Oncogene"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10555-007-9042-6","article-title":"ABCG2: Determining its relevance in clinical drug resistance","volume":"26","author":"Robey","year":"2007","journal-title":"Cancer Metastasis Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1124\/dmd.107.018044","article-title":"Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse","volume":"35","author":"Zhang","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.placenta.2007.08.004","article-title":"Breast cancer resistance protein: Mediating the trans-placental transfer of glyburide across the human placenta","volume":"29","author":"Gedeon","year":"2008","journal-title":"Placenta"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.taap.2008.07.006","article-title":"ABCG2\/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta","volume":"232","author":"Myllynen","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: Bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1097\/00001756-200211150-00014","article-title":"Localisation of breast cancer resistance protein in microvessel endothelium of human brain","volume":"13","author":"Cooray","year":"2002","journal-title":"Neuroreport"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1471-4159.2004.02537.x","article-title":"Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)","volume":"90","author":"Hori","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nm1186","article-title":"The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk","volume":"11","author":"Jonker","year":"2005","journal-title":"Nat. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1124\/mol.104.010439","article-title":"The breast cancer resistance protein (BCRP\/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin","volume":"67","author":"Merino","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/MCB.01621-06","article-title":"Multidrug transporter ABCG2\/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk","volume":"27","author":"Wagenaar","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.canlet.2005.04.024","article-title":"Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues","volume":"235","author":"Fetsch","year":"2006","journal-title":"Cancer Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.ejca.2004.05.010","article-title":"The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours","volume":"40","author":"Bart","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.bcp.2005.05.031","article-title":"Distribution of breast cancer resistance protein (BCRP\/ABCG2) mRNA expression along the human GI tract","volume":"70","author":"Gutmann","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1158\/1535-7163.MCT-07-2250","article-title":"Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-\/-\/Mdr1a\/1b-\/- (triple-knockout) and wild-type mice","volume":"7","author":"Marchetti","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/sj.ki.5002645","article-title":"The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane","volume":"73","author":"Huls","year":"2008","journal-title":"Kidney Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1124\/dmd.107.016352","article-title":"Evaluation of the role of breast cancer resistance protein (BCRP\/ABCG2) and multidrug resistance-associated protein 4 (MRP4\/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one)","volume":"35","author":"Mizuno","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1369\/jhc.5A6912.2006","article-title":"Breast cancer resistance protein (BCRP\/ABCG2) is expressed by progenitor cells\/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: Possible functional consequences","volume":"54","author":"Libbrecht","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/labinvest.3700127","article-title":"Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium","volume":"84","author":"Aust","year":"2004","journal-title":"Lab. Invest."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo","volume":"183","author":"Goodell","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1073\/pnas.192276999","article-title":"Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo","volume":"99","author":"Zhou","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1182\/blood.V99.2.507","article-title":"The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors","volume":"99","author":"Scharenberg","year":"2002","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"7","author":"Zhou","year":"2001","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"15649","DOI":"10.1073\/pnas.202607599","article-title":"The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria","volume":"99","author":"Jonker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e83976","DOI":"10.7554\/eLife.83976","article-title":"Nucleotide binding is the critical regulator of ABCG2 conformational transitions","volume":"12","author":"Gyongy","year":"2023","journal-title":"Elife"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1038\/s41467-021-24651-2","article-title":"Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism","volume":"12","author":"Yu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41594-018-0049-1","article-title":"Structural basis of small-molecule inhibition of human multidrug transporter ABCG2","volume":"25","author":"Jackson","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.canlet.2015.10.010","article-title":"Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade","volume":"370","author":"Chen","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-2141.2001.03122.x","article-title":"Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia","volume":"115","author":"Sargent","year":"2001","journal-title":"Br. J. Haematol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1182\/blood.V99.10.3763","article-title":"Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia","volume":"99","author":"Vellenga","year":"2002","journal-title":"Blood"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1182\/blood-2002-01-0271","article-title":"Low levels of ABCG2 expression in adult AML blast samples","volume":"100","author":"Abbott","year":"2002","journal-title":"Blood"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.leu.2402496","article-title":"Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)","volume":"16","author":"Wiemer","year":"2002","journal-title":"Leukemia"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00277-007-0269-7","article-title":"CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age","volume":"86","author":"Burnett","year":"2007","journal-title":"Ann. Hematol."},{"key":"ref_95","first-page":"6671","article-title":"Co-expression of ATP binding cassette transporters is associated with poor prognosis in acute myeloid leukemia","volume":"15","author":"Liu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3324\/haematol.2010.031823","article-title":"ATP Binding Cassette transporters associated with chemoresistance: Transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients","volume":"96","author":"Marzac","year":"2011","journal-title":"Haematologica"},{"key":"ref_97","first-page":"134","article-title":"Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia","volume":"88","author":"Broxterman","year":"2003","journal-title":"Haematologica"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.leukres.2003.09.002","article-title":"Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients","volume":"28","author":"Galimberti","year":"2004","journal-title":"Leuk. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1158\/1078-0432.CCR-04-1895","article-title":"MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia","volume":"11","author":"Benderra","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.exphem.2007.11.014","article-title":"MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia","volume":"36","author":"Ho","year":"2008","journal-title":"Exp. Hematol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.leukres.2004.06.004","article-title":"BCRP mRNA expression v. clinical outcome in 40 adult AML patients","volume":"29","author":"Uggla","year":"2005","journal-title":"Leuk. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.leukres.2010.01.008","article-title":"Fludarabine-based induction therapy does not overcome the negative effect of ABCG2 (BCRP) over-expression in adult acute myeloid leukemia patients","volume":"34","author":"Damiani","year":"2010","journal-title":"Leuk. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.bbmt.2016.05.002","article-title":"ABCG2, Cytogenetics, and Age Predict Relapse after Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission","volume":"22","author":"Damiani","year":"2016","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/sj.leu.2402541","article-title":"BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia","volume":"16","author":"Steinbach","year":"2002","journal-title":"Leukemia"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/pbc.25785","article-title":"Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia","volume":"63","author":"Bartholomae","year":"2016","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2217\/14622416.9.1.105","article-title":"ABC multidrug transporters: Structure, function and role in chemoresistance","volume":"9","author":"Sharom","year":"2008","journal-title":"Pharmacogenomics"},{"key":"ref_107","first-page":"6635","article-title":"Acquired mutations in the MXR\/BCRP\/ABCP gene alter substrate specificity in MXR\/BCRP\/ABCP-overexpressing cells","volume":"61","author":"Honjo","year":"2001","journal-title":"Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1110\/ps.051998406","article-title":"The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding","volume":"15","author":"Ejendal","year":"2006","journal-title":"Protein Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/jpet.109.163493","article-title":"Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport","volume":"333","author":"Cai","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/ijc.11484","article-title":"Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants","volume":"107","author":"Miwa","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"27841","DOI":"10.1074\/jbc.C700133200","article-title":"Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein","volume":"282","author":"Wakabayashi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_112","first-page":"9812","article-title":"A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/aje\/kws330","article-title":"Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: The PAGE Study","volume":"177","author":"Zhang","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"ref_114","first-page":"201","article-title":"ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout","volume":"17","author":"Roberts","year":"2017","journal-title":"Pharm. J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.3390\/ijms15059149","article-title":"Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population","volume":"15","author":"Zhou","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2013.06.044","article-title":"Association between the ABCG2 C421A polymorphism and Alzheimer\u2019s disease","volume":"550","author":"Feher","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.apsb.2019.01.007","article-title":"Development of precision medicine approaches based on inter-individual variability of BCRP\/ABCG2","volume":"9","author":"Chen","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00280-016-3166-8","article-title":"Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia","volume":"78","author":"Varatharajan","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_119","first-page":"201","article-title":"Genetic polymorphisms of ATP-binding cassette (ABC) proteins, overall survival and drug toxicity in patients with Acute Myeloid Leukemia","volume":"1","author":"Hampras","year":"2010","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.ejca.2011.03.032","article-title":"Prognostic value of the multidrug resistance transporter ABCG2 gene polymorphisms in Chinese patients with de novo acute leukaemia","volume":"47","author":"Wang","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1080\/10428194.2016.1231405","article-title":"Impact of ABC single nucleotide polymorphisms upon the efficacy and toxicity of induction chemotherapy in acute myeloid leukemia","volume":"58","author":"Montesinos","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.leukres.2007.10.011","article-title":"Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups","volume":"32","author":"Muller","year":"2008","journal-title":"Leuk. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.3324\/haematol.2012.075895","article-title":"Q141K polymorphism of ABCG2 protein is associated with poor prognosis in adult acute myeloid leukemia treated with idarubicin-based chemotherapy","volume":"98","author":"Tiribelli","year":"2013","journal-title":"Haematologica"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Jabalee, J., Towle, R., and Garnis, C. (2018). The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications. Cells, 7.","DOI":"10.3390\/cells7080093"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1158\/1535-7163.MCT-05-0102","article-title":"Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells","volume":"4","author":"Safaei","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Goler-Baron, V., and Assaraf, Y.G. (2011). Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016007"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/pmic.201600375","article-title":"Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles","volume":"17","author":"Samuel","year":"2017","journal-title":"Proteomics"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Goler-Baron, V., and Assaraf, Y.G. (2012). Overcoming multidrug resistance via photodestruction of ABCG2-rich extracellular vesicles sequestering photosensitive chemotherapeutics. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035487"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/(SICI)1097-0215(19970904)72:5<844::AID-IJC22>3.0.CO;2-7","article-title":"Anti-proliferative activity of a new class of taxanes (14beta-hydroxy-10-deacetylbaccatin III derivatives) on multidrug-resistance-positive human cancer cells","volume":"72","author":"Distefano","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1349-7006.2003.tb01465.x","article-title":"DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo","volume":"94","author":"Shionoya","year":"2003","journal-title":"Cancer Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1567201043480036","article-title":"The role of ABC transporters in drug resistance, metabolism and toxicity","volume":"1","author":"Glavinas","year":"2004","journal-title":"Curr. Drug Deliv."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1021\/cr4006236","article-title":"Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance","volume":"114","author":"Szakacs","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_133","first-page":"5850","article-title":"Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C","volume":"58","author":"Rabindran","year":"1998","journal-title":"Cancer Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"114346","DOI":"10.1016\/j.ejmech.2022.114346","article-title":"Targeting breast cancer resistance protein (BCRP\/ABCG2): Functional inhibitors and expression modulators","volume":"237","author":"Zattoni","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"114628","DOI":"10.1016\/j.ejmech.2022.114628","article-title":"Updated chemical scaffolds of ABCG2 inhibitors and their structure-inhibition relationships for future development","volume":"241","author":"Moinul","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"113017","DOI":"10.1016\/j.ejmech.2020.113017","article-title":"Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2","volume":"211","author":"Guragossian","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.2217\/fon.13.253","article-title":"Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP)","volume":"10","author":"Yang","year":"2014","journal-title":"Future Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1158\/1535-7163.MCT-12-0302","article-title":"The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2","volume":"11","author":"Sen","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1124\/dmd.115.066795","article-title":"Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure","volume":"44","author":"Elsby","year":"2016","journal-title":"Drug Metab. Dispos."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fphar.2016.00518","article-title":"Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations","volume":"7","author":"Miyata","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-014-9668-6","article-title":"Role of the breast cancer resistance protein (BCRP\/ABCG2) in drug transport--an update","volume":"17","author":"Mao","year":"2015","journal-title":"AAPS J."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0304-3835(99)00182-2","article-title":"Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR","volume":"146","author":"Miyake","year":"1999","journal-title":"Cancer Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1021\/jm8013822","article-title":"Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar","volume":"52","author":"Kuhnle","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejps.2008.07.008","article-title":"Dimethoxyaurones: Potent inhibitors of ABCG2 (breast cancer resistance protein)","volume":"35","author":"Sim","year":"2008","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejmech.2012.05.026","article-title":"Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells","volume":"54","author":"Yuan","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/s41598-020-79892-w","article-title":"Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles","volume":"11","author":"Kita","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-006-9302-8","article-title":"Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin","volume":"296","author":"Limtrakul","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Sorf, A., Sucha, S., Morell, A., Novotna, E., Staud, F., Zavrelova, A., Visek, B., Wsol, V., and Ceckova, M. (2020). Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4\/6 Inhibitors. Cancers, 12.","DOI":"10.3390\/cancers12061596"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Sabet, Z., Vagiannis, D., Budagaga, Y., Zhang, Y., Novotna, E., Hanke, I., Rozkos, T., and Hofman, J. (2022). Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214338"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Wang, J.Q., Li, J.Y., Teng, Q.X., Lei, Z.N., Ji, N., Cui, Q., Zeng, L., Pan, Y., Yang, D.H., and Chen, Z.S. (2020). Venetoclax, a BCL-2 Inhibitor, Enhances the Efficacy of Chemotherapeutic Agents in Wild-Type ABCG2-Overexpression-Mediated MDR Cancer Cells. Cancers, 12.","DOI":"10.3390\/cancers12020466"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1007\/s00018-021-03901-y","article-title":"Multidrug efflux transporter ABCG2: Expression and regulation","volume":"78","author":"Kukal","year":"2021","journal-title":"Cell. Mol. Life Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7147\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:14:44Z","timestamp":1760123684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,12]]},"references-count":151,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24087147"],"URL":"https:\/\/doi.org\/10.3390\/ijms24087147","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,12]]}}}