{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:13:00Z","timestamp":1777353180823,"version":"3.51.4"},"reference-count":92,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multivessel coronary artery disease (CAD) is characterized by underlying chronic vascular inflammation and occlusion in the coronary arteries, where these patients undergo coronary artery bypass grafting (CABG). Since post-cardiotomy inflammation is a well known phenomenon after CABG, attenuation of this inflammation is required to reduce perioperative morbidity and mortality. In this study, we aimed to phenotype circulating frequencies and intensities of monocyte subsets and monocyte migration markers, respectively, and to investigate the plasma level of inflammatory cytokines and chemokines between preoperative and postoperative CAD patients and later, to intervene the inflammation with sodium selenite. We found a higher amplitude of inflammation, postoperatively, in terms of CCR1high monocytes and significantly increased pro-inflammatory cytokines, IL-6, IL-8, and IL-1RA. Further, in vitro intervention with selenium displayed mitigating effects on the IL-6\/STAT-3 axis of mononuclear cells derived from postoperative CAD patients. In addition, in vitro selenium intervention significantly reduced IL-1\u03b2 production as well as decreased cleaved caspase-1 (p20) activity by preoperative (when stimulated) as well as postoperative CAD mononuclear cells. Though TNF-\u03b1 exhibited a positive correlation with blood troponin levels in postoperative CAD patients, there was no obvious effect of selenium on the TNF-\u03b1\/NF-\u03baB axis. In conclusion, anti-inflammatory selenium might be utilized to impede systemic inflammatory cytokine axes to circumvent aggravating atherosclerosis and further damage to the autologous bypass grafts during the post-surgical period.<\/jats:p>","DOI":"10.3390\/ijms24087198","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:28:12Z","timestamp":1681439292000},"page":"7198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunophenotyping of Monocyte Migration Markers and Therapeutic Effects of Selenium on IL-6 and IL-1\u03b2 Cytokine Axes of Blood Mononuclear Cells in Preoperative and Postoperative Coronary Artery Disease Patients"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-2613","authenticated-orcid":false,"given":"Max","family":"Wacker","sequence":"first","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ball","sequence":"additional","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-713X","authenticated-orcid":false,"given":"Hans-Dietmar","family":"Beer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Zurich, CH-8952 Schlieren, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-0419","authenticated-orcid":false,"given":"Ingo","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Medical Faculty of Ruhr-University Bochum, 44801 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Borucki","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faranak","family":"Azizzadeh","sequence":"additional","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Scherner","sequence":"additional","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-1733","authenticated-orcid":false,"given":"George","family":"Awad","sequence":"additional","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Wippermann","sequence":"additional","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Veluswamy","sequence":"additional","affiliation":[{"name":"Heart Surgery Research, Department of Cardiothoracic Surgery, Otto-von-Guericke University Hospital, Leipziger Stra\u00dfe 44, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"ref_1","unstructured":"Brown, J.C., Gerhardt, T.E., and Kwon, E. 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