{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:21:55Z","timestamp":1778858515573,"version":"3.51.4"},"reference-count":77,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008002","name":"Vancouver Coastal Health Research Institute","doi-asserted-by":"publisher","award":["RD47"],"award-info":[{"award-number":["RD47"]}],"id":[{"id":"10.13039\/501100008002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sudden sensorineural hearing loss (SSNHL) is an acquired idiopathic hearing loss. Serum levels of small, non-coding RNAs and microRNAs (miRNAs) miR-195-5p\/-132-3p\/-30a-3p\/-128-3p\/-140-3p\/-186-5p\/-375-3p\/-590-5p are differentially expressed in SSNHL patients within 28 days of hearing loss onset. This study determines if these changes persist by comparing the serum miRNA expression profile of SSNHL patients within 1 month of hearing loss onset with that of patients 3\u201312 months after hearing loss onset. We collected serum from consenting adult SSNHL patients at presentation or during clinic follow-up. We matched patient samples drawn 3\u201312 months after hearing loss onset (delayed group, n = 9 patients) by age and sex to samples drawn from patients within 28 days of hearing loss onset (immediate group, n = 14 patients). We compared the real-time PCR-determined expression levels of the target miRNAs between the two groups. We calculated the air conduction pure-tone-averaged (PTA) audiometric thresholds in affected ears at the initial and final follow-up visits. We undertook inter-group comparisons of hearing outcome status and initial and final PTA audiometric thresholds. There was no significant inter-group difference in miRNA expression level, hearing recovery status and initial and final affected ear PTA audiometric thresholds.<\/jats:p>","DOI":"10.3390\/ijms24087307","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T03:14:09Z","timestamp":1681701249000},"page":"7307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Expression Levels of MicroRNAs Differentially Expressed in Sudden Sensorineural Hearing Loss Patients\u2019 Serum Are Unchanged for up to 12 Months after Hearing Loss Onset"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-0169","authenticated-orcid":false,"given":"Reyhaneh","family":"Abgoon","sequence":"first","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Vancouver Coastal Health Research Institute, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-4689","authenticated-orcid":false,"given":"Printha","family":"Wijesinghe","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Vancouver Coastal Health Research Institute, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathie","family":"Garnis","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-9625","authenticated-orcid":false,"given":"Desmond A.","family":"Nunez","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Vancouver Coastal Health Research Institute, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Otolaryngology-Head & Neck Surgery, Vancouver General Hospital, Vancouver, BC V57 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/bib\/bby054","article-title":"Trends in the Development of MiRNA Bioinformatics Tools","volume":"20","author":"Chen","year":"2019","journal-title":"Brief. 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