{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:01:50Z","timestamp":1772571710845,"version":"3.50.1"},"reference-count":66,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Hebei Province","award":["H2020206629"],"award-info":[{"award-number":["H2020206629"]}]},{"name":"Natural Science Foundation of Hebei Province","award":["H2020206404"],"award-info":[{"award-number":["H2020206404"]}]},{"name":"Natural Science Foundation of Hebei Province","award":["H2021206181"],"award-info":[{"award-number":["H2021206181"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dilated cardiomyopathy (DCM) is characterized by left ventricular or biventricular enlargement with systolic dysfunction. To date, the underlying molecular mechanisms of dilated cardiomyopathy pathogenesis have not been fully elucidated, although some insights have been presented. In this study, we combined public database resources and a doxorubicin-induced DCM mouse model to explore the significant genes of DCM in full depth. We first retrieved six DCM-related microarray datasets from the GEO database using several keywords. Then we used the \u201cLIMMA\u201d (linear model for microarray data) R package to filter each microarray for differentially expressed genes (DEGs). Robust rank aggregation (RRA), an extremely robust rank aggregation method based on sequential statistics, was then used to integrate the results of the six microarray datasets to filter out the reliable differential genes. To further improve the reliability of our results, we established a doxorubicin-induced DCM model in C57BL\/6N mice, using the \u201cDESeq2\u201d software package to identify DEGs in the sequencing data. We cross-validated the results of RRA analysis with those of animal experiments by taking intersections and identified three key differential genes (including BEX1, RGCC and VSIG4) associated with DCM as well as many important biological processes (extracellular matrix organisation, extracellular structural organisation, sulphur compound binding, and extracellular matrix structural components) and a signalling pathway (HIF-1 signalling pathway). In addition, we confirmed the significant effect of these three genes in DCM using binary logistic regression analysis. These findings will help us to better understand the pathogenesis of DCM and may be key targets for future clinical management.<\/jats:p>","DOI":"10.3390\/ijms24087339","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T03:14:09Z","timestamp":1681701249000},"page":"7339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of Signature Genes of Dilated Cardiomyopathy Using Integrated Bioinformatics Analysis"],"prefix":"10.3390","volume":"24","author":[{"given":"Zhimin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Core Facilities and Centers, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejhf.1103","article-title":"Evolving concepts in dilated cardiomyopathy","volume":"20","author":"Merlo","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies","volume":"93","author":"Richardson","year":"1996","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/joim.12944","article-title":"Dilated cardiomyopathy: From epidemiologic to genetic phenotypes: A translational review of current literature","volume":"286","author":"Reichart","year":"2019","journal-title":"J. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/jcp.2008.060731","article-title":"Dilated cardiomyopathy: A review","volume":"62","author":"Luk","year":"2009","journal-title":"J. Clin. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41569-019-0284-0","article-title":"Genetics of dilated cardiomyopathy: Practical implications for heart failure management","volume":"17","author":"Rosenbaum","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/bioinformatics\/btr709","article-title":"Robust rank aggregation for gene list integration and meta-analysis","volume":"28","author":"Kolde","year":"2012","journal-title":"Bioinformatics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.jacc.2006.07.026","article-title":"Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies","volume":"48","author":"Barth","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiolgenomics.00094.2011","article-title":"Myocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy","volume":"44","author":"Gaertner","year":"2012","journal-title":"Physiol. Genom."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Molina-Navarro, M.M., Rosell\u00f3-Llet\u00ed, E., Ortega, A., Taraz\u00f3n, E., Otero, M., Mart\u00ednez-Dolz, L., Lago, F., Gonz\u00e1lez-Juanatey, J.R., Espa\u00f1a, F., and Garc\u00eda-Pav\u00eda, P. (2013). Differential gene expression of cardiac ion channels in human dilated cardiomyopathy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079792"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1152\/physiolgenomics.00014.2013","article-title":"Thymidine kinase and mtDNA depletion in human cardiomyopathy: Epigenetic and translational evidence for energy starvation","volume":"45","author":"Koczor","year":"2013","journal-title":"Physiol. Genom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/CCM.0000000000002207","article-title":"Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis","volume":"45","author":"Matkovich","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/cid\/cix506","article-title":"Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy","volume":"65","author":"Laugier","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1553-2712.2011.01185.x","article-title":"Logistic regression: A brief primer","volume":"18","author":"Stoltzfus","year":"2011","journal-title":"Acad. Emerg. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","article-title":"Contemporary definitions and classification of the cardiomyopathies: An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(16)31713-5","article-title":"Dilated cardiomyopathy","volume":"390","author":"Weintraub","year":"2017","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hibino, E., Ichiyama, Y., Tsukamura, A., Senju, Y., Morimune, T., Ohji, M., Maruo, Y., Nishimura, M., and Mori, M. (2022). Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity. BMC Biol., 20.","DOI":"10.1186\/s12915-022-01246-x"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/physiolgenomics.2001.6.1.19","article-title":"Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy","volume":"6","author":"Aronow","year":"2001","journal-title":"Physiol. Genom."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/s41467-017-02005-1","article-title":"BEX1 is an RNA-dependent mediator of cardiomyopathy","volume":"8","author":"Accornero","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1074\/jbc.M109354200","article-title":"RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase","volume":"277","author":"Badea","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.yexmp.2008.12.005","article-title":"Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells","volume":"86","author":"Fosbrink","year":"2009","journal-title":"Exp. Mol. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.yexmp.2016.09.004","article-title":"RGC-32 is expressed in the human atherosclerotic arterial wall: Role in C5b-9-induced cell proliferation and migration","volume":"101","author":"Vlaicu","year":"2016","journal-title":"Exp. Mol. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nrm2786","article-title":"Non-muscle myosin II takes centre stage in cell adhesion and migration","volume":"10","author":"Ma","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1083\/jcb.146.4.703","article-title":"Extranuclear apoptosis. The role of the cytoplasm in the execution phase","volume":"146","author":"Mills","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35070019","article-title":"Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing","volume":"3","author":"Sebbagh","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14495","DOI":"10.1073\/pnas.0601911103","article-title":"Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis","volume":"103","author":"Chang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1159\/000481975","article-title":"Response Gene to Complement-32 Promotes the Imbalance of Treg\/Th17 in Patients with Dilated Cardiomyopathy","volume":"43","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.109.213157","article-title":"Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy","volume":"106","author":"Baldeviano","year":"2010","journal-title":"Circ. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2249.2012.04598.x","article-title":"Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4+ T cells","volume":"169","author":"Chen","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1182\/blood.V100.5.1742.h81702001742_1742_1754","article-title":"Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis","volume":"100","author":"Ahn","year":"2002","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.3389\/fimmu.2019.02892","article-title":"Human Dendritic Cells Express the Complement Receptor Immunoglobulin Which Regulates T Cell Responses","volume":"10","author":"Munawara","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1002\/hep.25906","article-title":"Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells","volume":"56","author":"Jung","year":"2012","journal-title":"Hepatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molimm.2019.01.008","article-title":"Role of interleukin-17 in acute myocardial infarction","volume":"107","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/0148607114566854","article-title":"Malnutrition and Cachexia in Heart Failure","volume":"40","author":"Rahman","year":"2016","journal-title":"JPEN. J. Parenter. Enter. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10741-013-9393-8","article-title":"Could interferon-gamma be a therapeutic target for treating heart failure?","volume":"19","author":"Levick","year":"2014","journal-title":"Heart Fail. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/CIRCRESAHA.121.318005","article-title":"Immune Cells and Immunotherapy for Cardiac Injury and Repair","volume":"128","author":"Rurik","year":"2021","journal-title":"Circ. Res."},{"key":"ref_36","first-page":"15","article-title":"Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction","volume":"191","author":"Ma","year":"2018","journal-title":"Transl. Res. J. Lab. Clin. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s41467-017-01327-4","article-title":"VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1172\/JCI25673","article-title":"VSIG4, a B7 family-related protein, is a negative regulator of T cell activation","volume":"116","author":"Vogt","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular matrix structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1172\/JCI87491","article-title":"The extracellular matrix in myocardial injury, repair, and remodeling","volume":"127","author":"Frangogiannis","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/CIRCRESAHA.118.314438","article-title":"Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program","volume":"124","author":"Russo","year":"2019","journal-title":"Circ. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0735-1097(89)90360-4","article-title":"Cardiac interstitium in health and disease: The fibrillar collagen network","volume":"13","author":"Weber","year":"1989","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1006\/jmcc.1997.0420","article-title":"Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan","volume":"29","author":"Dixon","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/bst0320403","article-title":"Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins","volume":"32","author":"Takagi","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0021-9258(17)42252-6","article-title":"Thrombospondin 3 is a developmentally regulated heparin binding protein","volume":"269","author":"Qabar","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.jacc.2003.11.058","article-title":"Osteopontin modulates angiotensin II- induced fibrosis in the intact murine heart","volume":"43","author":"Collins","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/labinvest.3780313","article-title":"Tenascin-C Modulates Adhesion of Cardiomyocytes to Extracellular Matrix during Tissue Remodeling after Myocardial Infarction","volume":"81","author":"Hiroe","year":"2001","journal-title":"Lab. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.atherosclerosis.2009.07.046","article-title":"Periostin mediates vascular smooth muscle cell migration through the integrins \u03b1\u03bd\u03b23 and \u03b1\u03bd\u03b25 and focal adhesion kinase (FAK) pathway","volume":"208","author":"Li","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cdd.2008.12","article-title":"Biology of HIF-1\u03b1","volume":"15","author":"Weidemann","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1073\/pnas.88.13.5680","article-title":"Hypoxia-inducible nuclear factors bind to an enhancer element located 3\u2032 to the human erythropoietin gene","volume":"88","author":"Semenza","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","article-title":"Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation","volume":"23","author":"Hu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1172\/JCI0215337","article-title":"Ecto-5\u2032-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia","volume":"110","author":"Synnestvedt","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10684","DOI":"10.1073\/pnas.0901326106","article-title":"Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells","volume":"106","author":"Ahmad","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1056\/NEJM200003023420904","article-title":"Early expression of angiogenesis factors in acute myocardial ischemia and infarction","volume":"342","author":"Lee","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.02-0445fje","article-title":"Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs","volume":"17","author":"Wiesener","year":"2003","journal-title":"FASEB J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","article-title":"Oxygen, oxidative stress, hypoxia, and heart failure","volume":"115","author":"Giordano","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/cvr\/cvs014","article-title":"Unfavourable consequences of chronic cardiac HIF-1\u03b1 stabilization","volume":"94","author":"Krull","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1128\/MCB.01580-07","article-title":"Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein","volume":"28","author":"Lei","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCULATIONAHA.109.922427","article-title":"Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy","volume":"122","author":"Moslehi","year":"2010","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cardfail.2004.06.433","article-title":"Carvedilol Modulates the Expression of Hypoxia-Inducible Factor-1\u03b1 and Vascular Endothelial Growth Factor in a Rat Model of Volume-Overload Heart Failure","volume":"11","author":"Shyu","year":"2005","journal-title":"J. Card. Fail."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets\u2014Update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"Affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Smyth, G.K. (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol., 3.","DOI":"10.2202\/1544-6115.1027"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7339\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:16:40Z","timestamp":1760123800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,16]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24087339"],"URL":"https:\/\/doi.org\/10.3390\/ijms24087339","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,16]]}}}