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Union","award":["CV-PREVITAL"],"award-info":[{"award-number":["CV-PREVITAL"]}]},{"name":"European Union","award":["RC5100017A"],"award-info":[{"award-number":["RC5100017A"]}]},{"name":"European Union","award":["PR-0361"],"award-info":[{"award-number":["PR-0361"]}]},{"name":"European Union","award":["777377"],"award-info":[{"award-number":["777377"]}]},{"name":"European Union","award":["101016726"],"award-info":[{"award-number":["101016726"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fatty liver disease is most frequently related to metabolic dysfunction (MAFLD) and associated comorbidities, heightening the risk of cardiovascular disease, and is associated with higher hepatic production of IL32, a cytokine linked with lipotoxicity and endothelial activation. The aim of this study was to examine the relationship between circulating IL32 concentration and blood pressure control in individuals with metabolic dysfunction at high risk of MAFLD. IL32 plasma levels were measured by ELISA in 948 individuals with metabolic dysfunction enrolled in the Liver-Bible-2021 cohort. Higher circulating IL32 levels were independently associated with systolic blood pressure (estimate +0.008 log10 per 1 mmHg increase, 95% c.i. 0.002\u20130.015; p = 0.016), and inversely correlated with antihypertensive medications (estimate \u22120.189, 95% c.i. \u22120.291\u2013\u22120.088, p = 0.0002). Through multivariable analysis, IL32 levels predicted both systolic blood pressure (estimate 0.746, 95% c.i 0.173\u20131.318; p = 0.010) and impaired blood pressure control (OR 1.22, 95% c.i. 1.09\u20131.38; p = 0.0009) independently of demographic and metabolic confounders and of treatment. This study reveals that circulating IL32 levels are associated with impaired blood pressure control in individuals at risk of cardiovascular disease.<\/jats:p>","DOI":"10.3390\/ijms24087465","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:39:05Z","timestamp":1681868345000},"page":"7465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Circulating Interlukin-32 and Altered Blood Pressure Control in Individuals with Metabolic Dysfunction"],"prefix":"10.3390","volume":"24","author":[{"given":"Melissa","family":"Tomasi","sequence":"first","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-2046","authenticated-orcid":false,"given":"Alessandro","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Pelusi","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Margarita","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-6781","authenticated-orcid":false,"given":"Cristiana","family":"Bianco","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-5883","authenticated-orcid":false,"given":"Francesco","family":"Malvestiti","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Miano","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Department of Cardiology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden"},{"name":"Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Prati","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-0345","authenticated-orcid":false,"given":"Luca","family":"Valenti","sequence":"additional","affiliation":[{"name":"Precision Medicine Lab\u2014Department of Transfusion Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global Burden of NAFLD and NASH: Trends, Predictions, Risk Factors and Prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. 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