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de Catalunya (Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["PI18\/01535"],"award-info":[{"award-number":["PI18\/01535"]}]},{"name":"Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["FI19\/0352"],"award-info":[{"award-number":["FI19\/0352"]}]},{"name":"Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["FI21\/00093"],"award-info":[{"award-number":["FI21\/00093"]}]},{"name":"Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["CP20\/00072"],"award-info":[{"award-number":["CP20\/00072"]}]},{"name":"Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["2021SGR1475"],"award-info":[{"award-number":["2021SGR1475"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The role of both cannabis use and genetic background has been shown in the risk for psychosis. However, the effect of the interplay between cannabis and variability at the endocannabinoid receptor genes on the neurobiological underpinnings of psychosis remains inconclusive. Through a case-only design, including patients with a first-episode of psychosis (n = 40) classified as cannabis users (50%) and non-users (50%), we aimed to evaluate the interaction between cannabis use and common genetic variants at the endocannabinoid receptor genes on brain activity. Genetic variability was assessed by genotyping two Single Nucleotide Polymorphisms (SNP) at the cannabinoid receptor type 1 gene (CNR1; rs1049353) and cannabinoid receptor type 2 gene (CNR2; rs2501431). Functional Magnetic Resonance Imaging (fMRI) data were obtained while performing the n-back task. Gene \u00d7 cannabis interaction models evidenced a combined effect of CNR1 and CNR2 genotypes and cannabis use on brain activity in different brain areas, such as the caudate nucleus, the cingulate cortex and the orbitofrontal cortex. These findings suggest a joint role of cannabis use and cannabinoid receptor genetic background on brain function in first-episode psychosis, possibly through the impact on brain areas relevant to the reward circuit.<\/jats:p>","DOI":"10.3390\/ijms24087501","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T03:25:11Z","timestamp":1681961111000},"page":"7501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis"],"prefix":"10.3390","volume":"24","author":[{"given":"Maitane","family":"Oscoz-Irurozqui","sequence":"first","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Centro de Salud Mental Errenteria-Osakidetza, Av Galtzaraborda 69-75, 20100 Errenteria, Guip\u00fazcoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Almod\u00f3var-Pay\u00e1","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-5687","authenticated-orcid":false,"given":"Maria","family":"Guardiola-Ripoll","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-9407","authenticated-orcid":false,"given":"Amalia","family":"Guerrero-Pedraza","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Hospital Benito Menni CASM, C\/Doctor Antoni Pujadas 38, 08830 Sant Boi de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Hostalet","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Salvador","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Sant Rafael, Passeig de la Vall d\u2019Hebron, 107, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Maristany","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department, Hospital Sant Joan de D\u00e9u Research Foundation, Passeig de Sant Joan de D\u00e9u, 2, 08950 Esplugues de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Pomarol-Clotet","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-6241","authenticated-orcid":false,"given":"Mar","family":"Fatj\u00f3-Vilas","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Av Jord\u00e0 8, 08035 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"},{"name":"Departament de Biologia Evolutiva, Ecologia i Ci\u00e8ncies Ambientals, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal, 643, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.biopsych.2017.08.017","article-title":"Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register","volume":"83","author":"Hilker","year":"2018","journal-title":"Biol. 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