{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:17:28Z","timestamp":1790705848136,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The purpose of our study was to analyze abnormal neural regeneration activity in the cornea through means of confocal microscopy in rheumatoid arthritis patients with concomitant dry eye disease. We examined 40 rheumatoid arthritis patients with variable severity and 44 volunteer age- and gender-matched healthy control subjects. We found that all examined parameters were significantly lower (p &lt; 0.05) in rheumatoid arthritis patients as opposed to the control samples: namely, the number of fibers, the total length of the nerves, the number of branch points on the main fibers and the total nerve-fiber area. We examined further variables, such as age, sex and the duration of rheumatoid arthritis. Interestingly, we could not find a correlation between the above variables and abnormal neural structural changes in the cornea. We interpreted these findings via implementing our hypotheses. Correspondingly, one neuroimmunological link between dry eye and rheumatoid arthritis could be through the chronic Piezo2 channelopathy-induced K2P-TASK1 signaling axis. This could accelerate neuroimmune-induced sensitization on the spinal level in this autoimmune disease, with Langerhans-cell activation in the cornea and theorized downregulated Piezo1 channels in these cells. Even more importantly, suggested principal primary-damage-associated corneal keratocyte activation could be accompanied by upregulation of Piezo1. Both activation processes on the periphery would skew the plasticity of the Th17\/Treg ratio, resulting in Th17\/Treg imbalance in dry eye, secondary to rheumatoid arthritis. Hence, chronic somatosensory-terminal Piezo2 channelopathy-induced impaired Piezo2\u2013Piezo1 crosstalk could result in a mixed picture of disrupted functional regeneration but upregulated morphological regeneration activity of these somatosensory axons in the cornea, providing the demonstrated abnormal neural corneal morphology.<\/jats:p>","DOI":"10.3390\/ijms24087514","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T03:25:11Z","timestamp":1681961111000},"page":"7514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidence of Disruption in Neural Regeneration in Dry Eye Secondary to Rheumatoid Arthritis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-1306","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"Sonkodi","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Sport Medicine, Hungarian University of Sports Science, 1123 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Csorba","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Marsovszky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Balog","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Faculty of Medicine, Albert Szent-Gy\u00f6rgyi Health Center, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Kopper","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology, Hungarian University of Sports Science, 1123 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-1153","authenticated-orcid":false,"given":"Mikl\u00f3s D.","family":"Resch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s12192-020-01114-z","article-title":"Autologous extracellular Hsp70 exerts a dual role in rheumatoid arthritis","volume":"25","author":"Tukaj","year":"2020","journal-title":"Cell. Stress. Chaperones"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease: Report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul. Surf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jtos.2017.10.001","article-title":"Neuropathic pain and dry eye","volume":"16","author":"Galor","year":"2018","journal-title":"Ocul. Surf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"DES7","DOI":"10.1167\/iovs.17-23475","article-title":"Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions","volume":"59","author":"Shimazaki","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/1753425912461677","article-title":"In vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis","volume":"19","author":"Marsovszky","year":"2013","journal-title":"Innate Immun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/nn.4162","article-title":"Piezo2 is the principal mechanotransduction channel for proprioception","volume":"18","author":"Woo","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Bardoni, R., and Po\u00f3r, G. (2022). Osteoporosis in Light of a New Mechanism Theory of Delayed Onset Muscle Soreness and Non-Contact Anterior Cruciate Ligament Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169046"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sonkodi, B. (2022). Psoriasis, Is It a Microdamage of Our \u201cSixth Sense\u201d? A Neurocentric View. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911940"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00296-019-04419-0","article-title":"Cervical proprioceptive impairment in patients with rheumatoid arthritis","volume":"39","author":"Ulutatar","year":"2019","journal-title":"Rheumatol. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"612104","DOI":"10.3389\/fimmu.2020.612104","article-title":"The Joint-Brain Axis: Insights From Rheumatoid Arthritis on the Crosstalk Between Chronic Peripheral Inflammation and the Brain","volume":"11","author":"Suss","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Broce, I., Karch, C.M., Wen, N., Fan, C.C., Wang, Y., Tan, C.H., Kouri, N., Ross, O.A., Hoglinger, G.U., and Muller, U. (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med., 15.","DOI":"10.1371\/journal.pmed.1002487"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1515\/med-2022-0444","article-title":"Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes\u2014Watch out for Piezo2","volume":"17","author":"Sonkodi","year":"2022","journal-title":"Open. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/life13030657","article-title":"Miswired Proprioception in Amyotrophic Lateral Sclerosis in Relation to Pain Sensation (and in Delayed Onset Muscle Soreness)\u2014Is Piezo2 Channelopathy a Principal Transcription Activator in Proprioceptive Terminals Besides Being the Potential Primary Damage?","volume":"13","author":"Sonkodi","year":"2023","journal-title":"Life"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nagy, Z.F., Sonkodi, B., P\u00e1l, M., Kliv\u00e9nyi, P., and Sz\u00e9ll, M. (2023). Likely Pathogenic Variants of Cav1.3 and Nav1.1 Encoding Genes in Amyotrophic Lateral Sclerosis Could Elucidate the Dysregulated Pain Pathways. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030933"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1093\/hmg\/ddr248","article-title":"Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways","volume":"20","author":"Eleftherohorinou","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1007\/s12031-022-02015-9","article-title":"Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy","volume":"72","author":"Sonkodi","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"110070","DOI":"10.1016\/j.celrep.2021.110070","article-title":"Piezo1 and Piezo2 foster mechanical gating of K2P channels","volume":"37","author":"Glogowska","year":"2021","journal-title":"Cell. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00424-014-1664-2","article-title":"The CNS under pathophysiologic attack\u2014Examining the role of K2P channels","volume":"467","author":"Ehling","year":"2015","journal-title":"Pflug. Arch."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14559","DOI":"10.1074\/jbc.M800637200","article-title":"TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions","volume":"283","author":"Meuth","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.expneurol.2013.01.016","article-title":"Targeting two-pore domain potassium channels\u2014A promising strategy for treating T cell mediated autoimmunity","volume":"247","author":"Kieseier","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.expneurol.2012.08.021","article-title":"The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis","volume":"238","author":"Bittner","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/ar3245","article-title":"Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients","volume":"13","author":"Bittner","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2249.1999.01018.x","article-title":"Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA)","volume":"118","author":"Yanagihara","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., P\u00e1llinger, \u00c9., Radovits, T., Csulak, E., Shenker-Horv\u00e1th, K., Kopper, B., Buz\u00e1s, E.I., Syd\u00f3, N., and Merkely, B. (2022). CD3+\/CD56+ NKT-like Cells Show Imbalanced Control Immediately after Exercise in Delayed-Onset Muscle Soreness. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911117"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/08916930903510906","article-title":"Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis","volume":"43","author":"Albanesi","year":"2010","journal-title":"Autoimmunity"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"112604","DOI":"10.1016\/j.biopha.2021.112604","article-title":"Protective effect of Yangxue Jiedu Soup against psoriasis-like lesions by regulating TLR4\/NF-kappaB signaling pathway mediated by secretion of exosome HSP70","volume":"147","author":"Lv","year":"2022","journal-title":"Biomed. Pharm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12539-016-0188-1","article-title":"Structure-Based Drug Designing and Simulation Studies for Finding Novel Inhibitors of Heat Shock Protein (HSP70) as Suppressors for Psoriasis","volume":"10","author":"Mishra","year":"2018","journal-title":"Interdiscip. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/jdv.12929","article-title":"Calcitriol exerts anti-inflammatory effects in keratinocytes treated with autoantibodies from a patient with bullous pemphigoid","volume":"30","author":"Tukaj","year":"2016","journal-title":"J. Eur. Acad. Derm. Venereol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cei.12966","article-title":"The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis","volume":"189","author":"Schinnerling","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/jnc.15006","article-title":"Involvement of the Hsp70\/TLR4\/IL-6 and TNF-alpha pathways in delayed-onset muscle soreness","volume":"155","author":"Veras","year":"2020","journal-title":"J. Neurochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5606\/ArchRheumatol.2018.6753","article-title":"Effects of Tocilizumab Therapy on Serum Interleukin-33 and Interleukin-6 Levels in Patients With Rheumatoid Arthritis","volume":"33","author":"Choi","year":"2018","journal-title":"Arch. Rheumatol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Murdaca, G., Greco, M., Tonacci, A., Negrini, S., Borro, M., Puppo, F., and Gangemi, S. (2019). IL-33\/IL-31 Axis in Immune-Mediated and Allergic Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235856"},{"key":"ref_34","first-page":"451","article-title":"IL33 in rheumatoid arthritis: Potential contribution to pathogenesis","volume":"56","author":"Macedo","year":"2016","journal-title":"Rev. Bras. Reum. Engl. Ed."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1523\/JNEUROSCI.0247-20.2020","article-title":"Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea","volume":"40","author":"Gonzalez","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Berkes, I., and Koltai, E. (2020). Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage. Antioxidants, 9.","DOI":"10.3390\/antiox9030212"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"914985","DOI":"10.3389\/fncel.2022.914985","article-title":"Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes in vitro","volume":"16","author":"Koch","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1167\/iovs.07-0893","article-title":"Corneal involvement in rheumatoid arthritis: An in vivo confocal study","volume":"49","author":"Villani","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"abg5859","DOI":"10.1126\/sciadv.abg5859","article-title":"Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses","volume":"7","author":"Jairaman","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111307","DOI":"10.1016\/j.celrep.2022.111307","article-title":"A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration","volume":"40","author":"Efraim","year":"2022","journal-title":"Cell Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"aat9892","DOI":"10.1126\/scitranslmed.aat9892","article-title":"PIEZO2 mediates injury-induced tactile pain in mice and humans","volume":"10","author":"Szczot","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1016\/j.cub.2022.06.041","article-title":"Piezo acts as a molecular brake on wound closure to ensure effective inflammation and maintenance of epithelial integrity","volume":"32","author":"Zechini","year":"2022","journal-title":"Curr. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e65415","DOI":"10.7554\/eLife.65415","article-title":"Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing","volume":"10","author":"Holt","year":"2021","journal-title":"Elife"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Oswald, D.J., Lee, A., Trinidad, M., Chi, C., Ren, R., Rich, C.B., and Trinkaus-Randall, V. (2012). Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044574"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17696","DOI":"10.1038\/s41598-017-18089-0","article-title":"Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells","volume":"7","author":"Sugimoto","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.12.002","article-title":"Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: A critical review","volume":"57","author":"Maverakis","year":"2015","journal-title":"J. Autoimmun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"C1061","DOI":"10.1152\/ajpcell.00086.2022","article-title":"Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis","volume":"322","author":"Hurysz","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.actbio.2019.07.055","article-title":"Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage","volume":"97","author":"Inamdar","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Heged\u0171s, \u00c1., Kopper, B., and Berkes, I. (2022). Significantly Delayed Medium-Latency Response of the Stretch Reflex in Delayed-Onset Muscle Soreness of the Quadriceps Femoris Muscles Is Indicative of Sensory Neuronal Microdamage. J. Funct. Morphol. Kinesiol., 7.","DOI":"10.3390\/jfmk7020043"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sonkodi, B. (2022). Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation. Biomolecules, 12.","DOI":"10.3390\/biom12091207"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.actbio.2020.05.005","article-title":"Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis","volume":"111","author":"Chery","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/03008207.2021.2007902","article-title":"The potential role of mechanosensitive ion channels in substrate stiffness-regulated Ca2+ response in chondrocytes","volume":"63","author":"Du","year":"2022","journal-title":"Connect. Tissue Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"942148","DOI":"10.1155\/2014\/942148","article-title":"Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis","volume":"2014","author":"Hanyecz","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/ard.2008.103978","article-title":"Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis","volume":"69","author":"Berlo","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_55","first-page":"1210","article-title":"Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model","volume":"21","author":"Kim","year":"2015","journal-title":"Mol. Vis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1196\/annals.1351.019","article-title":"Epidemiological aspects of rheumatoid arthritis: The sex ratio","volume":"1069","author":"Kvien","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren\u2019s syndrome: A revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"108851","DOI":"10.1016\/j.exer.2021.108851","article-title":"Change patterns in the corneal sub-basal nerve and corneal aberrations in patients with dry eye disease: An artificial intelligence analysis","volume":"215","author":"Jing","year":"2022","journal-title":"Exp. Eye Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the Ocular Surface Disease Index","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ostrovski, I., Lovblom, L.E., Farooqi, M.A., Scarr, D., Boulet, G., Hertz, P., Wu, T., Halpern, E.M., Ngo, M., and Ng, E. (2015). Reproducibility of In Vivo Corneal Confocal Microscopy Using an Automated Analysis Program for Detection of Diabetic Sensorimotor Polyneuropathy. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142309"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7514\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:19:09Z","timestamp":1760123949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,19]]},"references-count":61,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["ijms24087514"],"URL":"https:\/\/doi.org\/10.3390\/ijms24087514","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,19]]}}}