{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:25:34Z","timestamp":1780788334060,"version":"3.54.1"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Poznan University of Medical Sciences","award":["502-14-11121500-41229"],"award-info":[{"award-number":["502-14-11121500-41229"]}]},{"name":"Poznan University of Medical Sciences","award":["2 P05E 098 30"],"award-info":[{"award-number":["2 P05E 098 30"]}]},{"name":"Scientific Research Committee","award":["502-14-11121500-41229"],"award-info":[{"award-number":["502-14-11121500-41229"]}]},{"name":"Scientific Research Committee","award":["2 P05E 098 30"],"award-info":[{"award-number":["2 P05E 098 30"]}]},{"name":"Institute of Human Genetics","award":["502-14-11121500-41229"],"award-info":[{"award-number":["502-14-11121500-41229"]}]},{"name":"Institute of Human Genetics","award":["2 P05E 098 30"],"award-info":[{"award-number":["2 P05E 098 30"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The significance of selenoproteins for the incidence of prematurity and oxidative-damage-related diseases in premature newborns is poorly understood. The latter are at risk for ROP as well as BPD, IVH, PDA, RDS, and NEC, which is particularly high for newborns with extremely low gestational age (ELGA) and extremely low birth weight (ELBW). This study evaluates the hypothesis that variation in the selenoprotein-encoding genes SELENOP, SELENOS, and GPX4 affects the risk of ROP and other comorbidities. The study included infants born \u2264 32 GA, matched for onset and progression of ROP into three groups: no ROP, spontaneously remitting ROP, and ROP requiring treatment. SNPs were determined with predesigned TaqMan SNP genotyping assays. We found the association of the SELENOP rs3877899A allele with ELGA (defined as &lt;28 GA), ROP requiring treatment, and ROP not responsive to treatment. The number of RBC transfusions, ELGA, surfactant treatment, and coexistence of the rs3877899A allele with ELGA were independent predictors of ROP onset and progression, accounting for 43.1% of the risk variation. In conclusion, the SELENOP rs3877899A allele associated with reduced selenium bioavailability may contribute to the risk of ROP and visual impairment in extremely preterm infants.<\/jats:p>","DOI":"10.3390\/ijms24087570","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T04:53:59Z","timestamp":1681966439000},"page":"7570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["SELENOP rs3877899 Variant Affects the Risk of Developing Advanced Stages of Retinopathy of Prematurity (ROP)"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-3126","authenticated-orcid":false,"given":"Ewa","family":"Strauss","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-2750","authenticated-orcid":false,"given":"Danuta","family":"Januszkiewicz-Lewandowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Szpitalna 27\/33, 60-572 Poznan, Poland"},{"name":"Department of Medical Diagnostics, Dobra Street 38a, 60-595 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Sobaniec","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gotz-Wi\u0119ckowska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.12688\/gatesopenres.13098.1","article-title":"Building a global policy agenda to prioritize preterm birth: A qualitative analysis on factors shaping global health policymaking","volume":"4","author":"Kassabian","year":"2020","journal-title":"Gates Open. 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