{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:31:43Z","timestamp":1790775103561,"version":"4.1.0"},"reference-count":179,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, and its incidence has been increasing in recent years because of the high prevalence of obesity and metabolic syndrome in the Western population. Alcohol-related liver disease (ArLD) is the most common cause of cirrhosis and constitutes the leading cause of cirrhosis-related deaths worldwide. Both NAFLD and ArLD constitute well-known causes of liver damage, with some similarities in their pathophysiology. For this reason, they can lead to the progression of liver disease, being responsible for a high proportion of liver-related events and liver-related deaths. Whether ArLD impacts the prognosis and progression of liver damage in patients with NAFLD is still a matter of debate. Nowadays, the synergistic deleterious effect of obesity and diabetes is clearly established in patients with ArLD and heavy alcohol consumption. However, it is still unknown whether low to moderate amounts of alcohol are good or bad for liver health. The measurement and identification of the possible synergistic deleterious effect of alcohol consumption in the assessment of patients with NAFLD is crucial for clinicians, since early intervention, advising abstinence and controlling cardiovascular risk factors would improve the prognosis of patients with both comorbidities. This article seeks to perform a comprehensive review of the pathophysiology of both disorders and measure the impact of alcohol consumption in patients with NAFLD.<\/jats:p>","DOI":"10.3390\/ijms24097791","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T02:06:35Z","timestamp":1682388395000},"page":"7791","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Fatty Liver Disease, Metabolism and Alcohol Interplay: A Comprehensive Review"],"prefix":"10.3390","volume":"24","author":[{"given":"Aitor","family":"Odriozola","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Santos-Laso","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Barrio","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Cabezas","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Iruzubieta","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Arias-Loste","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Rivas","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. 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Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-3973","authenticated-orcid":false,"given":"Emilio","family":"F\u00e1brega","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. Valdecilla 25, 39008 Santander, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-0172","authenticated-orcid":false,"given":"Javier","family":"Crespo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla Universitary Hospital, Av. 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Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41575-022-00688-6","article-title":"Global epidemiology of alcohol-associated cirrhosis and HCC: Trends, projections and risk factors","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases","volume":"59","author":"Rehm","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11901-017-0378-2","article-title":"Natural History of NAFLD\/NASH","volume":"16","author":"Ekstedt","year":"2017","journal-title":"Curr. Hepatol. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jceh.2022.10.002","article-title":"Spectrum, Screening, and Diagnosis of Alcohol-related Liver Disease","volume":"13","author":"Bataller","year":"2023","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMra2207599","article-title":"Alcohol-Associated Hepatitis","volume":"387","author":"Bataller","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Seitz, H.K., and Neuman, M.G. (2021). The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040858"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), and European Association for the Study of Obesity (EASO) (2016). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J. Hepatol., 64, 1388\u20131402.","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes","volume":"64","author":"Younossi","year":"2015","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"ref_13","unstructured":"Iruzubieta, P., Gonz\u00e1lez, M., Cabezas, J., Teresa Arias-Loste, M., and Crespo, J. (2018). Liver Research and Clinical Management, IntechOpen."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1053\/j.gastro.2005.03.084","article-title":"Sampling variability of liver biopsy in nonalcoholic fatty liver disease","volume":"128","author":"Ratziu","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hep.27173","article-title":"Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease","volume":"60","author":"Bedossa","year":"2014","journal-title":"Hepatology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"003","DOI":"10.1055\/s-0032-1306421","article-title":"Nonalcoholic Fatty Liver Disease: Pathologic Patterns and Biopsy Evaluation in Clinical Research Definition and Classification of Fatty Liver Disease","volume":"Volume 32","author":"Kleiner","year":"2012","journal-title":"Seminars in Liver Disease"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2008.01.016","article-title":"Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease","volume":"48","author":"Chalasani","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_20","first-page":"922","article-title":"Studies on the liver in diabetes mellitus. II. The significance of fatty metamorphosis and its correlation with insulin sensitivity","volume":"36","author":"Zimmerman","year":"1950","journal-title":"J. Lab. Clin. Med."},{"key":"ref_21","first-page":"912","article-title":"Studies of the liver in diabetes mellitus. I. Structural and functional abnormalities","volume":"36","author":"Zimmerman","year":"1950","journal-title":"J. Lab. Clin. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1038\/ajg.2010.152","article-title":"Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease","volume":"105","author":"Patton","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jhep.2016.01.025","article-title":"Metabolic interplay between white, beige, brown adipocytes and the liver","volume":"64","author":"Scheja","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2013.02.009","article-title":"Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation","volume":"17","author":"Deng","year":"2013","journal-title":"Cell Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nm1557","article-title":"Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions","volume":"13","author":"Yamauchi","year":"2007","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tips.2009.02.004","article-title":"Adiponectin in health and disease: Evaluation of adiponectin-targeted drug development strategies","volume":"30","author":"Shetty","year":"2009","journal-title":"Trends Pharmcol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1440-1746.2009.06039.x","article-title":"Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis","volume":"24","author":"Asano","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"(1998). Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. Br. J. Surg., 85, 1658\u20131662.","DOI":"10.1046\/j.1365-2168.1998.00938.x"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1210\/jcem.86.3.7305","article-title":"Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women","volume":"86","author":"Vayreda","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI117899","article-title":"The Expression of Tumor Necrosis Factor in Human Adipose Tissue Regulation by Obesity, Weight Loss, and Relationship to Lipoprotein Lipase","volume":"95","author":"Kern","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1126\/science.1160794","article-title":"A stress signaling pathway in adipose tissue regulates hepatic insulin resistance","volume":"322","author":"Sabio","year":"2008","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/gut.2010.214577","article-title":"Anti-inflammatory effects of excessive weight loss: Potent suppression of adipose interleukin 6 and tumour necrosis factor \u03b1 expression","volume":"59","author":"Moschen","year":"2010","journal-title":"Gut"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"13740","DOI":"10.1074\/jbc.M210689200","article-title":"Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes","volume":"278","author":"Senn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.2174\/138161210791208884","article-title":"Leptin: The Prototypic Adipocytokine its Role in, N.A.F.L.D","volume":"16","author":"Procaccini","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nature08991","article-title":"Adiponectin and AdipoR1 regulate PGC-1\u03b1 and mitochondria by Ca2+ and AMPK\/SIRT1","volume":"464","author":"Iwabu","year":"2010","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell Metab"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.1073\/pnas.94.12.6386","article-title":"Induction by leptin of uncoupling protein-2 and enzymes of fatty acid\u2009oxidation","volume":"94","author":"Zhou","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.94.9.4637","article-title":"Direct antidiabetic effect of leptin through triglyceride depletion of\u2009tissues","volume":"94","author":"Shimabukuro","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0168-8278(00)80242-1","article-title":"Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease","volume":"32","author":"Parlesak","year":"2000","journal-title":"J. Hepatol."},{"key":"ref_44","first-page":"453563","article-title":"Contribution of gut bacteria to liver pathobiology","volume":"2010","author":"Hines","year":"2010","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism","volume":"24","author":"Sayin","year":"2016","journal-title":"Cell Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.numecd.2012.02.007","article-title":"Gut-liver axis: The impact of gut microbiota on non-alcoholic fatty liver disease","volume":"22","author":"Compare","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"He, X., Ji, G., Jia, W., and Li, H. (2016). Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030300"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1113\/jphysiol.2011.219691","article-title":"Role of innate immunity and the microbiota in liver fibrosis: Crosstalk between the liver and gut","volume":"590","author":"Seki","year":"2012","journal-title":"J. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jhep.2017.01.005","article-title":"RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis","volume":"66","author":"Filliol","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000450983","article-title":"Bile Acid Uptake Transporters as Targets for Therapy","volume":"35","author":"Slijepcevic","year":"2017","journal-title":"Dig. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/19490976.2015.1127483","article-title":"Consequences of bile salt biotransformations by intestinal bacteria","volume":"7","author":"Ridlon","year":"2016","journal-title":"Gut Microbes."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-019-0704-8","article-title":"Macronutrient metabolism by the human gut microbiome: Major fermentation by-products and their impact on host health","volume":"7","author":"Oliphant","year":"2019","journal-title":"Microbiome"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsec\/fiu002","article-title":"Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease","volume":"91","author":"Michail","year":"2015","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1111\/acer.12900","article-title":"Microbiota Protects Mice against Acute Alcohol-Induced Liver Injury","volume":"39","author":"Chen","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26093","article-title":"Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol, N.A.S.H","volume":"57","author":"Zhu","year":"2013","journal-title":"Hepatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bbagen.2015.12.013","article-title":"Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice","volume":"1860","author":"Mir","year":"2016","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jnutbio.2015.08.012","article-title":"Glutamine supplementation attenuates ethanol-induced disruption of apical junctional complexes in colonic epithelium and ameliorates gut barrier dysfunction and fatty liver in mice","volume":"27","author":"Chaudhry","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Baker, S.S., Baker, R.D., Liu, W., Nowak, N.J., and Zhu, L. (2010). Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009570"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/path.4650","article-title":"Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers","volume":"238","author":"Zhu","year":"2016","journal-title":"J. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2019.08.018","article-title":"Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae","volume":"30","author":"Yuan","year":"2019","journal-title":"Cell Metab."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Iruzubieta, P., Medina, J.M., Fern\u00e1ndez-L\u00f3pez, R., Crespo, J., and de la Cruz, F. (2020). A role for gut microbiome fermentative pathways in fatty liver disease progression. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051369"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/s41591-022-02016-6","article-title":"Microbiome-derived ethanol in nonalcoholic fatty liver disease","volume":"28","author":"Meijnikman","year":"2022","journal-title":"Nat. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MCO.0b013e3283600d46","article-title":"Choline\u2019s role in maintaining liver function: New evidence for epigenetic mechanisms","volume":"16","author":"Mehedint","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/oby.21855","article-title":"Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model","volume":"25","author":"Han","year":"2017","journal-title":"Obesity"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.2337\/db09-0279","article-title":"Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene","volume":"58","author":"Kantartzis","year":"2009","journal-title":"Diabetes"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s00125-009-1285-z","article-title":"A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans","volume":"52","author":"Kotronen","year":"2009","journal-title":"Diabetologia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1194\/jlr.P900013-JLR200","article-title":"A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity","volume":"50","author":"Sookoian","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/hep.23622","article-title":"Homozygosity for the patatin-like phospholipase-3\/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease","volume":"51","author":"Valenti","year":"2010","journal-title":"Hepatology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","author":"Kozlitina","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.27490","article-title":"Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease","volume":"61","author":"Dongiovanni","year":"2015","journal-title":"Hepatology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2017.02.014","article-title":"Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD","volume":"67","author":"Luukkonen","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jhep.2016.07.045","article-title":"The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans","volume":"65","author":"Luukkonen","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent","volume":"150","author":"Mancina","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1038\/s41598-017-04991-0","article-title":"MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals","volume":"7","author":"Donati","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.24806","article-title":"Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents","volume":"55","author":"Santoro","year":"2011","journal-title":"Hepatology"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Petta, S., Miele, L., Bugianesi, E., Camm\u00e0, C., Rosso, C., Boccia, S., Cabibi, D., Di Marco, V., Grimaudo, S., and Grieco, A. (2014). Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087523"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1093\/hmg\/ddp357","article-title":"The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver","volume":"18","author":"Beer","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nri2359","article-title":"The endoplasmic reticulum stress response in immunity and autoimmunity","volume":"8","author":"Todd","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nm.2121","article-title":"A Novel Interaction Between the Regulatory Subunit of PI 3-Kinase and X-box Binding Protein-1 Modulates the Unfolded Protein Response","volume":"16","author":"Winnay","year":"2010","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cmet.2009.04.009","article-title":"The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis","volume":"9","author":"Sha","year":"2009","journal-title":"Cell Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2008.12.004","article-title":"Endoplasmic reticulum stress plays a central role in development of leptin resistance","volume":"9","author":"Ozcan","year":"2009","journal-title":"Cell Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/hep.23205","article-title":"Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression","volume":"50","author":"Bruce","year":"2009","journal-title":"Hepatology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0168-8278(01)00151-9","article-title":"The spectrum of liver disease in the general population: Lesson from the dionysos study","volume":"35","author":"Bellentani","year":"2001","journal-title":"J. Hepatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1465-3362.2009.00153.x","article-title":"Alcohol as a risk factor for liver cirrhosis: A systematic review and meta-analysis","volume":"29","author":"Rehm","year":"2010","journal-title":"Drug Alcohol. Rev."},{"key":"ref_90","unstructured":"Department of Health (2023, January 30). UK Chief Medical Officers\u2019 Low Risk Drinking Guidelines, Available online: https:\/\/www.gov.uk\/."},{"key":"ref_91","unstructured":"Cabezas, J., Lucey, M.R., and Bataller, R. (2023, January 30). Biomarkers for Monitoring Alcohol Use. Available online: https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/10.1002\/cld.571."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"An International Group (1981). Alcoholic liver disease: Morphological manifestations. Review by an international group. Lancet, 317, 707\u2013711.","DOI":"10.1016\/S0140-6736(81)91984-X"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/j.semdp.2006.11.002","article-title":"Alcoholic liver disease","volume":"23","author":"Yip","year":"2006","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2021.05.029","article-title":"Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease","volume":"75","author":"Lackner","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1053\/j.gastro.2014.01.018","article-title":"A Histologic Scoring System for Prognosis of Patients with Alcoholic Hepatitis","volume":"146","author":"Altamirano","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0168-8278(01)00223-9","article-title":"Dynamics of cytochrome P4502E1 activity in man: Induction by ethanol and disappearance during withdrawal phase","volume":"36","author":"Oneta","year":"2002","journal-title":"J. Hepatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1530-0277.1996.tb01947.x","article-title":"Nitric oxide and liver injury in alcohol-fed rats after lipopolysaccharide administration","volume":"20","author":"Chamulitrat","year":"1996","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.24017","article-title":"Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians","volume":"53","author":"Stickel","year":"2011","journal-title":"Hepatology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ajg.2015.137","article-title":"PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease","volume":"110","author":"Salameh","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/jhep.2003.50127","article-title":"Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal","volume":"37","author":"Bataller","year":"2003","journal-title":"Hepatology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/0006-291X(70)90982-4","article-title":"Hepatic microsomal ethanol oxidizing system (MEOS): Differentiation from alcohol dehydrogenase and NADPH oxidase","volume":"40","author":"Lieber","year":"1970","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"Seitz","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/acer.13546","article-title":"Carcinogenic Etheno DNA Adducts in Alcoholic Liver Disease: Correlation with Cytochrome P-4502E1 and Fibrosis","volume":"42","author":"Mueller","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/hep.22978","article-title":"Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease","volume":"50","author":"Wang","year":"2009","journal-title":"Hepatology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.redox.2014.08.009","article-title":"The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts","volume":"3","author":"Linhart","year":"2014","journal-title":"Redox. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.510230121","article-title":"Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol","volume":"23","author":"Albano","year":"1996","journal-title":"Hepatology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1055\/s-0037-1605371","article-title":"Epigenetics in Liver Fibrosis","volume":"37","author":"Massey","year":"2017","journal-title":"Semin. Liver. Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-0034-1397347","article-title":"MicroRNAs in alcoholic liver disease","volume":"35","author":"Szabo","year":"2015","journal-title":"Semin. Liver. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.yexmp.2015.08.001","article-title":"Increased DNA methylation in the livers of patients with alcoholic hepatitis","volume":"99","author":"Shen","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1152\/ajpgi.00575.2007","article-title":"Involvement of mammalian sirtuin 1 in the action of ethanol in the liver","volume":"294","author":"You","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"G178","DOI":"10.1152\/ajpgi.2000.279.1.G178","article-title":"Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver","volume":"279","author":"Lu","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1111\/acer.12483","article-title":"Micro-RNA-155 Deficiency Prevents Alcohol-Induced Serum Endotoxin Increase and Small Bowel Inflammation in Mice","volume":"38","author":"Lippai","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF02532134","article-title":"Effects of ethanol upon lipid metabolism","volume":"9","author":"Lieber","year":"1974","journal-title":"Lipids"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1530-0277.2008.00827.x","article-title":"Molecular mechanisms of alcoholic fatty liver","volume":"33","author":"Purohit","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"You","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1074\/jbc.M008791200","article-title":"The Transcriptional and DNA Binding Activity of Peroxisome Proliferator-activated Receptor \u03b1 Is Inhibited by Ethanol Metabolism","volume":"276","author":"Galli","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrgastro.2017.116","article-title":"Alcohol, adipose tissue and liver disease: Mechanistic links and clinical considerations","volume":"15","author":"Parker","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-1536-3-21","article-title":"Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis","volume":"3","author":"Guo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jhep.2015.06.013","article-title":"Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice","volume":"63","author":"Petrasek","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1189\/jlb.3AB1214-590R","article-title":"Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease","volume":"98","author":"Petrasek","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/liv.13430","article-title":"Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice","volume":"37","author":"Petrasek","year":"2017","journal-title":"Liver Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1189\/jlb.3A0716-310R","article-title":"Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease","volume":"102","author":"Bala","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Csak, T., Bala, S., Lippai, D., Kodys, K., Catalano, D., Iracheta-Vellve, A., and Szabo, G. (2015). MicroRNA-155 deficiency attenuates liver steatosis and fibrosis without reducing inflammation in a mouse model of steatohepatitis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129251"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/hep.29833","article-title":"Expression of microRNA-155 in inflammatory cells modulates liver injury","volume":"68","author":"Blaya","year":"2018","journal-title":"Hepatology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2016.01.035","article-title":"The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis","volume":"64","author":"Bala","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cmet.2018.01.007","article-title":"Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1\u03b1 Transactivation in Steatohepatitis","volume":"27","author":"Ouyang","year":"2018","journal-title":"Cell Metab."},{"key":"ref_129","unstructured":"French, S.W., and Bardag-Gorce, F. (2005). Signaling Pathways in Liver Diseases, Springer."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1136\/gutjnl-2021-324295","article-title":"Clinical, histological and molecular profiling of different stages of alcohol-related liver disease","volume":"71","author":"Argemi","year":"2022","journal-title":"Gut"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1136\/gutjnl-2013-306098","article-title":"CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis","volume":"63","author":"Altamirano","year":"2014","journal-title":"Gut"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1111\/acer.13871","article-title":"TLR7-let-7 Signaling Contributes to Ethanol-Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis","volume":"42","author":"Massey","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"35610","DOI":"10.1038\/srep35610","article-title":"LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis","volume":"6","author":"Odena","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"35610","DOI":"10.1038\/s41467-019-11004-3","article-title":"Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis","volume":"10","author":"Argemi","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jhep.2018.03.031","article-title":"Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis","volume":"69","author":"Brandl","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fphys.2020.00370","article-title":"Functional Microbial Responses to Alcohol Abstinence in Patients with Alcohol Use Disorder","volume":"11","author":"Gao","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/hep4.1947","article-title":"Intestinal virome in patients with alcohol use disorder and after abstinence","volume":"6","author":"Hsu","year":"2022","journal-title":"Hepatol. Commun."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jhep.2019.09.029","article-title":"The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease","volume":"72","author":"Chu","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jhep.2018.10.019","article-title":"Microbiome as a therapeutic target in alcohol-related liver disease","volume":"70","author":"Sarin","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Malnick, S.D.H., Alin, P., Somin, M., and Neuman, M.G. (2022). Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different. Int. J. Mol. Sci., 23, Available online: https:\/\/www.mdpi.com\/1422-0067\/23\/24\/16226\/htm.","DOI":"10.3390\/ijms232416226"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI24930","article-title":"Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease","volume":"115","author":"Tamura","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1172\/JCI116546","article-title":"Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium","volume":"92","author":"Spivey","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI4765","article-title":"Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas","volume":"103","author":"Faubion","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"G929","DOI":"10.1152\/ajpgi.00315.2013","article-title":"Colonic inflammation and secondary bile acids in alcoholic cirrhosis","volume":"306","author":"Kakiyama","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1007\/s10620-015-3776-8","article-title":"Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis","volume":"60","author":"Ferslew","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"16544","DOI":"10.1073\/pnas.1308331110","article-title":"STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease","volume":"110","author":"Petrasek","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"26794","DOI":"10.1074\/jbc.M116.736991","article-title":"Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes","volume":"291","author":"Petrasek","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/acer.13078","article-title":"A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury","volume":"40","author":"Wang","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1210\/jc.2006-0075","article-title":"Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: A preliminary study","volume":"91","author":"Chalasani","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1590\/S0004-27302010000400004","article-title":"Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus","volume":"54","author":"Ferreira","year":"2010","journal-title":"Arq. Bras. Endocrinol. Metab."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/0003-4819-132-2-200001180-00004","article-title":"Prevalence of and risk factors for hepatic steatosis in northern Italy","volume":"132","author":"Bellentani","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/hep.25887","article-title":"Pioglitazone and vitamin E for nonalcoholic steatohepatitis: A cost utility analysis","volume":"56","author":"Mahady","year":"2012","journal-title":"Hepatology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/hep.23789","article-title":"Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: A narrative review and clinical perspective of prospective data","volume":"52","author":"Ghouri","year":"2010","journal-title":"Hepatology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.510250120","article-title":"Excess weight risk factor for alcoholic liver disease","volume":"25","author":"Naveau","year":"1997","journal-title":"Hepatology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S1542-3565(05)00743-3","article-title":"Joint Effects of Body Weight and Alcohol on Elevated Serum Alanine Aminotransferase in the United States Population","volume":"3","author":"Ruhl","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/00365520802555991","article-title":"Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease","volume":"44","author":"Ekstedt","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.23527","article-title":"The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis","volume":"51","author":"Ascha","year":"2010","journal-title":"Hepatology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cgh.2015.11.019","article-title":"Effects of Alcohol Consumption on Hepatocarcinogenesis in Japanese Patients With Fatty Liver Disease","volume":"14","author":"Kawamura","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.3748\/wjg.v24.i13.1440","article-title":"Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis Retrospective Study","volume":"24","author":"Kimura","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_160","first-page":"147","article-title":"Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)","volume":"4","author":"Seitz","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jhep.2017.11.006","article-title":"The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease","volume":"68","author":"Boyle","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e0003","DOI":"10.1097\/HC9.0000000000000003","article-title":"Moderate alcohol consumption is associated with significant fibrosis progression in NAFLD","volume":"7","author":"Blomdahl","year":"2023","journal-title":"Hepatol. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1053\/jhep.2002.31782","article-title":"Risk factors of fibrosis in alcohol-induced liver disease","volume":"35","author":"Raynard","year":"2002","journal-title":"Hepatology"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/liv.13408","article-title":"Binge drinking and the risk of liver events: A population-based cohort study","volume":"37","author":"Puukka","year":"2017","journal-title":"Liver Int."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1192\/bjp.bp.110.091199","article-title":"Clinical recognition and recording of alcohol disorders by clinicians in primary and secondary care: Meta-analysis","volume":"201","author":"Mitchell","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/jama.2019.0007","article-title":"Interventions to Prevent Perinatal Depression: US Preventive Services Task Force Recommendation Statement","volume":"321","author":"Curry","year":"2019","journal-title":"JAMA"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1365-2036.2009.04141.x","article-title":"Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: The Rancho Bernardo Study","volume":"30","author":"Loomba","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/ajcn\/88.4.1097","article-title":"Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index","volume":"88","author":"Alatalo","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/MEG.0b013e328328f3ec","article-title":"Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients","volume":"21","author":"Cotrim","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jhep.2012.03.024","article-title":"Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"57","author":"Dunn","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/ajg.2009.361","article-title":"Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population","volume":"104","author":"Gunji","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1440-1746.2009.05998.x","article-title":"Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup","volume":"25","author":"Yamada","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2036.2010.04520.x","article-title":"Alcohol consumption appears to protect against non-alcoholic fatty liver disease","volume":"33","author":"Moriya","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/oby.2002.33","article-title":"Alcohol consumption in the severely obese: Relationship with the metabolic syndrome","volume":"10","author":"Dixon","year":"2002","journal-title":"Obes. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00535-010-0336-z","article-title":"Alcohol drinking patterns and the risk of fatty liver in Japanese men","volume":"46","author":"Hiramine","year":"2011","journal-title":"J. Gastroenterol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3748\/wjg.v18.i2.156","article-title":"Protective effect of alcohol consumption for fatty liver but not metabolic syndrome","volume":"18","author":"Hamaguchi","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/gutjnl-2011-300342","article-title":"Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: A population study using proton-magnetic resonance spectroscopy and transient elastography","volume":"61","author":"Wong","year":"2012","journal-title":"Gut"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/liv.12230","article-title":"Effect of lifetime alcohol consumption on the histological severity of non-alcoholic fatty liver disease","volume":"34","author":"Kwon","year":"2014","journal-title":"Liver Int."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jhep.2022.04.040","article-title":"Ethyl glucuronide in hair detects a high rate of harmful alcohol consumption in presumed non-alcoholic fatty liver disease","volume":"77","author":"Staufer","year":"2022","journal-title":"J. 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