{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:02:00Z","timestamp":1784919720021,"version":"3.55.0"},"reference-count":45,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Program of Henan Joint International Research Laboratory of Stem Cell Medicine","award":["31972901"],"award-info":[{"award-number":["31972901"]}]},{"name":"Open Program of Henan Joint International Research Laboratory of Stem Cell Medicine","award":["31571430"],"award-info":[{"award-number":["31571430"]}]},{"name":"Open Program of Henan Joint International Research Laboratory of Stem Cell Medicine","award":["31671234"],"award-info":[{"award-number":["31671234"]}]},{"name":"National Nature Science Foundation of China","award":["31972901"],"award-info":[{"award-number":["31972901"]}]},{"name":"National Nature Science Foundation of China","award":["31571430"],"award-info":[{"award-number":["31571430"]}]},{"name":"National Nature Science Foundation of China","award":["31671234"],"award-info":[{"award-number":["31671234"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Peritoneal inflammation remains a major cause of treatment failure in patients with kidney failure who receive peritoneal dialysis. Peritoneal inflammation is characterized by an increase in neutrophil infiltration. However, the molecular mechanisms that control neutrophil recruitment in peritonitis are not fully understood. ELMO and DOCK proteins form complexes which function as guanine nucleotide exchange factors to activate the small GTPase Rac to regulate F-actin dynamics during chemotaxis. In the current study, we found that deletion of the Elmo1 gene causes defects in chemotaxis and the adhesion of neutrophils. ELMO1 plays a role in the fMLP-induced activation of Rac1 in parallel with the PI3K and mTORC2 signaling pathways. Importantly, we also reveal that peritoneal inflammation is alleviated in Elmo1 knockout mice in the mouse model of thioglycollate-induced peritonitis. Our results suggest that ELMO1 functions as an evolutionarily conserved regulator for the activation of Rac to control the chemotaxis of neutrophils both in vitro and in vivo. Our results suggest that the targeted inhibition of ELMO1 may pave the way for the design of novel anti-inflammatory therapies for peritonitis.<\/jats:p>","DOI":"10.3390\/ijms24098103","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T13:54:46Z","timestamp":1682949286000},"page":"8103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis"],"prefix":"10.3390","volume":"24","author":[{"given":"Shuxiang","family":"Yu","sequence":"first","affiliation":[{"name":"School of Medicine, Shanghai University, Shanghai 200444, China"},{"name":"School of Life Sciences, Shanghai University, Shanghai 200444, China"},{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8496-4940","authenticated-orcid":false,"given":"Xiaoke","family":"Geng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojie","family":"Li","sequence":"additional","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Medicine, Shanghai University, Shanghai 200444, China"},{"name":"School of Life Sciences, Shanghai University, Shanghai 200444, China"},{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCULATIONAHA.118.035400","article-title":"Role of Allergic Inflammatory Cells in Coronary Artery Disease","volume":"138","author":"Niccoli","year":"2018","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci. 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