{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:03:23Z","timestamp":1776301403288,"version":"3.50.1"},"reference-count":127,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8N0171"],"award-info":[{"award-number":["CMRPG8N0171"]}]},{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CORPG8N0091"],"award-info":[{"award-number":["CORPG8N0091"]}]},{"name":"Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CORPG8N0121"],"award-info":[{"award-number":["CORPG8N0121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin\u2019s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring\u2019s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.<\/jats:p>","DOI":"10.3390\/ijms24098105","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T13:54:46Z","timestamp":1682949286000},"page":"8105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Melatonin and Kidney Health: From Fetal Stage to Later Life"],"prefix":"10.3390","volume":"24","author":[{"given":"Kuo-Shu","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yi","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"Department of Pediatrics, Kaohsiung Municipal Feng Shan Hospital\u2014Under the Management of Chang Gung Medical Foundation, Kaohsiung 830, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-528X","authenticated-orcid":false,"given":"Chien-Ning","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-6407","authenticated-orcid":false,"given":"You-Lin","family":"Tain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/BF01953050","article-title":"Melatonin and circadian control in mammals","volume":"45","author":"Armstrong","year":"1989","journal-title":"Experientia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: Under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e12525","DOI":"10.1111\/jpi.12525","article-title":"Melatonin and inflammation\u2014Story of a double-edged blade","volume":"65","author":"Hardeland","year":"2018","journal-title":"J. Pineal Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biopha.2006.01.002","article-title":"Melatonin receptors in humans: Biological role and clinical relevance","volume":"60","author":"Ekmekcioglu","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-019-03617-5","article-title":"Melatonin and its ubiquitous anticancer effects","volume":"462","author":"Bhattacharya","year":"2019","journal-title":"Mol. Cell Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.reprotox.2008.03.005","article-title":"Melatonin and pregnancy in the human","volume":"25","author":"Tamura","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"ref_7","first-page":"488","article-title":"Role of melatonin in embryo fetal development","volume":"7","author":"Voiculescu","year":"2014","journal-title":"J. Med. Life"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Minich, D.M., Henning, M., Darley, C., Fahoum, M., Schuler, C.B., and Frame, J. (2022). Is Melatonin the \u201cNext Vitamin D\u201d?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients, 14.","DOI":"10.3390\/nu14193934"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.2174\/0929867329666220105115755","article-title":"New Uses of Melatonin as a Drug; A Review","volume":"29","author":"Pohanka","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/bcpt.12411","article-title":"Paediatric Off-Label Use of Melatonin--A Register Linkage Study between the Norwegian Prescription Database and Patient Register","volume":"117","author":"Hartz","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-079X.2010.00814.x","article-title":"Update on the use of melatonin in pediatrics","volume":"50","author":"Gitto","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"414D","DOI":"10.2471\/BLT.17.206441","article-title":"The global burden of kidney disease and the sustainable development goals","volume":"96","author":"Luyckx","year":"2018","journal-title":"Bull. World Health Organ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S2040174414000580","article-title":"Evolution of DOHaD: The impact of environmental health sciences","volume":"6","author":"Haugen","year":"2014","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.semcdb.2018.05.024","article-title":"Evolution, kidney development, and chronic kidney disease","volume":"91","author":"Chevalier","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(13)60311-6","article-title":"Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease","volume":"382","author":"Luyckx","year":"2013","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/apha.12702","article-title":"Pregnancy as a critical window for blood pressure regulation in mother and child: Programming and reprogramming","volume":"219","author":"Paauw","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., and Tain, Y.L. (2021). The First Thousand Days: Kidney Health and Beyond. Healthcare, 9.","DOI":"10.3390\/healthcare9101332"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1021\/ja01543a060","article-title":"Isolation of melatonin, the pineal gland factor that lightens melanocytes","volume":"80","author":"Lerner","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/jpi.12364","article-title":"Melatonin biosynthesis in plants: Multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts","volume":"61","author":"Back","year":"2016","journal-title":"J. Pineal Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1007\/s00018-017-2617-7","article-title":"Melatonin, mitochondria, and the skin","volume":"74","author":"Slominski","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12639","DOI":"10.1111\/jpi.12639","article-title":"Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies","volume":"68","author":"Sato","year":"2020","journal-title":"J. Pineal Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e201700282","DOI":"10.1002\/jbio.201700282","article-title":"Aging of lymphoid organs: Can photobiomodulation reverse age-associated thymic involution via stimulation of extrapineal melatonin synthesis and bone marrow stem cells?","volume":"11","author":"Odinokov","year":"2018","journal-title":"J. Biophotonics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.00147.2022","article-title":"Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides","volume":"323","author":"Slominski","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.biocel.2005.08.020","article-title":"Melatonin","volume":"38","author":"Hardeland","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-079X.2009.00701.x","article-title":"Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines","volume":"47","author":"Hardeland","year":"2009","journal-title":"J. Pineal Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mce.2012.01.004","article-title":"Melatonin membrane receptors in peripheral tissues: Distribution and functions","volume":"351","author":"Slominski","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"E230","DOI":"10.1152\/ajpendo.00094.2013","article-title":"Melatonin acts through MT1\/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats","volume":"305","author":"Faria","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-079X.2006.00334.x","article-title":"Melatonin stimulates glucose transport via insulin receptor substrate-1\/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells","volume":"41","author":"Ha","year":"2006","journal-title":"J. Pineal Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/bies.201400017","article-title":"Understanding melatonin receptor pharmacology: Latest insights from mouse models, and their relevance to human disease","volume":"36","author":"Tosini","year":"2014","journal-title":"Bioessays"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ma, H., Kang, J., Fan, W., He, H., and Huang, F. (2021). ROR: Nuclear Receptor for Melatonin or Not?. Molecules, 26.","DOI":"10.3390\/molecules26092693"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1096\/fj.13-242040","article-title":"ROR\u03b1 and ROR \u03b3 are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D","volume":"28","author":"Slominski","year":"2014","journal-title":"FASEB J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1152\/physrev.00045.2021","article-title":"Circadian clocks of the kidney: Function, mechanism, and regulation","volume":"102","author":"Costello","year":"2022","journal-title":"Physiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-079X.1992.tb00054.x","article-title":"Effects of melatonin (in water metabolism and renal function in male Syrian hamsters (Mesocricetus auratus)","volume":"13","author":"Richardson","year":"1992","journal-title":"J. Pineal Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e148277","DOI":"10.1172\/JCI148277","article-title":"Circadian rhythms and renal pathophysiology","volume":"132","author":"Mohandas","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"623038","DOI":"10.3389\/fendo.2020.623038","article-title":"Maternal Serum Melatonin Increases During Pregnancy and Falls Immediately After Delivery Implicating the Placenta as a Major Source of Melatonin","volume":"11","author":"Ejaz","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.1998.tb00550.x","article-title":"Maternal-fetal transfer of melatonin in pregnant women near term","volume":"25","author":"Okatani","year":"1998","journal-title":"J. Pineal Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmt054","article-title":"Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology","volume":"20","author":"Reiter","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-079X.2008.00555.x","article-title":"Human placental trophoblasts synthesize melatonin and express its receptors","volume":"45","author":"Lanoix","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1600-079X.2012.01012.x","article-title":"Placental melatonin production and melatonin receptor expression are altered in preeclampsia: New insights into the role of this hormone in pregnancy","volume":"53","author":"Lanoix","year":"2012","journal-title":"J. Pineal Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000125008","article-title":"The Melatonin Receptors in Rat Ontogenesis","volume":"48","year":"1988","journal-title":"Neuroendocrinology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/cne.21152","article-title":"Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone","volume":"499","author":"Wu","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/07420528.2014.986576","article-title":"Embryonic development and maternal regulation of murine circadian clock function","volume":"32","author":"Landgraf","year":"2015","journal-title":"Chronobiol. Int."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mendez, N., Abarzua-Catalan, L., Vilches, N., Galdames, H.A., Spichiger, C., Richter, H.G., Valenzuela, G.J., Seron-Ferre, M., and Torres-Farfan, C. (2012). Timed maternal melatonin treatment reverses circadian disruption of the fetal adrenal clock imposed by exposure to constant light. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042713"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1242\/dev.01089","article-title":"Branching morphogenesis and kidney disease","volume":"131","author":"Shah","year":"2004","journal-title":"Development"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00467-011-1843-8","article-title":"Human nephron number: Implications for health and disease","volume":"26","author":"Bertram","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2215\/CJN.12581019","article-title":"A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT)","volume":"15","author":"Murugapoopathy","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"107661","DOI":"10.1016\/j.celrep.2020.107661","article-title":"Circadian Clock Regulation of Developmental Time in the Kidney","volume":"31","author":"Dan","year":"2020","journal-title":"Cell Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.3390\/ijms16034744","article-title":"Transcriptome analysis in rat kidneys: Importance of genes involved in programmed hypertension","volume":"16","author":"Tain","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2741\/4125","article-title":"Experimental models of melatonin-deficient hypertension","volume":"18","author":"Simko","year":"2013","journal-title":"Front. Biosci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., and Tain, Y.L. (2020). Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062232"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fendo.2019.00362","article-title":"Fetal programming of renal dysfunction and high blood pressure by chronodisruption","volume":"10","author":"Mendez","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cbf.897","article-title":"Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure","volume":"19","author":"Canatan","year":"2001","journal-title":"Cell Biochem. Funct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"18484","DOI":"10.3390\/ijms151018484","article-title":"Transcriptional regulation of programmed hypertension by melatonin: An epigenetic perspective","volume":"15","author":"Tain","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-079X.2007.00509.x","article-title":"Epigenetic regulation: A new research area for melatonin?","volume":"44","author":"Korkmaz","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., and Hsu, C.N. (2022). Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin. Antioxidants, 11.","DOI":"10.3390\/antiox11050924"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41574-018-0130-1","article-title":"Melatonin in type 2 diabetes mellitus and obesity","volume":"15","author":"Karamitri","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"791036","DOI":"10.3389\/fphys.2021.791036","article-title":"Protective Effect of Melatonin for Renal Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis","volume":"12","author":"Dun","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1159\/000525441","article-title":"The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?","volume":"53","author":"Theofilis","year":"2022","journal-title":"Am. J. Nephrol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/iub.2384","article-title":"Melatonin as a potential inhibitor of kidney cancer: A survey of the molecular processes","volume":"72","author":"Reiter","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_60","first-page":"1","article-title":"Trends in the use of complementary health approaches among adults: United States, 2002\u20132012","volume":"79","author":"Clarke","year":"2015","journal-title":"Natl. Health Stat. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40261-015-0368-5","article-title":"The Safety of Melatonin in Humans","volume":"36","author":"Andersen","year":"2016","journal-title":"Clin. Drug Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"104337","DOI":"10.1016\/j.phrs.2019.104337","article-title":"The usefulness of melatonin in the field of obstetrics and gynecology","volume":"147","author":"Genario","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1039977","DOI":"10.3389\/fnins.2022.1039977","article-title":"Maternal melatonin treatment rescues endocrine, inflammatory, and transcriptional deregulation in the adult rat female offspring from gestational chronodisruption","volume":"16","author":"Mendez","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s13105-010-0070-2","article-title":"Effects of antenatal, postpartum and post-weaning melatonin supplementation on blood pressure and renal antioxidant enzyme activities in spontaneously hypertensive rats","volume":"67","author":"Lee","year":"2011","journal-title":"J. Physiol. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/biolre\/iox115","article-title":"Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light","volume":"97","author":"Tain","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"283180","DOI":"10.1155\/2014\/283180","article-title":"Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction","volume":"2014","author":"Tain","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ajog.2016.07.036","article-title":"Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring","volume":"215","author":"Tain","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., Chan, J.Y.H., Lee, C.T., and Hsu, C.N. (2018). Maternal Melatonin Therapy Attenuates Methyl-Donor Diet-Induced Programmed Hypertension in Male Adult Rat Offspring. Nutrients, 10.","DOI":"10.3390\/nu10101407"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/jpi.12145","article-title":"Melatonin prevents maternal fructose intake-induced programmed hypertension in the offspring: Roles of nitric oxide and arachidonic acid metabolites","volume":"57","author":"Tain","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., Leu, S., Lee, W.C., Wu, K.L.H., and Chan, J.Y.H. (2018). Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring. Molecules, 23.","DOI":"10.3390\/molecules23040886"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jash.2014.01.009","article-title":"Melatonin attenuates prenatal dexamethasone-induced blood pressure increase in a rat model","volume":"8","author":"Tain","year":"2014","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fphys.2015.00377","article-title":"Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring","volume":"6","author":"Tain","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1538\/expanim.51.69","article-title":"Effects of maternal-melatonin treatment on open-field behaviors and hypertensive phenotype in spontaneously hypertensive rats\u2019 (SHR) offspring","volume":"51","author":"Kim","year":"2002","journal-title":"Exp. Anim."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2016.02.017","article-title":"Postnatal dexamethasone-induced programmed hypertension is related to the regulation of melatonin and its receptors","volume":"108","author":"Chang","year":"2016","journal-title":"Steroids"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jsbmb.2014.07.008","article-title":"Melatonin prevents neonatal dexamethasone induced programmed hypertension: Histone deacetylase inhibition","volume":"144","author":"Wu","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., Yang, H.W., Hou, C.Y., Chang-Chien, G.P., Lin, S., and Tain, Y.L. (2021). Melatonin Prevents Chronic Kidney Disease-Induced Hypertension in Young Rat Treated with Adenine: Implications of Gut Microbiota-Derived Metabolites. Antioxidants, 10.","DOI":"10.3390\/antiox10081211"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pedneo.2013.09.005","article-title":"Renoprotective effects of melatonin in young spontaneously hypertensive rats with L-NAME","volume":"55","author":"Cheng","year":"2014","journal-title":"Pediatr. Neonatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1600-079X.2010.00806.x","article-title":"Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats","volume":"49","author":"Tain","year":"2010","journal-title":"J. Pineal Res."},{"key":"ref_79","first-page":"2211","article-title":"Physiology and endocrinology symposium: Alterations in uteroplacental hemodynamics during melatonin supplementation in sheep and cattle","volume":"95","author":"Lemley","year":"2017","journal-title":"J. Anim. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12958-017-0297-7","article-title":"Effects of melatonin administration on embryo implantation and offspring growth in mice under different schedules of photoperiodic exposure","volume":"15","author":"Zhang","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_81","first-page":"624","article-title":"The Laboratory Rat: Relating Its Age with Human\u2019s","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MNH.0b013e32834d54ca","article-title":"Nitric oxide synthase derangements and hypertension in kidney disease","volume":"21","author":"Baylis","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41581-021-00429-z","article-title":"Nitric oxide signalling in kidney regulation and cardiometabolic health","volume":"17","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.freeradbiomed.2010.06.029","article-title":"Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine","volume":"49","author":"Tain","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., and Hsu, C.N. (2022). Perinatal Oxidative Stress and Kidney Health: Bridging the Gap between Animal Models and Clinical Reality. Antioxidants, 12.","DOI":"10.3390\/antiox12010013"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.freeradbiomed.2010.07.011","article-title":"Oxidative stress in development: Nature or nurture?","volume":"49","author":"Dennery","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41581-022-00648-y","article-title":"Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases","volume":"19","author":"Huynh","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s40620-022-01365-2","article-title":"Nutrient sensing, signaling transduction, and autophagy in podocyte injury: Implications for kidney disease","volume":"36","author":"Zha","year":"2023","journal-title":"J. Nephrol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/GRF.0b013e3182993a2e","article-title":"Role of placental nutrient sensing in developmental programming","volume":"56","author":"Jansson","year":"2013","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: Relation to autophagy and apoptosis","volume":"59","author":"Reiter","year":"2015","journal-title":"J. Pineal Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"113190","DOI":"10.1016\/j.fct.2022.113190","article-title":"Agomelatine, a structural analog of melatonin, improves kidney dysfunction through regulating the AMPK\/mTOR signaling pathway to promote autophagy in obese rats","volume":"165","author":"Promsan","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"5343462","DOI":"10.1155\/2018\/5343462","article-title":"Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced Programmed Hypertension in Male Rat Offspring","volume":"2018","author":"Lin","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/cbin.11899","article-title":"Melatonin prevents diabetes-induced nephropathy by modulating the AMPK\/SIRT1 axis: Focus on autophagy and mitochondrial dysfunction","volume":"46","author":"Siddhi","year":"2022","journal-title":"Cell Biol. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41440-018-0186-2","article-title":"The pivotal role of melatonin in ameliorating chronic kidney disease by suppression of the renin-angiotensin system in the kidney","volume":"42","author":"Ohashi","year":"2019","journal-title":"Hypertens. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00467-020-04496-5","article-title":"Renin-angiotensin system in mammalian kidney development","volume":"36","author":"Yosypiv","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., and Tain, Y.L. (2021). Targeting the renin\u2013angiotensin\u2013aldosterone system to prevent hypertension and kidney disease of developmental origins. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052298"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"R791","DOI":"10.1152\/ajpregu.00791.2010","article-title":"Renal programming: Cause for concern?","volume":"300","author":"Kett","year":"2011","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1023\/A:1020107915919","article-title":"Gastrointestinal melatonin: Localization, function, and clinical relevance","volume":"47","author":"Bubenik","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., and Tain, Y.L. (2020). Developmental programming and reprogramming of hypertension and kidney disease: Impact of tryptophan metabolism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228705"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/19490976.2016.1241357","article-title":"Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function","volume":"7","author":"Chu","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41581-018-0018-2","article-title":"The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease","volume":"14","author":"Yang","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000450619","article-title":"Uremic toxin-producing gut microbiota in rats with chronic kidney disease","volume":"135","author":"Kikuchi","year":"2017","journal-title":"Nephron"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11906-017-0722-5","article-title":"Microbial short-chain fatty acids and blood pressure regulation","volume":"19","author":"Pluznick","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fped.2017.00138","article-title":"The microbiome and blood pressure: Can microbes regulate our blood pressure?","volume":"5","author":"Reichert","year":"2017","journal-title":"Front. Pediatr."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Velasquez, M.T., Ramezani, A., Manal, A., and Raj, D.S. (2016). Trimethylamine N-Oxide: The good, the bad and the unknown. Toxins, 8.","DOI":"10.3390\/toxins8110326"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5689165","DOI":"10.1155\/2018\/5689165","article-title":"Perinatal Programming of Circadian Clock-Stress Crosstalk","volume":"2018","author":"Astiz","year":"2018","journal-title":"Neural. Plast."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/neuro.08.019.2009","article-title":"Prenatal stress, glucocorticoids and the programming of adult disease","volume":"3","author":"Cottrell","year":"2009","journal-title":"Front. Behav. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/fcp.12498","article-title":"Melatonin as a potential modulator of Nrf2","volume":"34","author":"Ahmadi","year":"2020","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s41598-017-01305-2","article-title":"Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways","volume":"7","author":"Janjetovic","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Stefan, J., Kim, T.K., Schedel, F., Janjetovic, Z., Crossman, D.K., Steinbrink, K., Slominski, R.M., Zmijewski, J., Tulic, M.K., and Reiter, R.J. (2021). Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses. Antioxidants, 10.","DOI":"10.3390\/antiox10040618"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e21803","DOI":"10.1096\/fj.202002556RRR","article-title":"Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease","volume":"35","author":"Joshi","year":"2021","journal-title":"FASEB J."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Kim, E.H., Ridlo, M.R., Lee, B.C., and Kim, G.A. (2020). Melatonin-Nrf2 Signaling Activates Peroxisomal Activities in Porcine Cumulus Cell-Oocyte Complexes. Antioxidant, 9.","DOI":"10.3390\/antiox9111080"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., Lin, Y.J., Yu, H.R., Lin, I.C., Sheen, J.M., Huang, L.T., and Tain, Y.L. (2019). Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163957"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: One of evolution\u2019s best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"9300","DOI":"10.1021\/bi050202d","article-title":"A novel metabolic pathway of melatonin: Oxidation by cytochrome c","volume":"44","author":"Semak","year":"2005","journal-title":"Biochemistry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/164_2016_6","article-title":"The Emerging Role of Mitochondrial Targeting in Kidney Disease","volume":"240","author":"Eirin","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1590\/1516-4446-2021-2156","article-title":"Melatonin use during pregnancy and lactation: A scoping review of human studies","volume":"44","author":"Vine","year":"2022","journal-title":"Braz. J. Psychiatry."},{"key":"ref_118","first-page":"138","article-title":"Melatonin antiplatelets effect through breastfeeding: A sobering case","volume":"25","author":"Luciani","year":"2019","journal-title":"Haemophilia"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"106","DOI":"10.32794\/mr11250025","article-title":"Are melatonin doses employed clinically adequate for melatonin-induced cytoprotection?","volume":"2","author":"Cardinali","year":"2019","journal-title":"Melatonin Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0024-3205(00)00955-3","article-title":"Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2","volume":"68","author":"Ossenia","year":"2000","journal-title":"Life Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0035-1565083","article-title":"Pharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review","volume":"66","author":"Zetner","year":"2015","journal-title":"Drug Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2006.06.020","article-title":"Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders","volume":"31","author":"Smits","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e12572","DOI":"10.1111\/jpi.12572","article-title":"A critical review of melatonin assays: Past and present","volume":"67","author":"Kennaway","year":"2019","journal-title":"J. Pineal Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/0748730415616678","article-title":"Prospective study on salivary evening melatonin and sleep before and after pinealectomy in humans","volume":"31","author":"Slawik","year":"2016","journal-title":"J. Biol. Rhythm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/1570159X14666161228122115","article-title":"Melatonin: Pharmacology, Functions and Therapeutic Benefits","volume":"15","author":"Tordjman","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R.Y., Xu, D.P., and Li, H.B. (2017). Dietary Sources and Bioactivities of Melatonin. Nutrients, 9.","DOI":"10.3390\/nu9040367"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Torres, A., Caverni-Mu\u00f1oz, A., and Gonz\u00e1lez Garc\u00eda, E. (2022). Mediterranean Diet and Chronic Kidney Disease (CKD): A Practical Approach. Nutrients, 15.","DOI":"10.3390\/nu15010097"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/9\/8105\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:27:19Z","timestamp":1760124439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/9\/8105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":127,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["ijms24098105"],"URL":"https:\/\/doi.org\/10.3390\/ijms24098105","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]}}}