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However, the application of sanguinarine has been limited due to its toxic side effects and a lack of clarity regarding its molecular mechanisms. To reduce the toxic side effects of sanguinarine, its cyanide derivative (1a) was first designed and synthesized in our previous research. In this study, we confirmed that 1a presents lower toxicity than sanguinarine but shows comparable anti-leukemia activity. Further biological studies using RNA-seq, lentiviral transfection, Western blotting, and flow cytometry analysis first revealed that both compounds 1 and 1a inhibited the proliferation and induced the apoptosis of leukemic cells by regulating the transcription of c-MET and then suppressing downstream pathways, including the MAPK, PI3K\/AKT and JAK\/STAT pathways. 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Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.2174\/1381612824666180829100601","article-title":"The Anticancer Effect of Sanguinarine: A Review","volume":"24","author":"Fu","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1111\/1751-7915.14017","article-title":"Sanguinarine synergistically potentiates aminoglycoside-mediated bacterial killing","volume":"15","author":"Lu","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e202200266","DOI":"10.1002\/cbdv.202200266","article-title":"A Computational Insight on the Inhibitory Potential of 8-Hydroxydihydr of Sanguinarine (8-HDS), a Pyridone Containing Analog of Sanguinarine, Against SARS CoV2","volume":"19","author":"Jena","year":"2022","journal-title":"Chem Biodivers."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejphar.2012.05.039","article-title":"The Anti-inflammatory Effects of Sanguinarine and Its Modulation of in Flammatory Mediators from Peritoneal Macrophages","volume":"689","author":"Niu","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"112142","DOI":"10.1016\/j.biopha.2021.112142","article-title":"Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids","volume":"143","author":"Khan","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109228","DOI":"10.1016\/j.cbpc.2021.109228","article-title":"Cardiotoxicity of sanguinarine via regulating apoptosis and MAPK pathways in zebrafish and HL1 cardiomyocytes","volume":"252","author":"Wang","year":"2021","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fmolb.2018.00021","article-title":"Toxicological Effects of Berberine and Sanguinarine","volume":"5","author":"Singh","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tang, Y., Xu, X., Li, J., Deng, L., and Mu, S. (2022). Synthesis and Antileukemia Activity Evaluation of Benzophenanthridine Alkaloid Derivatives. Molecules, 27.","DOI":"10.3390\/molecules27123934"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Laines-Hidalgo, J.I., Mu\u00f1oz-S\u00e1nchez, J.A., Loza-M\u00fcller, L., and V\u00e1zquez-Flota, F. (2022). An Update of the Sanguinarine and Benzophenanthridine Alkaloids\u2019 Biosynthesis and Their Applications. Molecules, 27.","DOI":"10.3390\/molecules27041378"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.2147\/DDDT.S276424","article-title":"Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model","volume":"14","author":"Yu","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biopha.2018.03.071","article-title":"Sanguinarine Inhibits Epithelial Ovarian Cancer Development via Regulating Long Non-coding RNA CASC2-EIF4A3 Axis and\/or Inhibiting NF-\u03baB Signaling or PI3K\/AKT\/mTOR Pathway","volume":"102","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fonc.2019.00285","article-title":"Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JAK2\/STAT3 Signaling","volume":"9","author":"Akhtar","year":"2019","journal-title":"Front Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.canlet.2019.05.042","article-title":"p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma","volume":"459","author":"Zhang","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"808855","DOI":"10.3389\/fphar.2022.808855","article-title":"HGF\/c-Met: A Key Promoter in Liver Regeneration","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Stefani, C., Miricescu, D., Stanescu, I., Nica, R.I., Greabu, M., Totan, A.R., and Jinga, M. (2021). (Growth Factors, PI3K\/AKT\/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are we Now?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910260"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102418","DOI":"10.1016\/j.ctrv.2022.102418","article-title":"Resistance Mechanisms to HER2-targeted Therapy in Aastroesophageal Adenocarcinoma: A Systematic Review","volume":"108","author":"Stroes","year":"2022","journal-title":"Cancer Treat. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-24367-3","article-title":"Structural basis of the activation of c-MET receptor","volume":"12","author":"Uchikawa","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s11030-021-10267-7","article-title":"Type II c-Met inhibitors: Molecular insight into crucial interactions for effective inhibition","volume":"26","author":"Damghani","year":"2021","journal-title":"Mol. Divers."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fcell.2020.00055","article-title":"The Function of the HGF\/c-Met Axis in Hepatocellular Carcinoma","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1039\/D1CS00755F","article-title":"Delivery strategies in treatments of leukemia","volume":"51","author":"Ci","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Roloff, G.W., Odenike, O., Bajel, A., Wei, A.H., Foley, N., and Uy, G.L. (2022). Contemporary Approach to Acute Myeloid Leukemia Therapy in 2022. Am. Soc. Clin. Oncol. Educ. Book, 568\u2013583.","DOI":"10.1200\/EDBK_349605"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"128346","DOI":"10.1016\/j.chemosphere.2020.128346","article-title":"Cadmium induced BEAS-2B cells apoptosis and mitochondria damage via MAPK signaling pathway","volume":"263","author":"Cao","year":"2020","journal-title":"Chemosphere"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.apsb.2019.08.002","article-title":"Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent","volume":"10","author":"Feng","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"114565","DOI":"10.1016\/j.ejmech.2022.114565","article-title":"Discovery of Fused Benzimidazole-imidazole Autophagic Flux Inhibitors for Treatment of Triple-negative Treast Cancer","volume":"240","author":"Yang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"108239","DOI":"10.1016\/j.abb.2019.108239","article-title":"Dynasore potentiates c-Met inhibitors against hepatocellular carcinoma through destabilizing c-Met","volume":"680","author":"Zaky","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"564601","DOI":"10.3389\/fcell.2020.564601","article-title":"PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance","volume":"8","author":"Rose","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ejvs.2019.11.003","article-title":"RNA-Seq Based Transcriptome Analysis of Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells","volume":"59","author":"Wang","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fcimb.2020.00097","article-title":"RNA-Seq revealed a circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection","volume":"10","author":"Lu","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1470-2045(05)70168-6","article-title":"The MAPK signalling pathways and colorectal cancer","volume":"6","author":"Fang","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-022-01503-1","article-title":"Molecular mechanism(s) of regulation(s) of c-MET\/HGF signaling in head and neck cancer","volume":"21","author":"Raj","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.onc.1200879","article-title":"Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2","volume":"14","author":"Besser","year":"1997","journal-title":"Oncogene"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phrs.2011.11.011","article-title":"Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma","volume":"65","author":"Gao","year":"2012","journal-title":"Pharmacol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0145-2126(98)00071-X","article-title":"Expression of hepatocyte growth factor and its receptor c-met in human leukemia-lymphoma cell lines","volume":"22","author":"Pons","year":"1998","journal-title":"Leuk. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"100315","DOI":"10.1016\/j.jbo.2020.100315","article-title":"c-Met expression in renal cell carcinoma with bone metastases","volume":"25","author":"Paiva","year":"2020","journal-title":"J. Bone Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-022-01522-y","article-title":"Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification","volume":"21","author":"Hu","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"694571","DOI":"10.3389\/fgene.2021.694571","article-title":"Upregulation of Linc00284 Promotes Lung Cancer Progression by Regulating the miR-205-3p\/c-Met Axis","volume":"12","author":"Sheng","year":"2021","journal-title":"Front. 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