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Miguel Servet program","award":["RD16\/0009\/0003"],"award-info":[{"award-number":["RD16\/0009\/0003"]}]},{"name":"ISCIII Miguel Servet program","award":["RICORS2040"],"award-info":[{"award-number":["RICORS2040"]}]},{"name":"ISCIII Miguel Servet program","award":["RD21\/0005\/0002"],"award-info":[{"award-number":["RD21\/0005\/0002"]}]},{"name":"ISCIII Miguel Servet program","award":["RD21\/0005\/0001"],"award-info":[{"award-number":["RD21\/0005\/0001"]}]},{"name":"ISCIII Miguel Servet program","award":["FEA 2021-BIB 05-21"],"award-info":[{"award-number":["FEA 2021-BIB 05-21"]}]},{"name":"ISCIII Miguel Servet program","award":["812699"],"award-info":[{"award-number":["812699"]}]},{"name":"ISCIII Miguel Servet program","award":["IJC2018-035187-I"],"award-info":[{"award-number":["IJC2018-035187-I"]}]},{"name":"ISCIII Miguel Servet program","award":["RYC2021-033343-I"],"award-info":[{"award-number":["RYC2021-033343-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mitochondrial dysfunction in cardiovascular and renal diseases, suggesting that maintaining mitochondrial homeostasis is a promising therapeutic strategy for CRS. In this review, we explore the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and how it contributes to the development and progression of the main vascular pathologies that could be affected by kidney injury and vice versa, and how this knowledge may guide the development of novel therapeutic strategies in CRS.<\/jats:p>","DOI":"10.3390\/ijms24098209","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T02:03:18Z","timestamp":1683165798000},"page":"8209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mitochondrial Dysfunction in the Cardio-Renal Axis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-3067","authenticated-orcid":false,"given":"Nerea","family":"Mendez-Barbero","sequence":"first","affiliation":[{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Faculty of Medicine and Biomedicine, Universidad Alfonso X El Sabio, 28037 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Oller","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Faculty of Medicine and Biomedicine, Universidad Alfonso X El Sabio, 28037 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-5689","authenticated-orcid":false,"given":"Ana","family":"Sanz","sequence":"additional","affiliation":[{"name":"Spain Nephrology Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"REDINREN Spain\/Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Ramos","sequence":"additional","affiliation":[{"name":"Spain Nephrology Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"REDINREN Spain\/Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Spain Nephrology Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"REDINREN Spain\/Ricors2040, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-6535","authenticated-orcid":false,"given":"Marta","family":"Ruiz-Ortega","sequence":"additional","affiliation":[{"name":"REDINREN Spain\/Ricors2040, 28029 Madrid, Spain"},{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-2359","authenticated-orcid":false,"given":"Sandra","family":"Rayego-Mateos","sequence":"additional","affiliation":[{"name":"REDINREN Spain\/Ricors2040, 28029 Madrid, Spain"},{"name":"Cellular Biology in Renal Diseases Laboratory, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1053\/j.ackd.2018.08.004","article-title":"Cardiorenal Syndrome: An Overview","volume":"25","author":"Ronco","year":"2018","journal-title":"Adv. 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