{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:15Z","timestamp":1792789455563,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP 21K11650"],"award-info":[{"award-number":["JP 21K11650"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>1,5-Anhydro-D-fructose (1,5-AF) is a bioactive monosaccharide that is produced by the glycogenolysis in mammalians and is metabolized to 1,5-anhydro-D-glucitol (1,5-AG). 1,5-AG is used as a marker of glycemic control in diabetes patients. 1,5-AF has a variety of physiological activities, but its effects on energy metabolism, including feeding behavior, are unclarified. The present study examined whether 1,5-AF possesses the effect of satiety. Peroral administration of 1,5-AF, and not of 1,5-AG, suppressed daily food intake. Intracerebroventricular (ICV) administration of 1,5-AF also suppressed feeding. To investigate the neurons targeted by 1,5-AF, we investigated c-Fos expression in the hypothalamus and brain stem. ICV injection of 1,5-AF significantly increased c-Fos positive oxytocin neurons and mRNA expression of oxytocin in the paraventricular nucleus (PVN). Moreover, 1,5-AF increased cytosolic Ca2+ concentration of oxytocin neurons in the PVN. Furthermore, the satiety effect of 1,5-AF was abolished in oxytocin knockout mice. These findings reveal that 1,5-AF activates PVN oxytocin neurons to suppress feeding, indicating its potential as the energy storage monitoring messenger to the hypothalamus for integrative regulation of energy metabolism.<\/jats:p>","DOI":"10.3390\/ijms24098248","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:24:32Z","timestamp":1683257072000},"page":"8248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["1,5-Anhydro-D-Fructose Exhibits Satiety Effects via the Activation of Oxytocin Neurons in the Paraventricular Nucleus"],"prefix":"10.3390","volume":"24","author":[{"given":"Masanori","family":"Nakata","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Monnkawa","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putra","family":"Santoso","sequence":"additional","affiliation":[{"name":"Department of Physiology, Division of Integrative Physiology, School of Medicine, Jichi Medical University, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yada","sequence":"additional","affiliation":[{"name":"Center for Integrative Physiology, Kansai Electric Power Medical Research Institute, Kyoto 604-8436, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuro","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Systems Biology in Thromboregulation, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima 890-8520, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Deng, B., Sullivan, M.A., Chen, C., Li, J., Powell, P.O., Hu, Z., and Gilbert, R.G. 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