{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:34:20Z","timestamp":1789425260304,"version":"build-2803163510"},"reference-count":143,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32130105"],"award-info":[{"award-number":["32130105"]}]},{"name":"National Natural Science Foundation of China","award":["2022YFD1800300"],"award-info":[{"award-number":["2022YFD1800300"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["32130105"],"award-info":[{"award-number":["32130105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800300"],"award-info":[{"award-number":["2022YFD1800300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CARS-40, China","award":["32130105"],"award-info":[{"award-number":["32130105"]}]},{"name":"CARS-40, China","award":["2022YFD1800300"],"award-info":[{"award-number":["2022YFD1800300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Infectious bursal disease virus (IBDV) is an immunosuppressive pathogen causing enormous economic losses to the poultry industry across the globe. As a double-stranded RNA virus, IBDV undergoes genetic mutation or recombination in replication during circulation among flocks, leading to the generation and spread of variant or recombinant strains. In particular, the recent emergence of variant IBDV causes severe immunosuppression in chickens, affecting the efficacy of other vaccines. It seems that the genetic mutation of IBDV during the battle against host response is an effective strategy to help itself to survive. Therefore, a comprehensive understanding of the viral genome diversity will definitely help to develop effective measures for prevention and control of infectious bursal disease (IBD). In recent years, considerable progress has been made in understanding the relation of genetic mutation and genomic recombination of IBDV to its pathogenesis using the reverse genetic technique. Therefore, this review focuses on our current genetic insight into the IBDV\u2019s genetic typing and viral genomic variation.<\/jats:p>","DOI":"10.3390\/ijms24098255","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:24:32Z","timestamp":1683257072000},"page":"8255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Genetic Insight into the Interaction of IBDV with Host\u2014A Clue to the Development of Novel IBDV Vaccines"],"prefix":"10.3390","volume":"24","author":[{"given":"Hui","family":"Gao","sequence":"first","affiliation":[{"name":"National Key Laboratory of Veterinary Public Health Security, Beijing 100193, China"},{"name":"Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, Beijing 100193, China"},{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-8393","authenticated-orcid":false,"given":"Yongqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Veterinary Public Health Security, Beijing 100193, China"},{"name":"Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, Beijing 100193, China"},{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Veterinary Public Health Security, Beijing 100193, China"},{"name":"Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, Beijing 100193, China"},{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-4794","authenticated-orcid":false,"given":"Shijun J.","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Veterinary Public Health Security, Beijing 100193, China"},{"name":"Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, Beijing 100193, China"},{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","unstructured":"Becht, H. 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