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Their importance and role were shadowed by the difficulty or incomplete available research methodology to study their biological presence and functionality. This review focuses on the current knowledge about the roles of phospholipids in the pathophysiology and therapy of cardiovascular diseases, which have been increasingly recognized. Used in singular formulation or in inclusive combinations with current drugs, phospholipids proved their positive and valuable effects not only in the protection of myocardial tissue, inflammation and fibrosis but also in angiogenesis, coagulation or cardiac regeneration more frequently in animal models as well as in human pathology. Thus, while mainly neglected by the scientific community, phospholipids present negligible side effects and could represent an ideal target for future therapeutic strategies in healing myocardial infarction. Acknowledging and understanding their mechanisms of action could offer a new perspective into novel therapeutic strategies for patients suffering an acute myocardial infarction, reducing the burden and improving the general social and economic outcome.<\/jats:p>","DOI":"10.3390\/ijms24098360","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T03:34:53Z","timestamp":1683516893000},"page":"8360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phospholipids, the Masters in the Shadows during Healing after Acute Myocardial Infarction"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-6657","authenticated-orcid":false,"given":"Dan-Valentin","family":"Pistritu","sequence":"first","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisia-Cristiana","family":"Vasiliniuc","sequence":"additional","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda","family":"Vasiliu","sequence":"additional","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena-Florentina","family":"Visinescu","sequence":"additional","affiliation":[{"name":"Faculty of Human Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana-Elena","family":"Visoiu","sequence":"additional","affiliation":[{"name":"Faculty of Human Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaranda","family":"Vizdei","sequence":"additional","affiliation":[{"name":"Faculty of Human Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Mart\u00ednez Anghel","sequence":"additional","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"},{"name":"Business Academy Aarhus, 30 S\u00f8nderh\u00f8j, 8260 Viby J, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoanela","family":"Tanca","sequence":"additional","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"},{"name":"Faculty of Human Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Bucur","sequence":"additional","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"},{"name":"Viron Molecular Medicine Institute, 201 Washington Street, Boston, MA 02108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Anamaria","family":"Liehn","sequence":"additional","affiliation":[{"name":"Victor Babes\u2019 National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania"},{"name":"Institute for Molecular Medicine, University of Southern Denmark, 25 J.B Winsl\u00f8ws Vej, 5230 Odense, Denmark"},{"name":"National Heart Center Singapore, 5 Hospital Dr., Singapore 169609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cpcardiol.2009.10.002","article-title":"Growing epidemic of coronary heart disease in low- and middle-income countries","volume":"35","author":"Gaziano","year":"2010","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_2","unstructured":"Mechanic, O.J., Gavin, M., and Grossman, S.A. (2023). StatPearls, StatPearls."},{"key":"ref_3","first-page":"224","article-title":"From atherosclerosis to atherothrombosis: From a silent chronic pathology to an acute critical event","volume":"73","author":"Scheen","year":"2018","journal-title":"Rev. Med. De Liege"},{"key":"ref_4","unstructured":"Writing Committee Members, Gulati, M., Levy, P.D., Mukherjee, D., Amsterdam, E., Bhatt, D.L., Birtcher, K.K., Blankstein, R., Boyd, J., and Bullock-Palmer, R.P. (2022). 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J. Am. Coll. Cardiol., 16, 54\u2013122."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/ATVBAHA.115.305504","article-title":"High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease","volume":"35","author":"Agarwala","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"McGranaghan, P., Kirwan, J.A., Garcia-Rivera, M.A., Pieske, B., Edelmann, F., Blaschke, F., Appunni, S., Saxena, A., Rubens, M., and Veledar, E. (2021). Lipid Metabolite Biomarkers in Cardiovascular Disease: Discovery and Biomechanism Translation from Human Studies. Metabolites, 11.","DOI":"10.3390\/metabo11090621"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/jcmm.13984","article-title":"The relationship between phospholipids and insulin resistance: From clinical to experimental studies","volume":"23","author":"Chang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_9","first-page":"H242","article-title":"Redistribution of phosphatidylethanolamine and phosphatidylserine precedes reperfusion-induced apoptosis","volume":"274","author":"Maulik","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"Kennelly","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bbalip.2011.09.009","article-title":"Phosphatidylcholine biosynthesis and lipoprotein metabolism","volume":"1821","author":"Cole","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12944-020-01278-8","article-title":"Alveolar lipids in pulmonary disease. A review","volume":"19","author":"Agudelo","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/ajrcmb.25.6.4616","article-title":"Phosphatidylcholine molecular species in lung surfactant: Composition in relation to respiratory rate and lung development","volume":"25","author":"Bernhard","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000342729","article-title":"Mucosal protection by phosphatidylcholine","volume":"30","author":"Stremmel","year":"2012","journal-title":"Dig. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.bbamem.2017.02.008","article-title":"Accumulation of phosphatidylcholine on gut mucosal surface is not dominated by electrostatic interactions","volume":"1859","author":"Korytowski","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3945\/ajcn.116.131771","article-title":"Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men","volume":"104","author":"Zheng","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0090-6980(01)00110-1","article-title":"Lysophosphatidic acid synthesis and release","volume":"64","author":"Pages","year":"2001","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCRESAHA.122.321036","article-title":"LPA(2) Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction","volume":"131","author":"Pei","year":"2022","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.7150\/thno.47913","article-title":"LPA(3)-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E3976","DOI":"10.1073\/pnas.1411694111","article-title":"Phosphatidylethanolamine deficiency disrupts alpha-synuclein homeostasis in yeast and worm models of Parkinson disease","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/excr.2000.4849","article-title":"Elevation in phosphatidylethanolamine is an early but not essential event for cardiac cell differentiation","volume":"256","author":"Xu","year":"2000","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.biophys.093008.131234","article-title":"The distribution and function of phosphatidylserine in cellular membranes","volume":"39","author":"Leventis","year":"2010","journal-title":"Annu. Rev. Biophys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0074-7742(02)50073-8","article-title":"Protein kinase C changes in diabetes: Is the concept relevant to neuropathy?","volume":"50","author":"Eichberg","year":"2002","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.plipres.2005.05.001","article-title":"Metabolism and functions of phosphatidylserine","volume":"44","author":"Vance","year":"2005","journal-title":"Prog. Lipid Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1550-2783-4-5","article-title":"Phospholipids and sports performance","volume":"4","author":"Jager","year":"2007","journal-title":"J. Int. Soc. Sport. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jcmg.2015.11.031","article-title":"Echocardiographic Ischemic Memory Imaging Through Complement-Mediated Vascular Adhesion of Phosphatidylserine-Containing Microbubbles","volume":"9","author":"Mott","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"782767","DOI":"10.3389\/fphys.2021.782767","article-title":"Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1253\/jcj.56.142","article-title":"Phosphatidylinositol and inositolphosphatide metabolism in hypertrophied rat heart","volume":"56","author":"Shoki","year":"1992","journal-title":"Jpn. Circ. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"H840","DOI":"10.1152\/ajpheart.00632.2019","article-title":"Gene therapy targeting cardiac phosphoinositide 3-kinase (p110alpha) attenuates cardiac remodeling in type 2 diabetes","volume":"318","author":"Prakoso","year":"2020","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.advenzreg.2006.01.005","article-title":"Diacylglycerol kinase and animal models: The pathophysiological roles in the brain and heart","volume":"46","author":"Goto","year":"2006","journal-title":"Adv. Enzym. Regul."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Paradies, G., Paradies, V., Ruggiero, F.M., and Petrosillo, G. (2019). Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects. Cells, 8.","DOI":"10.3390\/cells8070728"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13023-014-0119-3","article-title":"Sengers syndrome: Six novel AGK mutations in seven new families and review of the phenotypic and mutational spectrum of 29 patients","volume":"9","author":"Haghighi","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pediatrneurol.2020.03.009","article-title":"MEGDEL Syndrome","volume":"110","author":"Finsterer","year":"2020","journal-title":"Pediatr. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"F970","DOI":"10.1152\/ajprenal.00697.2013","article-title":"Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis","volume":"306","author":"Liu","year":"2014","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.3748\/wjg.v20.i39.14205","article-title":"Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease","volume":"20","author":"Paradies","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bbadis.2018.08.025","article-title":"The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease","volume":"1865","author":"Dudek","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tem.2021.01.006","article-title":"Cardiolipin, Mitochondria, and Neurological Disease","volume":"32","author":"Falabella","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Signorelli, P., Conte, C., and Albi, E. (2021). The Multiple Roles of Sphingomyelin in Parkinson\u2019s Disease. Biomolecules, 11.","DOI":"10.3390\/biom11091311"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s00125-020-05201-9","article-title":"Sphingomyelin and progression of renal and coronary heart disease in individuals with type 1 diabetes","volume":"63","author":"Harjutsalo","year":"2020","journal-title":"Diabetologia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ehf2.12453","article-title":"The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population","volume":"6","author":"Stenemo","year":"2019","journal-title":"ESC Heart Fail."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: Lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.cellsig.2007.12.006","article-title":"The sphingolipid salvage pathway in ceramide metabolism and signaling","volume":"20","author":"Kitatani","year":"2008","journal-title":"Cell Signal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.4049\/jimmunol.179.7.4829","article-title":"Aging up-regulates expression of inflammatory mediators in mouse adipose tissue","volume":"179","author":"Wu","year":"2007","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.122.318048","article-title":"Ceramide Metabolism in Cardiovascular Disease: A Network With High Therapeutic Potential","volume":"42","author":"Zietzer","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.atherosclerosis.2020.04.008","article-title":"Relationship between elevated plasma ceramides and plaque rupture in patients with ST-segment elevation myocardial infarction","volume":"302","author":"Pan","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/intimm\/dxz037","article-title":"Sphingosine 1-phosphate and inflammation","volume":"31","author":"Obinata","year":"2019","journal-title":"Int. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.21037\/apm-20-1255","article-title":"Sphingosine 1-phosphate and osteoporosis: Pathophysiology and therapeutic aspects-a narrative review","volume":"10","author":"Tian","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5551\/jat.RV17010","article-title":"Sphingosine 1-Phosphate and Atherosclerosis","volume":"25","author":"Kurano","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/path.4194","article-title":"Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors","volume":"230","author":"Liu","year":"2013","journal-title":"J. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2018.10.054","article-title":"Implementation of Phospholipids as Pharmacological Modalities for Postoperative Adhesions Prevention","volume":"842","author":"Tsaousi","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"102327","DOI":"10.1016\/j.jaut.2019.102327","article-title":"Autotaxin and chronic inflammatory diseases","volume":"104","author":"Magkrioti","year":"2019","journal-title":"J. Autoimmun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12944-015-0059-5","article-title":"The autotaxin-lysophosphatidic acid-lysophosphatidic acid receptor cascade: Proposal of a novel potential therapeutic target for treating glioblastoma multiforme","volume":"14","author":"Tabuchi","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1194\/jlr.R700020-JLR200","article-title":"Phosphatidylserine and phosphatidylethanolamine in mammalian cells: Two metabolically related aminophospholipids","volume":"49","author":"Vance","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.ircmb.2015.10.001","article-title":"Phosphatidylethanolamine Metabolism in Health and Disease","volume":"321","author":"Calzada","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"a009399","DOI":"10.1101\/cshperspect.a009399","article-title":"alpha-Synuclein in Parkinson\u2019s disease","volume":"2","author":"Stefanis","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40364-021-00346-0","article-title":"The role of phosphatidylserine on the membrane in immunity and blood coagulation","volume":"10","author":"Wang","year":"2022","journal-title":"Biomark. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2014.06.002","article-title":"Phosphatidylserine in the brain: Metabolism and function","volume":"56","author":"Kim","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.4049\/jimmunol.170.9.4840","article-title":"Phosphatidylserine on HIV envelope is a cofactor for infection of monocytic cells","volume":"170","author":"Callahan","year":"2003","journal-title":"J Immunol"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2165\/00007256-200636080-00003","article-title":"Effects of phosphatidylserine supplementation on exercising humans","volume":"36","author":"Kingsley","year":"2006","journal-title":"Sport. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.clinimag.2008.03.001","article-title":"Evaluation of renal ischemia-reperfusion injury in rabbits using microbubbles targeted to activated neutrophils","volume":"32","author":"Jing","year":"2008","journal-title":"Clin. Imaging"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1161\/01.CIR.102.22.2745","article-title":"Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes","volume":"102","author":"Lindner","year":"2000","journal-title":"Circulation"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e005249","DOI":"10.1161\/CIRCIMAGING.116.005249","article-title":"Detection of Myocarditis With Molecular Echo Imaging: Another Potential Application for the Phosphatidyl Serine Microbubble","volume":"9","author":"Porter","year":"2016","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbrc.2018.07.155","article-title":"Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms","volume":"506","author":"Janmey","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5483\/BMBRep.2014.47.7.088","article-title":"Phosphoinositide turnover in Toll-like receptor signaling and trafficking","volume":"47","author":"Le","year":"2014","journal-title":"BMB Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jbior.2018.09.014","article-title":"Diacylglycerol kinases: Relationship to other lipid kinases","volume":"71","author":"Ma","year":"2019","journal-title":"Adv. Biol. Regul."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tibs.2006.11.004","article-title":"Diacylglycerol, when simplicity becomes complex","volume":"32","author":"Carrasco","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.2337\/db10-0550","article-title":"The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models","volume":"60","author":"Opreanu","year":"2011","journal-title":"Diabetes"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"565316","DOI":"10.1155\/2011\/565316","article-title":"Apoptotic sphingolipid ceramide in cancer therapy","volume":"2011","author":"Huang","year":"2011","journal-title":"J. Lipids"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zhao, L., Spassieva, S.D., Jucius, T.J., Shultz, L.D., Shick, H.E., Macklin, W.B., Hannun, Y.A., Obeid, L.M., and Ackerman, S.L. (2011). A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLOS Genet., 7.","DOI":"10.1371\/journal.pgen.1002063"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1046\/j.1523-1755.1998.06707.x","article-title":"Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells","volume":"67","author":"Pfeilschifter","year":"1998","journal-title":"Kidney Int. Suppl."},{"key":"ref_71","first-page":"608","article-title":"Biology of disease. Analysis of autoimmune demyelination: Its impact upon multiple sclerosis","volume":"50","author":"Raine","year":"1984","journal-title":"Lab. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI43378","article-title":"Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice","volume":"121","author":"Holland","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbalip.2005.05.004","article-title":"The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis","volume":"1735","author":"Li","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.atherosclerosis.2007.09.018","article-title":"Ceramide: A common pathway for atherosclerosis?","volume":"196","author":"Bismuth","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"232","DOI":"10.14336\/AD.2021.0710","article-title":"Emerging Roles of Ceramide in Cardiovascular Diseases","volume":"13","author":"Shu","year":"2022","journal-title":"Aging Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10495-015-1102-8","article-title":"Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids","volume":"20","author":"Tommasino","year":"2015","journal-title":"Apoptosis"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/bcpt.12103","article-title":"Targeting the sphingosine kinase\/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases","volume":"114","author":"Schwalm","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-511X-11-3","article-title":"Health effects of dietary phospholipids","volume":"11","author":"Kullenberg","year":"2012","journal-title":"Lipids Health Dis."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Drescher, S., and van Hoogevest, P. (2020). The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12121235"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.jacc.2011.08.034","article-title":"Repair after myocardial infarction, between fantasy and reality: The role of chemokines","volume":"58","author":"Liehn","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/bph.14155","article-title":"Anti-inflammatory therapies in myocardial infarction: Failures, hopes and challenges","volume":"175","author":"Huang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"H1056","DOI":"10.1152\/ajpheart.00459.2021","article-title":"Guidelines for in vivo mouse models of myocardial infarction","volume":"321","author":"Lindsey","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/cphy.c150006","article-title":"Pathophysiology of Myocardial Infarction","volume":"5","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/HCO.0000000000000158","article-title":"Inflammation in cardiac injury, repair and regeneration","volume":"30","author":"Frangogiannis","year":"2015","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MOH.0000000000000103","article-title":"The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues","volume":"22","author":"Lyck","year":"2015","journal-title":"Curr. Opin. Hematol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"Ong","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: A neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Curaj, A., Schumacher, D., Rusu, M., Staudt, M., Li, X., Simsekyilmaz, S., Jankowski, V., Jankowski, J., Dumitrascu, A.R., and Hausenloy, D.J. (2020). Neutrophils Modulate Fibroblast Function and Promote Healing and Scar Formation after Murine Myocardial Infarction. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103685"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/cvr\/cvz050","article-title":"Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities","volume":"115","author":"Andreadou","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.trsl.2015.07.002","article-title":"Inflammation as a therapeutic target in myocardial infarction: Learning from past failures to meet future challenges","volume":"167","author":"Saxena","year":"2016","journal-title":"Transl. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/eci.12118","article-title":"Targeting inflammatory pathways in myocardial infarction","volume":"43","author":"Christia","year":"2013","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00011-022-01611-0","article-title":"Cytokine storm: Behind the scenes of the collateral circulation after acute myocardial infarction","volume":"71","author":"He","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0021-9150(89)90066-X","article-title":"Phospholipids and other lipids in angiographically assessed coronary artery disease","volume":"80","author":"Bovet","year":"1989","journal-title":"Atherosclerosis"},{"key":"ref_97","first-page":"H71","article-title":"Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion","volume":"251","author":"Das","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3389\/fphys.2018.01017","article-title":"Metabolomics Study of the Biochemical Changes in the Plasma of Myocardial Infarction Patients","volume":"9","author":"Zhu","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_99","first-page":"101037","article-title":"Cardiac phospholipidome is altered during ischemia and reperfusion in an ex vivo rat model","volume":"27","author":"Aveiro","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"101888","DOI":"10.1016\/j.arr.2023.101888","article-title":"Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing","volume":"86","author":"Wang","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1021\/acs.langmuir.1c00830","article-title":"Lipid Hydroperoxide Compromises the Membrane Structure Organization and Softens Bending Rigidity","volume":"37","author":"Scanavachi","year":"2021","journal-title":"Langmuir"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cbi.2019.01.032","article-title":"Oxidized phospholipids in Doxorubicin-induced cardiotoxicity","volume":"303","author":"Koleini","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Rivara, M.B., Ikizler, T.A., Ellis, C.D., Mehrotra, R., and Himmelfarb, J. (2015). Association of plasma F2-isoprostanes and isofurans concentrations with erythropoiesis-stimulating agent resistance in maintenance hemodialysis patients. BMC Nephrol., 16.","DOI":"10.1186\/s12882-015-0074-9"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.jacc.2015.01.050","article-title":"Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: The TNT trial","volume":"65","author":"Byun","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5483\/BMBRep.2008.41.8.560","article-title":"Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies","volume":"41","author":"Adibhatla","year":"2008","journal-title":"BMB Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1038\/s41598-017-04620-w","article-title":"Common lipid features of lethal ventricular tarchyarrhythmias (LVTAs) induced by myocardial infarction and myocardial ion channel diseases","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Deng, J., Jiang, Y., Chen, Z.B., Rhee, J.W., Deng, Y., and Wang, Z.V. (2023). Mitochondrial Dysfunction in Cardiac Arrhythmias. Cells, 12.","DOI":"10.3390\/cells12050679"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.freeradbiomed.2014.03.033","article-title":"Mitochondria and arrhythmias","volume":"71","author":"Yang","year":"2014","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1159\/000339029","article-title":"Electrophysiological effects of lysophosphatidylcholine on HL-1 cardiomyocytes assessed with a microelectrode array system","volume":"30","author":"Gizurarson","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1476-5381.1988.tb11448.x","article-title":"Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart","volume":"93","author":"Man","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1139\/y88-032","article-title":"Lysophosphatidylcholine metabolism and cardiac arrhythmias","volume":"66","author":"Giffin","year":"1988","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0022-2275(20)32021-6","article-title":"Increase in fragmented phosphatidylcholine in blood plasma by oxidative stress","volume":"41","author":"Frey","year":"2000","journal-title":"J. Lipid Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"716944","DOI":"10.3389\/fmed.2021.716944","article-title":"Increase in Plasma Oxidized Phosphatidylcholines (OxPCs) in Patients Presenting With ST-Elevation Myocardial Infarction (STEMI)","volume":"8","author":"Solati","year":"2021","journal-title":"Front. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/cvr\/cvy136","article-title":"Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids","volume":"115","author":"Yeang","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"11104","DOI":"10.1016\/S0021-9258(18)99133-7","article-title":"Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor","volume":"266","author":"Smiley","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"H1170","DOI":"10.1152\/ajpheart.00237.2020","article-title":"Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury","volume":"320","author":"Stamenkovic","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Law, S.H., Chan, M.L., Marathe, G.K., Parveen, F., Chen, C.H., and Ke, L.Y. (2019). An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051149"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1530-0277.1999.tb04209.x","article-title":"Prevention and treatment of liver fibrosis based on pathogenesis","volume":"23","author":"Lieber","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1006\/jmcc.1997.0522","article-title":"Phosphatidic acid: A potential signal transducer for cardiac hypertrophy","volume":"29","author":"Dhalla","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_124","first-page":"H651","article-title":"Phosphatidic acid increases intracellular free Ca2+ and cardiac contractile force","volume":"271","author":"Xu","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj3510459","article-title":"Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells","volume":"351","author":"Plo","year":"2000","journal-title":"Biochem. J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1582-4934.2004.tb00477.x","article-title":"Expression of phospholipase D isozymes in scar and viable tissue in congestive heart failure due to myocardial infarction","volume":"8","author":"Dent","year":"2004","journal-title":"J. Cell. Mol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1388-1981(02)00270-6","article-title":"Alterations of sarcolemmal phospholipase D and phosphatidate phosphohydrolase in congestive heart failure","volume":"1584","author":"Yu","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"16749","DOI":"10.1038\/s41598-018-35194-w","article-title":"Hepatokine alpha1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction","volume":"8","author":"Hakuno","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4829180","DOI":"10.1155\/2017\/4829180","article-title":"Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease","volume":"2017","author":"Patel","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"111498","DOI":"10.1016\/j.mad.2021.111498","article-title":"Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin\/IGF-1-like signaling in C. elegans","volume":"197","author":"Park","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"eade7864","DOI":"10.1126\/sciadv.ade7864","article-title":"Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis","volume":"9","author":"Johnson","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Schumacher, D., Curaj, A., Staudt, M., Cordes, F., Dumitrascu, A.R., Rolles, B., Beckers, C., Soppert, J., Rusu, M., and Simsekyilmaz, S. (2021). Phosphatidylserine Supplementation as a Novel Strategy for Reducing Myocardial Infarct Size and Preventing Adverse Left Ventricular Remodeling. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094401"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.jacc.2011.08.033","article-title":"Double-edged role of the CXCL12\/CXCR4 axis in experimental myocardial infarction","volume":"58","author":"Liehn","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1021\/acs.molpharmaceut.2c00707","article-title":"Phosphatidylserine in Diabetes Research","volume":"20","author":"Xiao","year":"2023","journal-title":"Mol. Pharm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1248\/bpb.b22-00001","article-title":"Phosphatidylserine-Specific Phospholipase A1 Alleviates Lipopolysaccharide-Induced Macrophage Inflammation by Inhibiting MAPKs Activation","volume":"45","author":"Zhang","year":"2022","journal-title":"Biol. Pharm. Bull."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s10753-021-01467-2","article-title":"New Insights and Novel Therapeutic Potentials for Macrophages in Myocardial Infarction","volume":"44","author":"Zhang","year":"2021","journal-title":"Inflammation"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cellsig.2019.04.015","article-title":"Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades","volume":"61","author":"Maciel","year":"2019","journal-title":"Cell Signal."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-94-007-3012-0_6","article-title":"Phosphoinositide 3-kinases in health and disease","volume":"58","author":"Ghigo","year":"2012","journal-title":"Subcell. Biochem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0065-230X(09)02002-8","article-title":"PI3K\/PTEN signaling in angiogenesis and tumorigenesis","volume":"102","author":"Jiang","year":"2009","journal-title":"Adv. Cancer Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"H1105","DOI":"10.1152\/ajpheart.00927.2006","article-title":"Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction","volume":"292","author":"Niizeki","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.med.47.1.21","article-title":"Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease","volume":"47","author":"Cohen","year":"1996","journal-title":"Annu. Rev. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00380-013-0366-6","article-title":"Diacylglycerol kinase alpha exacerbates cardiac injury after ischemia\/reperfusion","volume":"29","author":"Sasaki","year":"2014","journal-title":"Heart Vessel."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tcb.2020.09.004","article-title":"Cardiolipin in Immune Signaling and Cell Death","volume":"30","author":"Pizzuto","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"H1341","DOI":"10.1152\/ajpheart.00028.2018","article-title":"Mitochondrial bioenergetics and cardiolipin alterations in myocardial ischemia-reperfusion injury: Implications for pharmacological cardioprotection","volume":"315","author":"Paradies","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1016\/j.ymthe.2021.06.007","article-title":"Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction","volume":"29","author":"Jia","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/cvr\/cvaa046","article-title":"Vascular endothelial S1pr1 ameliorates adverse cardiac remodelling via stimulating reparative macrophage proliferation after myocardial infarction","volume":"117","author":"Kuang","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/FJC.0b013e31819b52d5","article-title":"Ceramide and mitochondria in ischemia\/reperfusion","volume":"53","author":"Novgorodov","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3646725","DOI":"10.1155\/2018\/3646725","article-title":"Ceramide and Ischemia\/Reperfusion Injury","volume":"2018","author":"He","year":"2018","journal-title":"J. Lipids"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"H246","DOI":"10.1152\/ajpheart.00638.2003","article-title":"Ceramide in the antiapoptotic effect of ischemic preconditioning","volume":"286","author":"Argaud","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIRCULATIONAHA.119.041882","article-title":"Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction","volume":"141","author":"Hadas","year":"2020","journal-title":"Circulation"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12944-015-0053-y","article-title":"Sphingolipids in cardiovascular diseases and metabolic disorders","volume":"14","author":"Borodzicz","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e82922","DOI":"10.1172\/jci.insight.82922","article-title":"Increased de novo ceramide synthesis and accumulation in failing myocardium","volume":"2","author":"Ji","year":"2017","journal-title":"JCI Insight"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/ATVBAHA.119.312880","article-title":"Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction","volume":"39","author":"Sposito","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mito.2011.08.011","article-title":"Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3","volume":"12","author":"Szczepanek","year":"2012","journal-title":"Mitochondrion"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/CIRCULATIONAHA.105.607135","article-title":"High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia\/reperfusion injury in vivo via the S1P3 lysophospholipid receptor","volume":"114","author":"Theilmeier","year":"2006","journal-title":"Circulation"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1253\/circj.CJ-14-0178","article-title":"Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction","volume":"78","author":"Waeber","year":"2014","journal-title":"Circ. J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/01.ATV.0000254669.12675.70","article-title":"Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor","volume":"27","author":"Walter","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e2200990","DOI":"10.1002\/adhm.202200990","article-title":"A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction","volume":"11","author":"Zheng","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"pe34","DOI":"10.1126\/scisignal.3141pe34","article-title":"Sphingolipids: The oil on the TRAFire that promotes inflammation","volume":"3","author":"Napolitano","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.5966\/sctm.2014-0273","article-title":"Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction","volume":"4","author":"Klyachkin","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311648","article-title":"S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction","volume":"122","author":"Yamada","year":"2018","journal-title":"Circ. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"5985375","DOI":"10.1155\/2022\/5985375","article-title":"Inhibition of SphK1\/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction","volume":"2022","author":"Wu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/nutrit\/nuu008","article-title":"Nuts and Legume Seeds for Cardiovascular Risk Reduction: Scientific Evidence and Mechanisms of Action","volume":"73","author":"Souza","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_164","first-page":"363","article-title":"Phytonutrient Deficiency: The Place of Palm Fruit","volume":"12","author":"Wattanapenpaiboon","year":"2003","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1008089715153","article-title":"Influence of Palm Oil (Elaesis Guineensis) on Health","volume":"53","author":"Ebong","year":"1999","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3109\/13880209.2012.656847","article-title":"Sinomenium Acutum: A Review of Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use","volume":"50","author":"Zhao","year":"2012","journal-title":"Pharm. Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"154749","DOI":"10.1016\/j.phymed.2023.154749","article-title":"Regulation of Phospholipid Peroxidation Signaling by a Traditional Chinese Medicine Formula for Coronary Heart Disease","volume":"114","author":"Ma","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/FJC.0b013e3182422c1a","article-title":"A Comparison between Imidapril and Ramipril on Attenuation of Ventricular Remodeling after Myocardial Infarction","volume":"59","author":"Watanabe","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s40262-021-01090-2","article-title":"Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation","volume":"61","author":"Angiolillo","year":"2022","journal-title":"Clin. Pharmacokinet."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF02850119","article-title":"Effects of Soy and Other Natural Products on LDL:HDL Ratio and Other Lipid Parameters: A Literature Review","volume":"20","author":"Hermansen","year":"2003","journal-title":"Adv. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1124\/jpet.104.070789","article-title":"Apolipoprotein A-IMilano and 1-Palmitoyl-2-Oleoyl Phosphatidylcholine Complex (ETC-216) Protects the in Vivo Rabbit Heart from Regional Ischemia-Reperfusion Injury","volume":"311","author":"Marchesi","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.tcm.2019.10.001","article-title":"Inflammatory bowel disease and the risk for cardiovascular disease: Does all inflammation lead to heart disease?","volume":"30","author":"Bigeh","year":"2020","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.amjmed.2022.08.012","article-title":"Inflammatory Bowel Disease and Cardiovascular Diseases","volume":"135","author":"Chen","year":"2022","journal-title":"Am. J. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s15006-022-0832-0","article-title":"Wirksamkeit von darml\u00f6slichem Lecithin (Phosphatidylcholin) zur Behandlung der Colitis ulcerosa: Eine Metaanalyse [Efficacy of enteric lecithin (phosphatidylcholine) in the treatment of ulcerative colitis: A meta-analysis]","volume":"164","author":"Stremmel","year":"2022","journal-title":"MMW Fortschr. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"603","DOI":"10.7326\/0003-4819-147-9-200711060-00004","article-title":"Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: A randomized trial","volume":"147","author":"Stremmel","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Lee, H.-J., Kim, B.-M., Lee, S.H., Sohn, J.-T., Choi, J.W., Cho, C.-W., Hong, H.-D., Rhee, Y.K., and Kim, H.-J. (2020). Ginseng-Induced Changes to Blood Vessel Dilation and the Metabolome of Rats. Nutrients, 12.","DOI":"10.3390\/nu12082238"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jgr.2017.11.006","article-title":"Bioactive Lipids in Gintonin-Enriched Fraction from Ginseng","volume":"43","author":"Cho","year":"2019","journal-title":"J. Ginseng Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yjmcc.2020.09.011","article-title":"Autotaxin Inhibition Reduces Cardiac Inflammation and Mitigates Adverse Cardiac Remodeling after Myocardial Infarction","volume":"149","author":"Tripathi","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.jcmg.2017.11.037","article-title":"Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden","volume":"11","author":"Kawai","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jconrel.2003.10.008","article-title":"Increased Accumulation of PEG-PE Micelles in the Area of Experimental Myocardial Infarction in Rabbits","volume":"94","author":"Lukyanov","year":"2004","journal-title":"J. Control. Release"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/0963689719843806","article-title":"MicroRNA-133a and Myocardial Infarction","volume":"28","author":"Xiao","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0167-5273(98)00108-9","article-title":"Diacylglycerol-Induced Protection against Injury during Ischemia and Reperfusion in the Rat Heart: Comparative Studies with Ischemic Preconditioning","volume":"65","author":"Goss","year":"1998","journal-title":"Int. J. Cardiol."},{"key":"ref_183","first-page":"553","article-title":"Myocardial 11C-Diacylglycerol Accumulation and Left Ventricular Remodeling in Patients after Myocardial Infarction","volume":"46","author":"Otani","year":"2005","journal-title":"J. Nucl. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-079X.2010.00759.x","article-title":"Melatonin, Cardiolipin and Mitochondrial Bioenergetics in Health and Disease","volume":"48","author":"Paradies","year":"2010","journal-title":"J. Pineal Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fphys.2014.00331","article-title":"Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons","volume":"5","author":"Beckmann","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bbrc.2018.06.054","article-title":"Sphingomyelin Phosphodiesterase 1 (SMPD1) Mediates the Attenuation of Myocardial Infarction-Induced Cardiac Fibrosis by Astaxanthin","volume":"503","author":"Shi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.bbagen.2017.03.007","article-title":"Astaxanthin Attenuated Pressure Overload-Induced Cardiac Dysfunction and Myocardial Fibrosis: Partially by Activating SIRT1","volume":"1861","author":"Zhang","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00395-016-0533-x","article-title":"Inhibition of Ceramide de Novo Synthesis as a Postischemic Strategy to Reduce Myocardial Reperfusion Injury","volume":"111","author":"Reforgiato","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1473-2165.2006.00257.x","article-title":"Clinical experience and safety using phosphatidylcholine injections for the localized reduction of subcutaneous fat: A multicentre, retrospective UK study","volume":"5","author":"Palmer","year":"2006","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_190","first-page":"5472","article-title":"Quantitative Analysis of Yeast Phospholipids and Sterols by High-Performance Liquid Chromatography-Evaporative Light-Scattering Detection","volume":"5","author":"Knittelfelder","year":"2017","journal-title":"Cold Spring Harb. Protoc."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/978-1-4419-6741-1_3","article-title":"Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS\/MS)","volume":"688","author":"Bielawski","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Aldana, J., Romero-Otero, A., and Cala, M.P. (2020). Exploring the Lipidome: Current Lipid Extraction Techniques for Mass Spectrometry Analysis. Metabolites, 10.","DOI":"10.3390\/metabo10060231"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"101145","DOI":"10.1016\/j.plipres.2021.101145","article-title":"A new update of MALDI-TOF mass spectrometry in lipid research","volume":"86","author":"Engel","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1007\/s00216-015-8633-2","article-title":"Optimizing the lipidomics workflow for clinical studies--practical considerations","volume":"407","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/nutrit\/nux030","article-title":"Association between plant-based diets and plasma lipids: A systematic review and meta-analysis","volume":"75","author":"Yokoyama","year":"2017","journal-title":"Nutr. Rev."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Desnoyers, M., Gilbert, K., and Rousseau, G. (2018). Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids: Dichotomy between Experimental and Clinical Studies. Mar. Drugs, 16.","DOI":"10.3390\/md16070234"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.15190\/d.2016.1","article-title":"Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer","volume":"4","author":"Nicolson","year":"2016","journal-title":"Discoveries"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1210\/jc.2015-3940","article-title":"Lipids, Lipoproteins, and Cardiovascular Disease: Clinical Pharmacology Now and in the Future","volume":"101","author":"Chait","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/9\/8360\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:30:24Z","timestamp":1760124624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/9\/8360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,6]]},"references-count":198,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["ijms24098360"],"URL":"https:\/\/doi.org\/10.3390\/ijms24098360","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,6]]}}}