{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:26:31Z","timestamp":1787073991469,"version":"build-2736575974"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Miguel Servet","award":["MS16\/00153-CP16\/00153- CPII21\/00008"],"award-info":[{"award-number":["MS16\/00153-CP16\/00153- CPII21\/00008"]}]},{"name":"Miguel Servet","award":["PI18\/00213"],"award-info":[{"award-number":["PI18\/00213"]}]},{"name":"Miguel Servet","award":["72160426"],"award-info":[{"award-number":["72160426"]}]},{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health)","award":["MS16\/00153-CP16\/00153- CPII21\/00008"],"award-info":[{"award-number":["MS16\/00153-CP16\/00153- CPII21\/00008"]}]},{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health)","award":["PI18\/00213"],"award-info":[{"award-number":["PI18\/00213"]}]},{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health)","award":["72160426"],"award-info":[{"award-number":["72160426"]}]},{"name":"European Regional Development Fund (ERDF)","award":["MS16\/00153-CP16\/00153- CPII21\/00008"],"award-info":[{"award-number":["MS16\/00153-CP16\/00153- CPII21\/00008"]}]},{"name":"European Regional Development Fund (ERDF)","award":["PI18\/00213"],"award-info":[{"award-number":["PI18\/00213"]}]},{"name":"European Regional Development Fund (ERDF)","award":["72160426"],"award-info":[{"award-number":["72160426"]}]},{"name":"CONICYT-Doctorado Becas Chile 2015","award":["MS16\/00153-CP16\/00153- CPII21\/00008"],"award-info":[{"award-number":["MS16\/00153-CP16\/00153- CPII21\/00008"]}]},{"name":"CONICYT-Doctorado Becas Chile 2015","award":["PI18\/00213"],"award-info":[{"award-number":["PI18\/00213"]}]},{"name":"CONICYT-Doctorado Becas Chile 2015","award":["72160426"],"award-info":[{"award-number":["72160426"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya","award":["MS16\/00153-CP16\/00153- CPII21\/00008"],"award-info":[{"award-number":["MS16\/00153-CP16\/00153- CPII21\/00008"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya","award":["PI18\/00213"],"award-info":[{"award-number":["PI18\/00213"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya","award":["72160426"],"award-info":[{"award-number":["72160426"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Methyltransferase-like protein 7A (METTL7A) is a member of the METTL family of methyltransferases.Little information is available regarding the cellular expression of METTL7A in the brain. METTL7A is commonly located in the endoplasmic reticulum and to a lesser extent, in the lipid droplets of some cells. Several studies have reported altered protein and RNA levels in different brain areas in schizophrenia. One of these studies found reduced protein levels of METTL7A in the cerebellar cortex in schizophrenia and stress murine models. Since there is limited information in the literature about METTL7A, we characterized its cellular and subcellular localizations in the human cerebellum using immunohistochemical analysis with laser confocal microscopy. Our study reveals a novel METTL7A localization in GFAP-positive cells, with higher expression in the end-feet of the Bergmann glia, which participate in the cerebrospinal fluid\u2013brain parenchyma barrier. Further 3D reconstruction image analysis showed that METTL7A was expressed in the contacts between the Bergmann glia and Purkinje neurons. METTL7A was also detected in lipid droplets in some cells in the white matter. The localization of METTL7A in the human cerebellar glia limitans could suggest a putative role in maintaining the cerebellar parenchyma homeostasis and in the regulation of internal cerebellar circuits by modulating the synaptic activity of Purkinje neurons.<\/jats:p>","DOI":"10.3390\/ijms24098405","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T03:34:53Z","timestamp":1683516893000},"page":"8405","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Novel Localization of METTL7A in Bergmann Glial Cells in Human Cerebellum"],"prefix":"10.3390","volume":"24","author":[{"given":"Am\u00e9rica","family":"Vera-Montecinos","sequence":"first","affiliation":[{"name":"Psiquiatria Molecular, Parc Sanitari Sant Joan de D\u00e9u, Institut de Recerca Sant Joan de D\u00e9u, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Galiano-Landeira","sequence":"additional","affiliation":[{"name":"Psiquiatria Molecular, Parc Sanitari Sant Joan de D\u00e9u, Institut de Recerca Sant Joan de D\u00e9u, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9530-6234","authenticated-orcid":false,"given":"M\u00f2nica","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Unitat de Microsc\u00f2pia Confocal i Imatge Cel\u00b7lular, Servei de Medicina Gen\u00e8tica i Molecular, Institut Pedi\u00e0tric de Malalties Rares (IPER), Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, 08950 Barcelona, Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u, Esplugues de Llobregat, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Vidal-Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Psiquiatria Molecular, Parc Sanitari Sant Joan de D\u00e9u, Institut de Recerca Sant Joan de D\u00e9u, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-7906","authenticated-orcid":false,"given":"Enrique","family":"Claro","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Ramos","sequence":"additional","affiliation":[{"name":"Psiquiatria Molecular, Parc Sanitari Sant Joan de D\u00e9u, Institut de Recerca Sant Joan de D\u00e9u, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM (Biomedical Network Research Center of Mental Health), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Faculty of Medicine, University of Vic-Central University of Catalonia, 08500 Vic, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13046-021-02209-w","article-title":"Induction of M6A Methylation in Adipocyte Exosomal LncRNAs Mediates Myeloma Drug Resistance","volume":"41","author":"Wang","year":"2022","journal-title":"J. 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