{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:53:23Z","timestamp":1784217203400,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Green Industry Science and Technology Leading Project of Hubei University of Technology","award":["XJ2021003301"],"award-info":[{"award-number":["XJ2021003301"]}]},{"name":"Green Industry Science and Technology Leading Project of Hubei University of Technology","award":["Y-HR2019-0325"],"award-info":[{"award-number":["Y-HR2019-0325"]}]},{"name":"Open Project Funding of Key Laboratory of Fermentation Engineering (Ministry of Education)","award":["XJ2021003301"],"award-info":[{"award-number":["XJ2021003301"]}]},{"name":"Open Project Funding of Key Laboratory of Fermentation Engineering (Ministry of Education)","award":["Y-HR2019-0325"],"award-info":[{"award-number":["Y-HR2019-0325"]}]},{"name":"Chinese Society of Clinical Oncology (CSCO) Jiangsu Hengrui Cancer Research Foundation","award":["XJ2021003301"],"award-info":[{"award-number":["XJ2021003301"]}]},{"name":"Chinese Society of Clinical Oncology (CSCO) Jiangsu Hengrui Cancer Research Foundation","award":["Y-HR2019-0325"],"award-info":[{"award-number":["Y-HR2019-0325"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chemotherapy-induced alopecia (CIA) is one of the common side effects in cancer treatment. The psychological distress caused by hair loss may cause patients to discontinue chemotherapy, affecting the efficacy of the treatment. The JAK inhibitor, Tofacitinib citrate (TFC), showed huge potential in therapeutic applications for treating baldness, but the systemic adverse effects of oral administration and low absorption rate at the target site limited its widespread application in alopecia. To overcome these problems, we designed phospholipid-calcium carbonate hybrid nanoparticles (PL\/ACC NPs) for a topical application to target deliver TFC. The results proved that PL\/ACC-TFC NPs showed excellent pH sensitivity and transdermal penetration in vitro. PL\/ACC NPs offered an efficient follicular targeting approach to deliver TFC in a Cyclophosphamide (CYP)-induced alopecia areata mouse model. Compared to the topical application of TFC solution, PL\/ACC-TFC NPs significantly inhibited apoptosis of mouse hair follicles and accelerated hair growth. These findings support that PL\/ACC-TFC NPs has the potential for topical application in preventing and mitigating CYP-induced Alopecia areata.<\/jats:p>","DOI":"10.3390\/ijms24098427","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T02:28:08Z","timestamp":1683599288000},"page":"8427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarrier Controls Chemotherapy-Induced Alopecia Areata"],"prefix":"10.3390","volume":"24","author":[{"given":"Yeneng","family":"Guan","sequence":"first","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqin","family":"Yan","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiang","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ruan","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaobo","family":"Yang","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ma","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-8857","authenticated-orcid":false,"given":"Hongmei","family":"Sun","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Zhu","sequence":"additional","affiliation":[{"name":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, School of Food and Biological Engineering, Hubei University of 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