{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:54:45Z","timestamp":1767970485915,"version":"3.49.0"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Micro RNAs (miRNAs) are a type of non-coding RNA (ncRNA) and typically interact with specific target mRNAs through complementary base pairing, affecting their translation and\/or stability. MiRNAs regulate nearly all cellular functions, including the cell fate of mesenchymal stromal cells (MSCs). It is now accepted that various pathologies arise at the stem level, and, in this scenario, the role played by miRNAs in the fate of MSCs becomes of primary concern. Here we have considered the existing literature in the field of miRNAs, MSCs and skin diseases, classified as inflammatory (such as psoriasis and atopic dermatitis-AD) and neoplastic (melanoma and non-melanoma-skin-cancer including squamous cell and basal cell carcinoma) diseases. In this scoping review article, the evidence recovered indicates that this topic has attracted attention, but it is still a matter of opinion. A protocol for this review was registered in PROSPERO with the registration number \u201cCRD42023420245\u201d. According to the different skin disorders and to the specific cellular mechanisms considered (cancer stem cells, extracellular vesicles, inflammation), miRNAs may play a pro- or anti-inflammatory, as well as a tumor suppressive, or supporting, role, indicating a complex regulation of their function. It is evident that the mode of action of miRNAs is more than a switch on\u2013off, and all the observed effects of their dysregulated expression must be checked in a detailed analysis of the targeted proteins. The involvement of miRNAs has been studied mainly for squamous cell carcinoma and melanoma, and much less in psoriasis and AD; different mechanisms have been considered, such as miRNAs included in extracellular vesicles derived both from MSCs or tumor cells, miRNAs involved in cancer stem cells formation, up to miRNAs as candidates to be new therapeutic tools.<\/jats:p>","DOI":"10.3390\/ijms24108502","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T03:32:27Z","timestamp":1683689547000},"page":"8502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["miRNAs, Mesenchymal Stromal Cells and Major Neoplastic and Inflammatory Skin Diseases: A Page Being Written: A Systematic Review"],"prefix":"10.3390","volume":"24","author":[{"given":"Mariangela","family":"Di Vincenzo","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Sciences\u2014Histology, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-1742","authenticated-orcid":false,"given":"Federico","family":"Diotallevi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences\u2014Dermatological Clinic, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Public Health\u2014Pharmacology, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-5991","authenticated-orcid":false,"given":"Gianluca","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Universit\u00e0 di Modena e Reggio Emilia, 41121 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Offidani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences\u2014Dermatological Clinic, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3740-0839","authenticated-orcid":false,"given":"Anna","family":"Campanati","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences\u2014Dermatological Clinic, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-3693","authenticated-orcid":false,"given":"Monia","family":"Orciani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences\u2014Histology, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"596.e1","DOI":"10.1016\/j.ajog.2019.12.016","article-title":"From 2646 to 15: Differentially regulated microRNAs between progenitors from normal myometrium and leiomyoma","volume":"222","author":"Lazzarini","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_3","first-page":"161","article-title":"The Role of MicroRNAs in Human Diseases","volume":"2","author":"Ardekani","year":"2010","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s12015-020-10095-6","article-title":"MicroRNA Profiling in Mesenchymal Stromal Cells: The Tissue Source as the Missing Piece in the Puzzle of Ageing","volume":"17","author":"Iezzi","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/B978-0-12-386015-6.00033-0","article-title":"MicroRNAs and mesenchymal stem cells","volume":"87","author":"Collino","year":"2011","journal-title":"Vitam. Horm."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Schoolmeesters, A., Eklund, T., Leake, D., Vermeulen, A., Smith, Q., Force Aldred, S., and Fedorov, Y. (2009). Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005605"},{"key":"ref_7","first-page":"696","article-title":"miRNA-429 suppresses osteogenic differentiation of human adipose-derived mesenchymal stem cells under oxidative stress via targeting SCD-1","volume":"19","author":"Lan","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"759596","DOI":"10.3389\/fgene.2021.759596","article-title":"TGF-Beta Induced Key Genes of Osteogenic and Adipogenic Differentiation in Human Mesenchymal Stem Cells and MiRNA-mRNA Regulatory Networks","volume":"12","author":"Du","year":"2021","journal-title":"Front. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1001\/jamadermatol.2018.2516","article-title":"Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa","volume":"154","author":"Campanati","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"816229","DOI":"10.3389\/fendo.2022.816229","article-title":"Mesenchymal Stem Cells Exposed to Persistently High Glucocorticoid Levels Develop Insulin-Resistance and Altered Lipolysis: A Promising In Vitro Model to Study Cushing\u2019s Syndrome","volume":"13","author":"Martino","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bonifazi, M., Di Vincenzo, M., Caffarini, M., Mei, F., Salati, M., Zuccatosta, L., Refai, M., Mattioli-Belmonte, M., Gasparini, S., and Orciani, M. (2020). How the Pathological Microenvironment Affects the Behavior of Mesenchymal Stem Cells in the Idiopathic Pulmonary Fibrosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218140"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1716246","DOI":"10.1155\/2018\/1716246","article-title":"Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells","volume":"2018","author":"Orciani","year":"2018","journal-title":"Stem. Cells Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/bjd.19892","article-title":"The less-known face of dupilumab: Its role in mesenchymal stem cells by interleukin-13 modulation","volume":"185","author":"Campanati","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00011-020-01412-3","article-title":"The efficacy of in vivo administration of Apremilast on mesenchymal stem cells derived from psoriatic patients","volume":"70","author":"Campanati","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Campanati, A., Orciani, M., Marani, A., Di Vincenzo, M., Magi, S., Gregoriou, S., Diotallevi, F., Martina, E., Radi, G., and Offidani, A. (2022). Mesenchymal Stem Cells Profile in Adult Atopic Dermatitis and Effect of IL4-IL13 Inflammatory Pathway Inhibition In Vivo: Prospective Case-Control Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11164759"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1111\/jdv.16058","article-title":"Mesenchymal stem cell profile in actinic keratosis and its modification after topical application of ingenol mebutate","volume":"34","author":"Campanati","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fcell.2019.00227","article-title":"Cushing Syndrome: The Role of MSCs in Wound Healing, Immunosuppression, Comorbidities, and Antioxidant Imbalance","volume":"7","author":"Caffarini","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1545784","DOI":"10.1155\/2018\/1545784","article-title":"Mesenchymal Stem Cells from Cervix and Age: New Insights into CIN Regression Rate","volume":"2018","author":"Orciani","year":"2018","journal-title":"Oxid Med. Cell Longev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12031-018-1216-x","article-title":"Mesenchymal Stem Cells from Nucleus Pulposus and Neural Differentiation Potential: A Continuous Challenge","volume":"67","author":"Lazzarini","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fphys.2018.00547","article-title":"Use of a 3D Floating Sphere Culture System to Maintain the Neural Crest-Related Properties of Human Dental Pulp Stem Cells","volume":"9","author":"Pisciotta","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Di Vincenzo, M., De Quattro, C., Rossato, M., Lazzarini, R., Delli Carpini, G., Ciavattini, A., and Orciani, M. (2022). A Possible Cause for the Differential Expression of a Subset of miRNAs in Mesenchymal Stem Cells Derived from Myometrium and Leiomyoma. Genes, 13.","DOI":"10.3390\/genes13071106"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41417-020-00291-4","article-title":"Roles of miRNA dysregulation in the pathogenesis of multiple myeloma","volume":"28","author":"Chen","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.7150\/thno.55664","article-title":"The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies","volume":"11","author":"Iaquinta","year":"2021","journal-title":"Theranostics"},{"key":"ref_24","first-page":"6685605","article-title":"Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Hepatic Stellate Cell Activation and Liver Fibrosis by Upregulating MicroRNA-455-3p through Suppression of p21-Activated Kinase-2","volume":"2021","author":"Zhou","year":"2021","journal-title":"Biomed Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41388-020-01486-7","article-title":"Mesenchymal stem cells-derived exosomal microRNA-139-5p restrains tumorigenesis in bladder cancer by targeting PRC1","volume":"40","author":"Jia","year":"2021","journal-title":"Oncogene"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/08916934.2020.1750011","article-title":"MiR-153-3p induces immune dysregulation by inhibiting PELI1 expression in umbilical cord-derived mesenchymal stem cells in patients with systemic lupus erythematosus","volume":"53","author":"Li","year":"2020","journal-title":"Autoimmunity"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.1038\/s41598-019-44536-1","article-title":"Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B","volume":"9","author":"Vishnubalaji","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: Towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3233\/CBM-210409","article-title":"Human mesenchymal stem cell derived exosomes inhibit the survival of human melanoma cells through modulating miR-138-5p\/SOX4 pathway","volume":"34","author":"Wang","year":"2022","journal-title":"Cancer Biomark."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41417-021-00392-8","article-title":"NEAT1 in bone marrow mesenchymal stem cell-derived extracellular vesicles promotes melanoma by inducing M2 macrophage polarization","volume":"29","author":"Yang","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.3389\/fimmu.2019.02459","article-title":"Melanoma-Derived Exosomes Induce PD-1 Overexpression and Tumor Progression via Mesenchymal Stem Cell Oncogenic Reprogramming","volume":"10","author":"Harmati","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_32","first-page":"261","article-title":"An integrative analysis of the micro-RNAs contributing in stemness, metastasis and B-Raf pathways in malignant melanoma and melanoma stem cell","volume":"23","author":"Sahranavardfard","year":"2021","journal-title":"Cell J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1515\/cmble-2015-0025","article-title":"Evaluation of the expressions pattern of MIR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells","volume":"20","author":"Fomeshi","year":"2015","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20193","DOI":"10.1002\/jcp.28619","article-title":"MicroRNA-203 reinforces stemness properties in melanoma and augments tumorigenesis in vivo","volume":"234","author":"Sahranavardfard","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/15476286.2021.1950463","article-title":"STAT3-induced ZBED3-AS1 promotes the malignant phenotypes of melanoma cells by activating PI3K\/AKT signaling pathway","volume":"18","author":"Wang","year":"2021","journal-title":"RNA Biol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Divisato, G., Piscitelli, S., Elia, M., Cascone, E., and Parisi, S. (2021). Micrornas and stem-like properties: The complex regulation underlying stemness maintenance and cancer development. Biomolecules, 11.","DOI":"10.3390\/biom11081074"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biocel.2016.11.004","article-title":"Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer","volume":"81","author":"Maadi","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13046-021-01840-x","article-title":"The roles of extracellular vesicles in the development, microenvironment, anticancer drug resistance, and therapy of head and neck squamous cell carcinoma","volume":"40","author":"Wang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Panvongsa, W., Pegtel, D.M., and Voortman, J. (2022). More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma. Cancers, 14.","DOI":"10.3390\/cancers14051160"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fitriana, M., Hwang, W.-L., Chan, P.Y., Hsueh, T.Y., and Liao, T.T. (2021). Roles of micrornas in regulating cancer stemness in head and neck cancers. Cancers, 13.","DOI":"10.3390\/cancers13071742"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/MOO.0b013e32835e1d6e","article-title":"MicroRNA aberrances in head and neck cancer: Pathogenetic and clinical significance","volume":"21","author":"Tu","year":"2013","journal-title":"Curr. Opin. Otolaryngol. Head. Neck. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.neo.2017.09.003","article-title":"Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells","volume":"19","author":"Subramanian","year":"2017","journal-title":"Neoplasia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/jcb.26379","article-title":"MicroRNA-142-5p induces cancer stem cell-like properties of cutaneous squamous cell carcinoma via inhibiting PTEN","volume":"119","author":"Bai","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13287-020-1576-3","article-title":"MicroRNA-495 confers inhibitory effects on cancer stem cells in oral squamous cell carcinoma through the HOXC6-mediated TGF-\u03b2 signaling pathway","volume":"11","author":"You","year":"2020","journal-title":"Stem Cell. Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20180","DOI":"10.18632\/oncotarget.7745","article-title":"Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis","volume":"7","author":"Yu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"651692","DOI":"10.3389\/fonc.2021.651692","article-title":"MiRNA-146a\/AKT\/\u03b2-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24","volume":"11","author":"Ghuwalewala","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13046-019-1300-2","article-title":"ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation","volume":"38","author":"Liu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12015-020-10082-x","article-title":"Preclinical Experimental Applications of miRNA Loaded BMSC Extracellular Vesicles","volume":"17","author":"Cetin","year":"2021","journal-title":"Stem. Cell. Rev. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/bjd.16659","article-title":"MiR-146a-5p correlates with clinical efficacy in patients with psoriasis treated with the tumour necrosis factor-alpha inhibitor adalimumab","volume":"179","author":"Recchioni","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11945","DOI":"10.18632\/oncotarget.7858","article-title":"Anti-TNF-\u03b1 treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells","volume":"7","author":"Prattichizzo","year":"2016","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2133.2011.10438.x","article-title":"The mesenchymal stem cell profile in psoriasis","volume":"165","author":"Orciani","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00403-014-1493-3","article-title":"Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17\/Th2 imbalance of psoriasis","volume":"306","author":"Campanati","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/exd.13139","article-title":"TNF-\u03b1 inhibitors reduce the pathological Th1 -Th17 \/Th2 imbalance in cutaneous mesenchymal stem cells of psoriasis patients","volume":"26","author":"Campanati","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2133.2012.10900.x","article-title":"Effect of biologic therapies targeting tumour necrosis factor-\u03b1 on cutaneous mesenchymal stem cells in psoriasis","volume":"167","author":"Campanati","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/cei.13141","article-title":"Indirect co-cultures of healthy mesenchymal stem cells restore the physiological phenotypical profile of psoriatic mesenchymal stem cells","volume":"193","author":"Campanati","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1684\/ejd.2018.3483","article-title":"Characterisation of the circular RNA landscape in mesenchymal stem cells from psoriatic skin lesions","volume":"29","author":"Liu","year":"2019","journal-title":"Eur. J. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/ijd.14197","article-title":"Levels of miR-31 and its target genes in dermal mesenchymal cells of patients with psoriasis","volume":"58","author":"Wang","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Hou, R.X., Liu, R.F., Zhao, X.C., Jia, Y.R., An, P., Hao, Z.P., Li, J.Q., Li, X.H., Yin, G.H., and Zhang, K.M. (2016). Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: Comparing the microRNA expression profile by microarray. Genet. Mol. Res., 15.","DOI":"10.4238\/gmr.15038631"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jdermsci.2022.02.001","article-title":"MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells","volume":"105","author":"Liu","year":"2022","journal-title":"J. Dermatol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/1346-8138.15369","article-title":"Role of SPRED1 in keratinocyte proliferation in psoriasis","volume":"47","author":"Li","year":"2020","journal-title":"J. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/JID.2015.409","article-title":"microRNAs in psoriasis","volume":"136","author":"Hawkes","year":"2016","journal-title":"J. Investig. Dermatol"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3389\/fphar.2018.01175","article-title":"Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1\/Th2 Responses","volume":"9","author":"Kim","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.2217\/fon-2020-0151","article-title":"Cancer stem cells, epigenetics, tumor microenvironment and future therapeutics in cutaneous malignant melanoma: A review","volume":"16","author":"Kyriakou","year":"2020","journal-title":"Future Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/jnci\/djt003","article-title":"The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression","volume":"105","author":"Dar","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1007\/s11033-021-06666-6","article-title":"The emerging role of miR-200 family in metastasis: Focus on EMT, CSCs, angiogenesis, and anoikis","volume":"48","author":"Babaei","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00106-014-2931-4","article-title":"Cancer stem cell phenotypes and miRNA","volume":"62","author":"Coordes","year":"2014","journal-title":"HNO"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e05436","DOI":"10.1016\/j.heliyon.2020.e05436","article-title":"MicroRNA profile in the squamous cell carcinoma: Prognostic and diagnostic roles","volume":"6","author":"Gholipour","year":"2020","journal-title":"Heliyon"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13046-020-01631-w","article-title":"Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-375 to downregulate ENAH and thus retard esophageal squamous cell carcinoma progression","volume":"39","author":"He","year":"2020","journal-title":"J. Exp. Clin. Can. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neo.2018.12.001","article-title":"PRRX1 Regulates Cellular Phenotype Plasticity and Dormancy of Head and Neck Squamous Cell Carcinoma Through miR-642b-3p","volume":"21","author":"Jiang","year":"2019","journal-title":"Neoplasia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"790589","DOI":"10.3389\/fonc.2021.790589","article-title":"The Role of Circular RNAs in the Drug Resistance of Cancers","volume":"11","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/cac2.12138","article-title":"EMT-associated microRNAs and their roles in cancer stemness and drug resistance","volume":"41","author":"Pan","year":"2021","journal-title":"Cancer Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"732702","DOI":"10.3389\/fonc.2021.732702","article-title":"Small Extracellular Vesicles in the Development, Diagnosis, and Possible Therapeutic Application of Esophageal Squamous Cell Carcinoma","volume":"11","author":"Zhao","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1128\/MCB.00079-16","article-title":"Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer","volume":"36","author":"Zhong","year":"2016","journal-title":"Mol. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/jcmm.17161","article-title":"MicroRNA-381 in human cancer: Its involvement in tumour biology and clinical applications potential","volume":"26","author":"Sha","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Takeda, Y.S., and Xu, Q. (2015). Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135111"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s13046-021-02193-1","article-title":"Novel approaches in cancer treatment: Preclinical and clinical development of small non-coding RNA therapeutics","volume":"40","author":"Cuciniello","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lungcan.2015.11.013","article-title":"Hsa-miR-1246 and hsa-miR-1290 are associated with stemness and invasiveness of non-small cell lung cancer","volume":"91","author":"Kim","year":"2016","journal-title":"Lung Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jiao, X., Qian, X., Wu, L., Li, B., Wang, Y., Kong, X., and Xiong, L. (2019). MicroRNA: The impact on cancer stemness and therapeutic resistance. Cells, 9.","DOI":"10.3390\/cells9010008"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1111\/jcmm.15054","article-title":"Long non-coding RNAs: How to regulate the metastasis of non\u2013small-cell lung cancer","volume":"24","author":"Fang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Korfiati, A., Grafanaki, K., Kyriakopoulos, G.C., Skeparnias, I., Georgiou, S., Sakellaropoulos, G., and Stathopoulos, C. (2022). Revisiting miRNA Association with Melanoma Recurrence and Metastasis from a Machine Learning Point of View. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031299"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Ohno, S.I., Drummen, G.P.C., and Kuroda, M. (2016). Focus on extracellular vesicles: Development of extracellular vesicle-based therapeutic systems. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17020172"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"857714","DOI":"10.3389\/fonc.2022.857714","article-title":"miR-139-5p Was Identified as Biomarker of Different Molecular Subtypes of Breast Carcinoma","volume":"12","author":"Sun","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.3748\/wjg.v22.i29.6652","article-title":"MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling","volume":"22","author":"Hyun","year":"2016","journal-title":"World J. Gastroenterol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/10\/8502\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:32:18Z","timestamp":1760124738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/10\/8502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":84,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["ijms24108502"],"URL":"https:\/\/doi.org\/10.3390\/ijms24108502","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]}}}