{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:43:56Z","timestamp":1790765036943,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Normandie Region (S\u00e9SAD research network, France)"},{"name":"European Union in the framework of the ERDF-ESF program 2014\u20132020 RN3A"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A series of 6-polyaminosteroid analogues of squalamine were synthesized with moderate to good yields and evaluated for their in vitro antimicrobial properties against both susceptible and resistant Gram-positive (vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus) and Gram-negative (carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa) bacterial strains. Minimum inhibitory concentrations against Gram-positive bacteria ranged from 4 to 16 \u00b5g\/mL for the most effective compounds, 4k and 4n, and showed an additive or synergistic effect with vancomycin or oxacillin. On the other hand, the derivative 4f, which carries a spermine moiety like that of the natural trodusquemine molecule, was found to be the most active derivative against all the resistant Gram-negative bacteria tested, with an MIC value of 16 \u00b5g\/mL. Our results suggest that 6-polyaminosteroid analogues of squalamine are interesting candidates for Gram-positive bacterial infection treatments, as well as potent adjuvants to fight Gram-negative bacterial resistance.<\/jats:p>","DOI":"10.3390\/ijms24108568","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T03:22:19Z","timestamp":1683775339000},"page":"8568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["6-Polyaminosteroid Squalamine Analogues Display Antibacterial Activity against Resistant Pathogens"],"prefix":"10.3390","volume":"24","author":[{"given":"Delphine","family":"Vergoz","sequence":"first","affiliation":[{"name":"Polymers, Biopolymers, Surfaces Laboratory, University of Rouen Normandie, INSA Rouen, CNRS, UMR 6270, 76000 Rouen, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-438X","authenticated-orcid":false,"given":"Sylvie","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Communication Bact\u00e9rienne et Strat\u00e9gies Anti-Infectieuses, University of Rouen Normandie, CBSA, 27000 Evreux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-1920","authenticated-orcid":false,"given":"C\u00e9cile","family":"Muller","sequence":"additional","affiliation":[{"name":"Communication Bact\u00e9rienne et Strat\u00e9gies Anti-Infectieuses, UNICAEN, Normandie University, UR4312, CBSA, 14032 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-1649","authenticated-orcid":false,"given":"Emmanuelle","family":"D\u00e9","sequence":"additional","affiliation":[{"name":"Polymers, Biopolymers, Surfaces Laboratory, University of Rouen 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