{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:09:39Z","timestamp":1760148579843,"version":"build-2065373602"},"reference-count":103,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)","award":["SEI-260003\/001147\/2020."],"award-info":[{"award-number":["SEI-260003\/001147\/2020."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Some transcripts that are not translated into proteins can be encoded by the mammalian genome. Long noncoding RNAs (lncRNAs) are noncoding RNAs that can function as decoys, scaffolds, and enhancer RNAs and can regulate other molecules, including microRNAs. Therefore, it is essential that we obtain a better understanding of the regulatory mechanisms of lncRNAs. In cancer, lncRNAs function through several mechanisms, including important biological pathways, and the abnormal expression of lncRNAs contributes to breast cancer (BC) initiation and progression. BC is the most common type of cancer among women worldwide and has a high mortality rate. Genetic and epigenetic alterations that can be regulated by lncRNAs may be related to early events of BC progression. Ductal carcinoma in situ (DCIS) is a noninvasive BC that is considered an important preinvasive BC early event because it can progress to invasive BC. Therefore, the identification of predictive biomarkers of DCIS-invasive BC progression has become increasingly important in an attempt to optimize the treatment and quality of life of patients. In this context, this review will address the current knowledge about the role of lncRNAs in DCIS and their potential contribution to the progression of DCIS to invasive BC.<\/jats:p>","DOI":"10.3390\/ijms24108733","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:56:57Z","timestamp":1684119417000},"page":"8733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetic Alterations in DCIS Progression: What Can lncRNAs Teach Us?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-3760","authenticated-orcid":false,"given":"Igor","family":"Petrone","sequence":"first","affiliation":[{"name":"Stem Cell Laboratory, Center for Bone Marrow Transplants, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"},{"name":"Stricto Sensu Graduate Program in Oncology, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-5325","authenticated-orcid":false,"given":"Everton Cruz dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Center for Bone Marrow Transplants, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"},{"name":"Stricto Sensu Graduate Program in Oncology, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Binato","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Center for Bone Marrow Transplants, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"},{"name":"Stricto Sensu Graduate Program in Oncology, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-0832","authenticated-orcid":false,"given":"Eliana","family":"Abdelhay","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Center for Bone Marrow Transplants, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"},{"name":"Stricto Sensu Graduate Program in Oncology, Brazilian National Cancer Institute\u2014INCA, Rio de Janeiro 20230-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e944014","DOI":"10.4161\/21541272.2014.944014","article-title":"Long Non-Coding RNAs as Emerging Regulators of Differentiation, Development, and Disease","volume":"5","author":"Dey","year":"2014","journal-title":"Transcription"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tcb.2011.04.001","article-title":"Long Noncoding RNAs and Human Disease","volume":"21","author":"Wapinski","year":"2011","journal-title":"Trends Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/cmdc.201300534","article-title":"Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease","volume":"9","author":"Bhan","year":"2014","journal-title":"ChemMedChem"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.coph.2012.02.001","article-title":"MicroRNAs Regulate and Provide Robustness to the Myogenic Transcriptional Network","volume":"12","author":"Gagan","year":"2012","journal-title":"Curr. 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