{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:24:17Z","timestamp":1790745857913,"version":"4.1.0"},"reference-count":259,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Sciences and Engineering Research Council of Canada","award":["RGPIN-2016-04414"],"award-info":[{"award-number":["RGPIN-2016-04414"]}]},{"name":"National Sciences and Engineering Research Council of Canada","award":["RGPIN-2017-05508"],"award-info":[{"award-number":["RGPIN-2017-05508"]}]},{"name":"National Sciences and Engineering Research Council of Canada","award":["PJT-186175"],"award-info":[{"award-number":["PJT-186175"]}]},{"name":"the Canadian Institutes of Health Research","award":["RGPIN-2016-04414"],"award-info":[{"award-number":["RGPIN-2016-04414"]}]},{"name":"the Canadian Institutes of Health Research","award":["RGPIN-2017-05508"],"award-info":[{"award-number":["RGPIN-2017-05508"]}]},{"name":"the Canadian Institutes of Health Research","award":["PJT-186175"],"award-info":[{"award-number":["PJT-186175"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Calcium is a highly positively charged ionic species. It regulates all cell types\u2019 functions and is an important second messenger that controls and triggers several mechanisms, including membrane stabilization, permeability, contraction, secretion, mitosis, intercellular communications, and in the activation of kinases and gene expression. Therefore, controlling calcium transport and its intracellular homeostasis in physiology leads to the healthy functioning of the biological system. However, abnormal extracellular and intracellular calcium homeostasis leads to cardiovascular, skeletal, immune, secretory diseases, and cancer. Therefore, the pharmacological control of calcium influx directly via calcium channels and exchangers and its outflow via calcium pumps and uptake by the ER\/SR are crucial in treating calcium transport remodeling in pathology. Here, we mainly focused on selective calcium transporters and blockers in the cardiovascular system.<\/jats:p>","DOI":"10.3390\/ijms24108803","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:37:51Z","timestamp":1684204671000},"page":"8803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System"],"prefix":"10.3390","volume":"24","author":[{"given":"Ghassan","family":"Bkaily","sequence":"first","affiliation":[{"name":"Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-4939-6625-7_14","article-title":"Intracellular Free Calcium Measurement Using Confocal Imaging","volume":"1527","author":"Bkaily","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1139\/cjpp-2014-0519","article-title":"Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells","volume":"93","author":"Bkaily","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1139\/cjpp-2017-0290","article-title":"Neuropeptide Y and its receptors in ventricular endocardial endothelial cells","volume":"95","author":"Jacques","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dhalla, N.S., Bhullar, S.K., and Shah, A.K. (2023). The Renin Angiotensin System in Cardiovascular Disease, Springer. Advances in Biochemistry in Health and Disease.","DOI":"10.1007\/978-3-031-14952-8"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/27094","article-title":"Calcium\u2014A life and death signal","volume":"395","author":"Berridge","year":"1998","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1440-1681.2007.04726.x","article-title":"Intracellular calcium in the fertilization and development of mammalian eggs","volume":"34","author":"Jones","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1139\/cjpp-2020-0399","article-title":"Vascular smooth muscle remodeling in health and disease","volume":"99","author":"Bkaily","year":"2021","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00226779","article-title":"Implication of the nucleus in excitation contraction coupling of heart cells","volume":"154","author":"Bkaily","year":"1996","journal-title":"Mol. Cell. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00204-022-03385-0","article-title":"Role of Ca2+ in healthy and pathologic cardiac function: From normal excitation-contraction coupling to mutations that cause inherited arrhythmia","volume":"97","author":"Keefe","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"BSR20211997","DOI":"10.1042\/BSR20211997","article-title":"Skeletal and cardiac muscle calcium transport regulation in health and disease","volume":"42","author":"Valentim","year":"2022","journal-title":"Biosci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bkaily, G., and Jacques, D. (2023). Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031998"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2013.10.072","article-title":"Calcium channels, external calcium concentration and cell proliferation","volume":"739","author":"Borowiec","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_13","first-page":"671","article-title":"Calcium signalling and control of cell proliferation by tyrosine kinase receptors (review)","volume":"10","author":"Munaron","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.2174\/092986709789878210","article-title":"Endothelial calcium machinery and angiogenesis: Understanding physiology to interfere with pathology","volume":"16","author":"Munaron","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1090765","DOI":"10.3389\/fcell.2022.1090765","article-title":"Targeting N-type calcium channels in young-onset of some neurological diseases","volume":"10","author":"Antunes","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2010.10.005","article-title":"Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells","volume":"50","author":"Avedanian","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1139\/Y08-115","article-title":"Nuclear membrane receptors and channels as targets for drug development in cardiovascular diseases","volume":"87","author":"Bkaily","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ceca.2006.09.002","article-title":"Calcium microdomains: Organization and function","volume":"40","author":"Berridge","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102670","DOI":"10.1016\/j.ceca.2022.102670","article-title":"TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP(3) receptors","volume":"108","author":"Curcic","year":"2022","journal-title":"Cell Calcium"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e162602","DOI":"10.1172\/jci.insight.162602","article-title":"Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains","volume":"7","author":"Ren","year":"2022","journal-title":"JCI Insight"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1073\/pnas.0610741104","article-title":"Imaging synaptosomal calcium concentration microdomains and vesicle fusion by using total internal reflection fluorescent microscopy","volume":"104","author":"Serulle","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1038\/s41598-023-30189-8","article-title":"The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses","volume":"13","author":"Toman","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0005-2736(94)90202-X","article-title":"Interaction of cord factor (alpha, alpha\u2019-trehalose-6,6\u2019-dimycolate) with phospholipids","volume":"1194","author":"Crowe","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1529\/biophysj.107.124909","article-title":"Modeling study of the effects of membrane surface charge on calcium microdomains and neurotransmitter release","volume":"95","author":"Catacuzzeno","year":"2008","journal-title":"Biophys. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7477","DOI":"10.1039\/D2CP05137K","article-title":"Surface charge density governs the ionic current rectification direction in asymmetric graphene oxide channels","volume":"25","author":"Li","year":"2023","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2220649120","DOI":"10.1073\/pnas.2220649120","article-title":"L-type Ca2+ channels mediate regulation of glutamate release by subthreshold potential changes","volume":"120","author":"Lee","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","first-page":"1472","article-title":"Distinctions in the molecular determinants of charged and neutral dihydropyridine block of L-type calcium channels","volume":"289","author":"An","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1152\/physrev.1979.59.3.606","article-title":"Mechanisms of action of transmitters and other substances on smooth muscle","volume":"59","author":"Bolton","year":"1979","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/jphysiol.1988.sp016916","article-title":"Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells","volume":"395","author":"Hagiwara","year":"1988","journal-title":"J. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.RES.0000256155.31133.49","article-title":"Ca2+ channel subtypes and pharmacology in the kidney","volume":"100","author":"Hayashi","year":"2007","journal-title":"Circ. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0143-4160(02)00239-7","article-title":"Pharmacological modulators of voltage-gated calcium channels and their therapeutical application","volume":"33","author":"Kochegarov","year":"2003","journal-title":"Cell Calcium"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/316391a0","article-title":"A variety of calcium channels","volume":"316","author":"Reuter","year":"1985","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/BF01945518","article-title":"Calcium channel modulation by beta-adrenergic neurotransmitters in the heart","volume":"43","author":"Reuter","year":"1987","journal-title":"Experientia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.ph.45.030183.002013","article-title":"Calcium channels in excitable cell membranes","volume":"45","author":"Tsien","year":"1983","journal-title":"Annu. Rev. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0022-2828(86)80941-5","article-title":"Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists","volume":"18","author":"Tsien","year":"1986","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev.bb.16.060187.001405","article-title":"Calcium channels: Mechanisms of selectivity, permeation, and block","volume":"16","author":"Tsien","year":"1987","journal-title":"Annu. Rev. Biophys. Biophys. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0166-2236(88)90194-4","article-title":"Multiple types of neuronal calcium channels and their selective modulation","volume":"11","author":"Tsien","year":"1988","journal-title":"Trends Neurosci."},{"key":"ref_38","first-page":"167","article-title":"Sodium-calcium interactions in mammalian smooth muscle","volume":"30","author":"Aaronson","year":"1978","journal-title":"Pharmacol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"702264","DOI":"10.3389\/fphar.2021.702264","article-title":"Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11064-018-2491-1","article-title":"AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise","volume":"44","author":"Benke","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.pa.23.040183.002105","article-title":"Mechanisms of calcium antagonist-induced vasodilation","volume":"23","author":"Cauvin","year":"1983","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1748-1716.1984.tb07537.x","article-title":"Characterization of two different calcium entry pathways in small mesenteric arteries from rat","volume":"122","year":"1984","journal-title":"Acta Physiol. Scand."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjp.0704468","article-title":"The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle","volume":"135","author":"McFadzean","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_44","unstructured":"Jolles, G., and Cordier, A. (1992). In Vitro Methods in Toxicology, Academic Press."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1023\/B:JOBB.0000008029.22650.c5","article-title":"The voltage-gated calcium channel gamma subunits: A review of the literature","volume":"35","author":"Black","year":"2003","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/316443a0","article-title":"A novel type of cardiac calcium channel in ventricular cells","volume":"316","author":"Nilius","year":"1985","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/316440a0","article-title":"Three types of neuronal calcium channel with different calcium agonist sensitivity","volume":"316","author":"Nowycky","year":"1985","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2017.00286","article-title":"Discovery and Development of Calcium Channel Blockers","volume":"8","author":"Godfraind","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_49","first-page":"1","article-title":"Protective effects of gallopamil against ischemia and reperfusion damage","volume":"78","author":"Ferrari","year":"1989","journal-title":"Z. Kardiol."},{"key":"ref_50","first-page":"1259","article-title":"Mechanisms of action of antiarrhthmic drugs: A medical approach","volume":"Volume 2","author":"Fozzard","year":"1986","journal-title":"The Heart and Cardiovascular System"},{"key":"ref_51","first-page":"754","article-title":"Analytical and Bioanalytical Techniques for the Quantification of the Calcium Channel Blocker\u2014Amlodipine: A Critical Review","volume":"51","author":"Kokilambigai","year":"2021","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/cvr\/cvw006","article-title":"L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity","volume":"109","author":"Torrente","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2170\/jjphysiol.53.165","article-title":"The gating and conductance properties of Cav3.2 low-voltage-activated T-type calcium channels","volume":"53","author":"Kaku","year":"2003","journal-title":"Jpn. J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/456183a","article-title":"Ion channels: The voltage-sensor quartet","volume":"456","author":"Bankston","year":"2008","journal-title":"Nature"},{"key":"ref_55","first-page":"3","article-title":"Voltage-gated calcium channels","volume":"37","author":"Kamkin","year":"2006","journal-title":"Usp Fiziol. Nauk."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00584528","article-title":"Slow calcium and potassium currents in frog skeletal muscle: Their relationship and pharmacologic properties","volume":"405","author":"Palade","year":"1985","journal-title":"Pflugers Arch."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.pa.17.040177.001053","article-title":"Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle","volume":"17","author":"Fleckenstein","year":"1977","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_58","first-page":"321","article-title":"Calcium antagonism and calcium entry blockade","volume":"38","author":"Godfraind","year":"1986","journal-title":"Pharmacol. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109262","DOI":"10.1016\/j.neuropharm.2022.109262","article-title":"CACNA1C (Ca(V)1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology","volume":"220","author":"Harrison","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-3495(78)85489-7","article-title":"Ionic channels in excitable membranes. Current problems and biophysical approaches","volume":"22","author":"Hille","year":"1978","journal-title":"Biophys. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0378-5955(95)00191-3","article-title":"Voltage-dependent Ca2+ channels in the spiral ganglion cells of guinea pig cochlea","volume":"91","author":"Hisashi","year":"1995","journal-title":"Hearth Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0031018","article-title":"Molecular properties of calcium channels","volume":"114","author":"Glossmann","year":"1990","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BFb0031020","article-title":"Pharmacological modulation of voltage-dependent calcium channels in intact cells","volume":"114","author":"Porzig","year":"1990","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1139\/y03-044","article-title":"Modulation of intracellular Ca2+ via L-type calcium channels in heart cells by the autoantibody directed against the second extracellular loop of the alpha1-adrenoceptors","volume":"81","author":"Bkaily","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_65","first-page":"H630","article-title":"Injection of protein kinase inhibitor into cultured heart cells blocks calcium slow channels","volume":"246","author":"Bkaily","year":"1984","journal-title":"Am. J. Physiol."},{"key":"ref_66","first-page":"H745","article-title":"Injection of guanosine 5\u2019-cyclic monophosphate into heart cells blocks calcium slow channels","volume":"248","author":"Bkaily","year":"1985","journal-title":"Am. J. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00929507","article-title":"Regulation of the calcium slow channel by cyclic GMP dependent protein kinase in chick heart cells","volume":"148","author":"Haddad","year":"1995","journal-title":"Mol. Cell Biochem."},{"key":"ref_68","first-page":"25","article-title":"Calmodulin is required for a full activation of the calcium slow channels in heart cells","volume":"11","author":"Bkaily","year":"1986","journal-title":"J. Cyclic Nucleotide Protein Phosphor. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1073\/pnas.83.17.6656","article-title":"Multiple calcium channels mediate neurotransmitter release from peripheral neurons","volume":"83","author":"Perney","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF00583789","article-title":"Dihydropyridine inhibition of neuronal calcium current and substance P release","volume":"409","author":"Rane","year":"1987","journal-title":"Pflugers Arch."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0006-3495(02)75539-2","article-title":"Mechanism of inactivation gating of human T-type (low-voltage activated) calcium channels","volume":"82","author":"Burgess","year":"2002","journal-title":"Biophys. J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1085\/jgp.96.3.603","article-title":"Mechanism of gating of T-type calcium channels","volume":"96","author":"Chen","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1113\/jphysiol.1989.sp017890","article-title":"Kinetic properties of the cardiac T-type calcium channel in the guinea-pig","volume":"419","author":"Droogmans","year":"1989","journal-title":"J. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ceca.2006.04.027","article-title":"T-type Ca2+ channels in non-vascular smooth muscles","volume":"40","author":"Fry","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/jphysiol.1985.sp015697","article-title":"Regulation of cytosolic calcium concentration in presynaptic nerve endings isolated from rat brain","volume":"363","author":"Nachshen","year":"1985","journal-title":"J. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sharma, A., Rahman, G., Gorelik, J., and Bhargava, A. (2023). Voltage-Gated T-Type Calcium Channel Modulation by Kinases and Phosphatases: The Old Ones, the New Ones, and the Missing Ones. Cells, 12.","DOI":"10.3390\/cells12030461"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.aad3647","article-title":"Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression","volume":"351","author":"Li","year":"2016","journal-title":"Science"},{"key":"ref_79","unstructured":"Lux, H.D.C., and Zucker, H. (1988). The Calcium Channel: Structure, Function and Implication, Springer."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1987.sp016865","article-title":"Single-channel recordings of three types of calcium channels in chick sensory neurones","volume":"394","author":"Fox","year":"1987","journal-title":"J. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.2451291","article-title":"Amiloride selectively blocks the low threshold (T) calcium channel","volume":"240","author":"Tang","year":"1988","journal-title":"Science"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/jphysiol.2010.199497","article-title":"T-type calcium channels and vascular function: The new kid on the block?","volume":"589","author":"Kuo","year":"2011","journal-title":"J. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e13862","DOI":"10.14814\/phy2.13862","article-title":"Pacemaking in cardiac tissue. From IK2 to a coupled-clock system","volume":"7","author":"Carmeliet","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1085\/jgp.200208770","article-title":"Custom distinctions in the interaction of G-protein beta subunits with N-type (CaV2.2) versus P\/Q-type (CaV2.1) calcium channels","volume":"121","author":"Agler","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.2447647","article-title":"Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons","volume":"239","author":"Hirning","year":"1988","journal-title":"Science"},{"key":"ref_86","first-page":"28","article-title":"Does the motor nerve terminal have only one transmitter release system and only one species of Ca2+ channel","volume":"12","author":"Quastel","year":"1986","journal-title":"Soc. Neurosci. Abstr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/B978-0-444-63326-2.00004-1","article-title":"The role of calcium channel mutations in human epilepsy","volume":"213","author":"Gambardella","year":"2014","journal-title":"Prog. Brain Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1523\/JNEUROSCI.0183-22.2022","article-title":"Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses","volume":"42","author":"Zhang","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_89","unstructured":"Bkaily, G. (1994). Ionic Channles in Vascular Smooth Muscle, Landes Company."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.1097\/00005344-199506263-00091","article-title":"Endothelin-1 activates the R-type Ca2+ channel in vascular smooth-muscle cells","volume":"26","author":"Bkaily","year":"1995","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1023\/A:1006887714302","article-title":"Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein","volume":"183","author":"Bkaily","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1006840228104","article-title":"The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells","volume":"172","author":"Bkaily","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-540-74806-9_3","article-title":"Actions of anesthetics on excitatory transmitter-gated channels","volume":"182","author":"Akk","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0033583513000061","article-title":"Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: Insights from Torpedo postsynaptic membranes","volume":"46","author":"Unwin","year":"2013","journal-title":"Q. Rev. Biophys."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.6382611","article-title":"Acetylcholine receptor: An allosteric protein","volume":"225","author":"Changeux","year":"1984","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Zhao, L., Ma, Y., Song, X., Wu, Y., Jin, P., and Chen, G. (J. Pain, 2023). PD-1: A new candidate target for analgesic peptide design, J. Pain, in press.","DOI":"10.1016\/j.jpain.2023.02.002"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12576-022-00850-4","article-title":"Glycine and GABAA receptors suppressively regulate the inspiratory-related calcium rise in the thoracic inspiratory cells of the neonatal rat","volume":"72","author":"Mikami","year":"2022","journal-title":"J. Physiol. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceca.2004.09.001","article-title":"ATP and vasopressin activate a single type of store-operated Ca2+ channel, identified by patch-clamp recording, in rat hepatocytes","volume":"37","author":"Rychkov","year":"2005","journal-title":"Cell Calcium"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1016\/S0021-9258(18)47626-0","article-title":"Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels","volume":"262","author":"Yamaguchi","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/gb-2011-12-3-218","article-title":"The transient receptor potential family of ion channels","volume":"12","author":"Nilius","year":"2011","journal-title":"Genome Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1523\/JNEUROSCI.2080-19.2023","article-title":"Mechanisms That Underlie Expression of Estradiol-Induced Excitatory Synaptic Potentiation in the Hippocampus Differ between Males and Females","volume":"43","author":"Jain","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Soda, T., Brunetti, V., Berra-Romani, R., and Moccia, F. (2023). The Emerging Role of N-Methyl-D-Aspartate (NMDA) Receptors in the Cardiovascular System: Physiological Implications, Pathological Consequences, and Therapeutic Perspectives. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043914"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/aps.2015.126","article-title":"The functions of TRPP2 in the vascular system","volume":"37","author":"Du","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"29488","DOI":"10.1074\/jbc.M504359200","article-title":"Organic cation permeation through the channel formed by polycystin-2","volume":"280","author":"Anyatonwu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"17232","DOI":"10.1074\/jbc.M112.354613","article-title":"Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating","volume":"287","author":"Petri","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"24959","DOI":"10.1074\/jbc.M105084200","article-title":"Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity","volume":"277","author":"Batelli","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biochi.2012.10.004","article-title":"TRPC1 protein forms only one type of native store-operated channels in HEK293 cells","volume":"95","author":"Skopin","year":"2013","journal-title":"Biochimie"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/bbrc.2001.4554","article-title":"Polycystin-2 is a novel cation channel implicated in defective intracellular Ca2+ homeostasis in polycystic kidney disease","volume":"282","author":"Vassilev","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/FJC.0000000000000398","article-title":"N-Methyl-D-Aspartate Receptor Signaling and Function in Cardiovascular Tissues","volume":"68","author":"McGee","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_110","first-page":"e2363","article-title":"Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant","volume":"113","author":"Lv","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_111","unstructured":"Aur\u00e9lie, G.P. (2007). Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades, CRC Press\/Taylor & Francis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"19987","DOI":"10.1074\/jbc.M312031200","article-title":"Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812","volume":"279","author":"Cai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1073\/pnas.98.3.1182","article-title":"Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel","volume":"98","author":"Kim","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb754","article-title":"Polycystin-2 is an intracellular calcium release channel","volume":"4","author":"Koulen","year":"2002","journal-title":"Nat. Cell. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1128\/MCB.23.7.2600-2607.2003","article-title":"Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia","volume":"23","author":"Luo","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1128\/MCB.25.18.8285-8298.2005","article-title":"PKD2 functions as an epidermal growth factor-activated plasma membrane channel","volume":"25","author":"Ma","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1681\/ASN.2004121146","article-title":"Nonspecific cation current associated with native polycystin-2 in HEK-293 cells","volume":"17","author":"Pelucchi","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.90277.2008","article-title":"Function and regulation of TRPP2 at the plasma membrane","volume":"297","author":"Tsiokas","year":"2009","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Wang, Q., Dai, X.Q., Li, Q., Wang, Z., Cantero Mdel, R., Li, S., Shen, J., Tu, J.C., Cantiello, H., and Chen, X.Z. (2012). Structural interaction and functional regulation of polycystin-2 by filamin. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040448"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1074\/jbc.M209996200","article-title":"Polycystin-1 activates and stabilizes the polycystin-2 channel","volume":"278","author":"Xu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"904881","DOI":"10.3389\/fcvm.2022.904881","article-title":"Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure","volume":"9","author":"Ding","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"102075","DOI":"10.1016\/j.ceca.2019.102075","article-title":"Recent progress in structural studies on canonical TRP ion channels","volume":"83","author":"Guo","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1540\/jsmr.58.50","article-title":"Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension","volume":"58","author":"Hiraishi","year":"2022","journal-title":"J. Smooth Muscle Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1113\/JP281104","article-title":"NMDA receptor membrane dynamics tunes the firing pattern of midbrain dopaminergic neurons","volume":"599","author":"Etchepare","year":"2021","journal-title":"J. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/molpharm.120.000218","article-title":"The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1\/GluN2A N-Methyl-d-Aspartate Receptors","volume":"99","author":"Perszyk","year":"2021","journal-title":"Mol. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Naz, R., Khan, A., Alghamdi, B.S., Ashraf, G.M., Alghanmi, M., Ahmad, A., Bashir, S.S., and Haq, Q.M.R. (2022). An Insight into Animal Glutamate Receptors Homolog of Arabidopsis thaliana and Their Potential Applications\u2014A Review. Plants, 11.","DOI":"10.3390\/plants11192580"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Gallo, S., Vitacolonna, A., and Crepaldi, T. (2023). NMDA Receptor and Its Emerging Role in Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032540"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fncel.2015.00135","article-title":"Cross-talk and regulation between glutamate and GABAB receptors","volume":"9","author":"Kantamneni","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ceca.2016.09.005","article-title":"Fast interaction between AMPA and NMDA receptors by intracellular calcium","volume":"60","author":"Rozov","year":"2016","journal-title":"Cell Calcium"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1523\/JNEUROSCI.17-01-00058.1997","article-title":"Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition","volume":"17","author":"Swanson","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41586-022-04637-w","article-title":"Opening of glutamate receptor channel to subconductance levels","volume":"605","author":"Yelshanskaya","year":"2022","journal-title":"Nature"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Miehl, C., and Gjorgjieva, J. (2022). Stability and learning in excitatory synapses by nonlinear inhibitory plasticity. PLoS Comput. Biol., 18.","DOI":"10.1101\/2022.03.28.486052"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fncel.2014.00401","article-title":"The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity","volume":"8","author":"Chater","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"102194","DOI":"10.1016\/j.ceca.2020.102194","article-title":"Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain","volume":"87","author":"Formisano","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.82.6.657","article-title":"Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes","volume":"82","author":"Yao","year":"1998","journal-title":"Circ. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00424-013-1405-y","article-title":"Sodium-calcium exchangers (NCX): Molecular hallmarks underlying the tissue-specific and systemic functions","volume":"466","author":"Khananshvili","year":"2014","journal-title":"Pflugers Arch."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Khananshvili, D. (2022). Structure-Based Function and Regulation of NCX Variants: Updates and Challenges. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010061"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1002\/cphy.c200031","article-title":"The Cardiac Na+-Ca2+ Exchanger: From Structure to Function","volume":"12","author":"Ottolia","year":"2021","journal-title":"Compr. Physiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"C415","DOI":"10.1152\/ajpcell.1998.274.2.C415","article-title":"Functional comparison of the three isoforms of the Na+\/Ca2+ exchanger (NCX1, NCX2, NCX3)","volume":"274","author":"Linck","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: Its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1016\/S0021-9258(17)37667-6","article-title":"Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na\/Ca exchanger","volume":"269","author":"Kofuji","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"C1250","DOI":"10.1152\/ajpcell.1997.272.4.C1250","article-title":"Tissue specificity and alternative splicing of the Na+\/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat","volume":"272","author":"Quednau","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/112_2015_23","article-title":"Towards Understanding the Role of the Na\u00b2\u207a-Ca\u00b2\u207a Exchanger Isoform 3","volume":"168","author":"Michel","year":"2015","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"11293","DOI":"10.1074\/jbc.M113.529388","article-title":"Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle","volume":"289","author":"Michel","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jocn.2006.07.013","article-title":"The role of the Na+\/Ca2+ exchanger (NCX) in neurons following ischaemia","volume":"14","author":"Jeffs","year":"2007","journal-title":"J. Clin. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.1016\/S0021-9258(17)36540-7","article-title":"Tissue-specific expression of Na+-Ca2+ exchanger isoforms","volume":"269","author":"Lee","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yjmcc.2013.06.001","article-title":"Na\/Ca exchange and contraction of the heart","volume":"61","author":"Ottolia","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1113\/jphysiol.1994.sp020037","article-title":"Local control of excitation-contraction coupling in rat heart cells","volume":"474","author":"Wier","year":"1994","journal-title":"J. Physiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1126\/science.2158147","article-title":"The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes","volume":"248","author":"Bridge","year":"1990","journal-title":"Science"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1139\/cjpp-2015-0107","article-title":"Na+-H(+) exchanger inhibitor prevents early death in hereditary cardiomyopathy","volume":"93","author":"Bkaily","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1139\/cjpp-2017-0265","article-title":"Na+-H(+) exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies","volume":"95","author":"Bkaily","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Tappia, P.S., Shah, A.K., Ramjiawan, B., and Dhalla, N.S. (2022). Modification of Ischemia\/Reperfusion-Induced Alterations in Subcellular Organelles by Ischemic Preconditioning. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073425"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.yjmcc.2005.01.003","article-title":"NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: Prevention by NHE-1 inhibitor","volume":"38","author":"Chahine","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"17230","DOI":"10.1021\/bi981521q","article-title":"Protein kinase C-dependent regulation of Na+\/Ca2+ exchanger isoforms NCX1 and NCX3 does not require their direct phosphorylation","volume":"37","author":"Iwamoto","year":"1998","journal-title":"Biochemistry"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"13609","DOI":"10.1074\/jbc.271.23.13609","article-title":"Phosphorylation-dependent regulation of cardiac Na+\/Ca2+ exchanger via protein kinase C","volume":"271","author":"Iwamoto","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"31650","DOI":"10.1074\/jbc.R112.355867","article-title":"Molecular identity and functional properties of the mitochondrial Na+\/Ca2+ exchanger","volume":"287","author":"Palty","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1073\/pnas.0908099107","article-title":"NCLX is an essential component of mitochondrial Na+\/Ca2+ exchange","volume":"107","author":"Palty","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2019.01.009","article-title":"Functional properties and mode of regulation of the mitochondrial Na+\/Ca2+ exchanger, NCLX","volume":"94","author":"Kostic","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00424-012-1122-y","article-title":"Mitochondrial Ca\u00b2\u207a homeostasis: Mechanism, role, and tissue specificities","volume":"464","author":"Pizzo","year":"2012","journal-title":"Pflugers Arch."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1038\/srep02766","article-title":"The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes","volume":"3","author":"Takeuchi","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Takeuchi, A., and Matsuoka, S. (2021). Physiological and Pathophysiological Roles of Mitochondrial Na+-Ca2+ Exchanger, NCLX, in Hearts. Biomolecules, 11.","DOI":"10.3390\/biom11121876"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/164_2017_1","article-title":"The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology","volume":"240","author":"Mishra","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1113\/jphysiol.2014.282319","article-title":"Na+\/Ca2+ exchange and Na+\/K+-ATPase in the heart","volume":"593","author":"Shattock","year":"2015","journal-title":"J. Physiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1105565","DOI":"10.3389\/fcell.2023.1105565","article-title":"Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension","volume":"11","author":"Breault","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.bbamcr.2015.04.008","article-title":"Structure and function of the mitochondrial calcium uniporter complex","volume":"1853","author":"Patron","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"7102","DOI":"10.1111\/jcmm.15341","article-title":"Mitochondrial ion channels as targets for cardioprotection","volume":"24","author":"Hausenloy","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"123755","DOI":"10.1016\/j.ijbiomac.2023.123755","article-title":"Mitochondrial cristae in health and disease","volume":"235","author":"Huang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e13946","DOI":"10.1111\/apha.13946","article-title":"Targeting the mitochondrial Ca2+ uniporter complex in cardiovascular disease","volume":"237","author":"Lozano","year":"2023","journal-title":"Acta Physiol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Ashok, D., Papanicolaou, K., Sidor, A., Wang, M., Solhjoo, S., Liu, T., and O\u2019Rourke, B. (2023). Mitochondrial Membrane Potential Instability on Reperfusion After Ischemia Does Not Depend on Mitochondrial Ca2+ Uptake. J. Biol. Chem., 104708.","DOI":"10.1016\/j.jbc.2023.104708"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"131369","DOI":"10.1016\/j.jhazmat.2023.131369","article-title":"Upregulation of mitochondrial calcium uniporter contributes to paraquat-induced neuropathology linked to Parkinson\u2019s disease via imbalanced OPA1 processing","volume":"453","author":"Duan","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_171","first-page":"1155","article-title":"Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review)","volume":"54","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e2217665120","DOI":"10.1073\/pnas.2217665120","article-title":"Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex","volume":"120","author":"Tsai","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e13951","DOI":"10.1111\/eci.13951","article-title":"CERS6 antisense RNA 1 promotes colon cancer via upregulating mitochondrial calcium uniporter","volume":"53","author":"Yu","year":"2023","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"C755","DOI":"10.1152\/ajpcell.1990.258.5.C755","article-title":"Mechanisms by which mitochondria transport calcium","volume":"258","author":"Gunter","year":"1990","journal-title":"Am. J. Physiol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"a004168","DOI":"10.1101\/cshperspect.a004168","article-title":"The plasma membrane Ca2+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium","volume":"3","author":"Brini","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Krebs, J. (2022). Structure, Function and Regulation of the Plasma Membrane Calcium Pump in Health and Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031027"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF01901136","article-title":"ATP-dependent Ca++-extrusion from human red cells","volume":"22","author":"Schatzmann","year":"1966","journal-title":"Experientia"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Cha\u0142upnik, P., and Szyma\u0144ska, E. (2023). Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031908"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/BST20220827","article-title":"The role of post-translational modifications in synaptic AMPA receptor activity","volume":"51","author":"Corti","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.abb.2008.02.026","article-title":"The plasma membrane Ca2+ ATPase of animal cells: Structure, function and regulation","volume":"476","author":"Domi","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Golubeva, E.A., Lavrov, M.I., Radchenko, E.V., and Palyulin, V.A. (2022). Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects. Biomolecules, 13.","DOI":"10.3390\/biom13010056"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4157(95)00017-8","article-title":"Structural organization, ion transport, and energy transduction of P-type ATPases","volume":"1286","author":"Juul","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/35015017","article-title":"Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution","volume":"405","author":"Toyoshima","year":"2000","journal-title":"Nature"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ceca.2005.06.032","article-title":"Exporting calcium from cells","volume":"38","author":"Guerini","year":"2005","journal-title":"Cell Calcium"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0021-9258(18)45848-6","article-title":"The Ca2+ pump of the plasma membrane","volume":"267","author":"Carafoli","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1742-4658.2005.04546.x","article-title":"Calcium\u2014A universal carrier of biological signals. Delivered on 3 July 2003 at the Special FEBS Meeting in Brussels","volume":"272","author":"Carafoli","year":"2005","journal-title":"FEBS J."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/jappl.2001.91.3.1438","article-title":"Invited review: Mechanisms of calcium handling in smooth muscles","volume":"91","author":"Sanders","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.14.3.389","article-title":"Adenosine triphosphate-linked concentration of calcium ions in a particulate fraction of rabbit muscle","volume":"14","author":"Ebashi","year":"1962","journal-title":"J. Cell Biol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"C382","DOI":"10.1152\/ajpcell.00198.2021","article-title":"Role of SERCA and sarcolipin in adaptive muscle remodeling","volume":"322","author":"Chambers","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Nemirovskaya, T.L., and Sharlo, K.A. (2022). Roles of ATP and SERCA in the Regulation of Calcium Turnover in Unloaded Skeletal Muscles: Current View and Future Directions. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136937"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e2200052","DOI":"10.1002\/bies.202200052","article-title":"Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump","volume":"44","author":"Zhang","year":"2022","journal-title":"Bioessays"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-3-030-12457-1_6","article-title":"A Role for SERCA Pumps in the Neurobiology of Neuropsychiatric and Neurodegenerative Disorders","volume":"1131","author":"Britzolaki","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"C843","DOI":"10.1152\/ajpcell.2001.280.4.C843","article-title":"Regulation of SERCA Ca2+ pump expression by cytoplasmic Ca2+ in vascular smooth muscle cells","volume":"280","author":"Wu","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Jaskulska, A., Janecka, A.E., and Gach-Janczak, K. (2020). Thapsigargin-From Traditional Medicine to Anticancer Drug. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010004"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ceca.2017.07.001","article-title":"SERCA control of cell death and survival","volume":"69","author":"Chemaly","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Dhalla, N.S., Elimban, V., Bartekova, M., and Adameova, A. (2022). Involvement of Oxidative Stress in the Development of Subcellular Defects and Heart Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020393"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1983.245.1.C1","article-title":"Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum","volume":"245","author":"Fabiato","year":"1983","journal-title":"Am. J. Physiol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1749-6632.1978.tb41979.x","article-title":"Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat, and frog hearts and from fetal and new-born rat ventricles","volume":"307","author":"Fabiato","year":"1978","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"15637","DOI":"10.1016\/S0021-9258(18)47774-5","article-title":"Isolation of the ryanodine receptor from cardiac sarcoplasmic reticulum and identity with the feet structures","volume":"262","author":"Inui","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0166-2236(88)90198-1","article-title":"Ryanodine receptor channel of sarcoplasmic reticulum","volume":"11","author":"Fill","year":"1988","journal-title":"Trends Neurosci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1085\/jgp.96.2.439","article-title":"Actions of ryanodine","volume":"96","author":"Sutko","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1152\/physrev.1977.57.1.71","article-title":"Calcium release from the sarcoplasmic reticulum","volume":"57","author":"Endo","year":"1977","journal-title":"Physiol. Rev."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Dhalla, N.S.R., Angel, A., and Pierce, G.N. (2004). Pathophysiology of Cardiovascular Disease, Kluwer Academic Publishers.","DOI":"10.1007\/978-1-4615-0453-5"},{"key":"ref_204","first-page":"679","article-title":"Characterization of multiple [3H]ryanodine binding sites on the Ca2+ release channel of sarcoplasmic reticulum from skeletal and cardiac muscle: Evidence for a sequential mechanism in ryanodine action","volume":"39","author":"Pessah","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1124\/pr.56.4.1","article-title":"Pharmacological modulation of sarcoplasmic reticulum function in smooth muscle","volume":"56","author":"Laporte","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1006\/bbrc.1995.2536","article-title":"Multiple types of ryanodine receptor\/Ca2+ release channels are expressed in vascular smooth muscle","volume":"215","author":"Neylon","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0143416002001987","article-title":"Molecular genetics of ryanodine receptors Ca2+-release channels","volume":"32","author":"Rossi","year":"2002","journal-title":"Cell Calcium"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1033300","DOI":"10.3389\/fphys.2022.1033300","article-title":"Ablation of Calsequestrin-1, Ca2+ unbalance, and susceptibility to heat stroke","volume":"13","author":"Protasi","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-3-030-67696-4_11","article-title":"IP(3) Receptor Biology and Endoplasmic Reticulum Calcium Dynamics in Cancer","volume":"59","author":"Parys","year":"2021","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/325159a0","article-title":"Inositol trisphosphate receptor localization in brain: Variable stoichiometry with protein kinase C","volume":"325","author":"Worley","year":"1987","journal-title":"Nature"},{"key":"ref_211","first-page":"423","article-title":"Molecular and functional diversity of inositol triphosphate-induced Ca2+ release","volume":"57","author":"Parys","year":"1995","journal-title":"Verh. K. Acad. Geneeskd. Belg."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1054\/ceca.1999.0021","article-title":"Molecular properties of inositol 1,4,5-trisphosphate receptors","volume":"25","author":"Patel","year":"1999","journal-title":"Cell Calcium"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ceca.2007.05.010","article-title":"Ion channels in smooth muscle: Regulation by the sarcoplasmic reticulum and mitochondria","volume":"42","author":"Chalmers","year":"2007","journal-title":"Cell Calcium"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/339468a0","article-title":"Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons","volume":"339","author":"Ross","year":"1989","journal-title":"Nature"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/306067a0","article-title":"Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate","volume":"306","author":"Streb","year":"1983","journal-title":"Nature"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature01268","article-title":"Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand","volume":"420","author":"Bosanac","year":"2002","journal-title":"Nature"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1529\/biophysj.106.088880","article-title":"The number and spatial distribution of IP3 receptors underlying calcium puffs in Xenopus oocytes","volume":"91","author":"Shuai","year":"2006","journal-title":"Biophys. J."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Magistroni, R., Mangolini, A., Guzzo, S., Testa, F., Rapan\u00e0, M.R., Mignani, R., Russo, G., di Virgilio, F., and Aguiari, G. (2019). TRPP2 dysfunction decreases ATP-evoked calcium, induces cell aggregation and stimulates proliferation in T lymphocytes. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1540-6"},{"key":"ref_219","first-page":"618","article-title":"Action of calcium ions on the duration of the action potential of the ventricular fiber of the rat and guinea pig","volume":"57","author":"Guilbault","year":"1965","journal-title":"J. Physiol."},{"key":"ref_220","first-page":"761","article-title":"Iproveratril: Experimental data on coronary dilatation and antiarrhythmic action","volume":"90","author":"Melville","year":"1964","journal-title":"Can. Med. Assoc. J."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.86.1.1","article-title":"Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology","volume":"86","author":"Bean","year":"1985","journal-title":"J. Gen. Physiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/j.1552-4604.1990.tb03454.x","article-title":"Experimental antiarteriosclerotic effects of calcium antagonists","volume":"30","author":"Fleckenstein","year":"1990","journal-title":"J. Clin. Pharmacol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00823597","article-title":"Diltiazem and verapamil prevent vitamin D3-induced myocardial calcium overload in rat papillary muscle: Assessment with PVC ETH-123 calcium-selective microelectrodes","volume":"10","author":"Gasser","year":"1996","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_224","first-page":"309","article-title":"Drug Action and Cellular Calcium Regulation","volume":"16","author":"Janis","year":"1987","journal-title":"Adv. Drug Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2147\/JMDH.S374887","article-title":"Calcium Channel Blocker Toxicity: A Practical Approach","volume":"15","author":"Alshaya","year":"2022","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1989.tb24074.x","article-title":"Molecular properties of dihydropyridine-sensitive calcium channels","volume":"560","author":"Catterall","year":"1989","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/mol.114.097659","article-title":"Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels","volume":"88","author":"Catterall","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"ref_228","first-page":"S13","article-title":"Protective effects of various calcium antagonists against experimental arteriosclerosis","volume":"6","author":"Frey","year":"1992","journal-title":"J. Hum. Hypertens"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"C607","DOI":"10.1152\/ajpcell.1989.257.4.C607","article-title":"Differential blockade of agonist- and depolarization-induced 45Ca2+ influx in smooth muscle cells","volume":"257","author":"Cauvin","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/10739680600930347","article-title":"Ca2+ signaling, TRP channels, and endothelial permeability","volume":"13","author":"Tiruppathi","year":"2006","journal-title":"Microcirculation"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2011.11.044","article-title":"Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood-brain barrier endothelial cells","volume":"1436","author":"Berrout","year":"2012","journal-title":"Brain Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s10072-022-06586-8","article-title":"Anti-dementia drugs: A descriptive study of the prescription pattern in Italy","volume":"44","author":"Ippoliti","year":"2023","journal-title":"Neurol. Sci."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"121509","DOI":"10.1016\/j.lfs.2023.121509","article-title":"A novel approach to repositioning memantine for metabolic syndrome-induced steatohepatitis: Modulation of hepatic autophagy, inflammation, and fibrosis","volume":"319","author":"Zakaria","year":"2023","journal-title":"Life Sci."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1046\/j.1471-4159.1996.67010317.x","article-title":"Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer\u2019s disease","volume":"67","author":"Matsushima","year":"1996","journal-title":"J. Neurochem."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/13543784.2016.1241764","article-title":"Investigational calcium channel blockers for the treatment of hypertension","volume":"25","author":"Tamargo","year":"2016","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bbamem.2012.11.019","article-title":"The \u03b12\u03b4 subunits of voltage-gated calcium channels","volume":"1828","author":"Dolphin","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00424-008-0491-8","article-title":"The non-excitable smooth muscle: Calcium signaling and phenotypic switching during vascular disease","volume":"456","author":"House","year":"2008","journal-title":"Pflugers Arch."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1874467208666150507105845","article-title":"Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?","volume":"8","author":"Striessnig","year":"2015","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/19336950.2019.1688910","article-title":"Elementary calcium signaling in arterial smooth muscle","volume":"13","author":"Fan","year":"2019","journal-title":"Channels"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.lfs.2012.01.007","article-title":"GPER regulates endothelin-dependent vascular tone and intracellular calcium","volume":"91","author":"Meyer","year":"2012","journal-title":"Life Sci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000354252","article-title":"The G protein-coupled estrogen receptor 1 (GPER1\/GPR30) agonist G-1 regulates vascular smooth muscle cell Ca\u00b2\u207a handling","volume":"50","author":"Holm","year":"2013","journal-title":"J. Vasc. Res."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Bkaily, G., Simon, Y., Normand, A., Jazzar, A., Najibeddine, H., Khalil, A., and Jacques, D. (2022). Short-Communication: Short-Term Treatment with Taurine Prevents the Development of Cardiac Hypertrophy and Early Death in Hereditary Cardiomyopathy of the Hamster and Is Sex-Dependent. Nutrients, 14.","DOI":"10.3390\/nu14163287"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1139\/y03-021","article-title":"Isradipine prevents the development of spontaneously occurring cardiac necrosis in cardiomyopathic hamster","volume":"81","author":"Jacques","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pupt.2008.09.006","article-title":"Ion channel regulation of intracellular calcium and airway smooth muscle function","volume":"22","author":"Karner","year":"2009","journal-title":"Pulm Pharmacol. Ther."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1172\/JCI119146","article-title":"Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide","volume":"99","author":"Quignard","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Berridge, M.J. (2001). The versatility and complexity of calcium signalling. Novartis Found Symp., 239.","DOI":"10.1002\/0470846674.ch6"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Bager, J.E., Manhem, K., Andersson, T., Hjerpe, P., Bengtsson-Bostr\u00f6m, K., Ljungman, C., and Mourtzinis, G. (2023). Hypertension: Sex-related differences in drug treatment, prevalence and blood pressure control in primary care. J. Hum. Hypertens., 1\u20139.","DOI":"10.1038\/s41371-023-00801-5"},{"key":"ref_248","unstructured":"Vanhoutte, P.M. (1981). New Perspectives on Calcium Antagonists, American Physiological Society."},{"key":"ref_249","unstructured":"Rubin, R.P. (1981). New Perspectives on Calcium Antagonists, American Physiological Society."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"C119","DOI":"10.1152\/ajpcell.2001.280.1.C119","article-title":"Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells","volume":"280","author":"Yingst","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1073\/pnas.0936131100","article-title":"Nifedipine facilitates neurotransmitter release independently of calcium channels","volume":"100","author":"Hirasawa","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"2185457","DOI":"10.1080\/08037051.2023.2185457","article-title":"What is resistant arterial hypertension?","volume":"32","author":"Shalaeva","year":"2023","journal-title":"Blood Press."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1139\/cjpp-2019-0313","article-title":"Taurine and cardiac disease: State of the art and perspectives","volume":"98","author":"Bkaily","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Jazzar, A., Jacques, D., and Bkaily, G. (2021). Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via beta-alanine-Sensitive Na+-Taurine Symporter. Nutrients, 13.","DOI":"10.3390\/nu13113686"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2007.06.033","article-title":"Characterization of SN-6, a novel Na+\/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes","volume":"573","author":"Niu","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Bkaily, G., Simon, Y., Jazzar, A., Najibeddine, H., Normand, A., and Jacques, D. (2021). High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080883"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1073\/pnas.1816685116","article-title":"Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic","volume":"116","author":"Batiste","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"102356","DOI":"10.1016\/j.coph.2023.102356","article-title":"Drug development for the treatment of RyR1-related skeletal muscle diseases","volume":"69","author":"Murayama","year":"2023","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrc3803","article-title":"Mitochondrial ROS in cancer: Initiators, amplifiers or an Achilles\u2019 heel?","volume":"14","author":"Sabharwal","year":"2014","journal-title":"Nat. Rev. Cancer"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/10\/8803\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:35:36Z","timestamp":1760124936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/10\/8803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":259,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["ijms24108803"],"URL":"https:\/\/doi.org\/10.3390\/ijms24108803","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]}}}