{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:56:07Z","timestamp":1784346967099,"version":"3.55.0"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2016R1C1B2016274, 2021R1A2C1012846 and 2021R1I1A1A01059706"],"award-info":[{"award-number":["NRF-2016R1C1B2016274, 2021R1A2C1012846 and 2021R1I1A1A01059706"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease and Parkinson\u2019s disease are the two most common neurodegenerative diseases in the world, and their incidence rates are increasing as our society ages. This creates a significant social and economic burden. Although the exact cause and treatment methods for these diseases are not yet known, research suggests that Alzheimer\u2019s disease is caused by amyloid precursor protein, while \u03b1-synuclein acts as a causative agent in Parkinson\u2019s disease. The accumulation of abnormal proteins such as these can lead to symptoms such as loss of protein homeostasis, mitochondrial dysfunction, and neuroinflammation, which ultimately result in the death of nerve cells and the progression of neurodegenerative diseases. The medications currently available for these diseases only delay their progression and have many adverse effects, which has led to increased interest in developing natural products with fewer adverse effects. In this study, we selected specific keywords and thesis content to investigate natural products that are effective in treating Alzheimer\u2019s and Parkinson\u2019s diseases. We reviewed 16 papers on natural products and found that they showed promising mechanisms of action such as antioxidant, anti-inflammatory, and mitochondrial function improvement. Other natural products with similar properties could also be considered potential treatments for neurodegenerative diseases, and they can be consumed as part of a healthy diet rather than as medicine.<\/jats:p>","DOI":"10.3390\/ijms24108827","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:04:05Z","timestamp":1684289045000},"page":"8827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Natural Products as the Potential to Improve Alzheimer\u2019s and Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-0280","authenticated-orcid":false,"given":"Sung Wook","family":"Kim","sequence":"first","affiliation":[{"name":"College of Korea Medicine, Woosuk University, Jeonju-si 54986, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Korea Medicine, Woosuk University, Jeonju-si 54986, Republic of Korea"},{"name":"Da Capo Co., Ltd., Jeonju-si 54986, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-4468","authenticated-orcid":false,"given":"Bumjung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oriental Health Management, Kyung Hee Cyber University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabsik","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Korea Medicine, Woosuk University, Jeonju-si 54986, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Uk","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Korea Medicine, Woosuk University, Jeonju-si 54986, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/j.1582-4934.2008.00402.x","article-title":"Neuronal cell death in neurodegenerative diseases: Recurring themes around protein handling","volume":"12","author":"Gorman","year":"2008","journal-title":"J. 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