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of British Columbia","award":["FRN-143345"],"award-info":[{"award-number":["FRN-143345"]}]},{"name":"University of British Columbia","award":["FRN-183775"],"award-info":[{"award-number":["FRN-183775"]}]},{"name":"University of British Columbia","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"University of British Columbia","award":["88887.691765\/2022-00"],"award-info":[{"award-number":["88887.691765\/2022-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Liquid biopsies have emerged as a promising tool for the detection of metastases as well as local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a patient\u2019s blood, urine, or other body fluids for the detection of biomarkers, including circulating tumor cells or tumor-derived DNA\/RNA that have been shed into the bloodstream. Studies have shown that liquid biopsies can detect lung cancer metastases with high accuracy and sensitivity, even before they are visible on imaging scans. Such tests are valuable for early intervention and personalized treatment, aiming to improve patient outcomes. Liquid biopsies are also minimally invasive compared to traditional tissue biopsies, which require the removal of a sample of the tumor for further analysis. This makes liquid biopsies a more convenient and less risky option for patients, particularly those who are not good candidates for invasive procedures due to other medical conditions. While liquid biopsies for lung cancer metastases and relapse are still being developed and validated, they hold great promise for improving the detection and treatment of this deadly disease. Herein, we summarize available and novel approaches to liquid biopsy tests for lung cancer metastases and recurrence detection and describe their applications in clinical practice.<\/jats:p>","DOI":"10.3390\/ijms24108894","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:09:44Z","timestamp":1684397384000},"page":"8894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-1651","authenticated-orcid":false,"given":"Vanessa G. 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-4410","authenticated-orcid":false,"given":"Jessica","family":"Trejo","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Benard","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5177-0887","authenticated-orcid":false,"given":"Ana Laura","family":"Seneda","sequence":"additional","affiliation":[{"name":"Molecular Oncology Laboratory, Experimental Research Unit, School of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu, SP 18618-687, 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BC V5Z 1L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica N.","family":"Hasimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, Faculty of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathie","family":"Garnis","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada"},{"name":"Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan L.","family":"Lam","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of 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