{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:13:50Z","timestamp":1790014430295,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"budget theme on State Assignment","award":["122031700094-5"],"award-info":[{"award-number":["122031700094-5"]}]},{"name":"budget theme on State Assignment","award":["MK-1641.2022.3."],"award-info":[{"award-number":["MK-1641.2022.3."]}]},{"name":"President of the Russian Federation","award":["122031700094-5"],"award-info":[{"award-number":["122031700094-5"]}]},{"name":"President of the Russian Federation","award":["MK-1641.2022.3."],"award-info":[{"award-number":["MK-1641.2022.3."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The goal of the research was to study the levels of adipokines and their associations with unstable atherosclerotic plaques in patients with coronary atherosclerosis and abdominal obesity (AO). Methods: The study included 145 men aged 38\u201379 with atherosclerosis of the coronary arteries (CA) and stable angina pectoris II-III FC who were hospitalized for coronary bypass surgery (2011\u20132022). The final analysis included 116 patients. Notably, 70 men had stable plaques in the CA (of which 44.3% had AO), and 46 men had unstable plaques in the CA (of which 43.5% had AO). Adipocytokine levels were determined using multiplex analysis (Human Metabolic Hormone V3 panel). Results: In the subgroup of patients with unstable plaques, patients with AO had a GLP-1 level that was 1.5 times higher and a lipocalin-2 level that was 2.1 times lower, respectively. GLP-1 is direct, and lipocalin-2 is inversely associated with AO in patients with unstable plaques. Among patients with AO, the level of lipocalin-2 in patients with unstable plaques was 2.2 times lower than in patients with stable plaques in the CA. The level of lipocalin-2 was inversely associated with the presence of unstable atherosclerotic plaques in the CA. Conclusion: GLP-1 is directly associated with AO in patients with unstable atherosclerotic plaques. Lipocalin-2 is inversely associated with unstable atherosclerotic plaques in patients with AO.<\/jats:p>","DOI":"10.3390\/ijms24108937","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:09:44Z","timestamp":1684397384000},"page":"8937","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adipokine-Cytokine Profile in Patients with Unstable Atherosclerotic Plaques and Abdominal Obesity"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-4664","authenticated-orcid":false,"given":"Evgeniia V.","family":"Garbuzova (Striukova)","sequence":"first","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2013Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-2549","authenticated-orcid":false,"given":"Victoriya S.","family":"Shramko","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2013Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-4186","authenticated-orcid":false,"given":"Elena V.","family":"Kashtanova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2013Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-0280","authenticated-orcid":false,"given":"Yana V.","family":"Polonskaya","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2013Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-6540","authenticated-orcid":false,"given":"Ekaterina M.","family":"Stakhneva","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2013Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey V.","family":"Kurguzov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cNational Medical Research Center named after Academician E.N. Meshalkin\u201d Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-1258","authenticated-orcid":false,"given":"Ivan S.","family":"Murashov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cNational Medical Research Center named after Academician E.N. Meshalkin\u201d Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-3357","authenticated-orcid":false,"given":"Alexander M.","family":"Chernyavsky","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cNational Medical Research Center named after Academician E.N. Meshalkin\u201d Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-8362","authenticated-orcid":false,"given":"Yuliya I.","family":"Ragino","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2013Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.26442\/20751753.2021.4.200832","article-title":"Obesity. Clinical recommendations","volume":"23","author":"Dedov","year":"2021","journal-title":"Cons. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5114\/aoms.2013.33181","article-title":"Biochemistry of Adipose Tissue: An Endocrine Organ","volume":"9","author":"Coelho","year":"2013","journal-title":"Arch. Med. 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