{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:58:36Z","timestamp":1789765116589,"version":"4.0.1"},"reference-count":57,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Zielona Gora","award":["222267\/E-545\/S\/2019"],"award-info":[{"award-number":["222267\/E-545\/S\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aging-related anemia contributes to frailty syndrome, cognitive decline and early mortality. The study aim was to evaluate inflammaging in relation to anemia as a prognostic indicator in affected older patients. The participants (73.0 \u00b1 7.2 years) were allocated into anemic (n = 47) and non-anemic (n = 66) groups. The hematological variables RBC, MCV, MCH, RDW, iron and ferritin were significantly lower, whereas erythropoietin EPO and transferrin Tf tended toward higher values in the anemic group. Approx. 26% of individuals demonstrated transferrin saturation TfS &lt; 20%, which clearly indicates age-related iron deficiency. The cut-off values for pro-inflammatory cytokine IL-1\u03b2, TNF\u03b1 and hepcidin were 5.3 ng\/mL, 97.7 ng\/mL and 9.4 ng\/mL, respectively. High IL-1\u03b2 negatively affected Hb concentration (rs = \u22120.581, p &lt; 0.0001). Relatively high odds ratios were observed for IL-1\u03b2 (OR = 72.374, 95%Cl 19.688\u2013354.366) and peripheral blood mononuclear cells CD34 (OR = 3.264, 95%Cl 1.263\u20138.747) and CD38 (OR = 4.398, 95%Cl 1.701\u201311.906), which together indicates a higher probability of developing anemia. The results endorse the interplay between inflammatory status and iron metabolism and demonstrated a high usefulness of IL-1\u03b2 in identification of the underlying causes of anemia, while CD34 and CD38 appeared useful in compensatory response assessment and, in the longer term, as part of a comprehensive approach to anemia monitoring in older adults.<\/jats:p>","DOI":"10.3390\/ijms24108944","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:09:44Z","timestamp":1684397384000},"page":"8944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Inflammation in Age-Associated Changes in Red Blood System"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-2993","authenticated-orcid":false,"given":"Eryk","family":"Wacka","sequence":"first","affiliation":[{"name":"Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-5782","authenticated-orcid":false,"given":"Edyta","family":"Wawrzyniak-Gramacka","sequence":"additional","affiliation":[{"name":"Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tylutka","sequence":"additional","affiliation":[{"name":"Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-1886","authenticated-orcid":false,"given":"Barbara","family":"Morawin","sequence":"additional","affiliation":[{"name":"Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Gutowicz","sequence":"additional","affiliation":[{"name":"Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-9850","authenticated-orcid":false,"given":"Agnieszka","family":"Zembron-Lacny","sequence":"additional","affiliation":[{"name":"Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12185-012-1007-z","article-title":"Anemia and Mortality in Older Persons: Does the Type of Anemia Affect Survival?","volume":"95","author":"Shavelle","year":"2012","journal-title":"Int. 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